Overview

Also Known As: B6N, Black 6N

This is an NIH subline of C57BL/6. It was separated from C57BL/6J in 1951. Five SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. This strain does not have the deletion in the Nnt gene that has been found in the C57BL/6J strain (Stock No. 000664).

Genetic overview

Genetic Background	Generation
	Contact Technical Support (2018-07-27 00:00:00)

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Research Applications

Research Tools
Developmental Biology Research
Sensorineural Research
Cell Biology Research
Mouse/Human Gene Homologs

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Base Price

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$21.45 Domestic price for male 3-week

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Details

Important Note

This strain is homozygous for Crb1^rd8, the retinal degeneration 8 mutation. Photoreceptor degeneration is observed in spots, caused by retinal folds and pseudorosettes, found in the fundus of the eye.

Detailed Description

This is an NIH subline of C57BL/6. It was separated from C57BL/6J in 1951. 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. Both C57BL/6ByJ and C57BL/6NJ type as follows: 08-015199792-M (rs3709624) is C; 11-004367508-M (rs3659787) is A; 13-041017317-M (rs3722313) is C; 15-057561875-M (rs3702158) is G; 19-049914266-M (rs3724876) is T. C57BL/6J types as follows: 08-015199792-M is T; 11-004367508-M is G; 13-041017317-M is T; 15-057561875-M is A; 19-049914266-M is G (Petkov and Wiles 2005.) This strain does not have the deletion in the Nnt gene that has been found in the C57BL/6J strain (Stock No. 000664). C57BL/6NJ mice are homozygous for Cyfip2^M1N, a spontaneous mutation in the cytoplasmic FMR1 interacting protein 2 that results in an amino acid substitution of phenylalanine for serine at position 968 (S968F). The mutation is found in all C57BL/6N substrains but is not present in the C57BL/6J strain or substrains. The mutation results in 45% lower acute response to cocaine as measured by locomotor hyperactivity.

Development

In 1951 C57BL/6J, then at generation F32, were sent from The Jackson Laboratory to The National Institute of Health where they were maintained via sibling mating for decades. In 1980 this subline reached F126 and in 1984 embryos were cryopreserved at the NIH cryopreservation facility. In approximately 1994 some of these embryos were thawed and maintained via sibling mating and this subline was referred to as B6(e84) to specify that it derived from the embryos frozen in 1984. In September and October of 1997 a new set of embryos were cryopreserved from this thawed line by backcrossing +F6 females to their +F5 fathers. In 2005 some of these embryos frozen in 1997 were sent to The Jackson Laboratory where they were thawed and gave rise to C57BL/6NJ. Thus, C57BL/6NJ is devoid of mutations that may have arisen in any C57BL/6N sublines that remained on the shelf after the 1984 freeze. The embryos received by The Jackson Laboratory were thawed, the colony expanded, and re-frozen immediately. This strain is maintained with frequent replenishment from this frozen stock in order to arrest genetic drift.

Selected References

Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94PubMed: 21921910 MGI: J:177037
Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. 2013. C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science 342(6165):1508-12PubMed: 24357318 MGI: J:203183
Simon MM; Greenaway S; White JK; Fuchs H; Gailus-Durner V; Wells S; Sorg T; Wong K; Bedu E; Cartwright EJ; Dacquin R; Djebali S; Estabel J; Graw J; Ingham NJ; Jackson IJ; Lengeling A; Mandillo S; Marvel J; Meziane H; Preitner F; Puk O; Roux M; Adams DJ; Atkins S; Ayadi A; Becker L; Blake A; Brooker D; Cater H; Champy MF; Combe R; Danecek P; di Fenza A; Gates H; Gerdin AK; Golini E; Hancock JM; Hans W; Holter SM; Hough T; Jurdic P; Keane TM; Morgan H; Muller W; Neff F; Nicholson G; Pasche B; Roberson LA; R. 2013. A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol 14(7):R82PubMed: 23902802 MGI: J:220417
Fontaine DA; Davis DB. 2016. Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65(1):25-33PubMed: 26696638 MGI: J:231066
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295

View All References

Genetics

Crb1^rd8

Allele Symbol: Crb1^rd8

Allele Name	retinal degeneration 8
Allele Type	Spontaneous
Allele Synonym(s)	Crb1^rd8; retinal degeneration 8
Gene Symbol and Name	Crb1, crumbs family member 1, photoreceptor morphogenesis associated
Gene Synonym(s)	7530426H14Rik; A930008G09Rik; RIKEN cDNA 7530426H14 gene; RIKEN cDNA A930008G09 gene; LCA8; 7530426H14Rik; RP12; A930008G09Rik
Strain of Origin	C57BL/6By or C57BL/6N
Chromosome	1
Molecular Note	The mutation in the rd8 mouse has been identified as a single base deletion at nt3481 in the gene. This deletion causes a frame shift and a premature stop codon that truncates the transmembrane and cytoplasmic domain of the protein after amino acid 1207. This mutation has been found to be present in all sublines of C57BL/6N and in C57BL/6ByJ, but not in any C57BL/6J subline. It occurred sometime between transfer of mice from JAX to NIH, in 1951, and from NIH to Donald Bailey, in 1961.

Nlrp12^C57BL/6N

Allele Symbol: Nlrp12^C57BL/6N

Allele Name	C57BL/6N
Allele Type	Spontaneous (Not Applicable)
Allele Synonym(s)	Nlrp12^C57BL/6N; C57BL/6N
Gene Symbol and Name	Nlrp12, NLR family, pyrin domain containing 12
Gene Synonym(s)	FCAS2; Nalp12; NALP12; PYPAF7; PAN6; RNO2; RNO; CLR19.3; NACHT, LRR and PYD containing protein 12; Nalp12
Strain of Origin	C57BL/6N
Chromosome	7
Molecular Note	A sequence variant is identified in C57BL/6N (C) as compared to C57BL/6J (T) at position 3,222,538 (version mm9-NCB1m37). The polymorphism is located in the C-terminal leucine-rich repeat domain and results in a lysine to arginine change at amino acid residue 1034.

Cyfip2^M1N

Allele Symbol: Cyfip2^M1N

Allele Name	mutation 1, National Institutes of Health
Allele Type	Spontaneous
Allele Synonym(s)	mutation 1, National Institutes of Health; Cyfip2^M1N
Gene Symbol and Name	Cyfip2, cytoplasmic FMR1 interacting protein 2
Gene Synonym(s)	AU022376; expressed sequence AA930218; 6430511D02Rik; 1500004I01Rik; RIKEN cDNA 6430511D02 gene; expressed sequence AU022376; AA930218; 1500004I01Rik; PIR121; mKIAA1168; 6430511D02Rik; RIKEN cDNA 1500004I01 gene; Pir121; EIEE65
Strain of Origin	C57BL/6N
Chromosome	11
Molecular Note	An G to A mutation at 46,036,117 base pair (bp) of chromosome 11 (mm9) occured between 1961 and 1974 in the C57BL/6N strain that resulted in the amino acid substitution of phenylalanine for serine at position 968 (S968F). This mutation is found in all C57BL/6N substrains (C57BL/6NCrl, C57BL/6NTac and C57BL/6NJ) but is not present in the C57BL/6J strain or substrains (C57BL/6Ei, C57BL/6EiJ, C57BL/6ByJ and C57BL/6By). The mutation destabilizes the protein leading to decreased half-life.

Cox7a2l^s

Allele Symbol: Cox7a2l^s

Allele Name	short
Allele Type	Not Applicable (Not Specified)
Allele Synonym(s)	Cox7a2l^s; short
Gene Symbol and Name	Cox7a2l, cytochrome c oxidase subunit 7A2 like
Gene Synonym(s)	COX7RP; SIG-81; SIG81; silica-induced gene 81; Silg81; COX7AR; EB1
Strain of Origin	multiple strains
Chromosome	17
General Note	Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T⁺ Itpr3^tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.
Molecular Note	This allele contains a 6 bp microdeletion causing the loss of two amino acids and truncating the protein to 111 amino acids instead of 113 amino acids. It is found in BALB/cAnCrl, BALB/cJ, C57BL/6Cr, C57BL/6JCrl, C57BL/6JOlaHsd, C57BL/6NCrl, C57BL/6NJcl, C57BL/6NHsd, C57BL/6NTac, C57BL/6NJ, B6(CG)-Tyr/J, C57BL/6JClr, C57BL/6JArc, C57BL/6JJcl, C57BL/6JJmsSlc, C57BL/6JOla, C57BL/6JOlaHsd, C57BL/6JRcc, C57BL/6JRccHsd, C57BL/6JBom, and C57BL/6JBomTac mice.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- General Purpose

Genotype: Crb1^rd8 related

Developmental Biology Research
- Eye Defects
Sensorineural Research
- Retinal Degeneration
Cell Biology Research
- Defects in Cell Adhesion Molecules
Mouse/Human Gene Homologs
- Retinitis pigmentosa 12; Leber congenital amaurosis (CLA)

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Cdh23^ahl/Cdh23^ahl
C57BL/6NJ

hearing/vestibular/ear phenotype

cochlear hair cell degeneration
- degeneration of outer hair cells is more extensive than that of inner hair cells and losses of both are more severe in the base of the cochlea than in the apex

cochlear inner hair cell degeneration

cochlear outer hair cell degeneration

nervous system phenotype

cochlear hair cell degeneration
- degeneration of outer hair cells is more extensive than that of inner hair cells and losses of both are more severe in the base of the cochlea than in the apex

cochlear inner hair cell degeneration

cochlear outer hair cell degeneration

Phenotype Information

Body Weight Information - JAX^® Mice Strain C57BL/6NJ (005304)
Festing Inbred Strain Characteristics: C57BL

References

Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94PubMed: 21921910 MGI: J:177037
Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. 2013. C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science 342(6165):1508-12PubMed: 24357318 MGI: J:203183
Simon MM; Greenaway S; White JK; Fuchs H; Gailus-Durner V; Wells S; Sorg T; Wong K; Bedu E; Cartwright EJ; Dacquin R; Djebali S; Estabel J; Graw J; Ingham NJ; Jackson IJ; Lengeling A; Mandillo S; Marvel J; Meziane H; Preitner F; Puk O; Roux M; Adams DJ; Atkins S; Ayadi A; Becker L; Blake A; Brooker D; Cater H; Champy MF; Combe R; Danecek P; di Fenza A; Gates H; Gerdin AK; Golini E; Hancock JM; Hans W; Holter SM; Hough T; Jurdic P; Keane TM; Morgan H; Muller W; Neff F; Nicholson G; Pasche B; Roberson LA; R. 2013. A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol 14(7):R82PubMed: 23902802 MGI: J:220417
Fontaine DA; Davis DB. 2016. Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65(1):25-33PubMed: 26696638 MGI: J:231066
Timmermans S; Van Montagu M; Libert C. 2017. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A 114(34):9158-9163PubMed: 28784771 MGI: J:244295

Additional References

Toye AA; Lippiat JD; Proks P; Shimomura K; Bentley L; Hugill A; Mijat V; Goldsworthy M; Moir L; Haynes A; Quarterman J; Freeman HC; Ashcroft FM; Cox RD. 2005. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48(4):675-86PubMed: 15729571 MGI: J:106692
Fahlstrom A; Yu Q; Ulfhake B. 2011. Behavioral changes in aging female C57BL/6 mice. Neurobiol Aging 32(10):1868-80PubMed: 20005598 MGI: J:176712
Ulland TK; Jain N; Hornick EE; Elliott EI; Clay GM; Sadler JJ; Mills KA; Janowski AM; Volk AP; Wang K; Legge KL; Gakhar L; Bourdi M; Ferguson PJ; Wilson ME; Cassel SL; Sutterwala FS. 2016. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun 7:13180PubMed: 27779193 MGI: J:238047
Kirkpatrick SL; Bryant CD. 2014. Behavioral architecture of opioid reward and aversion in C57BL/6 substrains. Front Behav Neurosci 8:450PubMed: 25628547 MGI: J:244302
Mekada K; Hirose M; Murakami A; Yoshiki A. 2015. Development of SNP markers for C57BL/6N-derived mouse inbred strains. Exp Anim 64(1):91-100PubMed: 25341966 MGI: J:262268
Hull RL; Willard JR; Struck MD; Barrow BM; Brar GS; Andrikopoulos S; Zraika S. 2017. High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains. J Endocrinol 233(1):53-64PubMed: 28138002 MGI: J:266358
Moore BA; Roux MJ; Sebbag L; Cooper A; Edwards SG; Leonard BC; Imai DM; Griffey S; Bower L; Clary D; Lloyd KCK; Herault Y; Thomasy SM; Murphy CJ; Moshiri A. 2018. A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice. Invest Ophthalmol Vis Sci 59(6):2252-2261PubMed: 29847629 MGI: J:267615
Lilue J; Doran AG; Fiddes IT; Abrudan M; Armstrong J; Bennett R; Chow W; Collins J; Collins S; Czechanski A; Danecek P; Diekhans M; Dolle DD; Dunn M; Durbin R; Earl D; Ferguson-Smith A; Flicek P; Flint J; Frankish A; Fu B; Gerstein M; Gilbert J; Goodstadt L; Harrow J; Howe K; Ibarra-Soria X; Kolmogorov M; Lelliott CJ; Logan DW; Loveland J; Mathews CE; Mott R; Muir P; Nachtweide S; Navarro FCP; Odom DT; Park N; Pelan S; Pham SK; Quail M; Reinholdt L; Romoth L; Shirley L; Sisu C; Sjoberg-Herrera M; Stanke M; Steward C; Thomas M; Threadgold G; Thybert D; Torrance J; Wong K; Wood J; Yalcin B; Yang F; Adams DJ; Paten B; Keane TM. 2018. Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci. Nat Genet 50(11):1574-1583PubMed: 30275530 MGI: J:267883
Timmermans S; Libert C. 2018. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. JCI Insight 3(13)PubMed: 29997285 MGI: J:267911
Fisher-Wellman KH; Ryan TE; Smith CD; Gilliam LA; Lin CT; Reese LR; Torres MJ; Neufer PD. 2016. A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice. Diabetes 65(11):3249-3261PubMed: 27495226 MGI: J:269107
Huynh FK; Hu X; Lin Z; Johnson JD; Hirschey MD. 2018. Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. J Inherit Metab Dis 41(1):59-72PubMed: 28726069 MGI: J:271771
Geuther BQ; Deats SP; Fox KJ; Murray SA; Braun RE; White JK; Chesler EJ; Lutz CM; Kumar V. 2019. Robust mouse tracking in complex environments using neural networks. Commun Biol 2:124PubMed: 30937403 MGI: J:275426
Ferland RJ; Smith J; Papandrea D; Gracias J; Hains L; Kadiyala SB; O'Brien B; Kang EY; Beyer BS; Herron BJ. 2017. Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus. G3 (Bethesda) 7(8):2545-2558PubMed: 28620084 MGI: J:276198
Anderson EJP; Ghamari-Langroudi M; Cakir I; Litt MJ; Chen V; Reggiardo RE; Millhauser GL; Cone RD. 2019. Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor. J Neuroendocrinol 31(1):e12670PubMed: 30561082 MGI: J:278900
Kang SK; Hawkins NA; Kearney JA. 2019. C57BL/6J and C57BL/6N substrains differentially influence phenotype severity in the Scn1a (+/-) mouse model of Dravet syndrome. Epilepsia Open 4(1):164-169PubMed: 30868126 MGI: J:280110
Cope ZA; Young JW. 2017. The Five-Choice Continuous Performance Task (5C-CPT): A Cross-Species Relevant Paradigm for Assessment of Vigilance and Response Inhibition in Rodents. Curr Protoc Neurosci 78:9.56.1-9.56.18PubMed: 28046200 MGI: J:282687
Kirkpatrick SL; Goldberg LR; Yazdani N; Babbs RK; Wu J; Reed ER; Jenkins DF; Bolgioni AF; Landaverde KI; Luttik KP; Mitchell KS; Kumar V; Johnson WE; Mulligan MK; Cottone P; Bryant CD. 2017. Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating. Biol Psychiatry 81(9):757-769PubMed: 27914629 MGI: J:284015

Additional - Cox7a2l^s related

Additional - Crb1^rd8 related

Additional - Cyfip2^M1N related

Additional - Nlrp12^C57BL/6N related

Technical Support

Contact Technical Support

Genotyping Protocols
- Separated PCR:GAL Panel
- End Point Analysis:H2^b
- End Point Analysis:H2^b-EP
- End Point Analysis:Crb1^rd8
- End Point Analysis:Kif1a
- End Point Analysis:Smcx/Smcy-Sex Determination Assay
- Sanger sequencing:H2^b
- Sanger sequencing:Gabra2^C57BL/6J
- Genotyping resources and troubleshooting
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Dietary Information
- New Diet as of March 2015: Lab Diet® 5K0Q (6% fat)
Breeding Considerations

This strain is a good breeder.
- Additional Breeding and Husbandry Support
Mating System
- Inbred x Inbred
Appearance
- black
  Related Genotype: a/a
Citation
When using the C57BL/6NJ mouse strain in a publication, please include JAX stock #005304 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Pricing & Availability

Readily Available

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Volume Pricing Details

QUANTITY	VOLUME PRICING

Volume Pricing Program
Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached
Sexes: Sexes of the same strain may be combined to reach minimum quantity levels to receive the volume pricing
Shipment: All shipping destinations qualify

Cryorecovery - Pricing

Service	Genotype	Price
	Inbred, 1 pair minimum will be supplied

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: B6N, Black 6N

Genetic overview

Research Applications

Base Price

Volume Pricing Available!

Important Note

Detailed Description

Development

Selected References

Crb1rd8

Allele Symbol: Crb1rd8

Nlrp12C57BL/6N

Allele Symbol: Nlrp12C57BL/6N

Cyfip2M1N

Allele Symbol: Cyfip2M1N

Cox7a2ls

Allele Symbol: Cox7a2ls

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Crb1rd8 related

Mammalian Phenotype Terms by Genotype

Genotype: Cdh23ahl/Cdh23ahlC57BL/6NJ

hearing/vestibular/ear phenotype

nervous system phenotype

Phenotype Information

References

Additional References

Additional - Cox7a2ls related

Additional - Crb1rd8 related

Additional - Cyfip2M1N related

Additional - Nlrp12C57BL/6N related

Genotyping Protocols

Dietary Information

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Crb1^rd8

Allele Symbol: Crb1^rd8

Nlrp12^C57BL/6N

Allele Symbol: Nlrp12^C57BL/6N

Cyfip2^M1N

Allele Symbol: Cyfip2^M1N

Cox7a2l^s

Allele Symbol: Cox7a2l^s

Genotype: Crb1^rd8 related

Genotype: Cdh23^ahl/Cdh23^ahl
C57BL/6NJ

Additional - Cox7a2l^s related

Additional - Crb1^rd8 related

Additional - Cyfip2^M1N related

Additional - Nlrp12^C57BL/6N related