JAX Mouse Strain Datasheet - 005304

C57BL/6NJ

Stock No:: 005304

Inbred Strain

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Overview

Also Known As: B6N, Black 6N

This is an NIH subline of C57BL/6. It was separated from C57BL/6J in 1951. Five SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. This strain does not have the deletion in the Nnt gene that has been found in the C57BL/6J strain (Stock No. 000664).

Genetic overview

Genetic Background	Generation
	F?+5pF3pF10 (14-AUG-14)

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Research Applications

Research Tools
Cell Biology Research
Developmental Biology Research
Sensorineural Research

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$20.83 Domestic price for male 3-week

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Details

Important Note

This strain is homozygous for Crb1^rd8, the retinal degeneration 8 mutation. Photoreceptor degeneration is observed in spots, caused by retinal folds and pseudorosettes, found in the fundus of the eye.

Detailed Description

This is an NIH subline of C57BL/6. It was separated from C57BL/6J in 1951. 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. Both C57BL/6ByJ and C57BL/6NJ type as follows: 08-015199792-M (rs3709624) is C; 11-004367508-M (rs3659787) is A; 13-041017317-M (rs3722313) is C; 15-057561875-M (rs3702158) is G; 19-049914266-M (rs3724876) is T. C57BL/6J types as follows: 08-015199792-M is T; 11-004367508-M is G; 13-041017317-M is T; 15-057561875-M is A; 19-049914266-M is G (Petkov and Wiles 2005.) This strain does not have the deletion in the Nnt gene that has been found in the C57BL/6J strain (Stock No. 000664). C57BL/6NJ mice are homozygous for Cyfip2^M1N, a spontaneous mutation in the cytoplasmic FMR1 interacting protein 2 that results in an amino acid substitution of phenylalanine for serine at position 968 (S968F). The mutation is found in all C57BL/6N substrains but is not present in the C57BL/6J strain or substrains. The mutation results in 45% lower acute response to cocaine as measured by locomotor hyperactivity.

Development

In 1951 C57BL/6J, then at generation F32, were sent from The Jackson Laboratory to The National Institute of Health where they were maintained via sibling mating for decades. In 1980 this subline reached F126 and in 1984 embryos were cryopreserved at the NIH cryopreservation facility. In approximately 1994 some of these embryos were thawed and maintained via sibling mating and this subline was referred to as B6(e84) to specify that it derived from the embryos frozen in 1984. In September and October of 1997 a new set of embryos were cryopreserved from this thawed line by backcrossing +F6 females to their +F5 fathers. In 2005 some of these embryos frozen in 1997 were sent to The Jackson Laboratory where they were thawed and gave rise to C57BL/6NJ. Thus, C57BL/6NJ is devoid of mutations that may have arisen in any C57BL/6N sublines that remained on the shelf after the 1984 freeze. The embryos received by The Jackson Laboratory were thawed, the colony expanded, and re-frozen immediately. This strain is maintained with frequent replenishment from this frozen stock in order to arrest genetic drift.

Selected References

Fontaine DA; Davis DB. 2016. Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65(1):25-33. PubMed: 26696638 MGI: J:231066
Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94. PubMed: 21921910 MGI: J:177037
Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. 2013. C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science 342(6165):1508-12. PubMed: 24357318 MGI: J:203183
Simon MM; Greenaway S; White JK; Fuchs H; Gailus-Durner V; Wells S; Sorg T; Wong K; Bedu E; Cartwright EJ; Dacquin R; Djebali S; Estabel J; Graw J; Ingham NJ; Jackson IJ; Lengeling A; Mandillo S; Marvel J; Meziane H; Preitner F; Puk O; Roux M; Adams DJ; Atkins S; Ayadi A; Becker L; Blake A; Brooker D; Cater H; Champy MF; Combe R; Danecek P; di Fenza A; Gates H; Gerdin AK; Golini E; Hancock JM; Hans W; Holter SM; Hough T; Jurdic P; Keane TM; Morgan H; Muller W; Neff F; Nicholson G; Pasche B; Roberson LA; R. 2013. A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol 14(7):R82. PubMed: 23902802 MGI: J:220417

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Genetics

Crb1^rd8

Allele Symbol: Crb1^rd8

Allele Name	retinal degeneration 8
Allele Type	Spontaneous
Allele Synonym(s)	Rd8^-; nmf144
Gene Symbol and Name	Crb1, crumbs family member 1, photoreceptor morphogenesis associated
Gene Synonym(s)	7530426H14Rik; 7530426H14Rik; A930008G09Rik; A930008G09Rik; LCA8; RIKEN cDNA 7530426H14 gene; RIKEN cDNA A930008G09 gene; RP12
Strain of Origin	C57BL/6By or C57BL/6N
Chromosome	1
Molecular Note	The mutation in the rd8 mouse has been identified as a single base deletion at nt3481 in the gene. This deletion causes a frame shift and a premature stop codon that truncates the transmembrane and cytoplasmic domain of the protein after amino acid 1207. This mutation has been found to be present in all sublines of C57BL/6N and in C57BL/6ByJ, but not in any C57BL/6J subline. It occurred sometime between transfer of mice from JAX to NIH, in 1951, and from NIH to Donald Bailey, in 1961.

Cyfip2^M1N

Allele Symbol: Cyfip2^M1N

Allele Name	mutation 1, National Institutes of Health
Allele Type	Spontaneous
Allele Synonym(s)	Cyfip2^B6N
Gene Symbol and Name	Cyfip2, cytoplasmic FMR1 interacting protein 2
Gene Synonym(s)	1500004I01Rik; 1500004I01Rik; 6430511D02Rik; 6430511D02Rik; AA930218; AU022376; EIEE65; PIR121; Pir121; RIKEN cDNA 1500004I01 gene; RIKEN cDNA 6430511D02 gene; expressed sequence AA930218; expressed sequence AU022376; mKIAA1168
Strain of Origin	C57BL/6N
Chromosome	11
Molecular Note	An G to A mutation at 46,036,117 base pair (bp) of chromosome 11 (mm9) occured between 1961 and 1974 in the C57BL/6N strain that resulted in the amino acid substitution of phenylalanine for serine at position 968 (S968F). This mutation is found in all C57BL/6N substrains (C57BL/6NCrl, C57BL/6NTac and C57BL/6NJ) but is not present in the C57BL/6J strain or substrains (C57BL/6Ei, C57BL/6EiJ, C57BL/6ByJ and C57BL/6By). The mutation destabilizes the protein leading to decreased half-life.

Nlrp12^C57BL/6N

Allele Symbol: Nlrp12^C57BL/6N

Allele Name	C57BL/6N
Allele Type	Spontaneous (Not Applicable)
Allele Synonym(s)	Nlrp12^B6N
Gene Symbol and Name	Nlrp12, NLR family, pyrin domain containing 12
Gene Synonym(s)	CLR19.3; FCAS2; NACHT, LRR and PYD containing protein 12; NALP12; Nalp12; Nalp12; PAN6; PYPAF7; RNO; RNO2
Strain of Origin	C57BL/6N
Chromosome	7
Molecular Note	A sequence variant is identified in C57BL/6N (C) as compared to C57BL/6J (T) at position 3,222,538 (version mm9-NCB1m37). The polymorphism is located in the C-terminal leucine-rich repeat domain and results in a lysine to arginine change at amino acid residue 1034.

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- General Purpose

Genotype: Crb1^rd8 related

Cell Biology Research
- Defects in Cell Adhesion Molecules
Developmental Biology Research
- Eye Defects
Sensorineural Research
- Retinal Degeneration

Mammalian Phenotype Terms by Genotype

Genotype: Cdh23^ahl/Cdh23^ahl
C57BL/6NJ

hearing/vestibular/ear phenotype

cochlear hair cell degeneration
- degeneration of outer hair cells is more extensive than that of inner hair cells and losses of both are more severe in the base of the cochlea than in the apex

cochlear inner hair cell degeneration

cochlear outer hair cell degeneration

nervous system phenotype

cochlear hair cell degeneration
- degeneration of outer hair cells is more extensive than that of inner hair cells and losses of both are more severe in the base of the cochlea than in the apex

cochlear inner hair cell degeneration

cochlear outer hair cell degeneration

Phenotype Information

Body Weight Information - JAX^® Mice Strain C57BL/6NJ (005304)

Festing Inbred Strain Characteristics: C57BL

References

Fontaine DA; Davis DB. 2016. Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. Diabetes 65(1):25-33. PubMed: 26696638 MGI: J:231066
Keane TM; Goodstadt L; Danecek P; White MA; Wong K; Yalcin B; Heger A; Agam A; Slater G; Goodson M; Furlotte NA; Eskin E; Nellaker C; Whitley H; Cleak J; Janowitz D; Hernandez-Pliego P; Edwards A; Belgard TG; Oliver PL; McIntyre RE; Bhomra A; Nicod J; Gan X; Yuan W; van der Weyden L; Steward CA; Bala S; Stalker J; Mott R; Durbin R; Jackson IJ; Czechanski A; Guerra-Assuncao JA; Donahue LR; Reinholdt LG; Payseur BA; Ponting CP; Birney E; Flint J; Adams DJ. 2011. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477(7364):289-94. PubMed: 21921910 MGI: J:177037
Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. 2013. C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science 342(6165):1508-12. PubMed: 24357318 MGI: J:203183
Simon MM; Greenaway S; White JK; Fuchs H; Gailus-Durner V; Wells S; Sorg T; Wong K; Bedu E; Cartwright EJ; Dacquin R; Djebali S; Estabel J; Graw J; Ingham NJ; Jackson IJ; Lengeling A; Mandillo S; Marvel J; Meziane H; Preitner F; Puk O; Roux M; Adams DJ; Atkins S; Ayadi A; Becker L; Blake A; Brooker D; Cater H; Champy MF; Combe R; Danecek P; di Fenza A; Gates H; Gerdin AK; Golini E; Hancock JM; Hans W; Holter SM; Hough T; Jurdic P; Keane TM; Morgan H; Muller W; Neff F; Nicholson G; Pasche B; Roberson LA; R. 2013. A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol 14(7):R82. PubMed: 23902802 MGI: J:220417

Additional References

Toye AA; Lippiat JD; Proks P; Shimomura K; Bentley L; Hugill A; Mijat V; Goldsworthy M; Moir L; Haynes A; Quarterman J; Freeman HC; Ashcroft FM; Cox RD. 2005. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48(4):675-86. PubMed: 15729571 MGI: J:106692
Ulland TK; Jain N; Hornick EE; Elliott EI; Clay GM; Sadler JJ; Mills KA; Janowski AM; Volk AP; Wang K; Legge KL; Gakhar L; Bourdi M; Ferguson PJ; Wilson ME; Cassel SL; Sutterwala FS. 2016. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun 7:13180. PubMed: 27779193 MGI: J:238047

Additional - Crb1^rd8 related

Aleman TS; Cideciyan AV; Aguirre GK; Huang WC; Mullins CL; Roman AJ; Sumaroka A; Olivares MB; Tsai FF; Schwartz SB; Vandenberghe LH; Limberis MP; Stone EM; Bell P; Wilson JM; Jacobson SG. 2011. Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model. Invest Ophthalmol Vis Sci 52(9):6898-910. PubMed: 21757580 MGI: J:181396
Ardeljan D; Wang Y; Park S; Shen D; Chu XK; Yu CR; Abu-Asab M; Tuo J; Eberhart CG; Olsen TW; Mullins RF; White G; Wadsworth S; Scaria A; Chan CC. 2014. Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration. PLoS One 9(4):e95900. PubMed: 24780906 MGI: J:215272
Barber AC; Hippert C; Duran Y; West EL; Bainbridge JW; Warre-Cornish K; Luhmann UF; Lakowski J; Sowden JC; Ali RR; Pearson RA. 2013. Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A 110(1):354-9. PubMed: 23248312 MGI: J:192521
Boatright JH; Dalal N; Chrenek MA; Gardner C; Ziesel A; Jiang Y; Grossniklaus HE; Nickerson JM. 2015. Methodologies for analysis of patterning in the mouse RPE sheet. Mol Vis 21:40-60. PubMed: 25593512 MGI: J:227581
Borras T; Smith MH; Buie LK. 2015. A Novel Mgp-Cre Knock-In Mouse Reveals an Anticalcification/Antistiffness Candidate Gene in the Trabecular Meshwork and Peripapillary Scleral Region. Invest Ophthalmol Vis Sci 56(4):2203-14. PubMed: 25711639 MGI: J:230973
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. PubMed: 11853768 MGI: J:75095
Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. PubMed: 16332269 MGI: J:156373
Chang B; Hurd R; Wang J; Nishina P. 2013. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci 54(7):4974-81. PubMed: 23800770 MGI: J:198916
Chen M; Glenn JV; Dasari S; McVicar C; Ward M; Colhoun L; Quinn M; Bierhaus A; Xu H; Stitt AW. 2014. RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization. PLoS One 9(2):e89548. PubMed: 24586862 MGI: J:213819
Chen Q; Qiu F; Zhou K; Matlock HG; Takahashi Y; Rajala RVS; Yang Y; Moran E; Ma JX. 2017. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARalpha. Diabetes 66(6):1671-1682. PubMed: 28270521 MGI: J:246071
Chen Y; Sawada O; Kohno H; Le YZ; Subauste C; Maeda T; Maeda A. 2013. Autophagy protects the retina from light-induced degeneration. J Biol Chem 288(11):7506-18. PubMed: 23341467 MGI: J:196891
Dando SJ; Naranjo Golborne C; Chinnery HR; Ruitenberg MJ; McMenamin PG. 2016. A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. Glia 64(8):1331-49. PubMed: 27189804 MGI: J:232788
Datta P; Allamargot C; Hudson JS; Andersen EK; Bhattarai S; Drack AV; Sheffield VC; Seo S. 2015. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A 112(32):E4400-9. PubMed: 26216965 MGI: J:226512
Flynn E; Ueda K; Auran E; Sullivan JM; Sparrow JR. 2014. Fundus autofluorescence and photoreceptor cell rosettes in mouse models. Invest Ophthalmol Vis Sci 55(9):5643-52. PubMed: 25015357 MGI: J:230135
Fontaine V; Monteiro E; Brazhnikova E; Lesage L; Balducci C; Guibout L; Feraille L; Elena PP; Sahel JA; Veillet S; Lafont R. 2016. Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo. PLoS One 11(12):e0167793. PubMed: 27992460 MGI: J:256799
Greferath U; Vessey KA; Jobling AI; Mills SA; Bui BV; He Z; Nag N; Ohtsu H; Fletcher EL. 2014. The role of histamine in the retina: studies on the Hdc knockout mouse. PLoS One 9(12):e116025. PubMed: 25545149 MGI: J:225379
Herrmann P; Cowing JA; Cristante E; Liyanage SE; Ribeiro J; Duran Y; Abelleira Hervas L; Carvalho LS; Bainbridge JW; Luhmann UF; Ali RR. 2015. Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age. Neurobiol Aging 36(9):2637-48. PubMed: 26234657 MGI: J:226268
Hippert C; Graca AB; Barber AC; West EL; Smith AJ; Ali RR; Pearson RA. 2015. Muller glia activation in response to inherited retinal degeneration is highly varied and disease-specific. PLoS One 10(3):e0120415. PubMed: 25793273 MGI: J:233438
Ji X; Liu Y; Hurd R; Wang J; Fitzmaurice B; Nishina PM; Chang B. 2016. Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, theta. Invest Ophthalmol Vis Sci 57(3):877-88. PubMed: 26978024 MGI: J:237977
Kohno H; Maeda T; Perusek L; Pearlman E; Maeda A. 2014. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol 192(8):3816-27. PubMed: 24639355 MGI: J:210001
Lakowski J; Baron M; Bainbridge J; Barber AC; Pearson RA; Ali RR; Sowden JC. 2010. Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells. Hum Mol Genet 19(23):4545-59. PubMed: 20858907 MGI: J:165574
Liegel RP; Ronchetti A; Sidjanin DJ. 2014. Alkylglycerone phosphate synthase (AGPS) deficient mice: models for rhizomelic chondrodysplasia punctate type 3 (RCDP3) malformation syndrome. Mol Genet Metab Rep 1:299-311. PubMed: 25197626 MGI: J:224576
Low BE; Krebs MP; Joung JK; Tsai SQ; Nishina PM; Wiles MV. 2014. Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci 55(1):387-95. PubMed: 24346171 MGI: J:206789
Luhmann UF; Carvalho LS; Holthaus SM; Cowing JA; Greenaway S; Chu CJ; Herrmann P; Smith AJ; Munro PM; Potter P; Bainbridge JW; Ali RR. 2015. The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors. Hum Mol Genet 24(1):128-41. PubMed: 25147295 MGI: J:216513
Luhmann UF; Carvalho LS; Robbie SJ; Cowing JA; Duran Y; Munro PM; Bainbridge JW; Ali RR. 2013. Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration. Exp Eye Res 107:80-7. PubMed: 23232206 MGI: J:210432
Mattapallil MJ; Wawrousek EF; Chan CC; Zhao H; Roychoudhury J; Ferguson TA; Caspi RR. 2012. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 53(6):2921-7. PubMed: 22447858 MGI: J:182353
Mehalow AK; Kameya S; Smith RS; Hawes NL; Denegre JM; Young JA; Bechtold L; Haider NB; Tepass U; Heckenlively JR; Chang B; Naggert JK; Nishina PM. 2003. CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Hum Mol Genet 12(17):2179-89. PubMed: 12915475 MGI: J:85459
Mirza M; Volz C; Karlstetter M; Langiu M; Somogyi A; Ruonala MO; Tamm ER; Jagle H; Langmann T. 2013. Correction: Progressive Retinal Degeneration and Glial Activation in the CLN6 Mouse Model of Neuronal Ceroid Lipofuscinosis: A Beneficial Effect of DHA and Curcumin Supplementation. PLoS One 8(10):. PubMed: 24130650 MGI: J:209126
Nagai N; Ju M; Izumi-Nagai K; Robbie SJ; Bainbridge JW; Gale DC; Pierre E; Krauss AH; Adamson P; Shima DT; Ng YS. 2015. Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability. Am J Pathol 185(9):2534-49. PubMed: 26188133 MGI: J:226071
Nagai N; Lundh von Leithner P; Izumi-Nagai K; Hosking B; Chang B; Hurd R; Adamson P; Adamis AP; Foxton RH; Ng YS; Shima DT. 2014. Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction. Invest Ophthalmol Vis Sci 55(6):3709-19. PubMed: 24845632 MGI: J:230019
Pak JS; Lee EJ; Craft CM. 2015. The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation. Mol Vis 21:1281-94. PubMed: 26664249 MGI: J:228289
Perkins GA; Scott R; Perez A; Ellisman MH; Johnson JE; Fox DA. 2012. Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption. Mol Vis 18:3029-48. PubMed: 23288995 MGI: J:192587
Ramkumar N; Harvey BM; Lee JD; Alcorn HL; Silva-Gagliardi NF; McGlade CJ; Bestor TH; Wijnholds J; Haltiwanger RS; Anderson KV. 2015. Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet 11(10):e1005551. PubMed: 26496195 MGI: J:227336
Ramkumar N; Omelchenko T; Silva-Gagliardi NF; McGlade CJ; Wijnholds J; Anderson KV. 2016. Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol 18(12):1281-1291. PubMed: 27870829 MGI: J:238551
Sahu B; Chavali VR; Alapati A; Suk J; Bartsch DU; Jablonski MM; Ayyagari R. 2015. Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model. Mol Vis 21:273-84. PubMed: 25814825 MGI: J:220824
Samardzija M; Caprara C; Heynen SR; Willcox DeParis S; Meneau I; Traber G; Agca C; von Lintig J; Grimm C. 2014. A mouse model for studying cone photoreceptor pathologies. Invest Ophthalmol Vis Sci 55(8):5304-13. PubMed: 25034607 MGI: J:230121
Schnabolk G; Stauffer K; O'Quinn E; Coughlin B; Kunchithapautham K; Rohrer B. 2014. A comparative analysis of C57BL/6J and 6N substrains; chemokine/cytokine expression and susceptibility to laser-induced choroidal neovascularization. Exp Eye Res 129:18-23. PubMed: 25305577 MGI: J:230320
Vessey KA; Greferath U; Jobling AI; Phipps JA; Ho T; Waugh M; Fletcher EL. 2012. Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMD. Invest Ophthalmol Vis Sci 53(12):7833-46. PubMed: 23074204 MGI: J:214216
Vessey KA; Waugh M; Jobling AI; Phipps JA; Ho T; Trogrlic L; Greferath U; Fletcher EL. 2015. Assessment of retinal function and morphology in aging Ccl2 knockout mice. Invest Ophthalmol Vis Sci 56(2):1238-52. PubMed: 25626968 MGI: J:230980
Wang X; Zhao L; Zhang J; Fariss RN; Ma W; Kretschmer F; Wang M; Qian HH; Badea TC; Diamond JS; Gan WB; Roger JE; Wong WT. 2016. Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. J Neurosci 36(9):2827-42. PubMed: 26937019 MGI: J:231674
Wang Y; Abu-Asab MS; Yu CR; Tang Z; Shen D; Tuo J; Li X; Chan CC. 2014. Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration. Lab Invest 94(6):674-82. PubMed: 24709779 MGI: J:210964
Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. PubMed: 21052544 MGI: J:166679
Zhang N; Kolesnikov AV; Jastrzebska B; Mustafi D; Sawada O; Maeda T; Genoud C; Engel A; Kefalov VJ; Palczewski K. 2013. Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest 123(1):121-37. PubMed: 23221340 MGI: J:194158

Additional - Nlrp12^C57BL/6N related

Ulland TK; Jain N; Hornick EE; Elliott EI; Clay GM; Sadler JJ; Mills KA; Janowski AM; Volk AP; Wang K; Legge KL; Gakhar L; Bourdi M; Ferguson PJ; Wilson ME; Cassel SL; Sutterwala FS. 2016. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun 7:13180. PubMed: 27779193 MGI: J:238047

Also Known As: B6N, Black 6N

Genetic overview

Research Applications

Base Price

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Important Note

Detailed Description

Development

Selected References

Crb1rd8

Allele Symbol: Crb1rd8

Cyfip2M1N

Allele Symbol: Cyfip2M1N

Nlrp12C57BL/6N

Allele Symbol: Nlrp12C57BL/6N

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Crb1rd8 related

Mammalian Phenotype Terms by Genotype

Genotype: Cdh23ahl/Cdh23ahlC57BL/6NJ

hearing/vestibular/ear phenotype

nervous system phenotype

Phenotype Information

References

Additional References

Additional - Crb1rd8 related

Additional - Nlrp12C57BL/6N related

Genotyping Protocols

Dietary Information

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Mating System

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Animal Health Reports

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Crb1^rd8

Allele Symbol: Crb1^rd8

Cyfip2^M1N

Allele Symbol: Cyfip2^M1N

Nlrp12^C57BL/6N

Allele Symbol: Nlrp12^C57BL/6N

Genotype: Crb1^rd8 related

Genotype: Cdh23^ahl/Cdh23^ahl
C57BL/6NJ

Additional - Crb1^rd8 related

Additional - Nlrp12^C57BL/6N related