Mice homozygous for the reeler 4 Jackson remutation are smaller than their littermates by 2 weeks of age and have an ataxia such that they lean side-to-side when trying to walk and often fall over on their side. Many die by wean age. At 3 and 3.5 weeks of age histological assessment reveals scrambled layering in the cortex, smaller than normal cerebellum with scrambled Purkinje and granule cells, and neurons of the hippocampal gyrus scattered in an irregular wavy layer.
The reeler 4 Jackson mutation arose spontaneously in the B6.129S2-Irf1tm1Mak/J strain (Stock No. 002762) at The Jackson Laboratory. This mutation has been maintained via ovarian transplant backcross-intercross to C57BL/6J and the targeted mutation has been bred out of this strain.
|Allele Name||reeler 4 Jackson|
|Gene Symbol and Name||Reln, reelin|
|Strain of Origin||B6.129S2-Irf1tm1Mak/J|
|Molecular Note||Non-complementation with the original reeler mutation suggests that these two mutations are alleles of the same gene.|