Mice homozygous for the shiverer Jackson mutation can be identified at 12 days of age by a generalized tremor during locomotion and the severity of the phenotype progresses with age and includes a loss of coordination of the hindlimbs. Deficiency of myelin from the central nervous system has been found at 7 weeks of age, the earliest time-point assessed.
The shiverer Jackson mutation arose spontaneously in 2002 on the BALB/cJ inbred background at The Jackson Laboratory and has been maintained on this background by sibling inbreeding.
|Allele Name||shiverer Jackson|
|Gene Symbol and Name||Mbp, myelin basic protein|
|Strain of Origin||BALB/cJ|
|Molecular Note||This spontaneous mutation was shown to be an allele of the myelin basic protein gene by its failure to complement the original shiverer mutation.|