Overview

This strain is extinct. Search JAX® Mice Database for other shmy alleles.

Genetic overview

Genetic Background	Generation

shmy^2J

Allele Type	Gene Symbol	Gene Name
Spontaneous	shmy	shimmy

Marker(s)

	Marker Symbol	Marker Name
	H2	histocompatibility-2, MHC

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Research Applications

Neurobiology Research

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Details

Detailed Description

Mice homozygous for the shimmy 2 Jackson mutation have a shaking wobbling gait evident by 5 weeks of age and appear to vibrate when held by their tails.

Development

The shimmy 2 Jackson mutation arose spontaneously in 2001 on B10.D1-H2^q/SgJ when that strain was at generation F28. This strain has been maintained via sibling mating primarily homozygous females with heterozygous males.

Control Suggestions

Heterozygote from the colony

Additional Information

Considerations for Choosing Controls

Selected References

Ward-Bailey P; Samples R; Wang J; Donahue LR; Bronson R; Davisson M. 2005. A Neurological Mutation on Chromosome 14 named Shimmy 2 Jackson MGI Direct Data SubmissionMGI: J:98755

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Genetics

shmy^2J

Allele Symbol: shmy^2J

Allele Name	shimmy 2 Jackson
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	shmy, shimmy
Gene Synonym(s)
Strain of Origin	B10.D1-H2^q/SgJ
Chromosome	14
Molecular Note	This mutation was shown to be an allele of shmy by complementation testing versus the original shmy mutation.

H2

Marker Symbol: H2

Marker Synonym(s)
Chromosome(s)	17

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: shmy^2J related

Neurobiology Research
- Ataxia (Movement) Defects

Mammalian Phenotype Terms by Genotype

References

Ward-Bailey P; Samples R; Wang J; Donahue LR; Bronson R; Davisson M. 2005. A Neurological Mutation on Chromosome 14 named Shimmy 2 Jackson MGI Direct Data SubmissionMGI: J:98755

Additional - H2 related

Additional - shmy^2J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

Males homozygous for shimmy (shmy) do not breed, but males homozygous for the shimmy 2 Jackson re-mutation have been shown to breed, albeit with less success than female homozygotes.
- Additional Breeding and Husbandry Support
Appearance
- black, unaffected
  Related Genotype: a/a shmy^2J/+
  
  black, affected
  Related Genotype: a/a shmy^2J/shmy^2J

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General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Genetic overview

Marker(s)

Research Applications

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

shmy2J

Allele Symbol: shmy2J

H2

Marker Symbol: H2

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: shmy2J related

Mammalian Phenotype Terms by Genotype

References

Additional - H2 related

Additional - shmy2J related

Genotyping Protocols

Breeding Considerations

Appearance

Terms Of Use

Licensing Information

shmy^2J

Allele Symbol: shmy^2J

Genotype: shmy^2J related

Additional - shmy^2J related