This NOD subline, which separated from NOD/ShiLtJ in 1992, has the same diabetes phenotype as NOD/ShiLtJ with similar onset. However, in addition to many SNP variants this strain also has an intragenic deletion of Icam2, which results in a null allele. No impact on the diabetes phenotype has been attributed to this loss of Icam2.
Read More +The NOD/ShiLtDvs inbred substrain separated from NOD/ShiLt in 1992, before that strain reached generation F70. It was maintained by sibling inbreeding in the laboratory of Dr. David Serreze and embryos were cryopreserved in 2007 at generation +F39. The 111,160 bp deletion on Chromozome 3 was present in NOD/ShiLt before the separation of this substrain and the spontaneous Icam2m1Dvs null mutation that is specific to this substrain arose in approximately the year 2000.
Allele Name | deficient |
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Allele Type | Spontaneous |
Allele Synonym(s) | C5-; C5-d; C5-def; C5-deficient; HcHfib2; hco |
Gene Symbol and Name | Hc, hemolytic complement |
Gene Synonym(s) | |
Strain of Origin | multiple strains |
Chromosome | 2 |
General Note | This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, A/J, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211) |
Molecular Note | A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, A/J, AKR/J, DBA/2J, I/LnJ, KK/HlJ, MOLF/EiJ, NZB/B1NJ, RF/J, ST/bJ SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. |
Allele Name | age related hearing loss 1 |
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Allele Type | Spontaneous |
Allele Synonym(s) | Cdh23753A; mdfw |
Gene Symbol and Name | Cdh23, cadherin 23 (otocadherin) |
Gene Synonym(s) | |
Strain of Origin | multiple strains |
Chromosome | 10 |
Molecular Note | Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G to A transition at coding nucleotide position 753 of Cdh23 (SNP rs257098870). This hypomorphic allele changes splice donor site G-GT to A-GT, causing frame skipping of exon 7. This is predicted to delete part of the 2nd and 3rd ectodomains and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: 129S1/SvImJ, C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ. |
Allele Name | g7 variant |
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Allele Type | Not Applicable |
Allele Synonym(s) | H-2g7; H-2g7 |
Gene Symbol and Name | H2, histocompatibility-2, MHC |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
General Note | The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2g7 |
Allele Name | mutation 2 |
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Allele Type | Spontaneous |
Allele Synonym(s) | 9A |
Gene Symbol and Name | mt-Tr, mitochondrially encoded tRNA arginine |
Gene Synonym(s) | |
Strain of Origin | various |
Chromosome | MT |
General Note | This polymorphism is present in ALR/Lt, NOD/ShiLtDvs, and SKH2/J. A variant with 10 adenines is found in A/J, ALS/Lt, NOD/ShiLtJ and NZB/B1NJ. |
Molecular Note | The adenine repeat in the D stem is polymorphic with 9 adenines in this allele. |
Allele Name | mutation 1 |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Il2, interleukin 2 |
Gene Synonym(s) | |
Strain of Origin | multiple strains |
Chromosome | 3 |
Molecular Note | This hypoactive polymorphism, found in MRL/MpJ, SJL/J, and NOD/ShiLtJ inbred strains, includes a smaller polyglutamine tract predicted to shorten the first alpha helix, which forms part of the IL2 receptor binding site. |
Allele Name | deletion |
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Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Gpr84, G protein-coupled receptor 84 |
Gene Synonym(s) | |
Strain of Origin | multiple strains |
Chromosome | 15 |
Molecular Note | This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1. |
Allele Name | mutation 1, David V Serreze |
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Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Icam2, intercellular adhesion molecule 2 |
Gene Synonym(s) | |
Strain of Origin | NOD/ShiLtDvs |
Chromosome | 11 |
Molecular Note | Exome sequencing shows this spontaneous intragenic deletion removes all exons except the last one (ENSMUSE00000374954) and this mutation is believed to have arisen in the NOD/ShiLtDvs inbred substrain in approximately the year 2000. |
Allele Name | deletion, Chr 3, Edward H Leiter 1 |
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Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | Del1Lt |
Gene Symbol and Name | Del(3)1Lt, deletion, Chr 3, Edward H Leiter 1 |
Gene Synonym(s) | |
Strain of Origin | NOD/ShiLtJ |
Chromosome | 3 |
Molecular Note | This spontaneous 111,169 bp deletion spans from Chr 3: 24,170,854 bp to 24,282,022 bp (GRCm38/mm10), and includes several QTL and the gene N-acetylated alpha-linked acidic dipeptidase-like 2 |
When using the NOD/ShiLtDvs mouse strain in a publication, please include JAX stock #005100 in your Materials and Methods section.
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