These mice carry a spontaneous mutation characterized by tremors
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Qk | quaking |
This strain might still be segregating for m and Leprdb although neither mutation has been seen phenotypically since before 2005.
Qkqk-2J homozygotes display rapid tremors by approximately 2 weeks of age. Histological examination at 3 weeks of age reveals holes in the striatum of the cortex and cerebellum and in the myelin of the spinal cord. Vision and hearing appear normal.
The quaking 2 Jackson mutation arose spontaneously in November, 2003, in the strain BKS.Cg-m +/+ Leprdb/J at The Jackson Laboratory when that strain was at F99. The parents of the quaking pups were heterozygous carriers for Leprdb and it is probable that they were heterozygous for misty (m) as well. Siblings of a first generation quaking mutant were bred together and proven to be heterozygous by producing quaking and wild-type offspring. The line was again bred from progeny tested heterozygous siblings and an F3 homozygous female was then the donor for ovarian transplant. The host was bred to C57BL/6J to produce N1 heterozygous offspring, which were intercrossed. Neither Leprdb nor m homozygotes have been found since the F1 generation, but these recessive mutations may still be segregating in this line.
When using the quaking 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #005089 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Qk<qk-2J> |
Frozen Mouse Embryo | B6.Cg-Qk<qk-2J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Qk<qk-2J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Qk<qk-2J>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Qk<qk-2J>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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