B6.Cg-Qki^qk-2J/GrsrJ

Stock number: 005089
Product name: quaking 2 Jackson
Research areas: Apoptosis Research, Cell Biology Research, Neurobiology Research

Description

These mice carry a spontaneous mutation characterized by tremors

Detailed description

Qki^qk-2J homozygotes display rapid tremors by approximately 2 weeks of age. Histological examination at 3 weeks of age reveals holes in the striatum of the cortex and cerebellum and in the myelin of the spinal cord. Vision and hearing appear normal.

Development

The quaking 2 Jackson mutation arose spontaneously in November, 2003, in the strain BKS.Cg-m +/+ Lepr^db/J at The Jackson Laboratory when that strain was at F99. The parents of the quaking pups were heterozygous carriers for Lepr^db and it is probable that they were heterozygous for misty (m) as well. Siblings of a first generation quaking mutant were bred together and proven to be heterozygous by producing quaking and wild-type offspring. The line was again bred from progeny tested heterozygous siblings and an F3 homozygous female was then the donor for ovarian transplant. The host was bred to C57BL/6J to produce N1 heterozygous offspring, which were intercrossed. Neither Lepr^db nor m homozygotes have been found since the F1 generation, but these recessive mutations may still be segregating in this line.

Allele

Symbol: Qki^qk-2J
Name: quaking 2 Jackson
MGI accession ID: MGI:3575120
Generation method: Spontaneous
Marker symbol: Qki
Marker name: quaking, KH domain containing RNA binding
Chromosome: 17
Strain of origin: BKS.Cg-Dock7^m +/+ Lepr^db/J