JAX
Mouse Strain Datasheet - 005078
NOD.Cg-Il1r1tm1Roml/HetJ
Also Known As: IL-1RI-
These Il1r1 knock-out mice exhibit a reduced inflammatory response and no response to interleukin-1 alpha or beta.
Donating Investigator
Helen Thomas, St Vincent's Institute
Genetic overview
| Genetic Background | Generation |
|---|---|
|
NOD |
|
Il1r1tm1Roml
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Il1r1 | interleukin 1 receptor, type I |
Research Applications
- Diabetes and Obesity Research
- Cancer Research
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
Mice homozygous for the Il1r1tm1Roml targeted mutation develop normally, exhibit a reduced inflammatory response and no response to interleukin-1 alpha or beta. Homozygous mice have a reduced acute phase and delayed type hypersensitivity response and are highly susceptible to Listeria monocytogenes infection. Equilibrium binding experiments using radiolabeled anti-mouse IL1R1 antibody, 35F5, show no detectable expression of IL1R1 protein in primary murine embryonic fibroblasts (Labow et al, 1997). NOD females homozygous for the Il1r1tm1Roml mutation experience a slight, yet significant delay in diabetes development, with an overall incidence of 75% compared to 100% in wild types. There is no statistical difference between mutant and wild type NOD mice in diabetes development following cyclophosphamide treatment or in the rate at which they mediate autoimmune rejection of syngeneic fetal pancreatic grafts. Adoptive transfer of NOD.Cg-Tg(TcraBDC2.5)1DoiTg(TcrbBDC2.5)2Doi Prkdc scid spleen cells results in diabetes onset in irradiated NOD.Cg-Il1r1tm1Roml recipients at 20 days post-transfer, compared to 11 days in wild type recipients. Introduction of the Il1r1tm1Roml mutation does not alter the rate of diabetes development in NOD.Cg-Tg(8.3TCR) mice (Thomaset al, 2004). Islets isolated from Il1r1 homozygous mice are resistant to toxic effects of cytokines.
This mutant mouse strain may be useful in studies of the role of interleukin-1receptor type 1 in autoimmune diseases such as type 1 diabetes.
Development
A construct containing a neomycin expression cassette replacing approximately a 1 kb region, including the exon encoding the signal peptide and possibly containing an ATG initiation codon of Il1r1, rendering the sequence out of frame after the insertion, was transfected into W9.5 (129S1/SvImJ derived) ) embryonic stem cells (ES cells). ). These ES cells were injected into C57BL/6 blastocysts. To establish a colony and germ line transmission chimeric mice were backcrossed to C57BL/6 or 129/Sv and intercrossed to generate homozygotes (Labow et al, 1997). Thomas et al, 2004, subsequently backcrossed this mutation to NOD/LtJ for 10 generations prior to intercrossing to fix the mutation to homozygosity. A genome wide scan confirmed that all known Idd markers were homozygous for the NOD allele. In 2004, the Type 1 Diabetes Resource received NOD.Cg-Il1r1tm1Roml/HetJ at generation N10F7.
Control Suggestions
Selected References
- Thomas HE; Irawaty W; Darwiche R; Brodnicki TC; Santamaria P; Allison J; Kay TW. 2004. IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse. Diabetes 53(1):113-121. PubMed: 14693705MGI: J:87251
Il1r1tm1Roml
Allele Symbol: Il1r1tm1Roml
| Allele Name | targeted mutation 1, Mark A Labow |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | IL-1RI-deficient; IL-1RI-; IL-1rKO |
| Gene Symbol and Name | Il1r1, interleukin 1 receptor, type I |
| Gene Synonym(s) | CD121A; CD121a; D2S1473; IL-1 receptor alpha chain; IL-1R-alpha; IL-1R1; IL-iR; IL1R; IL1RA; Il1r-1; Il1r-1; P80 |
| Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Chromosome | 1 |
| Molecular Note | A neomycin resistance cassette replaced an ~ 1 kb region of the DNA and included one exon of the gene, which encodes the signal peptide and contains a possible ATG initiation codon. |
| Mutations Made By | Dr. Mark Labow, Novartis Corporation |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
- NOD Congenics with Mutations Affecting Cytokine Production by Autoreactive T Cells
- Type 1 Diabetes (IDDM) Analysis Strains
Genotype: Il1r1tm1Roml related
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
Mammalian Phenotype Terms by Genotype
Genotype: Il1r1tm1Roml/Il1r1tm1Roml
NOD.Cg-Il1r1tm1Roml
cellular phenotype
- abnormal cell death
- islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma (MGI Ref ID J:87251)
immune system phenotype
- decreased susceptibility to autoimmune diabetes
- adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days) 100% in knockouts by 20 days) (MGI Ref ID J:87251)
- spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age (MGI Ref ID J:87251)
References
- Thomas HE; Irawaty W; Darwiche R; Brodnicki TC; Santamaria P; Allison J; Kay TW. 2004. IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse. Diabetes 53(1):113-121. PubMed: 14693705MGI: J:87251
Additional - Il1r1tm1Roml related
- Alugupalli KR; Akira S; Lien E; Leong JM. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. J Immunol 178(6):3740-9. PubMed: 17339472MGI: J:144277
- Anthony DA; Andrews DM; Chow M; Watt SV; House C; Akira S; Bird PI; Trapani JA; Smyth MJ. 2010. A role for granzyme M in TLR4-driven inflammation and endotoxicosis. J Immunol 185(3):1794-803. PubMed: 20585036MGI: J:162467
- Avital A; Goshen I; Kamsler A; Segal M; Iverfeldt K; Richter-Levin G; Yirmiya R. 2003. Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus 13(7):826-34. PubMed: 14620878MGI: J:180427
- Bajayo A; Bar A; Denes A; Bachar M; Kram V; Attar-Namdar M; Zallone A; Kovacs KJ; Yirmiya R; Bab I. 2012. Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual. Proc Natl Acad Sci U S A 109(38):15455-60. PubMed: 22949675MGI: J:190149
- Bajayo A; Goshen I; Feldman S; Csernus V; Iverfeldt K; Shohami E; Yirmiya R; Bab I. 2005. Central IL-1 receptor signaling regulates bone growth and mass. Proc Natl Acad Sci U S A 102(36):12956-61. PubMed: 16126903MGI: J:101424
- Barbosa FL; Lin M; Santhiago MR; Singh V; Agrawal V; Wilson SE. 2012. Interleukin-1 receptor role in the viability of corneal myofibroblasts. Exp Eye Res 96(1):65-9. PubMed: 22251454MGI: J:196771
- Bauer C; Kielian T; Wyatt TA; Romberger DJ; West WW; Gleason AM; Poole JA. 2013. Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice. Am J Respir Cell Mol Biol 48(6):781-9. PubMed: 23492189MGI: J:211745
- Belisle SE; Tisoncik JR; Korth MJ; Carter VS; Proll SC; Swayne DE; Pantin-Jackwood M; Tumpey TM; Katze MG. 2010. Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection. J Virol 84(24):12576-88. PubMed: 20926563MGI: J:166538
- Bellocchio S; Montagnoli C; Bozza S; Gaziano R; Rossi G; Mambula SS; Vecchi A; Mantovani A; Levitz SM; Romani L. 2004. The contribution of the toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 172(5):3059-69. PubMed: 14978111MGI: J:88227
- Bertin-Maghit S; Pang D; O'Sullivan B; Best S; Duggan E; Paul S; Thomas H; Kay TW; Harrison LC; Steptoe R; Thomas R. 2011. Interleukin-1beta produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy. Diabetes 60(1):248-57. PubMed: 20980463MGI: J:170298
- Blumberg H; Dinh H; Trueblood ES; Pretorius J; Kugler D; Weng N; Kanaly ST; Towne JE; Willis CR; Kuechle MK; Sims JE; Peschon JJ. 2007. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med 204(11):2603-14. PubMed: 17908936MGI: J:126327
- Blyszczuk P; Kania G; Dieterle T; Marty RR; Valaperti A; Berthonneche C; Pedrazzini T; Berger CT; Dirnhofer S; Matter CM; Penninger JM; Luscher TF; Eriksson U. 2009. Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circ Res 105(9):912-20. PubMed: 19762681MGI: J:169954
- Bozza S; Zelante T; Moretti S; Bonifazi P; Deluca A; D'Angelo C; Giovannini G; Garlanda C; Boon L; Bistoni F; Puccetti P; Mantovani A; Romani L. 2008. Lack of Toll IL-1R8 Exacerbates Th17 Cell Responses in Fungal Infection. J Immunol 180(6):4022-31. PubMed: 18322211MGI: J:132934
- Brydges SD; Broderick L; McGeough MD; Pena CA; Mueller JL; Hoffman HM. 2013. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest :. PubMed: 24084736MGI: J:203992
- Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. PubMed: 19501000MGI: J:150054
- Bujak M; Dobaczewski M; Chatila K; Mendoza LH; Li N; Reddy A; Frangogiannis NG. 2008. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 173(1):57-67. PubMed: 18535174MGI: J:137121
- Campbell IK; van Nieuwenhuijze A; Segura E; O'Donnell K; Coghill E; Hommel M; Gerondakis S; Villadangos JA; Wicks IP. 2011. Differentiation of inflammatory dendritic cells is mediated by NF-kappaB1-dependent GM-CSF production in CD4 T cells. J Immunol 186(9):5468-77. PubMed: 21421852MGI: J:172752
- Castro-Jorge LA; Pretto CD; Smith AB; Foreman O; Carnahan KE; Spindler KR. 2017. A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis. J Virol 91(4):. PubMed: 27903802MGI: J:239321
- Chae JJ; Cho YH; Lee GS; Cheng J; Liu PP; Feigenbaum L; Katz SI; Kastner DL. 2011. Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1beta Activation and Severe Autoinflammation in Mice. Immunity 34(5):755-68. PubMed: 21600797MGI: J:172117
- Chen LY; Yang-Yen HF; Tsai CC; Thio CL; Chuang HL; Yang LT; Shen LF; Song IW; Liu KM; Huang YT; Liu FT; Chang YJ; Chen YT; Yen JJ. 2017. Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis. J Invest Dermatol 137(4):894-904. PubMed: 28017833MGI: J:240181
- Churg A; Zhou S; Wang X; Wang R; Wright JL. 2009. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40(4):482-90. PubMed: 18931327MGI: J:159269
- Cohen PE; Pollard JW. 1998. Normal sexual function in male mice lacking a functional type I interleukin-1 (IL-1) receptor. Endocrinology 139(2):815-8. PubMed: 9449661MGI: J:109008
- Conforti-Andreoni C; Spreafico R; Qian HL; Riteau N; Ryffel B; Ricciardi-Castagnoli P; Mortellaro A. 2011. Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. J Immunol 187(11):5842-50. PubMed: 22058415MGI: J:179683
- Couillin I; Vasseur V; Charron S; Gasse P; Tavernier M; Guillet J; Lagente V; Fick L; Jacobs M; Coelho FR; Moser R; Ryffel B. 2009. IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J Immunol 183(12):8195-202. PubMed: 20007584MGI: J:157458
- Court N; Vasseur V; Vacher R; Fremond C; Shebzukhov Y; Yeremeev VV; Maillet I; Nedospasov SA; Gordon S; Fallon PG; Suzuki H; Ryffel B; Quesniaux VF. 2010. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol 184(12):7057-70. PubMed: 20488784MGI: J:161134
- Deckert M; Virna S; Sakowicz-Burkiewicz M; Lutjen S; Soltek S; Bluethmann H; Schluter D. 2007. Interleukin-1 receptor type 1 is essential for control of cerebral but not systemic listeriosis. Am J Pathol 170(3):990-1002. PubMed: 17322383MGI: J:118657
- Descamps D; Le Gars M; Balloy V; Barbier D; Maschalidi S; Tohme M; Chignard M; Ramphal R; Manoury B; Sallenave JM. 2012. Toll-like receptor 5 (TLR5), IL-1beta secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing. Proc Natl Acad Sci U S A 109(5):1619-24. PubMed: 22307620MGI: J:182039
- Di Paolo NC; Miao EA; Iwakura Y; Murali-Krishna K; Aderem A; Flavell RA; Papayannopoulou T; Shayakhmetov DM. 2009. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 31(1):110-21. PubMed: 19576795MGI: J:151628
- Doisne JM; Soulard V; Becourt C; Amniai L; Henrot P; Havenar-Daughton C; Blanchet C; Zitvogel L; Ryffel B; Cavaillon JM; Marie JC; Couillin I; Benlagha K. 2011. Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol 186(2):662-6. PubMed: 21169541MGI: J:168762
- Dostert C; Guarda G; Romero JF; Menu P; Gross O; Tardivel A; Suva ML; Stehle JC; Kopf M; Stamenkovic I; Corradin G; Tschopp J. 2009. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One 4(8):e6510. PubMed: 19652710MGI: J:152483
- Doz E; Noulin N; Boichot E; Guenon I; Fick L; Le Bert M; Lagente V; Ryffel B; Schnyder B; Quesniaux VF; Couillin I. 2008. Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol 180(2):1169-78. PubMed: 18178857MGI: J:130941
- Drennan MB; Stijlemans B; Van den Abbeele J; Quesniaux VJ; Barkhuizen M; Brombacher F; De Baetselier P; Ryffel B; Magez S. 2005. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol 175(4):2501-9. PubMed: 16081822MGI: J:107495
- Drexler SK; Bonsignore L; Masin M; Tardivel A; Jackstadt R; Hermeking H; Schneider P; Gross O; Tschopp J; Yazdi AS. 2012. Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A 109(45):18384-9. PubMed: 23090995MGI: J:191239
- Embry CA; Franchi L; Nunez G; Mitchell TC. 2011. Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A. Sci Signal 4(171):ra28. PubMed: 21540455MGI: J:185335
- Engler H; Bailey MT; Engler A; Stiner-Jones LM; Quan N; Sheridan JF. 2008. Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. Psychoneuroendocrinology 33(1):108-17. PubMed: 18037570MGI: J:140079
- Eriksson U; Kurrer MO; Sonderegger I; Iezzi G; Tafuri A; Hunziker L; Suzuki S; Bachmaier K; Bingisser RM; Penninger JM; Kopf M. 2003. Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med 197(3):323-31. PubMed: 12566416MGI: J:124689
- Fejer G; Wegner MD; Gyory I; Cohen I; Engelhard P; Voronov E; Manke T; Ruzsics Z; Dolken L; Prazeres da Costa O; Branzk N; Huber M; Prasse A; Schneider R; Apte RN; Galanos C; Freudenberg MA. 2013. Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. Proc Natl Acad Sci U S A 110(24):E2191-8. PubMed: 23708119MGI: J:197404
- Freigang S; Ampenberger F; Weiss A; Kanneganti TD; Iwakura Y; Hersberger M; Kopf M. 2013. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 14(10):1045-53. PubMed: 23995233MGI: J:208219
- Fremond CM; Togbe D; Doz E; Rose S; Vasseur V; Maillet I; Jacobs M; Ryffel B; Quesniaux VF. 2007. IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol 179(2):1178-89. PubMed: 17617611MGI: J:149392
- Gasse P; Mary C; Guenon I; Noulin N; Charron S; Schnyder-Candrian S; Schnyder B; Akira S; Quesniaux VF; Lagente V; Ryffel B; Couillin I. 2007. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117(12):3786-99. PubMed: 17992263MGI: J:130776
- Gasse P; Riteau N; Charron S; Girre S; Fick L; Petrilli V; Tschopp J; Lagente V; Quesniaux VF; Ryffel B; Couillin I. 2009. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 179(10):903-13. PubMed: 19218193MGI: J:164986
- Gomes MT; Campos PC; Oliveira FS; Corsetti PP; Bortoluci KR; Cunha LD; Zamboni DS; Oliveira SC. 2013. Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection. J Immunol 190(7):3629-38. PubMed: 23460746MGI: J:194921
- Goshen I; Avital A; Kreisel T; Licht T; Segal M; Yirmiya R. 2009. Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement. J Neurosci 29(11):3395-403. PubMed: 19295146MGI: J:147047
- Goshen I; Kreisel T; Ben-Menachem-Zidon O; Licht T; Weidenfeld J; Ben-Hur T; Yirmiya R. 2008. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 13(7):717-28. PubMed: 17700577MGI: J:151068
- Goshen I; Kreisel T; Ounallah-Saad H; Renbaum P; Zalzstein Y; Ben-Hur T; Levy-Lahad E; Yirmiya R. 2007. A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology 32(8-10):1106-15. PubMed: 17976923MGI: J:140080
- Goshen I; Yirmiya R; Iverfeldt K; Weidenfeld J. 2003. The role of endogenous interleukin-1 in stress-induced adrenal activation and adrenalectomy-induced adrenocorticotropic hormone hypersecretion. Endocrinology 144(10):4453-8. PubMed: 12960098MGI: J:85770
- Graves DT; Nooh N; Gillen T; Davey M; Patel S; Cottrell D; Amar S. 2001. Il-1 plays a critical role in oral, but not dermal, wound healing. J Immunol 167(9):5316-20. PubMed: 11673547MGI: J:72674
- Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. PubMed: 21349431MGI: J:168972
- Harry GJ; Funk JA; Lefebvre d'Hellencourt C; McPherson CA; Aoyama M. 2008. The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation. Brain Res 1194:8-20. PubMed: 18191113MGI: J:131904
- Jaillon S; Moalli F; Ragnarsdottir B; Bonavita E; Puthia M; Riva F; Barbati E; Nebuloni M; Cvetko Krajinovic L; Markotic A; Valentino S; Doni A; Tartari S; Graziani G; Montanelli A; Delneste Y; Svanborg C; Garlanda C; Mantovani A. 2014. The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity 40(4):621-32. PubMed: 24745336MGI: J:209948
- Ji H; Pettit A; Ohmura K; Ortiz-Lopez A; Duchatelle V; Degott C; Gravallese E; Mathis D; Benoist C. 2002. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med 196(1):77-85. PubMed: 12093872MGI: J:132920
- Josephs MD; Solorzano CC; Taylor M; Rosenberg JJ; Topping D; Abouhamze A; Mackay SL; Hirsch E; Hirsh D; Labow M; Moldawer LL. 2000. Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra. Am J Physiol Regul Integr Comp Physiol 278(4):R824-30. PubMed: 10749768MGI: J:61600
- Jung C; Meinzer U; Montcuquet N; Thachil E; Chateau D; Thiebaut R; Roy M; Alnabhani Z; Berrebi D; Dussaillant M; Pedruzzi E; Thenet S; Cerf-Bensussan N; Hugot JP; Barreau F. 2012. Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. J Clin Invest 122(6):2239-51. PubMed: 22565313MGI: J:190499
- Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 169(3):1459-66. PubMed: 12133972MGI: J:120707
- Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. PubMed: 19006696MGI: J:142395
- Kim ML; Chae JJ; Park YH; De Nardo D; Stirzaker RA; Ko HJ; Tye H; Cengia L; DiRago L; Metcalf D; Roberts AW; Kastner DL; Lew AM; Lyras D; Kile BT; Croker BA; Masters SL. 2015. Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta. J Exp Med 212(6):927-38. PubMed: 26008898MGI: J:224778
- Labow M; Shuster D; Zetterstrom M; Nunes P; Terry R; Cullinan EB ; Bartfai T ; Solorzano C ; Moldawer LL ; Chizzonite R ; McIntyre KW. 1997. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immunol 159(5):2452-61. PubMed: 9278338MGI: J:42373
- Leibundgut-Landmann S; Weidner K; Hilbi H; Oxenius A. 2011. Nonhematopoietic cells are key players in innate control of bacterial airway infection. J Immunol 186(5):3130-7. PubMed: 21270399MGI: J:169394
- Lucey EC; Keane J; Kuang PP; Snider GL; Goldstein RH. 2002. Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice. Lab Invest 82(1):79-85. PubMed: 11796828MGI: J:126680
- Mankan AK; Canli O; Schwitalla S; Ziegler P; Tschopp J; Korn T; Greten FR. 2011. TNF-{alpha}-dependent loss of IKK{beta}-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. Proc Natl Acad Sci U S A 108(16):6567-72. PubMed: 21464320MGI: J:171365
- Martinon F; Petrilli V; Mayor A; Tardivel A; Tschopp J. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440(7081):237-41. PubMed: 16407889MGI: J:124226
- Masters SL; Gerlic M; Metcalf D; Preston S; Pellegrini M; O'Donnell JA; McArthur K; Baldwin TM; Chevrier S; Nowell CJ; Cengia LH; Henley KJ; Collinge JE; Kastner DL; Feigenbaum L; Hilton DJ; Alexander WS; Kile BT; Croker BA. 2012. NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity 37(6):1009-23. PubMed: 23219391MGI: J:191055
- Mayer-Barber KD; Barber DL; Shenderov K; White SD; Wilson MS; Cheever A; Kugler D; Hieny S; Caspar P; Nunez G; Schlueter D; Flavell RA; Sutterwala FS; Sher A. 2010. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol 184(7):3326-30. PubMed: 20200276MGI: J:160077
- McCandless EE; Budde M; Lees JR; Dorsey D; Lyng E; Klein RS. 2009. IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. J Immunol 183(1):613-20. PubMed: 19535637MGI: J:150113
- McGeough MD; Pena CA; Mueller JL; Pociask DA; Broderick L; Hoffman HM; Brydges SD. 2012. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol 189(6):2707-11. PubMed: 22904305MGI: J:189914
- McKenzie MD; Dudek NL; Mariana L; Chong MM; Trapani JA; Kay TW; Thomas HE. 2006. Perforin and Fas induced by IFN{gamma} and TNF{alpha} mediate beta cell death by OT-I CTL. Int Immunol 18(6):837-46. PubMed: 16574667MGI: J:109099
- McKenzie MD; Jamieson E; Jansen ES; Scott CL; Huang DC; Bouillet P; Allison J; Kay TW; Strasser A; Thomas HE. 2010. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 59(3):644-52. PubMed: 19959756MGI: J:164154
- Mizgerd JP; Lupa MM; Hjoberg J; Vallone JC; Warren HB; Butler JP; Silverman ES. 2004. Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am J Physiol Lung Cell Mol Physiol 286(6):L1302-10. PubMed: 14966082MGI: J:108146
- Moayeri M; Crown D; Newman ZL; Okugawa S; Eckhaus M; Cataisson C; Liu S; Sastalla I; Leppla SH. 2010. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog 6(12):e1001222. PubMed: 21170303MGI: J:168096
- Moreland JG; Fuhrman RM; Wohlford-Lenane CL; Quinn TJ; Benda E; Pruessner JA; Schwartz DA. 2001. TNF-alpha and IL-1 beta are not essential to the inflammatory response in LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol 280(1):L173-80. PubMed: 11133507MGI: J:107839
- Murphy AJ; Kraakman MJ; Kammoun HL; Dragoljevic D; Lee MK; Lawlor KE; Wentworth JM; Vasanthakumar A; Gerlic M; Whitehead LW; DiRago L; Cengia L; Lane RM; Metcalf D; Vince JE; Harrison LC; Kallies A; Kile BT; Croker BA; Febbraio MA; Masters SL. 2016. IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome. Cell Metab 23(1):155-64. PubMed: 26603191MGI: J:232742
- Noursadeghi M; Bickerstaff MC; Herbert J; Moyes D; Cohen J; Pepys MB. 2002. Production of granulocyte colony-stimulating factor in the nonspecific acute phase response enhances host resistance to bacterial infection. J Immunol 169(2):913-9. PubMed: 12097396MGI: J:123857
- Qian J; Zhu L; Li Q; Belevych N; Chen Q; Zhao F; Herness S; Quan N. 2012. Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A 109(30):12189-94. PubMed: 22778412MGI: J:186478
- Quinton LJ; Jones MR; Robson BE; Mizgerd JP. 2009. Mechanisms of the hepatic acute-phase response during bacterial pneumonia. Infect Immun 77(6):2417-26. PubMed: 19289507MGI: J:149372
- Rabeony H; Pohin M; Vasseur P; Petit-Paris I; Jegou JF; Favot L; Frouin E; Boutet MA; Blanchard F; Togbe D; Ryffel B; Bernard FX; Lecron JC; Morel F. 2015. IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome. Eur J Immunol 45(10):2847-57. PubMed: 26147228MGI: J:233058
- Raivich G; Liu ZQ; Kloss CU; Labow M; Bluethmann H; Bohatschek M. 2002. Cytotoxic potential of proinflammatory cytokines: combined deletion of TNF receptors TNFR1 and TNFR2 prevents motoneuron cell death after facial axotomy in adult mouse. Exp Neurol 178(2):186-93. PubMed: 12504878MGI: J:118490
- Rectenwald JE; Moldawer LL; Huber TS; Seeger JM; Ozaki CK. 2000. Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation 102(14):1697-702. PubMed: 11015350MGI: J:130541
- Reiniger N; Lee MM; Coleman FT; Ray C; Golan DE; Pier GB. 2007. Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun 75(4):1598-608. PubMed: 17283089MGI: J:119764
- Ronchi F; Basso C; Preite S; Reboldi A; Baumjohann D; Perlini L; Lanzavecchia A; Sallusto F. 2016. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1beta production by myeloid cells. Nat Commun 7:11541. PubMed: 27189410MGI: J:239926
- Rosenzweig HL; Galster KT; Planck SR; Rosenbaum JT. 2009. NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci 50(4):1746-53. PubMed: 19074813MGI: J:146667
- Salio M; Chimenti S; De Angelis N; Molla F; Maina V; Nebuloni M; Pasqualini F; Latini R; Garlanda C; Mantovani A. 2008. Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction. Circulation 117(8):1055-64. PubMed: 18268142MGI: J:148653
- Samardzija M; Wenzel A; Thiersch M; Frigg R; Reme C; Grimm C. 2006. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 47(12):5181-90. PubMed: 17122101MGI: J:123100
- Satoskar AR; Okano M; Connaughton S; Raisanen-Sokolwski A; David JR; Labow M. 1998. Enhanced Th2-like responses in IL-1 type 1 receptor-deficient mice. Eur J Immunol 28(7):2066-74. PubMed: 9692874MGI: J:83038
- Saxena A; Chen W; Su Y; Rai V; Uche OU; Li N; Frangogiannis NG. 2013. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol 191(9):4838-48. PubMed: 24078695MGI: J:206237
- Schmitz N; Kurrer M; Bachmann MF; Kopf M. 2005. Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol 79(10):6441-8. PubMed: 15858027MGI: J:98377
- Schmitz N; Kurrer M; Kopf M. 2003. The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Eur J Immunol 33(4):991-1000. PubMed: 12672065MGI: J:82863
- Schultz J; Schwarz A; Neidhold S; Burwinkel M; Riemer C; Simon D; Kopf M; Otto M; Baier M. 2004. Role of interleukin-1 in prion disease-associated astrocyte activation. Am J Pathol 165(2):671-8. PubMed: 15277240MGI: J:91520
- Sporri R; Joller N; Albers U; Hilbi H; Oxenius A. 2006. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J Immunol 176(10):6162-71. PubMed: 16670325MGI: J:131762
- Stock AT; Hansen JA; Sleeman MA; McKenzie BS; Wicks IP. 2016. GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease. J Exp Med 213(10):1983-98. PubMed: 27595596MGI: J:237282
- Sutton C; Brereton C; Keogh B; Mills KH; Lavelle EC. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203(7):1685-91. PubMed: 16818675MGI: J:124398
- Szretter KJ; Gangappa S; Lu X; Smith C; Shieh WJ; Zaki SR; Sambhara S; Tumpey TM; Katz JM. 2007. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol 81(6):2736-44. PubMed: 17182684MGI: J:153325
- Timoshanko JR; Kitching AR; Iwakura Y; Holdsworth SR; Tipping PG. 2004. Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis. Am J Pathol 164(6):1967-77. PubMed: 15161633MGI: J:91098
- Tortola L; Rosenwald E; Abel B; Blumberg H; Schafer M; Coyle AJ; Renauld JC; Werner S; Kisielow J; Kopf M. 2012. Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest 122(11):3965-76. PubMed: 23064362MGI: J:193548
- Trunk G; Oxenius A. 2012. Innate instruction of CD4+ T cell immunity in respiratory bacterial infection. J Immunol 189(2):616-28. PubMed: 22723524MGI: J:189793
- Weber FC; Esser PR; Muller T; Ganesan J; Pellegatti P; Simon MM; Zeiser R; Idzko M; Jakob T; Martin SF. 2010. Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity. J Exp Med 207(12):2609-19. PubMed: 21059855MGI: J:176873
- Wei J; Waithman J; Lata R; Mifsud NA; Cebon J; Kay T; Smyth MJ; Sadler AJ; Chen W. 2010. Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion. J Immunol 185(10):6013-22. PubMed: 20956347MGI: J:165777
- Willart MA; Deswarte K; Pouliot P; Braun H; Beyaert R; Lambrecht BN; Hammad H. 2012. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med 209(8):1505-17. PubMed: 22802353MGI: J:189157
- Wolf G; Gabay E; Tal M; Yirmiya R; Shavit Y. 2006. Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice. Pain 120(3):315-24. PubMed: 16426759MGI: J:112801
- Wolf G; Yirmiya R; Goshen I; Iverfeldt K; Holmlund L; Takeda K; Shavit Y. 2003. Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects. Pain 104(3):471-80. PubMed: 12927619MGI: J:118738
- Zaiss MM; Maslowski KM; Mosconi I; Guenat N; Marsland BJ; Harris NL. 2013. IL-1beta suppresses innate IL-25 and IL-33 production and maintains helminth chronicity. PLoS Pathog 9(8):e1003531. PubMed: 23935505MGI: J:214162
- Zhang H; Ching S; Chen Q; Li Q; An Y; Quan N. 2008. Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain. Neuroscience 157(4):895-907. PubMed: 18950689MGI: J:144882
- Zhang X; Hester SE; Kennett MJ; Karanikas AT; Bendor L; Place DE; Harvill ET. 2011. Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis. Infect Immun 79(1):527-41. PubMed: 20974829MGI: J:167554