Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No gene product (mRNA or protein) is detected by Northern blot analysis of cardiac tissue or Southern blot analysis. Cardiac ventribular myocytes isolated from homozygotes exhibit a 50% reduction in inwardly rectifying potassium ion currents under physiological and elevated extracellular potassium ion concentration levels. This mutant mouse strain may be useful in studies of potassium ion dependent cardiac electrophysiology.

These <i> Kcnj12</i> knock-out mice exhibit a reduction in inwardly rectifying potassium ion currents in cardiac ventribular myocytes.

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