PN/nBSwUmabJ mice develop a predominantly female lupus-like syndrome with age (Walker et al., 1978).  Characteristics of the systemic lupus erythemoatosus syndrome include: abnormalities in B and T cell function, hypergammaglobulinemia, antibody production against multiple autoantigens, severe systemic perivasculitis and vasculitis, and immune complex-mediated  glomerulonephritis (Walker et al.,1978, Luzina et al., 1999, Davidson et al., 1982, Handwerger  et al.,1999).  Perivascular and vascular infiltrates are composed of unusual phenotypic markers characteristic of both T and B cells (Luzina et al, 1999).  By three months of age 88-100% of mice have IgG autoantibodies (Handwerger et al., 1999). Death usually occurs earlier in females as a result of glomerulonephritis and arteritis. The disease progression is accelerated in the female offspring of NZB and PN F1 crosses (Walker  et al., 1986).  PN/nBSwUmabJ mice develop hearing loss and otic capsule sclerosis demonstrating some parallels to human cochlear autoimmune osteogenesis (Khan et al., 2000).

These mice develop hearing loss and otic capsule sclerosis as well as a predominantly female lupus-like syndrome.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.