These transgenic mice express Green Fluorescent Protein (GFP) under the direction of the mouse <i>Mnx1</i> (also called Hlxb9) promoter. Mice homozygous for the transgenic insert are viable, fertile, do not display any gross behavioral abnormalities, but are smaller in size than wildtype littermates. Homozygous pups born to homozygous females have a high mortality rate. Transgenic mice display distinct expression of GFP in dendrites, axons and soma of spinal motor neurons, allowing identification, isolation and purification of spinal motor neurons by FACS. GFP expression mimics endogenous HLXB9 expression pattern. Fluorescence is detected in axons, dendrites and processes of spinal motor neurons at embryonic day 9.5 to postnatal day 10 aged mice. This mutant mouse strain represents a model that may be useful for purification and in vivo tracking of spinal motor neurons.

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Mice homozygous for the transgene display distinct expression of GFP in dendrites, axons and soma of spinal motor neurons at embryonic day 9.5 to postnatal day 10 aged mice. Expression mimics endogenous HLXB9 expression pattern. This mutant mouse strain represents a model that may be useful for purification and <em>in vivo</em> tracking of spinal motor neurons.

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