These mice carry an ENU-induced mutation characterized by eye defects.
The Jackson Laboratory cannot guarantee that cryorecovery of strains from the discontinued NIH-funded Neuroscience Mutagenesis Facility (NMF) will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.Read More +
Routine ophthalmoscopic examination at 8 weeks of age revealed unusual spots on the retina and in the vitreous body, in addition to scarring and scleralization of the cornea. The colony is maintained through normal breeding. Standard pathology work-up on one mutant (122 days of age) showed a cataract and dysplastic retina with folds in one eye; the other eye appeared normal. There was also a mineral deposit in the wall of the middle ear.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
When using the C57BL/6J-Nmf128/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #004851 in your Materials and Methods section.