This strain carries the same trisomic segment as other strains that are models for Down syndrome, but may have advantages in that transmission of the trisomic segment through the female germline is greater and males are fertile.Read More +
Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind.
The trisomic segment in the Rb(12.Ts171665Dn)2Cje strain is genetically identical to the Ts65Dn strains, Stock No. 001924 and Stock No. 005252, with trisomy of the Chr 16 genes, from Mrpl39 to the distal telomere. Quantitative PCR confirmed the triplication of Chr 16 genes from App to Mx1. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Trisomic mice are 20% smaller in size than controls. This strain serves a model for Down syndrome.
The Clcc1m1J spontaneous mutation, which causes increased sensitivity to endoplasmic reticulum stress in the cerebellum, is a homozygous strain characteristic of C3H/HeSnJ (Jia et al., 2015) so is segregating in this strain.
The Rb(12.Ts171665Dn)2Cje strain was the result of a spontaneous fusion between the small Ts65Dn marker chromosome (carrying the distal end of Chr 16) and Chr 12, forming a Robertsonian fusion chromosome. This Robertsonian chromosome was found among the progeny of a mating between a trisomic Ts65Dn female, B6EiC3Sn a/A - Ts(1716)65Dn (Stock No. 001924) and a diploid B6EiC3SnF1 male. Quantitative PCR confirmed the triplication of Chr 16 genes from App to Mx1, the same as in Ts65Dn strains.
|Allele Name||Robertsonian translocation, Chr 12 and T17<16>Dn, Charles J Epstein 2|
|Allele Type||Not Applicable|
|Allele Synonym(s)||Robertsonian translocation, Chr 12 and T1716Dn, Charles J Epstein 2; Rb(12.Ts171665Dn)2Cje|
|Gene Symbol and Name||Rb(12.Ts171665Dn)2Cje, Robertsonian translocation, Chr 12 and T17<16>Dn, Charles J Epstein 2|
|Gene Synonym(s)||Ts(Rb(12.1716))2Cje; Rb(12.T171665Dn)2Cje|
|Strain of Origin||Not Specified|
|Molecular Note||A female mouse with 40 chromosomes and 41 arms was detected by chromosome analysis of progeny from T171665Dn mice. This mouse had a unique biarmed chromosome that appeared to be the result of a fusion between chromosome 12 and the marker chromosome T(1716)65Dn.|
When using the B6EiC3Sn-Rb(12.Ts171665Dn)2Cje/CjeDnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #004850 in your Materials and Methods section.
|Heterozygous Females and Wild-type Males for Rb(12.Ts17<16>65Dn)2Cje|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
|Frozen Mouse Embryo||$2,595.00 per straw or vial|
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