This strain carries the same trisomic segment as other strains that are models for Down syndrome, but may have advantages in that transmission of the trisomic segment through the female germline is greater and males are fertile.
Read More +Genetic Background | Generation |
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N11+N28
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Rb(12.Ts171665Dn)2Cje | Robertsonian translocation, Chr 12 and T17<16>Dn, Charles J Epstein 2 |
Starting at:
$247.50 Domestic price for female 4-week |
408.00 Domestic price for breeder pair |
Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this colony. Animals that are homozygous for rd1 will be blind.
The trisomic segment in the Rb(12.Ts171665Dn)2Cje strain is genetically identical to the Ts65Dn strains, Stock No. 001924 and Stock No. 005252, with trisomy of the Chr 16 genes, from Mrpl39 to the distal telomere. Quantitative PCR confirmed the triplication of Chr 16 genes from App to Mx1. Transmission of the chromosome 16 segmental trisomy through the female germline is significantly improved over Ts65Dn (43% versus 24%). Dendritic spines on granule cells in the fascia dentata are enlarged in size and decreased in density (Villar AJ, et al. 2005). Unlike Ts65Dn, males are fertile. Trisomic mice are 20% smaller in size than controls. This strain serves a model for Down syndrome.
The Clcc1m1J spontaneous mutation, which causes increased sensitivity to endoplasmic reticulum stress in the cerebellum, is a homozygous strain characteristic of C3H/HeSnJ (Jia et al., 2015) so is segregating in this strain.
The Rb(12.Ts171665Dn)2Cje strain was the result of a spontaneous fusion between the small Ts65Dn marker chromosome (carrying the distal end of Chr 16) and Chr 12, forming a Robertsonian fusion chromosome. This Robertsonian chromosome was found among the progeny of a mating between a trisomic Ts65Dn female, B6EiC3Sn a/A - Ts(1716)65Dn (Stock No. 001924) and a diploid B6EiC3SnF1 male. Quantitative PCR confirmed the triplication of Chr 16 genes from App to Mx1, the same as in Ts65Dn strains.
Allele Name | Robertsonian translocation, Chr 12 and T17<16>Dn, Charles J Epstein 2 |
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Allele Type | Not Applicable |
Allele Synonym(s) | Rb2Cje; Ts(Rb(12.1716))2Cje; Ts2; Ts2Cje |
Gene Symbol and Name | Rb(12.Ts171665Dn)2Cje, Robertsonian translocation, Chr 12 and T17<16>Dn, Charles J Epstein 2 |
Gene Synonym(s) | |
Strain of Origin | Not Specified |
Chromosome | UN |
Molecular Note | A female mouse with 40 chromosomes and 41 arms was detected by chromosome analysis of progeny from T171665Dn mice. This mouse had a unique biarmed chromosome that appeared to be the result of a fusion between chromosome 12 and the marker chromosome T(1716)65Dn. |
When using the B6EiC3Sn-Rb(12.Ts171665Dn)2Cje/CjeDnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #004850 in your Materials and Methods section.
Service/Product | Description | Price |
---|---|---|
Heterozygous Females and Wild-type Males for Rb(12.Ts17<16>65Dn)2Cje |
Frozen Mouse Embryo | B6EiC3Sn-Rb(12.Ts17<16>65Dn)2Cje/CjeDnJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6EiC3Sn-Rb(12.Ts17<16>65Dn)2Cje/CjeDnJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6EiC3Sn-Rb(12.Ts17<16>65Dn)2Cje/CjeDnJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6EiC3Sn-Rb(12.Ts17<16>65Dn)2Cje/CjeDnJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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