JAX
Mouse Strain Datasheet - 004847
B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
Also Known As: R26CreER
These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions.
Donating Investigator
Jeremy Nathans, Johns Hopkins University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+N2F3
(19-SEP-16) |
Gt(ROSA)26Sortm1(cre/ERT)Nat
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Inducible, Recombinase-expressing) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Research Applications
- Research Tools
- Developmental Biology Research
- Internal/Organ Research
- Reproductive Biology Research
Detailed Description
These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. The mutant allele consists of a fusion product involving Cre recombinase and an altered version of the mouse estrogen receptor ligand binding domain. The mutant ligand binding domain does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the CRE/ESR1 protein can only gain access to the nuclear compartment to mediate recombination after exposure to tamoxifen. Tamoxifen administration will also induce Cre recombination in the developing embryos of treated mothers. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
Development
A targeting vector containing a PGK-neo cassette and Cre recombinase/estrogen receptor ligand-binding domain fusion protein sequence was used to insert the fusion protein into a site located within intron 1 of the GT(ROSA)26Sor locus. The construct was introduced into 129X1/SvJ x 129S1/Sv-derived R1-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Correctly targeted ES cells were injected into C57BL/6J blastocysts to obtain chimeric animals.
Expression Data
| Expressed Gene | cre/ER, cre inducible estrogen receptor, bacteriophage P1/Human |
|---|---|
| Site of Expression | tamoxifen-inducible cre; when crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions |
Control Suggestions
Selected References
- Badea TC; Wang Y; Nathans J. 2003. A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci 23(6):2314-22. PubMed: 12657690MGI: J:84747
Gt(ROSA)26Sortm1(cre/ERT)Nat
Allele Symbol: Gt(ROSA)26Sortm1(cre/ERT)Nat
| Allele Name | targeted mutation 1, Jeremy Nathans |
|---|---|
| Allele Type | Targeted (Inducible, Recombinase-expressing) |
| Allele Synonym(s) | CreERT1; Gt(ROSA)26Sortm1(cre/Esr1)Nat; R26CreER; R26ERCre; R26RNatCre |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | cre/ER, cre inducible estrogen receptor, bacteriophage P1/Human |
| Site of Expression | tamoxifen-inducible cre; when crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Chromosome | 6 |
| Molecular Note | A cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen. |
| Mutations Made By | Tudor Badea, Johns Hopkins University |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Inducible
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: Gt(ROSA)26Sortm1(cre/ERT)Nat related
- Developmental Biology Research
- Internal/Organ Defects
- ovary; uterus
- Internal/Organ Defects
- Internal/Organ Research
- Other Organ Defects
- Reproductive Biology Research
- Developmental Defects Affecting Gonads
- germ cell deficient
- Fertility Defects
- Developmental Defects Affecting Gonads
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat
normal phenotype
- no abnormal phenotype detected
- (MGI Ref ID J:84747)
References
- Badea TC; Wang Y; Nathans J. 2003. A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci 23(6):2314-22. PubMed: 12657690MGI: J:84747
Additional - Gt(ROSA)26Sortm1(cre/ERT)Nat related
- Abraira VE; Kuehn ED; Chirila AM; Springel MW; Toliver AA; Zimmerman AL; Orefice LL; Boyle KA; Bai L; Song BJ; Bashista KA; O'Neill TG; Zhuo J; Tsan C; Hoynoski J; Rutlin M; Kus L; Niederkofler V; Watanabe M; Dymecki SM; Nelson SB; Heintz N; Hughes DI; Ginty DD. 2017. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell 168(1-2):295-310.e19. PubMed: 28041852MGI: J:239228
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