JAX
Mouse Strain Datasheet - 004847
B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
Also Known As: R26CreER
These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions.
Donating Investigator
Jeremy Nathans, Johns Hopkins University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+N2F5
|
Gt(ROSA)26Sortm1(cre/ERT)Nat
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Inducible, Recombinase-expressing) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Research Applications
- Research Tools
- Developmental Biology Research
- Internal/Organ Research
- Reproductive Biology Research
Detailed Description
These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. The mutant allele consists of a fusion product involving Cre recombinase and an altered version of the mouse estrogen receptor ligand binding domain. The mutant ligand binding domain does not bind natural ligand at physiological concentrations but will bind the synthetic ligand, 4-hydroxytamoxifen. Restricted to the cytoplasm, the CRE/ESR1 protein can only gain access to the nuclear compartment to mediate recombination after exposure to tamoxifen. Tamoxifen administration will also induce Cre recombination in the developing embryos of treated mothers. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
Development
A targeting vector containing a PGK-neo cassette and Cre recombinase/estrogen receptor ligand-binding domain fusion protein sequence was used to insert the fusion protein into a site located within intron 1 of the GT(ROSA)26Sor locus. The construct was introduced into 129X1/SvJ x 129S1/Sv-derived R1-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Correctly targeted ES cells were injected into C57BL/6J blastocysts to obtain chimeric animals.
Expression Data
| Expressed Gene | cre/ER, cre inducible estrogen receptor, bacteriophage P1/Human |
|---|---|
| Site of Expression | tamoxifen-inducible cre; when crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions |
Control Suggestions
Selected References
- Badea TC; Wang Y; Nathans J. 2003. A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci 23(6):2314-22. PubMed: 12657690MGI: J:84747
Gt(ROSA)26Sortm1(cre/ERT)Nat
Allele Symbol: Gt(ROSA)26Sortm1(cre/ERT)Nat
| Allele Name | targeted mutation 1, Jeremy Nathans |
|---|---|
| Allele Type | Targeted (Inducible, Recombinase-expressing) |
| Allele Synonym(s) | CreERT1; Gt(ROSA)26Sortm1(cre/Esr1)Nat; R26CreER; R26ERCre; R26RNatCre |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | cre/ER, cre inducible estrogen receptor, bacteriophage P1/Human |
| Site of Expression | tamoxifen-inducible cre; when crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Chromosome | 6 |
| Molecular Note | A cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen. |
| Mutations Made By | Tudor Badea, Johns Hopkins University |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Inducible
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: Gt(ROSA)26Sortm1(cre/ERT)Nat related
- Developmental Biology Research
- Internal/Organ Defects
- ovary; uterus
- Internal/Organ Defects
- Internal/Organ Research
- Other Organ Defects
- Reproductive Biology Research
- Developmental Defects Affecting Gonads
- germ cell deficient
- Fertility Defects
- Developmental Defects Affecting Gonads
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1(cre/ERT)Nat
B6.129-Gt(ROSA)26Sortm1(cre/Esr1)Nat
normal phenotype
- no abnormal phenotype detected
- (MGI Ref ID J:84747)
References
- Badea TC; Wang Y; Nathans J. 2003. A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. J Neurosci 23(6):2314-22. PubMed: 12657690MGI: J:84747
Additional - Gt(ROSA)26Sortm1(cre/ERT)Nat related
- Abraira VE; Kuehn ED; Chirila AM; Springel MW; Toliver AA; Zimmerman AL; Orefice LL; Boyle KA; Bai L; Song BJ; Bashista KA; O'Neill TG; Zhuo J; Tsan C; Hoynoski J; Rutlin M; Kus L; Niederkofler V; Watanabe M; Dymecki SM; Nelson SB; Heintz N; Hughes DI; Ginty DD. 2017. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell 168(1-2):295-310.e19. PubMed: 28041852MGI: J:239228
- Badea TC; Cahill H; Ecker J; Hattar S; Nathans J. 2009. Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells. Neuron 61(6):852-64. PubMed: 19323995MGI: J:147350
- Badea TC; Hua ZL; Smallwood PM; Williams J; Rotolo T; Ye X; Nathans J. 2009. New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. PLoS One 4(11):e7859. PubMed: 19924248MGI: J:155417
- Badea TC; Williams J; Smallwood P; Shi M; Motajo O; Nathans J. 2012. Combinatorial expression of brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis. J Neurosci 32(3):995-1007. PubMed: 22262898MGI: J:179888
- Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6(4):309-22. PubMed: 20362536MGI: J:158953
- Campolo F; Gori M; Favaro R; Nicolis S; Pellegrini M; Botti F; Rossi P; Jannini EA; Dolci S. 2013. Essential role of sox2 for the establishment and maintenance of the germ cell line. Stem Cells :. PubMed: 23553930MGI: J:196968
- Cellurale C; Girnius N; Jiang F; Cavanagh-Kyros J; Lu S; Garlick DS; Mercurio AM; Davis RJ. 2012. Role of JNK in mammary gland development and breast cancer. Cancer Res 72(2):472-81. PubMed: 22127926MGI: J:181146
- Cellurale C; Sabio G; Kennedy NJ; Das M; Barlow M; Sandy P; Jacks T; Davis RJ. 2011. Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation. Mol Cell Biol 31(7):1565-76. PubMed: 21282468MGI: J:170101
- Chen J; Chen J; Zhu Y; Liang C; Zhao HB. 2014. Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders. Biochem Biophys Res Commun 448(1):28-32. PubMed: 24732355MGI: J:219459
- Chiang PM; Ling J; Jeong YH; Price DL; Aja SM; Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Natl Acad Sci U S A 107(37):16320-4. PubMed: 20660762MGI: J:164406
- Choi EJ; Chen W; Jun K; Arthur HM; Young WL; Su H. 2014. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. PLoS One 9(2):e88511. PubMed: 24520391MGI: J:212952
- Chong MM; Rasmussen JP; Rundensky AY; Littman DR. 2008. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med 205(9):2005-17. PubMed: 18725527MGI: J:138683
- Chong MM; Zhang G; Cheloufi S; Neubert TA; Hannon GJ; Littman DR. 2010. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev 24(17):1951-60. PubMed: 20713509MGI: J:163823
- Collins C; Wang J; Miao H; Bronstein J; Nawer H; Xu T; Figueroa M; Muntean AG; Hess JL. 2014. C/EBPalpha is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proc Natl Acad Sci U S A 111(27):9899-904. PubMed: 24958854MGI: J:212177
- Cornacchia D; Dileep V; Quivy JP; Foti R; Tili F; Santarella-Mellwig R; Antony C; Almouzni G; Gilbert DM; Buonomo SB. 2012. Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells. EMBO J 31(18):3678-90. PubMed: 22850673MGI: J:188030
- Cowley DO; Rivera-Perez JA; Schliekelman M; He YJ; Oliver TG; Lu L; O'Quinn R; Salmon ED; Magnuson T; Van Dyke T. 2009. Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol 29(4):1059-71. PubMed: 19075002MGI: J:145744
- Das M; Jiang F; Sluss HK; Zhang C; Shokat KM; Flavell RA; Davis RJ. 2007. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A 104(40):15759-64. PubMed: 17893331MGI: J:131766
- Doan LT; Javier AL; Furr NM; Nguyen KL; Cho KW; Monuki ES. 2012. A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate. PLoS One 7(9):e44009. PubMed: 22984456MGI: J:192898
- Dubois CL; Shih HP; Seymour PA; Patel NA; Behrmann JM; Ngo V; Sander M. 2011. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One 6(8):e23131. PubMed: 21829703MGI: J:176523
- Ferguson SM; Raimondi A; Paradise S; Shen H; Mesaki K; Ferguson A; Destaing O; Ko G; Takasaki J; Cremona O; O' Toole E; De Camilli P. 2009. Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell 17(6):811-22. PubMed: 20059951MGI: J:161127
- Flora A; Klisch TJ; Schuster G; Zoghbi HY. 2009. Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326(5958):1424-7. PubMed: 19965762MGI: J:155047
- Fu X; Zhao JX; Zhu MJ; Foretz M; Viollet B; Dodson MV; Du M. 2013. AMP-activated protein kinase alpha1 but not alpha2 catalytic subunit potentiates myogenin expression and myogenesis. Mol Cell Biol 33(22):4517-25. PubMed: 24043309MGI: J:206092
- Furumoto Y; Charles N; Olivera A; Leung WH; Dillahunt S; Sargent JL; Tinsley K; Odom S; Scott E; Wilson TM; Ghoreschi K; Kneilling M; Chen M; Lee DM; Bolland S; Rivera J. 2011. PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability. Blood 118(20):5466-75. PubMed: 21926349MGI: J:178784
- Gantier MP; McCoy CE; Rusinova I; Saulep D; Wang D; Xu D; Irving AT; Behlke MA; Hertzog PJ; Mackay F; Williams BR. 2011. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res 39(13):5692-703. PubMed: 21447562MGI: J:174036
- Gantier MP; Stunden HJ; McCoy CE; Behlke MA; Wang D; Kaparakis-Liaskos M; Sarvestani ST; Yang YH; Xu D; Corr SC; Morand EF; Williams BR. 2012. A miR-19 regulon that controls NF-kappaB signaling. Nucleic Acids Res 40(16):8048-58. PubMed: 22684508MGI: J:198890
- Garrido-Martin EM; Nguyen HL; Cunningham TA; Choe SW; Jiang Z; Arthur HM; Lee YJ; Oh SP. 2014. Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models--brief report. Arterioscler Thromb Vasc Biol 34(10):2232-6. PubMed: 25082229MGI: J:227170
- Ghosh S; Lau H; Simons BW; Powell JD; Meyers DJ; De Marzo AM; Berman DM; Lotan TL. 2011. PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol 360(2):329-42. PubMed: 22015718MGI: J:178714
- Ghosh S; Varela L; Sood A; Park BH; Lotan TL. 2013. mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss. Cancer Res 73(16):5218-31. PubMed: 23774212MGI: J:200612
- Goodwin ML; Jin H; Straessler K; Smith-Fry K; Zhu JF; Monument MJ; Grossmann A; Randall RL; Capecchi MR; Jones KB. 2014. Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment. Cancer Cell 26(6):851-62. PubMed: 25453902MGI: J:217462
- Gu B; Lambert JP; Cockburn K; Gingras AC; Rossant J. 2017. AIRE is a critical spindle-associated protein in embryonic stem cells. Elife 6:. PubMed: 28742026MGI: J:242967
- Haldar M; Hedberg ML; Hockin MF; Capecchi MR. 2009. A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res 69(8):3657-64. PubMed: 19351831MGI: J:147728
- Hamdane N; Stefanovsky VY; Tremblay MG; Nemeth A; Paquet E; Lessard F; Sanij E; Hannan R; Moss T. 2014. Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body. PLoS Genet 10(8):e1004505. PubMed: 25121932MGI: J:228597
- Harms MJ; Ishibashi J; Wang W; Lim HW; Goyama S; Sato T; Kurokawa M; Won KJ; Seale P. 2014. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab 19(4):593-604. PubMed: 24703692MGI: J:213153
- Holmes JB; Akman G; Wood SR; Sakhuja K; Cerritelli SM; Moss C; Bowmaker MR; Jacobs HT; Crouch RJ; Holt IJ. 2015. Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proc Natl Acad Sci U S A 112(30):9334-9. PubMed: 26162680MGI: J:225987
- Husson H; Moreno S; Smith LA; Smith MM; Russo RJ; Pitstick R; Sergeev M; Ledbetter SR; Bukanov NO; Lane M; Zhang K; Billot K; Carlson G; Shah J; Meijer L; Beier DR; Ibraghimov-Beskrovnaya O. 2016. Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis. Hum Mol Genet 25(11):2245-2255. PubMed: 27053712MGI: J:236705
- Huynh A; DuPage M; Priyadharshini B; Sage PT; Quiros J; Borges CM; Townamchai N; Gerriets VA; Rathmell JC; Sharpe AH; Bluestone JA; Turka LA. 2015. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol 16(2):188-96. PubMed: 25559257MGI: J:223233
- Ikeda Y; Morioka S; Matsumoto K; Ninomiya-Tsuji J. 2014. TAK1 binding protein 2 is essential for liver protection from stressors. PLoS One 9(2):e88037. PubMed: 24498425MGI: J:212972
- Inoue S; Li WY; Tseng A; Beerman I; Elia AJ; Bendall SC; Lemonnier F; Kron KJ; Cescon DW; Hao Z; Lind EF; Takayama N; Planello AC; Shen SY; Shih AH; Larsen DM; Li Q; Snow BE; Wakeham A; Haight J; Gorrini C; Bassi C; Thu KL; Murakami K; Elford AR; Ueda T; Straley K; Yen KE; Melino G; Cimmino L; Aifantis I; Levine RL; De Carvalho DD; Lupien M; Rossi DJ; Nolan GP; Cairns RA; Mak TW. 2016. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer Cell 30(2):337-48. PubMed: 27424808MGI: J:234913
- Iverson SV; Comstock KM; Kundert JA; Schmidt EE. 2011. Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice. Hepatology 54(2):655-63. PubMed: 21538442MGI: J:234606
- Jacobs DT; Silva LM; Allard BA; Schonfeld MP; Chatterjee A; Talbott GC; Beier DR; Tran PV. 2016. Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome. Dis Model Mech 9(7):789-98. PubMed: 27482817MGI: J:234171
- Jeanne M; Jorgensen J; Gould DB. 2015. Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention. Circulation 131(18):1555-65. PubMed: 25753534MGI: J:234321
- Jones C; Roper VC; Foucher I; Qian D; Banizs B; Petit C; Yoder BK; Chen P. 2008. Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet 40(1):69-77. PubMed: 18066062MGI: J:131308
- Jones KB; Barrott JJ; Xie M; Haldar M; Jin H; Zhu JF; Monument MJ; Mosbruger TL; Langer EM; Randall RL; Wilson RK; Cairns BR; Ding L; Capecchi MR. 2016. The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. Oncogene :. PubMed: 26947017MGI: J:230795
- Kissig M; Ishibashi J; Harms MJ; Lim HW; Stine RR; Won KJ; Seale P. 2017. PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing. EMBO J 36(11):1528-1542. PubMed: 28408438MGI: J:243350
- Kourepini E; Aggelakopoulou M; Alissafi T; Paschalidis N; Simoes DC; Panoutsakopoulou V. 2014. Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Proc Natl Acad Sci U S A 111(9):E856-65. PubMed: 24550510MGI: J:207403
- Kuhne C; Puk O; Graw J; Hrabe de Angelis M; Schutz G; Wurst W; Deussing JM. 2012. Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J Comp Neurol 520(14):3150-80. PubMed: 22886732MGI: J:187372
- Li J; Miao L; Shieh D; Spiotto E; Li J; Zhou B; Paul A; Schwartz RJ; Firulli AB; Singer HA; Huang G; Wu M. 2016. Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification. Cell Rep 15(1):158-70. PubMed: 27052172MGI: J:235083
- Liu C; Bakeri H; Li T; Swaroop A. 2012. Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma. Hum Mol Genet 21(8):1848-60. PubMed: 22228100MGI: J:181885
- Liu C; Wang Y; Smallwood PM; Nathans J. 2008. An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci 28(22):5641-53. PubMed: 18509025MGI: J:136390
- Lodhi IJ; Link DC; Semenkovich CF. 2015. Acute ether lipid deficiency affects neutrophil biology in mice. Cell Metab 21(5):652-3. PubMed: 25955199MGI: J:225850
- Lodhi IJ; Wei X; Yin L; Feng C; Adak S; Abou-Ezzi G; Hsu FF; Link DC; Semenkovich CF. 2015. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metab 21(1):51-64. PubMed: 25565205MGI: J:219976
- Lu TL; Chang JL; Liang CC; You LR; Chen CM. 2007. Tumor spectrum, tumor latency and tumor incidence of the pten-deficient mice. PLoS One 2(11):e1237. PubMed: 18043744MGI: J:130367
- Macfarlan TS; Gifford WD; Agarwal S; Driscoll S; Lettieri K; Wang J; Andrews SE; Franco L; Rosenfeld MG; Ren B; Pfaff SL. 2011. Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A. Genes Dev 25(6):594-607. PubMed: 21357675MGI: J:169674
- Mangale VS; Hirokawa KE; Satyaki PR; Gokulchandran N; Chikbire S; Subramanian L; Shetty AS; Martynoga B; Paul J; Mai MV; Li Y; Flanagan LA; Tole S; Monuki ES. 2008. Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science 319(5861):304-9. PubMed: 18202285MGI: J:130167
- Milosevic I; Giovedi S; Lou X; Raimondi A; Collesi C; Shen H; Paradise S; O'Toole E; Ferguson S; Cremona O; Camilli PD. 2011. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron 72(4):587-601. PubMed: 22099461MGI: J:178947
- Mohr S; Doebele C; Comoglio F; Berg T; Beck J; Bohnenberger H; Alexe G; Corso J; Strobel P; Wachter A; Beissbarth T; Schnutgen F; Cremer A; Haetscher N; Gollner S; Rouhi A; Palmqvist L; Rieger MA; Schroeder T; Bonig H; Muller-Tidow C; Kuchenbauer F; Schutz E; Green AR; Urlaub H; Stegmaier K; Humphries RK; Serve H; Oellerich T. 2017. Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Cancer Cell 31(4):549-562.e11. PubMed: 28399410MGI: J:242493
- Morioka S; Broglie P; Omori E; Ikeda Y; Takaesu G; Matsumoto K; Ninomiya-Tsuji J. 2014. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol 204(4):607-23. PubMed: 24535827MGI: J:208251
- Morioka S; Inagaki M; Komatsu Y; Mishina Y; Matsumoto K; Ninomiya-Tsuji J. 2012. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood 120(18):3846-57. PubMed: 22972987MGI: J:191285
- Nakatsu F; Baskin JM; Chung J; Tanner LB; Shui G; Lee SY; Pirruccello M; Hao M; Ingolia NT; Wenk MR; De Camilli P. 2012. PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its impact on plasma membrane identity. J Cell Biol 199(6):1003-16. PubMed: 23229899MGI: J:195235
- Nalbandian A; Llewellyn KJ; Nguyen C; Monuki ES; Kimonis VE. 2015. Targeted excision of VCP R155H mutation by Cre-LoxP technology as a promising therapeutic strategy for valosin-containing protein disease. Hum Gene Ther Methods 26(1):13-24. PubMed: 25545721MGI: J:232691
- Nichol PF; Corliss RF; Tyrrell JD; Graham B; Reeder A; Saijoh Y. 2011. Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. J Pediatr Surg 46(1):90-6. PubMed: 21238647MGI: J:170635
- Nishio M; Sugimachi K; Goto H; Wang J; Morikawa T; Miyachi Y; Takano Y; Hikasa H; Itoh T; Suzuki SO; Kurihara H; Aishima S; Leask A; Sasaki T; Nakano T; Nishina H; Nishikawa Y; Sekido Y; Nakao K; Shin-Ya K; Mimori K; Suzuki A. 2016. Dysregulated YAP1/TAZ and TGF-beta signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A 113(1):E71-80. PubMed: 26699479MGI: J:228499
- Olson LE ; Soriano P. 2009. Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis. Dev Cell 16(2):303-13. PubMed: 19217431MGI: J:146617
- Ostrowski LE; Yin W; Rogers TD; Busalacchi KB; Chua M; O'Neal WK; Grubb BR. 2009. Conditional Deletion of Dnaic1 in a Murine Model of Primary Ciliary Dyskinesia Causes Chronic Rhinosinusitis. Am J Respir Cell Mol Biol :. PubMed: 19675306MGI: J:155730
- Park EJ; Grabinska KA; Guan Z; Stranecky V; Hartmannova H; Hodanova K; Baresova V; Sovova J; Jozsef L; Ondruskova N; Hansikova H; Honzik T; Zeman J; Hulkova H; Wen R; Kmoch S; Sessa WC. 2014. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab 20(3):448-57. PubMed: 25066056MGI: J:215785
- Park JA; Sharif AS; Shiomi T; Kobzik L; Kasahara DI; Tschumperlin DJ; Voynow J; Drazen JM. 2013. Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. Am J Physiol Lung Cell Mol Physiol 304(10):L701-7. PubMed: 23564510MGI: J:196680
- Park SO; Wankhede M; Lee YJ; Choi EJ; Fliess N; Choe SW; Oh SH; Walter G; Raizada MK; Sorg BS; Oh SP. 2009. Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J Clin Invest 119(11):3487-96. PubMed: 19805914MGI: J:154620
- Penzo M; Molteni R; Suda T; Samaniego S; Raucci A; Habiel DM; Miller F; Jiang HP; Li J; Pardi R; Palumbo R; Olivotto E; Kew RR; Bianchi ME; Marcu KB. 2010. Inhibitor of NK-kappaB kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis. J Immunol 184(8):4497-509. PubMed: 20231695MGI: J:159873
- Prashar P; Yadav PS; Samarjeet F; Bandyopadhyay A. 2014. Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol 389(2):192-207. PubMed: 24583261MGI: J:209351
- Qian D; Jones C; Rzadzinska A; Mark S; Zhang X; Steel KP; Dai X; Chen P. 2007. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306(1):121-33. PubMed: 17433286MGI: J:122585
- Roy A; de Melo J; Chaturvedi D; Thein T; Cabrera-Socorro A; Houart C; Meyer G; Blackshaw S; Tole S. 2013. LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis. J Neurosci 33(16):6877-84. PubMed: 23595746MGI: J:196967
- Sabharwal P; Lee C; Park S; Rao M; Sockanathan S. 2011. GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron 71(6):1058-70. PubMed: 21943603MGI: J:178550
- Sajgo S; Ali S; Popescu O; Badea TC. 2016. Dynamic expression of transcription factor Brn3b during mouse cranial nerve development. J Comp Neurol 524(5):1033-61. PubMed: 26356988MGI: J:231113
- Sajgo S; Ghinia MG; Shi M; Liu P; Dong L; Parmhans N; Popescu O; Badea TC. 2014. Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice. PLoS One 9(3):e91435. PubMed: 24608965MGI: J:215125
- Schulze RJ; Weller SG; Schroeder B; Krueger EW; Chi S; Casey CA; McNiven MA. 2013. Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J Cell Biol 203(2):315-26. PubMed: 24145164MGI: J:207947
- Shen H; Ferguson SM; Dephoure N; Park R; Yang Y; Volpicelli-Daley L; Gygi S; Schlessinger J; De Camilli P. 2011. Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell 22(4):493-502. PubMed: 21169560MGI: J:182890
- Shetty AS; Godbole G; Maheshwari U; Padmanabhan H; Chaudhary R; Muralidharan B; Hou PS; Monuki ES; Kuo HC; Rema V; Tole S. 2013. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A 110(50):E4913-21. PubMed: 24262147MGI: J:205196
- Shin NY; Choi H; Neff L; Wu Y; Saito H; Ferguson SM; De Camilli P; Baron R. 2014. Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts. J Cell Biol 207(1):73-89. PubMed: 25287300MGI: J:223884
- Shiomi T; Tschumperlin DJ; Park JA; Sunnarborg SW; Horiuchi K; Blobel CP; Drazen JM. 2011. TNF-alpha-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells. Am J Respir Cell Mol Biol 45(2):376-85. PubMed: 21097655MGI: J:186821
- Siggs OM; Stockenhuber A; Deobagkar-Lele M; Bull KR; Crockford TL; Kingston BL; Crawford G; Anzilotti C; Steeples V; Ghaffari S; Czibik G; Bellahcene M; Watkins H; Ashrafian H; Davies B; Woods A; Carling D; Yavari A; Beutler B; Cornall RJ. 2016. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A 113(26):E3706-15. PubMed: 27303042MGI: J:234285
- Simons BW; Hurley PJ; Huang Z; Ross AE; Miller R; Marchionni L; Berman DM; Schaeffer EM. 2012. Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2):246-55. PubMed: 22960283MGI: J:190538
- Straessler KM; Jones KB; Hu H; Jin H; van de Rijn M; Capecchi MR. 2013. Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell 23(2):215-27. PubMed: 23410975MGI: J:194308
- Takaesu G; Inagaki M; Takubo K; Mishina Y; Hess PR; Dean GA; Yoshimura A; Matsumoto K; Suda T; Ninomiya-Tsuji J. 2012. TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS One 7(11):e51073. PubMed: 23226465MGI: J:194994
- Takai H; Wang RC; Takai KK; Yang H; de Lange T. 2007. Tel2 regulates the stability of PI3K-related protein kinases. Cell 131(7):1248-59. PubMed: 18160036MGI: J:141633
- Takai H; Xie Y; de Lange T; Pavletich NP. 2010. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 24(18):2019-30. PubMed: 20801936MGI: J:164024
- Tran PV; Talbott GC; Turbe-Doan A; Jacobs DT; Schonfeld MP; Silva LM; Chatterjee A; Prysak M; Allard BA; Beier DR. 2014. Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models. J Am Soc Nephrol :. PubMed: 24700869MGI: J:213263
- Van Handel B; Montel-Hagen A; Sasidharan R; Nakano H; Ferrari R; Boogerd CJ; Schredelseker J; Wang Y; Hunter S; Org T; Zhou J; Li X; Pellegrini M; Chen JN; Orkin SH; Kurdistani SK; Evans SM; Nakano A; Mikkola HK. 2012. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell 150(3):590-605. PubMed: 22863011MGI: J:187883
- Vassen L; Beauchemin H; Lemsaddek W; Krongold J; Trudel M; Moroy T. 2014. Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression. PLoS One 9(5):e96636. PubMed: 24800817MGI: J:217367
- Vernia S; Cavanagh-Kyros J; Barrett T; Jung DY; Kim JK; Davis RJ. 2013. Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway. Genes Dev 27(21):2345-55. PubMed: 24186979MGI: J:202882
- Vernia S; Edwards YJ; Han MS; Cavanagh-Kyros J; Barrett T; Kim JK; Davis RJ. 2016. An alternative splicing program promotes adipose tissue thermogenesis. Elife 5:. PubMed: 27635635MGI: J:236975
- Wakabayashi N; Shin S; Slocum SL; Agoston ES; Wakabayashi J; Kwak MK; Misra V; Biswal S; Yamamoto M; Kensler TW. 2010. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal 3(130):ra52. PubMed: 20628156MGI: J:185406
- Wang Q; Huang C; Xue M; Zhang X. 2011. Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing. Bone 48(3):524-32. PubMed: 21056707MGI: J:170281
- Wang R; Dillon CP; Shi LZ; Milasta S; Carter R; Finkelstein D; McCormick LL; Fitzgerald P; Chi H; Munger J; Green DR. 2011. The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation. Immunity 35(6):871-82. PubMed: 22195744MGI: J:179281
- Weinlich R; Oberst A; Dillon CP; Janke LJ; Milasta S; Lukens JR; Rodriguez DA; Gurung P; Savage C; Kanneganti TD; Green DR. 2013. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep 5(2):340-8. PubMed: 24095739MGI: J:203778
- Wolf G; Yang P; Fuchtbauer AC; Fuchtbauer EM; Silva AM; Park C; Wu W; Nielsen AL; Pedersen FS; Macfarlan TS. 2015. The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses. Genes Dev 29(5):538-54. PubMed: 25737282MGI: J:219938
- Ye X; Wang Y; Rattner A; Nathans J. 2011. Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney. Development 138(6):1161-72. PubMed: 21343368MGI: J:170839
- Yoo SE; Chen L; Na R; Liu Y; Rios C; Van Remmen H; Richardson A; Ran Q. 2012. Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free Radic Biol Med 52(9):1820-7. PubMed: 22401858MGI: J:183246
- Yun S; Saijoh Y; Hirokawa KE; Kopinke D; Murtaugh LC; Monuki ES; Levine EM. 2009. Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development 136(23):3895-906. PubMed: 19906857MGI: J:154982
- Zhao F; Edwards R; Dizon D; Afrasiabi K; Mastroianni JR; Geyfman M; Ouellette AJ; Andersen B; Lipkin SM. 2010. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol 338(2):270-9. PubMed: 20025862MGI: J:156704
- Zheng L; Njauw CN; Martins-Green M. 2007. A hCXCR1 transgenic mouse model containing a conditional color-switching system for imaging of hCXCL8/IL-8 functions in vivo. J Leukoc Biol 82(5):1247-56. PubMed: 17704296MGI: J:127327
- Zhou X; Xiang Y; Ding X; Garrard WT. 2013. Loss of an Igkappa gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation. Mol Cell Biol 33(10):2091-101. PubMed: 23508106MGI: J:204030
- Zhu Y; Chen J; Liang C; Zong L; Chen J; Jones RO; Zhao HB. 2015. Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss. Neuroscience 284:719-29. PubMed: 25451287MGI: J:221450