This allele has a tau-lacZ sequence inserted into the endogenous start site in place of exon 1, resulting in a null allele with an expressed reporter. Staining of heterozygotes at 2 days of age shows expression in dorsal root ganglion cell bodies and projections in dorsal spinal cord and skin. Homozygotes have a drastic reduction in the number of L4 and L5 dorsal root ganglion neurons, with only 8% of wildtype numbers for L5, yet normal numbers of parvalbumin positive L5 neurons. Dorsal root ganglion neurons in these homozygotes lack expression of the NTRK1-type neuronal proteins CALCA, TRPV1, and TRPM8, and staining for the NTKR3-type neuronal markers parvalbumin and ER81 shows normal levels of staining. Thus, there are normal numbers of NTRK3+ proprioceptive neurons but a lack of NTRK1-type nociceptive/thermoceptive sensory neurons due solely to the absence of NTRK1. Homozygotes die prematurely.

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This allele has a tau-lacZ sequence inserted into the endogenous start site in place of exon 1, resulting in a null allele with an expressed reporter.

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