These mice carry an ENU-induced mutation characterized by circling, head tossing behavior, and deafness.
The Jackson Laboratory cannot guarantee that cryorecovery of strains from the discontinued NIH-funded Neuroscience Mutagenesis Facility (NMF) will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.Read More +
The mutants exhibit (bi-directional) circling and head tossing behavior by 4 weeks of age, and of 3 mutants tested for auditory brainstem responses (at 6 weeks of age) 2 were found to be deaf and 1 hearing impaired. Standard pathology work-up on two mutants (95 or 173 days of age), including serial sections of the ears of one animal (95 days of age) showed no abnormalities. Whole ear exam performed on a third mutant (47 days of age) also showed no abnormalities.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility, 172|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf172, neuroscience mutagenesis facility, 172|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutant was identified in an ENU mutagenesis screen.|
When using the C57BL/6J-nmf172/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #004818 in your Materials and Methods section.