JAX Mouse Strain Datasheet - 004781

B6.129P2-Lyz2^tm1(cre)Ifo/J

Stock No:: 004781 |; LysMcre

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Overview

Also Known As: LysMcre

The LysMcre knock-in/knockout allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

Donating Investigator

Irmgard Foerster, University of Duesseldorf

Genetic overview

Genetic Background	Generation
	N6F?+N1F6 (17-JUN-15)

Lyz2^tm1(cre)Ifo

Allele Type	Gene Symbol	Gene Name
Targeted (Recombinase-expressing)	Lyz2	lysozyme 2

View Genetics

Research Applications

Developmental Biology Research
Hematological Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Research Tools

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Base Price

Starting at:

$246.50 Domestic price for female 4-week

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Details

Detailed Description

The LysMcre knock-in allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the myeloid cell lineage, including monocytes, mature macrophages, and granulocytes. Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating myeloid cell-specific targeted mutants.

View cre expression characterization.

Development

A targeting vector was designed to insert a frt-flanked neomycin resistance gene and Cre recombinase cDNA sequence (with nuclear localization signal) into the ATG-start site within exon 1 of the lysozyme 2 gene (Lyz2). The construct was electroporated into 129P2/OlaHsd-derived E14.1 embryonic stem (ES) cells. Correctly targeted ES cells were transiently transfected with a Flp expression vector to remove the frt-flanked neo cassette. ES cells that had successfully undergone Flp recombination were injected in blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. The donating investigator reported that mutant mice were then backcrossed to C57BL/6 mice for at least six generations prior to sending to The Jackson Laboratory Repository (see SNP notes below).

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 3 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	myeloid cells - including monocytes, mature macrophages, and granulocytes

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Clausen BE; Burkhardt C; Reith W; Renkawitz R; Forster I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-77. PubMed: 10621974 MGI: J:67924

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Genetics

Lyz2^tm1(cre)Ifo

Allele Symbol: Lyz2^tm1(cre)Ifo

Allele Name	targeted mutation 1, Irmgard Forster
Allele Type	Targeted (Recombinase-expressing)
Allele Synonym(s)	(LyzM)-Cre; L^Cre; LC; Lys-cre; LysCre; LysM Cre; LysM-Cre; LysM^Cre; LysMCre; LysMcre; Lystm1(cre)Ifo; Lyz-cre; Lyz2Cre; LyzCre; lysM/cre
Gene Symbol and Name	Lyz2, lysozyme 2
Gene Synonym(s)	AI326280; LYZF1; LZM; Lys; Lysm; Lysz; Lyz; Lyz1; Lyzs; Lyzs; Lzm; Lzm-s1; Lzm-s1; Lzp; M lysozyme structural 1; expressed sequence AI326280; lysozyme
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	myeloid cells - including monocytes, mature macrophages, and granulocytes
Strain of Origin	129P2/OlaHsd
Chromosome	10
Molecular Note	An NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice.
Mutations Made By	Irmgard Foerster, University of Duesseldorf

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Developmental Biology Research
- Internal/Organ Defects
  - hematopoietic defects
- Lymphoid Tissue Defects
  - hematopoietic defects
Hematological Research
- Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Immunodeficiency
- Lymphoid Tissue Defects
  - hematopoietic development
Internal/Organ Research
- Lymphoid Tissue Defects
Research Tools
- Cre-lox System
  - Cre Recombinase Expression
- Genetics Research
  - Mutagenesis and Transgenesis: Cre-lox System
  - Tissue/Cell Markers
  - Tissue/Cell Markers: Cre-lox System
- Immunology, Inflammation and Autoimmunity Research
  - Macrophage Deficiency

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Genotype: Lyz2^tm1(cre)Ifo related

Developmental Biology Research
- Internal/Organ Defects
  - Lymphoid Tissue Defects
- Lymphoid Tissue Defects
  - hematopoietic defects
Hematological Research
- Hematopoietic Defects
- Immunological Defects
- Neutrophil Defects
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimentally induced rheumatoid arthritis
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
  - genes regulating susceptibility to infectious disease and endotoxin
- Growth Factors/Receptors/Cytokines
- Immunodeficiency
  - Neutrophil Defects
- Inflammation
  - Neutrophil defects
- Lymphoid Tissue Defects
  - hematopoietic development
Internal/Organ Research
- Gastrointestinal Defects
- Lymphoid Tissue Defects
Research Tools
- Cancer Research
  - Leukemia
- Cre-lox System
  - Cre Recombinase Expression
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System
- Hematological Research
- Immunology, Inflammation and Autoimmunity Research
  - Macrophage Deficiency
  - genes regulating susceptibility to infectious disease and endotoxin

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Lyz2^tm1(cre)Ifo/*Lyz2⁺
involves: 129P2/OlaHsd C57BL/6

hematopoietic system phenotype

enlarged spleen
- rare

immune system phenotype

enlarged spleen
- rare

References

Clausen BE; Burkhardt C; Reith W; Renkawitz R; Forster I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-77. PubMed: 10621974 MGI: J:67924

Additional References

Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. PubMed: 10023769 MGI: J:53681

Additional - Lyz2^tm1(cre)Ifo related

Abad C; Nobuta H; Li J; Kasai A; Yong WH; Waschek JA. 2014. Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma. J Leukoc Biol 95(2):357-67. PubMed: 24068730 MGI: J:209539
Abdolazimi Y; Stojanova Z; Segil N. 2016. Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development 143(5):841-50. PubMed: 26932672 MGI: J:229889
Abdullah Z; Geiger S; Nino-Castro A; Bottcher JP; Muraliv E; Gaidt M; Schildberg FA; Riethausen K; Flossdorf J; Krebs W; Chakraborty T; Kurts C; Schultze JL; Knolle PA; Klotz L. 2012. Lack of PPARgamma in myeloid cells confers resistance to Listeria monocytogenes infection. PLoS One 7(5):e37349. PubMed: 22629382 MGI: J:196535
Abram CL; Roberge GL; Hu Y; Lowell CA. 2014. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods 408:89-100. PubMed: 24857755 MGI: J:230410
Abshire MY; Thomas KS; Owen KA; Bouton AH. 2011. Macrophage motility requires distinct {alpha}5{beta}1/FAK and {alpha}4{beta}1/paxillin signaling events. J Leukoc Biol 89(2):251-7. PubMed: 21084629 MGI: J:168496
Acharya M; Mukhopadhyay S; Paidassi H; Jamil T; Chow C; Kissler S; Stuart LM; Hynes RO; Lacy-Hulbert A. 2010. alphav Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest 120(12):4445-52. PubMed: 21099114 MGI: J:171863
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Ahn GO; Seita J; Hong BJ; Kim YE; Bok S; Lee CJ; Kim KS; Lee JC; Leeper NJ; Cooke JP; Kim HJ; Kim IH; Weissman IL; Brown JM. 2014. Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8. Proc Natl Acad Sci U S A 111(7):2698-703. PubMed: 24497508 MGI: J:206831
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Bourquard N; Ng CJ; Reddy ST. 2011. Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response. Biochem J 436(1):91-100. PubMed: 21361875 MGI: J:172089
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Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. PubMed: 19201688 MGI: J:159775
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Also Known As: LysMcre

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Lyz2tm1(cre)Ifo

Allele Symbol: Lyz2tm1(cre)Ifo

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Genotype: cre related

Genotype: Lyz2tm1(cre)Ifo related

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Genotype: Lyz2tm1(cre)Ifo/Lyz2+involves: 129P2/OlaHsd * C57BL/6

hematopoietic system phenotype

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Lyz2^tm1(cre)Ifo

Allele Symbol: Lyz2^tm1(cre)Ifo

Genotype: Lyz2^tm1(cre)Ifo related

Genotype: Lyz2^tm1(cre)Ifo/*Lyz2⁺
involves: 129P2/OlaHsd C57BL/6

Additional - Lyz2^tm1(cre)Ifo related