JAX Mouse Strain Datasheet - 004781

B6.129P2-Lyz2^tm1(cre)Ifo/J

Stock No:: 004781 |; LysMcre

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Overview

Also Known As: LysMcre

The LysMcre knock-in/knockout allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

Donating Investigator

Irmgard Foerster, University of Duesseldorf

Genetic overview

Genetic Background	Generation
	N6F?+N1F6 (17-JUN-15)

Lyz2^tm1(cre)Ifo

Allele Type	Gene Symbol	Gene Name
Targeted (Recombinase-expressing)	Lyz2	lysozyme 2

View Genetics

Research Applications

Developmental Biology Research
Hematological Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Research Tools

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Base Price

Starting at:

$246.50 Domestic price for female 4-week

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Details

Detailed Description

The LysMcre knock-in allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in deletion of the targeted gene in the myeloid cell lineage, including monocytes, mature macrophages, and granulocytes. Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating myeloid cell-specific targeted mutants.

View cre expression characterization.

Development

A targeting vector was designed to insert a frt-flanked neomycin resistance gene and Cre recombinase cDNA sequence (with nuclear localization signal) into the ATG-start site within exon 1 of the lysozyme 2 gene (Lyz2). The construct was electroporated into 129P2/OlaHsd-derived E14.1 embryonic stem (ES) cells. Correctly targeted ES cells were transiently transfected with a Flp expression vector to remove the frt-flanked neo cassette. ES cells that had successfully undergone Flp recombination were injected in blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. The donating investigator reported that mutant mice were then backcrossed to C57BL/6 mice for at least six generations prior to sending to The Jackson Laboratory Repository (see SNP notes below).

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 3 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	myeloid cells - including monocytes, mature macrophages, and granulocytes

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Clausen BE; Burkhardt C; Reith W; Renkawitz R; Forster I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-77. PubMed: 10621974 MGI: J:67924

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Genetics

Lyz2^tm1(cre)Ifo

Allele Symbol: Lyz2^tm1(cre)Ifo

Allele Name	targeted mutation 1, Irmgard Forster
Allele Type	Targeted (Recombinase-expressing)
Allele Synonym(s)	(LyzM)-Cre; L^Cre; LC; Lys-cre; LysCre; LysM Cre; LysM-Cre; LysM^Cre; LysMCre; LysMcre; Lystm1(cre)Ifo; Lyz-cre; Lyz2Cre; LyzCre; lysM/cre
Gene Symbol and Name	Lyz2, lysozyme 2
Gene Synonym(s)	AI326280; LYZF1; LZM; Lys; Lysm; Lysz; Lyz; Lyz1; Lyzs; Lyzs; Lzm; Lzm-s1; Lzm-s1; Lzp; M lysozyme structural 1; expressed sequence AI326280; lysozyme
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	myeloid cells - including monocytes, mature macrophages, and granulocytes
Strain of Origin	129P2/OlaHsd
Chromosome	10
Molecular Note	An NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice.
Mutations Made By	Irmgard Foerster, University of Duesseldorf

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Developmental Biology Research
- Internal/Organ Defects
  - hematopoietic defects
- Lymphoid Tissue Defects
  - hematopoietic defects
Hematological Research
- Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Immunodeficiency
- Lymphoid Tissue Defects
  - hematopoietic development
Internal/Organ Research
- Lymphoid Tissue Defects
Research Tools
- Cre-lox System
  - Cre Recombinase Expression
- Genetics Research
  - Mutagenesis and Transgenesis: Cre-lox System
  - Tissue/Cell Markers
  - Tissue/Cell Markers: Cre-lox System
- Immunology, Inflammation and Autoimmunity Research
  - Macrophage Deficiency

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Genotype: Lyz2^tm1(cre)Ifo related

Developmental Biology Research
- Internal/Organ Defects
  - Lymphoid Tissue Defects
- Lymphoid Tissue Defects
  - hematopoietic defects
Hematological Research
- Hematopoietic Defects
- Immunological Defects
- Neutrophil Defects
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - experimentally induced rheumatoid arthritis
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
  - genes regulating susceptibility to infectious disease and endotoxin
- Growth Factors/Receptors/Cytokines
- Immunodeficiency
  - Neutrophil Defects
- Inflammation
  - Neutrophil defects
- Lymphoid Tissue Defects
  - hematopoietic development
Internal/Organ Research
- Gastrointestinal Defects
- Lymphoid Tissue Defects
Research Tools
- Cancer Research
  - Leukemia
- Cre-lox System
  - Cre Recombinase Expression
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System
- Hematological Research
- Immunology, Inflammation and Autoimmunity Research
  - Macrophage Deficiency
  - genes regulating susceptibility to infectious disease and endotoxin

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Lyz2^tm1(cre)Ifo/*Lyz2⁺
involves: 129P2/OlaHsd C57BL/6

hematopoietic system phenotype

enlarged spleen
- rare

immune system phenotype

enlarged spleen
- rare

References

Clausen BE; Burkhardt C; Reith W; Renkawitz R; Forster I. 1999. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-77. PubMed: 10621974 MGI: J:67924

Additional References

Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. PubMed: 10023769 MGI: J:53681

Additional - Lyz2^tm1(cre)Ifo related

Abad C; Nobuta H; Li J; Kasai A; Yong WH; Waschek JA. 2014. Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastoma. J Leukoc Biol 95(2):357-67. PubMed: 24068730 MGI: J:209539
Abdolazimi Y; Stojanova Z; Segil N. 2016. Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development 143(5):841-50. PubMed: 26932672 MGI: J:229889
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Abram CL; Roberge GL; Hu Y; Lowell CA. 2014. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods 408:89-100. PubMed: 24857755 MGI: J:230410
Abshire MY; Thomas KS; Owen KA; Bouton AH. 2011. Macrophage motility requires distinct {alpha}5{beta}1/FAK and {alpha}4{beta}1/paxillin signaling events. J Leukoc Biol 89(2):251-7. PubMed: 21084629 MGI: J:168496
Acharya M; Mukhopadhyay S; Paidassi H; Jamil T; Chow C; Kissler S; Stuart LM; Hynes RO; Lacy-Hulbert A. 2010. alphav Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest 120(12):4445-52. PubMed: 21099114 MGI: J:171863
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Bourquard N; Ng CJ; Reddy ST. 2011. Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response. Biochem J 436(1):91-100. PubMed: 21361875 MGI: J:172089
Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. PubMed: 18548006 MGI: J:137646
Braune J; Weyer U; Matz-Soja M; Hobusch C; Kern M; Kunath A; Kloting N; Kralisch S; Bluher M; Gebhardt R; Zavros Y; Bechmann I; Gericke M. 2017. Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism. Diabetologia 60(5):889-899. PubMed: 28233033 MGI: J:241519
Brocker CN; Yue J; Kim D; Qu A; Bonzo JA; Gonzalez FJ. 2017. Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells. Am J Physiol Gastrointest Liver Physiol 312(3):G283-G299. PubMed: 28082284 MGI: J:241954
Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. PubMed: 19201688 MGI: J:159775
Brydges SD; Broderick L; McGeough MD; Pena CA; Mueller JL; Hoffman HM. 2013. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest :. PubMed: 24084736 MGI: J:203992
Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. PubMed: 19501000 MGI: J:150054
Bryson KJ; Millington OR; Mokgethi T; McGachy HA; Brombacher F; Alexander J. 2011. BALB/c Mice Deficient in CD4 T Cell IL-4Ralpha Expression Control Leishmania mexicana Load although Female but Not Male Mice Develop a Healer Phenotype. PLoS Negl Trop Dis 5(1):e930. PubMed: 21245915 MGI: J:168069
Butcher BA; Kim L; Panopoulos AD; Watowich SS; Murray PJ; Denkers EY. 2005. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol 174(6):3148-52. PubMed: 15749841 MGI: J:97691
Buxade M; Lunazzi G; Minguillon J; Iborra S; Berga-Bolanos R; Del Val M; Aramburu J; Lopez-Rodriguez C. 2012. Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5. J Exp Med 209(2):379-93. PubMed: 22312110 MGI: J:181691
Buxbaum LU. 2015. Interleukin-10 from T cells, but not macrophages and granulocytes, is required for chronic disease in Leishmania mexicana infection. Infect Immun 83(4):1366-71. PubMed: 25605773 MGI: J:229278
Byles V; Covarrubias AJ; Ben-Sahra I; Lamming DW; Sabatini DM; Manning BD; Horng T. 2013. The TSC-mTOR pathway regulates macrophage polarization. Nat Commun 4:2834. PubMed: 24280772 MGI: J:206148
Caballero-Franco C; Choo MK; Sano Y; Ritprajak P; Sakurai H; Otsu K; Mizoguchi A; Park JM. 2013. Tuning of protein kinase circuitry by p38alpha is vital for epithelial tissue homeostasis. J Biol Chem 288(33):23788-97. PubMed: 23836897 MGI: J:203451
Caglayan E; Stauber B; Collins AR; Lyon CJ; Yin F; Liu J; Rosenkranz S; Erdmann E; Peterson LE; Ross RS; Tangirala RK; Hsueh WA. 2008. Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis. Diabetes 57(9):2470-9. PubMed: 18511847 MGI: J:141807
Cain DW; O'Koren EG; Kan MJ; Womble M; Sempowski GD; Hopper K; Gunn MD; Kelsoe G. 2013. Identification of a tissue-specific, C/EBPbeta-dependent pathway of differentiation for murine peritoneal macrophages. J Immunol 191(9):4665-75. PubMed: 24078688 MGI: J:206241
Camell CD; Nguyen KY; Jurczak MJ; Christian BE; Shulman GI; Shadel GS; Dixit VD. 2015. Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity. J Biol Chem 290(49):29402-13. PubMed: 26438821 MGI: J:227132
Campbell L; Emmerson E; Davies F; Gilliver SC; Krust A; Chambon P; Ashcroft GS; Hardman MJ. 2010. Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med 207(9):1825-33. PubMed: 20733032 MGI: J:165719
Cao AT; Yao S; Stefka AT; Liu Z; Qin H; Liu H; Evans-Marin HL; Elson CO; Nagler CR; Cong Y. 2014. TLR4 regulates IFN-gamma and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation. J Leukoc Biol 96(5):895-905. PubMed: 25015957 MGI: J:220139
Cao X; Wei G; Fang H; Guo J; Weinstein M; Marsh CB; Ostrowski MC; Tridandapani S. 2004. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol 172(8):4851-7. PubMed: 15067063 MGI: J:89105
Cao Y; Brombacher F; Tunyogi-Csapo M; Glant TT; Finnegan A. 2007. Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Arthritis Rheum 56(3):861-70. PubMed: 17330244 MGI: J:168136
Cao Z; Lis R; Ginsberg M; Chavez D; Shido K; Rabbany SY; Fong GH; Sakmar TP; Rafii S; Ding BS. 2016. Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nat Med 22(2):154-62. PubMed: 26779814 MGI: J:233341
Capietto AH; Kim S; Sanford DE; Linehan DC; Hikida M; Kumosaki T; Novack DV; Faccio R. 2013. Down-regulation of PLCgamma2-beta-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer. J Exp Med 210(11):2257-71. PubMed: 24127488 MGI: J:206537
Capitini CM; Nasholm NM; Chien CD; Larabee SM; Qin H; Song YK; Klover PJ; Hennighausen L; Khan J; Fry TJ. 2014. Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD. Blood 124(12):1976-86. PubMed: 25079358 MGI: J:214606
Carlson BA; Yoo MH; Conrad M; Gladyshev VN; Hatfield DL; Park JM. 2011. Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. Mol Immunol 49(1-2):311-6. PubMed: 21943784 MGI: J:177348
Carow B; Reuschl AK; Gavier-Widen D; Jenkins BJ; Ernst M; Yoshimura A; Chambers BJ; Rottenberg ME. 2013. Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis. PLoS Pathog 9(7):e1003442. PubMed: 23853585 MGI: J:213369
Carow B; Ye X; Gavier-Widen D; Bhuju S; Oehlmann W; Singh M; Skold M; Ignatowicz L; Yoshimura A; Wigzell H; Rottenberg ME. 2011. Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner. J Biol Chem 286(30):26873-87. PubMed: 21622562 MGI: J:175389
Carrillo-de Sauvage MA; Maatouk L; Arnoux I; Pasco M; Sanz Diez A; Delahaye M; Herrero MT; Newman TA; Calvo CF; Audinat E; Tronche F; Vyas S. 2013. Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation. Cell Death Differ 20(11):1546-57. PubMed: 24013726 MGI: J:228995
Castillo EF; Dekonenko A; Arko-Mensah J; Mandell MA; Dupont N; Jiang S; Delgado-Vargas M; Timmins GS; Bhattacharya D; Yang H; Hutt J; Lyons CR; Dobos KM; Deretic V. 2012. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A 109(46):E3168-76. PubMed: 23093667 MGI: J:191229
Cekic C; Day YJ; Sag D; Linden J. 2014. Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. Cancer Res 74(24):7250-9. PubMed: 25377469 MGI: J:218223
Celhar T; Hopkins R; Thornhill SI; De Magalhaes R; Hwang SH; Lee HY; Yasuga H; Jones LA; Casco J; Lee B; Thamboo TP; Zhou XJ; Poidinger M; Connolly JE; Wakeland EK; Fairhurst AM. 2015. RNA sensing by conventional dendritic cells is central to the development of lupus nephritis. Proc Natl Acad Sci U S A 112(45):E6195-204. PubMed: 26512111 MGI: J:227472
Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2):1099-106. PubMed: 19124753 MGI: J:143484
Chakraborty M; Lou C; Huan C; Kuo MS; Park TS; Cao G; Jiang XC. 2013. Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis. J Clin Invest 123(4):1784-97. PubMed: 23549085 MGI: J:197606
Chang SH; Lu YC; Li X; Hsieh WY; Xiong Y; Ghosh M; Evans T; Elemento O; Hla T. 2013. Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. J Biol Chem 288(7):4908-21. PubMed: 23223443 MGI: J:195564
Chaurasia B; Mauer J; Koch L; Goldau J; Kock AS; Bruning JC. 2010. Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol 30(17):4354-66. PubMed: 20584979 MGI: J:163291
Chen CC; Wang L; Plikus MV; Jiang TX; Murray PJ; Ramos R; Guerrero-Juarez CF; Hughes MW; Lee OK; Shi S; Widelitz RB; Lander AD; Chuong CM. 2015. Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell 161(2):277-90. PubMed: 25860610 MGI: J:222861
Chen EP; Markosyan N; Connolly E; Lawson JA; Li X; Grant GR; Grosser T; FitzGerald GA; Smyth EM. 2014. Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. Carcinogenesis 35(8):1788-97. PubMed: 24590894 MGI: J:212500
Chen HZ; Guo S; Li ZZ; Lu Y; Jiang DS; Zhang R; Lei H; Gao L; Zhang X; Zhang Y; Wang L; Zhu LH; Xiang M; Zhou Y; Wan Q; Dong H; Liu DP; Li H. 2014. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci 34(36):11897-912. PubMed: 25186738 MGI: J:216134
Chen K; Liu M; Liu Y; Yoshimura T; Shen W; Le Y; Durum S; Gong W; Wang C; Gao JL; Murphy PM; Wang JM. 2013. Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis. J Clin Invest 123(4):1694-704. PubMed: 23454745 MGI: J:197568
Chen L; Yang G; Monslow J; Todd L; Cormode DP; Tang J; Grant GR; DeLong JH; Tang SY; Lawson JA; Pure E; Fitzgerald GA. 2014. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proc Natl Acad Sci U S A 111(18):6828-33. PubMed: 24753592 MGI: J:211086
Chen L; Yang G; Xu X; Grant G; Lawson JA; Bohlooly-Y M; FitzGerald GA. 2013. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation 127(2):233-43. PubMed: 23204105 MGI: J:210141
Chen Z; Shen H; Sun C; Yin L; Tang F; Zheng P; Liu Y; Brink R; Rui L. 2015. Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity. Am J Physiol Endocrinol Metab 308(6):E460-9. PubMed: 25628422 MGI: J:220716
Cheng S; Zhao SL; Nelson B; Kesavan C; Qin X; Wergedal J; Mohan S; Xing W. 2012. Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice. PLoS One 7(3):e32887. PubMed: 22403721 MGI: J:186937
Cheng WY; Huynh H; Chen P; Pena-Llopis S; Wan Y. 2016. Macrophage PPARgamma inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone. Elife 5:. PubMed: 27692066 MGI: J:238498
Cherepanova OA; Gomez D; Shankman LS; Swiatlowska P; Williams J; Sarmento OF; Alencar GF; Hess DL; Bevard MH; Greene ES; Murgai M; Turner SD; Geng YJ; Bekiranov S; Connelly JJ; Tomilin A; Owens GK. 2016. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med 22(6):657-65. PubMed: 27183216 MGI: J:239720
Chiarella SE; Soberanes S; Urich D; Morales-Nebreda L; Nigdelioglu R; Green D; Young JB; Gonzalez A; Rosario C; Misharin AV; Ghio AJ; Wunderink RG; Donnelly HK; Radigan KA; Perlman H; Chandel NS; Budinger GR; Mutlu GM. 2014. beta(2)-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest 124(7):2935-46. PubMed: 24865431 MGI: J:213275
Chinen I; Nakahama T; Kimura A; Nguyen NT; Takemori H; Kumagai A; Kayama H; Takeda K; Lee S; Hanieh H; Ripley B; Millrine D; Dubey PK; Nyati KK; Fujii-Kuriyama Y; Chowdhury K; Kishimoto T. 2015. The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis. Int Immunol 27(8):405-15. PubMed: 25862525 MGI: J:230909
Cho KW; Morris DL; DelProposto JL; Geletka L; Zamarron B; Martinez-Santibanez G; Meyer KA; Singer K; O'Rourke RW; Lumeng CN. 2014. An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation. Cell Rep 9(2):605-17. PubMed: 25310975 MGI: J:218539
Cho SH; Chen JA; Sayed F; Ward ME; Gao F; Nguyen TA; Krabbe G; Sohn PD; Lo I; Minami S; Devidze N; Zhou Y; Coppola G; Gan L. 2015. SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1beta. J Neurosci 35(2):807-18. PubMed: 25589773 MGI: J:217723
Choi EJ; Chen W; Jun K; Arthur HM; Young WL; Su H. 2014. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. PLoS One 9(2):e88511. PubMed: 24520391 MGI: J:212952
Choi SH; Wiesner P; Almazan F; Kim J; Miller YI. 2012. Spleen tyrosine kinase regulates AP-1 dependent transcriptional response to minimally oxidized LDL. PLoS One 7(2):e32378. PubMed: 22384232 MGI: J:185297
Choi SH; Yin H; Ravandi A; Armando A; Dumlao D; Kim J; Almazan F; Taylor AM; McNamara CA; Tsimikas S; Dennis EA; Witztum JL; Miller YI. 2013. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One 8(12):e83145. PubMed: 24376657 MGI: J:225168
Chong MM; Metcalf D; Jamieson E; Alexander WS; Kay TW. 2005. Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood 106(5):1668-75. PubMed: 15899915 MGI: J:118492
Chudnovskiy A; Mortha A; Kana V; Kennard A; Ramirez JD; Rahman A; Remark R; Mogno I; Ng R; Gnjatic S; Amir ED; Solovyov A; Greenbaum B; Clemente J; Faith J; Belkaid Y; Grigg ME; Merad M. 2016. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell 167(2):444-456.e14. PubMed: 27716507 MGI: J:236522
Clemens RA; Lenox LE; Kambayashi T; Bezman N; Maltzman JS; Nichols KE; Koretzky GA. 2007. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol 178(7):4606-14. PubMed: 17372019 MGI: J:145136
Cloots RH; Sankaranarayanan S; de Theije CC; Poynter ME; Terwindt E; van Dijk P; Hakvoort TB; Lamers WH; Kohler SE. 2013. Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice. Am J Physiol Lung Cell Mol Physiol 305(5):L364-76. PubMed: 23831616 MGI: J:210115
Coady A; Sil A. 2015. MyD88-dependent signaling drives host survival and early cytokine production during Histoplasma capsulatum infection. Infect Immun 83(4):1265-75. PubMed: 25583527 MGI: J:229281
Colegio OR; Chu NQ; Szabo AL; Chu T; Rhebergen AM; Jairam V; Cyrus N; Brokowski CE; Eisenbarth SC; Phillips GM; Cline GW; Phillips AJ; Medzhitov R. 2014. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513(7519):559-63. PubMed: 25043024 MGI: J:217115
Collazo MM; Paraiso KH; Park MY; Hazen AL; Kerr WG. 2012. Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP. Eur J Immunol 42(7):1785-95. PubMed: 22535653 MGI: J:187777
Corzo CA; Cotter MJ; Cheng P; Cheng F; Kusmartsev S; Sotomayor E; Padhya T; McCaffrey TV; McCaffrey JC; Gabrilovich DI. 2009. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol 182(9):5693-701. PubMed: 19380816 MGI: J:147709
Coudriet GM; He J; Trucco M; Mars WM; Piganelli JD. 2010. Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS One 5(11):e15384. PubMed: 21072211 MGI: J:166840
Covarrubias R; Wilhelm AJ; Major AS. 2014. Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells. PLoS One 9(7):e102236. PubMed: 25050824 MGI: J:219015
Cramer T; Yamanishi Y; Clausen BE; Forster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS. 2003. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112(5):645-57. PubMed: 12628185 MGI: J:107682
Cremasco V; Benasciutti E; Cella M; Kisseleva M; Croke M; Faccio R. 2010. Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells. PLoS One 5(1):e8909. PubMed: 20111715 MGI: J:157619
Croker BA; Krebs DL; Zhang JG; Wormald S; Willson TA; Stanley EG; Robb L; Greenhalgh CJ; Forster I; Clausen BE; Nicola NA; Metcalf D; Hilton DJ; Roberts AW; Alexander WS. 2003. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4(6):540-5. PubMed: 12754505 MGI: J:83645
Croxford AL; Lanzinger M; Hartmann FJ; Schreiner B; Mair F; Pelczar P; Clausen BE; Jung S; Greter M; Becher B. 2015. The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity. Immunity 43(3):502-14. PubMed: 26341401 MGI: J:233647
Csoka B; Nemeth ZH; Toro G; Idzko M; Zech A; Koscso B; Spolarics Z; Antonioli L; Cseri K; Erdelyi K; Pacher P; Hasko G. 2015. Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing. FASEB J 29(9):3626-37. PubMed: 26060214 MGI: J:225524
Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3):491-501. PubMed: 19733096 MGI: J:152690
Curtis AM; Fagundes CT; Yang G; Palsson-McDermott EM; Wochal P; McGettrick AF; Foley NH; Early JO; Chen L; Zhang H; Xue C; Geiger SS; Hokamp K; Reilly MP; Coogan AN; Vigorito E; FitzGerald GA; O'Neill LA. 2015. Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci U S A 112(23):7231-6. PubMed: 25995365 MGI: J:223291
D'Amico L; Mahajan S; Capietto AH; Yang Z; Zamani A; Ricci B; Bumpass DB; Meyer M; Su X; Wang-Gillam A; Weilbaecher K; Stewart SA; DeNardo DG; Faccio R. 2016. Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer. J Exp Med 213(5):827-40. PubMed: 27045006 MGI: J:233071
Dalmas E; Toubal A; Alzaid F; Blazek K; Eames HL; Lebozec K; Pini M; Hainault I; Montastier E; Denis RG; Ancel P; Lacombe A; Ling Y; Allatif O; Cruciani-Guglielmacci C; Andre S; Viguerie N; Poitou C; Stich V; Torcivia A; Foufelle F; Luquet S; Aron-Wisnewsky J; Langin D; Clement K; Udalova IA; Venteclef N. 2015. Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med 21(6):610-8. PubMed: 25939064 MGI: J:228467
Damgaard RB; Walker JA; Marco-Casanova P; Morgan NV; Titheradge HL; Elliott PR; McHale D; Maher ER; McKenzie AN; Komander D. 2016. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell 166(5):1215-1230.e20. PubMed: 27523608 MGI: J:236075
Dann A; Poeck H; Croxford AL; Gaupp S; Kierdorf K; Knust M; Pfeifer D; Maihoefer C; Endres S; Kalinke U; Meuth SG; Wiendl H; Knobeloch KP; Akira S; Waisman A; Hartmann G; Prinz M. 2012. Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci 15(1):98-106. PubMed: 22138643 MGI: J:180319
Decque A; Joffre O; Magalhaes JG; Cossec JC; Blecher-Gonen R; Lapaquette P; Silvin A; Manel N; Joubert PE; Seeler JS; Albert ML; Amit I; Amigorena S; Dejean A. 2016. Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing. Nat Immunol 17(2):140-9. PubMed: 26657003 MGI: J:234678
Dejda A; Mawambo G; Cerani A; Miloudi K; Shao Z; Daudelin JF; Boulet S; Oubaha M; Beaudoin F; Akla N; Henriques S; Menard C; Stahl A; Delisle JS; Rezende FA; Labrecque N; Sapieha P. 2014. Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. J Clin Invest 124(11):4807-22. PubMed: 25271625 MGI: J:217614
Dellinger MT; Meadows SM; Wynne K; Cleaver O; Brekken RA. 2013. Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS One 8(9):e74686. PubMed: 24023956 MGI: J:207561
Deng M; Scott MJ; Loughran P; Gibson G; Sodhi C; Watkins S; Hackam D; Billiar TR. 2013. Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis. J Immunol 190(10):5152-60. PubMed: 23562812 MGI: J:202568
Deng Z; Ma S; Zhou H; Zang A; Fang Y; Li T; Shi H; Liu M; Du M; Taylor PR; Zhu HH; Chen J; Meng G; Li F; Chen C; Zhang Y; Jia XM; Lin X; Zhang X; Pearlman E; Li X; Feng GS; Xiao H. 2015. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol 16(6):642-52. PubMed: 25915733 MGI: J:232837
Derecki NC; Cronk JC; Lu Z; Xu E; Abbott SB; Guyenet PG; Kipnis J. 2012. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 484(7392):105-9. PubMed: 22425995 MGI: J:183878
Desai TJ; Brownfield DG; Krasnow MA. 2014. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507(7491):190-4. PubMed: 24499815 MGI: J:207468
Devarajan A; Grijalva VR; Bourquard N; Meriwether D 3rd; Imaizumi S; Shin BC; Devaskar SU; Reddy ST. 2012. Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western diet. Mol Genet Metab 107(3):416-27. PubMed: 22864055 MGI: J:189668
Diamanti MA; Gupta J; Bennecke M; De Oliveira T; Ramakrishnan M; Braczynski AK; Richter B; Beli P; Hu Y; Saleh M; Mittelbronn M; Dikic I; Greten FR. 2017. IKKalpha controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med 214(2):423-437. PubMed: 28082356 MGI: J:240695
Ding X; Lucas T; Marcuzzi GP; Pfister H; Eming SA. 2015. Distinct Functions of Epidermal and Myeloid-Derived VEGF-A in Skin Tumorigenesis Mediated by HPV8. Cancer Res 75(2):330-43. PubMed: 25414138 MGI: J:217472
Drexler SK; Bonsignore L; Masin M; Tardivel A; Jackstadt R; Hermeking H; Schneider P; Gross O; Tschopp J; Yazdi AS. 2012. Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A 109(45):18384-9. PubMed: 23090995 MGI: J:191239
Du Y; Yang M; Lee S; Behrendt CL; Hooper LV; Saghatelian A; Wan Y. 2012. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes Dev 26(12):1306-11. PubMed: 22713870 MGI: J:184823
Duarte S; Kato H; Kuriyama N; Suko K; Ishikawa TO; Busuttil RW; Herschman HR; Coito AJ. 2014. Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. PLoS One 9(5):e96913. PubMed: 24819536 MGI: J:216254
Dupont N; Jiang S; Pilli M; Ornatowski W; Bhattacharya D; Deretic V. 2011. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J 30(23):4701-11. PubMed: 22068051 MGI: J:180161
Dzhagalov I; St John A; He YW. 2007. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood 109(4):1620-6. PubMed: 17062731 MGI: J:137502
Eash KJ; Greenbaum AM; Gopalan PK; Link DC. 2010. CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest 120(7):2423-31. PubMed: 20516641 MGI: J:163726
Eash KJ; Means JM; White DW; Link DC. 2009. CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood 113(19):4711-9. PubMed: 19264920 MGI: J:150156
Edwards JR; Perrien DS; Fleming N; Nyman JS; Ono K; Connelly L; Moore MM; Lwin ST; Yull FE; Mundy GR; Elefteriou F. 2013. Silent information regulator (Sir)T1 inhibits NF-kappaB signaling to maintain normal skeletal remodeling. J Bone Miner Res 28(4):960-9. PubMed: 23172686 MGI: J:210142
Eftychi C; Karagianni N; Alexiou M; Apostolaki M; Kollias G. 2012. Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia. PLoS One 7(2):e31550. PubMed: 22348103 MGI: J:211916
Eguchi J; Kong X; Tenta M; Wang X; Kang S; Rosen ED. 2013. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes 62(10):3394-403. PubMed: 23835343 MGI: J:208945
Eijkelkamp N; Heijnen CJ; Willemen HL; Deumens R; Joosten EA; Kleibeuker W; den Hartog IJ; van Velthoven CT; Nijboer C; Nassar MA; Dorn GW 2nd; Wood JN; Kavelaars A. 2010. GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci 30(6):2138-49. PubMed: 20147541 MGI: J:157847
El Kasmi KC; Holst J; Coffre M; Mielke L; de Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG Jr; Alexander W; Vignali DA; Watowich SS; Ernst M; Hilton DJ; Murray PJ. 2006. General nature of the STAT3-activated anti-inflammatory response. J Immunol 177(11):7880-8. PubMed: 17114459 MGI: J:140695
El Kasmi KC; Qualls JE; Pesce JT; Smith AM; Thompson RW; Henao-Tamayo M; Basaraba RJ; Konig T; Schleicher U; Koo MS; Kaplan G; Fitzgerald KA; Tuomanen EI; Orme IM; Kanneganti TD; Bogdan C; Wynn TA; Murray PJ. 2008. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol 9(12):1399-406. PubMed: 18978793 MGI: J:143229
El Kasmi KC; Smith AM; Williams L; Neale G; Panopolous A; Watowich SS; Hacker H; Foxwell BM; Murray PJ. 2007. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 179(11):7215-9. PubMed: 18025162 MGI: J:133009
Elliott ER; Van Ziffle JA; Scapini P; Sullivan BM; Locksley RM; Lowell CA. 2011. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol 187(8):4319-30. PubMed: 21918195 MGI: J:179306
Fang C; Yu J; Luo Y; Chen S; Wang W; Zhao C; Sun Z; Wu W; Guo W; Han Z; Hu X; Liao F; Feng X. 2015. Tsc1 is a Critical Regulator of Macrophage Survival and Function. Cell Physiol Biochem 36(4):1406-18. PubMed: 26159807 MGI: J:238381
Fang LY; Izumi K; Lai KP; Liang L; Li L; Miyamoto H; Lin WJ; Chang C. 2013. Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling. Cancer Res 73(18):5633-46. PubMed: 23878190 MGI: J:204387
Fantin A; Vieira JM; Gestri G; Denti L; Schwarz Q; Prykhozhij S; Peri F; Wilson SW; Ruhrberg C. 2010. Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 116(5):829-40. PubMed: 20404134 MGI: J:163512
Feeley EM; Pilla-Moffett DM; Zwack EE; Piro AS; Finethy R; Kolb JP; Martinez J; Brodsky IE; Coers J. 2017. Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc Natl Acad Sci U S A 114(9):E1698-E1706. PubMed: 28193861 MGI: J:241213
Feng D; Dai S; Liu F; Ohtake Y; Zhou Z; Wang H; Zhang Y; Kearns A; Peng X; Zhu F; Hayat U; Li M; He Y; Xu M; Zhao C; Cheng M; Zhang L; Wang H; Yang X; Ju C; Bryda EC; Gordon J; Khalili K; Hu W; Li S; Qin X; Gao B. 2016. Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clin Invest 126(6):2321-33. PubMed: 27159394 MGI: J:237074
Feng Y; Zou L; Chen C; Li D; Chao W. 2014. Role of cardiac- and myeloid-MyD88 signaling in endotoxin shock: a study with tissue-specific deletion models. Anesthesiology 121(6):1258-69. PubMed: 25089642 MGI: J:234897
Ferreira Tojais N; Peghaire C; Franzl N; Larrieu-Lahargue F; Jaspard B; Reynaud A; Moreau C; Couffinhal T; Duplaa C; Dufourcq P. 2014. Frizzled7 controls vascular permeability through the Wnt-canonical pathway and cross-talk with endothelial cell junction complexes. Cardiovasc Res 103(2):291-303. PubMed: 24866384 MGI: J:230008
Ferri F; Parcelier A; Petit V; Gallouet AS; Lewandowski D; Dalloz M; van den Heuvel A; Kolovos P; Soler E; Squadrito ML; De Palma M; Davidson I; Rousselet G; Romeo PH. 2015. TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation. Nat Commun 6:8900. PubMed: 26592194 MGI: J:228017
Festuccia WT; Pouliot P; Bakan I; Sabatini DM; Laplante M. 2014. Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS One 9(4):e95432. PubMed: 24740015 MGI: J:215205
Fini MA; Monks J; Farabaugh SM; Wright RM. 2011. Contribution of xanthine oxidoreductase to mammary epithelial and breast cancer cell differentiation in part modulates inhibitor of differentiation-1. Mol Cancer Res 9(9):1242-54. PubMed: 21775420 MGI: J:205223
Finney BA; Schweighoffer E; Navarro-Nunez L; Benezech C; Barone F; Hughes CE; Langan SA; Lowe KL; Pollitt AY; Mourao-Sa D; Sheardown S; Nash GB; Smithers N; Reis e Sousa C; Tybulewicz VL; Watson SP. 2012. CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood 119(7):1747-56. PubMed: 22186994 MGI: J:181715
Fond AM; Lee CS; Schulman IG; Kiss RS; Ravichandran KS. 2015. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest 125(7):2748-58. PubMed: 26075824 MGI: J:224549
Fong CH; Bebien M; Didierlaurent A; Nebauer R; Hussell T; Broide D; Karin M; Lawrence T. 2008. An antiinflammatory role for IKKbeta through the inhibition of 'classical' macrophage activation. J Exp Med 205(6):1269-76. PubMed: 18490491 MGI: J:137075
Fontana MF; Baccarella A; Pancholi N; Pufall MA; Herbert DR; Kim CC. 2015. JUNB is a key transcriptional modulator of macrophage activation. J Immunol 194(1):177-86. PubMed: 25472994 MGI: J:230687
Fooksman DR; Nussenzweig MC; Dustin ML. 2014. Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node. J Immunol 192(3):1004-12. PubMed: 24376270 MGI: J:207304
Freigang S; Ampenberger F; Weiss A; Kanneganti TD; Iwakura Y; Hersberger M; Kopf M. 2013. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 14(10):1045-53. PubMed: 23995233 MGI: J:208219
Freitas do Rosario AP; Lamb T; Spence P; Stephens R; Lang A; Roers A; Muller W; O'Garra A; Langhorne J. 2012. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol 188(3):1178-90. PubMed: 22205023 MGI: J:180758
Fujiwara Y; Piemontese M; Liu Y; Thostenson JD; Xiong J; O'Brien CA. 2016. RANKL (Receptor Activator of NFkappaB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice. J Biol Chem 291(48):24838-24850. PubMed: 27733688 MGI: J:237636
Fukunaga T; Zou W; Warren JT; Teitelbaum SL. 2014. Vinculin regulates osteoclast function. J Biol Chem 289(19):13554-64. PubMed: 24675074 MGI: J:214132
Gabanyi I; Muller PA; Feighery L; Oliveira TY; Costa-Pinto FA; Mucida D. 2016. Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell 164(3):378-91. PubMed: 26777404 MGI: J:230661
Gais P; Reim D; Jusek G; Rossmann-Bloeck T; Weighardt H; Pfeffer K; Altmayr F; Janssen KP; Holzmann B. 2012. Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J Immunol 188(12):5833-7. PubMed: 22586041 MGI: J:188968
Gales A; Conduche A; Bernad J; Lefevre L; Olagnier D; Beraud M; Martin-Blondel G; Linas MD; Auwerx J; Coste A; Pipy B. 2010. PPARgamma controls Dectin-1 expression required for host antifungal defense against Candida albicans. PLoS Pathog 6(1):e1000714. PubMed: 20062524 MGI: J:203908
Gallina G; Dolcetti L; Serafini P; De Santo C; Marigo I; Colombo MP; Basso G; Brombacher F; Borrello I; Zanovello P; Bicciato S; Bronte V. 2006. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116(10):2777-90. PubMed: 17016559 MGI: J:114986
Galvan MD; Foreman DB; Zeng E; Tan JC; Bohlson SS. 2012. Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells. J Immunol 188(8):3716-23. PubMed: 22422887 MGI: J:184063
Gamrekelashvili J; Giagnorio R; Jussofie J; Soehnlein O; Duchene J; Briseno CG; Ramasamy SK; Krishnasamy K; Limbourg A; Kapanadze T; Ishifune C; Hinkel R; Radtke F; Strobl LJ; Zimber-Strobl U; Napp LC; Bauersachs J; Haller H; Yasutomo K; Kupatt C; Murphy KM; Adams RH; Weber C; Limbourg FP. 2016. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun 7:12597. PubMed: 27576369 MGI: J:241907
Gao H; Danzi MC; Choi CS; Taherian M; Dalby-Hansen C; Ellman DG; Madsen PM; Bixby JL; Lemmon VP; Lambertsen KL; Brambilla R. 2017. Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Cell Rep 18(1):198-212. PubMed: 28052249 MGI: J:240627
Gao L; Brenner D; Llorens-Bobadilla E; Saiz-Castro G; Frank T; Wieghofer P; Hill O; Thiemann M; Karray S; Prinz M; Weishaupt JH; Martin-Villalba A. 2015. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med 212(4):469-80. PubMed: 25779632 MGI: J:222289
Gao L; Gulculer GS; Golbach L; Block H; Zarbock A; Martin-Villalba A. 2016. Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion. Elife 5:. PubMed: 27763263 MGI: J:238743
Garcia-Martin R; Alexaki VI; Qin N; Rubin de Celis MF; Economopoulou M; Ziogas A; Gercken B; Kotlabova K; Phieler J; Ehrhart-Bornstein M; Bornstein SR; Eisenhofer G; Breier G; Bluher M; Hampe J; El-Armouche A; Chatzigeorgiou A; Chung KJ; Chavakis T. 2015. Adipocyte-Specific Hypoxia-Inducible Factor 2alpha Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation. Mol Cell Biol 36(3):376-93. PubMed: 26572826 MGI: J:235908
Garrido-Martin EM; Nguyen HL; Cunningham TA; Choe SW; Jiang Z; Arthur HM; Lee YJ; Oh SP. 2014. Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models--brief report. Arterioscler Thromb Vasc Biol 34(10):2232-6. PubMed: 25082229 MGI: J:227170
Gaudreault N; Kumar N; Olivas VR; Eberle D; Rapp JH; Raffai RL. 2012. Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice. PLoS One 7(5):e35816. PubMed: 22606237 MGI: J:187245
Gaultier A; Arandjelovic S; Niessen S; Overton CD; Linton MF; Fazio S; Campana WM; Cravatt BF 3rd; Gonias SL. 2008. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood 111(11):5316-25. PubMed: 18369152 MGI: J:136163
Gautier EL; Chow A; Spanbroek R; Marcelin G; Greter M; Jakubzick C; Bogunovic M; Leboeuf M; van Rooijen N; Habenicht AJ; Merad M; Randolph GJ. 2012. Systemic analysis of PPARgamma in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity. J Immunol 189(5):2614-24. PubMed: 22855714 MGI: J:189849
Gautier EL; Ivanov S; Williams JW; Huang SC; Marcelin G; Fairfax K; Wang PL; Francis JS; Leone P; Wilson DB; Artyomov MN; Pearce EJ; Randolph GJ. 2014. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med 211(8):1525-31. PubMed: 25024137 MGI: J:214723
Gaya M; Castello A; Montaner B; Rogers N; Reis e Sousa C; Bruckbauer A; Batista FD. 2015. Host response. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection. Science 347(6222):667-72. PubMed: 25657250 MGI: J:218229
Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2012 Direct Data Submission from Genetic Resource Science :. MGI: J:184579
Ghosh T; Aprea J; Nardelli J; Engel H; Selinger C; Mombereau C; Lemonnier T; Moutkine I; Schwendimann L; Dori M; Irinopoulou T; Henrion-Caude A; Benecke AG; Arnold SJ; Gressens P; Calegari F; Groszer M. 2014. MicroRNAs Establish Robustness and Adaptability of a Critical Gene Network to Regulate Progenitor Fate Decisions during Cortical Neurogenesis. Cell Rep 7(6):1779-88. PubMed: 24931612 MGI: J:211776
Gibbs JE; Blaikley J; Beesley S; Matthews L; Simpson KD; Boyce SH; Farrow SN; Else KJ; Singh D; Ray DW; Loudon AS. 2012. The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A 109(2):582-7. PubMed: 22184247 MGI: J:180129
Gilmour J; Assi SA; Jaegle U; Kulu D; van de Werken H; Clarke D; Westhead DR; Philipsen S; Bonifer C. 2014. A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification. Development 141(12):2391-401. PubMed: 24850855 MGI: J:221276
Glogauer M; Marchal CC; Zhu F; Worku A; Clausen BE; Foerster I; Marks P; Downey GP; Dinauer M; Kwiatkowski DJ. 2003. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol 170(11):5652-7. PubMed: 12759446 MGI: J:83457
Goeritzer M; Schlager S; Radovic B; Madreiter CT; Rainer S; Thomas G; Lord CC; Sacks J; Brown AL; Vujic N; Obrowsky S; Sachdev V; Kolb D; Chandak PG; Graier WF; Sattler W; Brown JM; Kratky D. 2014. Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis. J Lipid Res 55(12):2562-75. PubMed: 25316883 MGI: J:217163
Goh YP; Henderson NC; Heredia JE; Red Eagle A; Odegaard JI; Lehwald N; Nguyen KD; Sheppard D; Mukundan L; Locksley RM; Chawla A. 2013. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A 110(24):9914-9. PubMed: 23716700 MGI: J:197388
Gold MJ; Antignano F; Hughes MR; Zaph C; McNagny KM. 2016. Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice. Eur J Immunol 46(1):122-30. PubMed: 26518471 MGI: J:234448
Goldberg SR; Georgiou J; Glogauer M; Grynpas MD. 2012. A 3D scanning confocal imaging method measures pit volume and captures the role of Rac in osteoclast function. Bone 51(1):145-52. PubMed: 22561898 MGI: J:186186
Gomes AL; Teijeiro A; Buren S; Tummala KS; Yilmaz M; Waisman A; Theurillat JP; Perna C; Djouder N. 2016. Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma. Cancer Cell 30(1):161-75. PubMed: 27411590 MGI: J:233522
Gonzalez-Teran B; Cortes JR; Manieri E; Matesanz N; Verdugo A; Rodriguez ME; Gonzalez-Rodriguez A; Valverde A; Martin P; Davis RJ; Sabio G. 2013. Eukaryotic elongation factor 2 controls TNF-alpha translation in LPS-induced hepatitis. J Clin Invest 123(1):164-78. PubMed: 23202732 MGI: J:194180
Gonzalez-Teran B; Matesanz N; Nikolic I; Verdugo MA; Sreeramkumar V; Hernandez-Cosido L; Mora A; Crainiciuc G; Saiz ML; Bernardo E; Leiva-Vega L; Rodriguez E; Bondia V; Torres JL; Perez-Sieira S; Ortega L; Cuenda A; Sanchez-Madrid F; Nogueiras R; Hidalgo A; Marcos M; Sabio G. 2016. p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration. EMBO J 35(5):536-52. PubMed: 26843485 MGI: J:230427
Goossens P; Gijbels MJ; Zernecke A; Eijgelaar W; Vergouwe MN; van der Made I; Vanderlocht J; Beckers L; Buurman WA; Daemen MJ; Kalinke U; Weber C; Lutgens E; de Winther MP. 2010. Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 12(2):142-53. PubMed: 20674859 MGI: J:163078
Gordon EJ; Rao S; Pollard JW; Nutt SL; Lang RA; Harvey NL. 2010. Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development 137(22):3899-910. PubMed: 20978081 MGI: J:167063
Gordts PL; Foley EM; Lawrence R; Sinha R; Lameda-Diaz C; Deng L; Nock R; Glass CK; Erbilgin A; Lusis AJ; Witztum JL; Esko JD. 2014. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab 20(5):813-26. PubMed: 25440058 MGI: J:218789
Gordy C; Pua H; Sempowski GD; He YW. 2011. Regulation of steady-state neutrophil homeostasis by macrophages. Blood 117(2):618-29. PubMed: 20980680 MGI: J:168403
Goren I; Allmann N; Yogev N; Schurmann C; Linke A; Holdener M; Waisman A; Pfeilschifter J; Frank S. 2009. A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol 175(1):132-47. PubMed: 19528348 MGI: J:150035
Graham DB; Osborne DG; Piotrowski JT; Gomez TS; Gmyrek GB; Akilesh HM; Dani A; Billadeau DD; Swat W. 2014. Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. PLoS One 9(6):e98606. PubMed: 24886983 MGI: J:217340
Grant L; Shearer KD; Czopek A; Lees EK; Owen C; Agouni A; Workman J; Martin-Granados C; Forrester JV; Wilson HM; Mody N; Delibegovic M. 2014. Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism. Diabetes 63(2):456-70. PubMed: 24186864 MGI: J:209005
Greenblatt MB; Aliprantis A; Hu B; Glimcher LH. 2010. Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med 207(5):923-31. PubMed: 20421389 MGI: J:160937
Gregor MF; Misch ES; Yang L; Hummasti S; Inouye KE; Lee AH; Bierie B; Hotamisligil GS. 2013. The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep 3(5):1430-9. PubMed: 23623498 MGI: J:198494
Greten FR; Arkan MC; Bollrath J; Hsu LC; Goode J; Miething C; Goktuna SI; Neuenhahn M; Fierer J; Paxian S; Van Rooijen N; Xu Y; O'Cain T; Jaffee BB; Busch DH; Duyster J; Schmid RM; Eckmann L; Karin M. 2007. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130(5):918-31. PubMed: 17803913 MGI: J:129928
Greten FR; Eckmann L; Greten TF; Park JM; Li ZW; Egan LJ; Kagnoff MF; Karin M. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285-96. PubMed: 15294155 MGI: J:91947
Grivennikov SI; Tumanov AV; Liepinsh DJ; Kruglov AA; Marakusha BI; Shakhov AN; Murakami T; Drutskaya LN; Forster I; Clausen BE; Tessarollo L; Ryffel B; Kuprash DV; Nedospasov SA. 2005. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22(1):93-104. PubMed: 15664162 MGI: J:95684
Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. PubMed: 21349431 MGI: J:168972
Guler R; Parihar SP; Savvi S; Logan E; Schwegmann A; Roy S; Nieuwenhuizen NE; Ozturk M; Schmeier S; Suzuki H; Brombacher F. 2015. IL-4Ralpha-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice. PLoS One 10(3):e0121070. PubMed: 25790379 MGI: J:229197
Gunzl P; Bauer K; Hainzl E; Matt U; Dillinger B; Mahr B; Knapp S; Binder BR; Schabbauer G. 2010. Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation. J Leukoc Biol 88(6):1259-69. PubMed: 20884649 MGI: J:166946
Gupte R; Muse GW; Chinenov Y; Adelman K; Rogatsky I. 2013. Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A 110(36):14616-21. PubMed: 23950223 MGI: J:200982
Hah YS; Cheon YH; Lim HS; Cho HY; Park BH; Ka SO; Lee YR; Jeong DW; Kim HO; Han MK; Lee SI. 2014. Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-kappaB activation. PLoS One 9(2):e87733. PubMed: 24498364 MGI: J:212845
Hahm E; Li J; Kim K; Huh S; Rogelj S; Cho J. 2013. Extracellular protein disulfide isomerase regulates ligand-binding activity of alphaMbeta2 integrin and neutrophil recruitment during vascular inflammation. Blood 121(19):3789-800, S1-15. PubMed: 23460613 MGI: J:197556
Hall AB; Gakidis MA; Glogauer M; Wilsbacher JL; Gao S; Swat W; Brugge JS. 2006. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity 24(3):305-16. PubMed: 16546099 MGI: J:113323
Hall KC; Hill D; Otero M; Plumb DA; Froemel D; Dragomir CL; Maretzky T; Boskey A; Crawford HC; Selleri L; Goldring MB; Blobel CP. 2013. ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes. Mol Cell Biol 33(16):3077-90. PubMed: 23732913 MGI: J:204569
Han MS; Barrett T; Brehm MA; Davis RJ. 2016. Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma. Cell Rep 15(1):19-26. PubMed: 27052181 MGI: J:235078
Han MS; Jung DY; Morel C; Lakhani SA; Kim JK; Flavell RA; Davis RJ. 2013. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339(6116):218-22. PubMed: 23223452 MGI: J:192551
Hao W; Decker Y; Schnoder L; Schottek A; Li D; Menger MD; Fassbender K; Liu Y. 2016. Deficiency of IkappaB Kinase beta in Myeloid Cells Reduces Severity of Experimental Autoimmune Encephalomyelitis. Am J Pathol 186(5):1245-57. PubMed: 26968344 MGI: J:232052
Hara T; Mimura K; Abe T; Shioi G; Seiki M; Sakamoto T. 2011. Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. J Biol Chem 286(37):32542-51. PubMed: 21778228 MGI: J:176742
Hara T; Nakaoka HJ; Hayashi T; Mimura K; Hoshino D; Inoue M; Nagamura F; Murakami Y; Seiki M; Sakamoto T. 2017. Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes. Proc Natl Acad Sci U S A 114(22):E4416-E4424. PubMed: 28507122 MGI: J:242286
Hardbower DM; Asim M; Luis PB; Singh K; Barry DP; Yang C; Steeves MA; Cleveland JL; Schneider C; Piazuelo MB; Gobert AP; Wilson KT. 2017. Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Proc Natl Acad Sci U S A 114(5):E751-E760. PubMed: 28096401 MGI: J:240745
Hardbower DM; Singh K; Asim M; Verriere TG; Olivares-Villagomez D; Barry DP; Allaman MM; Washington MK; Peek RM Jr; Piazuelo MB; Wilson KT. 2016. EGFR regulates macrophage activation and function in bacterial infection. J Clin Invest 126(9):3296-312. PubMed: 27482886 MGI: J:237254
Harvey CJ; Thimmulappa RK; Sethi S; Kong X; Yarmus L; Brown RH; Feller-Kopman D; Wise R; Biswal S. 2011. Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model. Sci Transl Med 3(78):78ra32. PubMed: 21490276 MGI: J:170808
Hashimoto M; Ayada T; Kinjyo I; Hiwatashi K; Yoshida H; Okada Y; Kobayashi T; Yoshimura A. 2009. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Cancer Sci 100(4):730-6. PubMed: 19469017 MGI: J:150670
Hasselblatt P; Gresh L; Kudo H; Guinea-Viniegra J; Wagner EF. 2008. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene 27(47):6102-9. PubMed: 18679426 MGI: J:140139
He JQ; Katschke KJ Jr; Gribling P; Suto E; Lee WP; Diehl L; Eastham-Anderson J; Ponakala A; Komuves L; Egen JG; van Lookeren Campagne M. 2013. CRIg mediates early Kupffer cell responses to adenovirus. J Leukoc Biol 93(2):301-6. PubMed: 23225913 MGI: J:193858
He XY; Xiang C; Zhang CX; Xie YY; Chen L; Zhang GX; Lu Y; Liu G. 2015. p53 in the Myeloid Lineage Modulates an Inflammatory Microenvironment Limiting Initiation and Invasion of Intestinal Tumors. Cell Rep 13(5):888-97. PubMed: 26565902 MGI: J:228954
He Z; Zhu HH; Bauler TJ; Wang J; Ciaraldi T; Alderson N; Li S; Raquil MA; Ji K; Wang S; Shao J; Henry RR; King PD; Feng GS. 2013. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A 110(1):E79-88. PubMed: 23236157 MGI: J:192542
Heitmann L; Rani R; Dawson L; Perkins C; Yang Y; Downey J; Holscher C; Herbert DR. 2012. TGF-beta-responsive myeloid cells suppress type 2 immunity and emphysematous pathology after hookworm infection. Am J Pathol 181(3):897-906. PubMed: 22901754 MGI: J:189927
Heo KS; Cushman HJ; Akaike M; Woo CH; Wang X; Qiu X; Fujiwara K; Abe J. 2014. ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis. Circulation 130(2):180-91. PubMed: 25001623 MGI: J:224432
Herbert DR; Holscher C; Mohrs M; Arendse B; Schwegmann A; Radwanska M; Leeto M; Kirsch R; Hall P; Mossmann H; Claussen B; Forster I; Brombacher F. 2004. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20(5):623-35. PubMed: 15142530 MGI: J:114751
Hernandez ED; Lee SJ; Kim JY; Duran A; Linares JF; Yajima T; Muller TD; Tschop MH; Smith SR; Diaz-Meco MT; Moscat J. 2014. A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Cell Metab 20(3):499-511. PubMed: 25043814 MGI: J:215606
Herrera-Merchan A; Arranz L; Ligos JM; de Molina A; Dominguez O; Gonzalez S. 2012. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Nat Commun 3:623. PubMed: 22233633 MGI: J:225016
Hevener AL; Olefsky JM; Reichart D; Nguyen MT; Bandyopadyhay G; Leung HY; Watt MJ; Benner C; Febbraio MA; Nguyen AK; Folian B; Subramaniam S; Gonzalez FJ; Glass CK; Ricote M. 2007. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 117(6):1658-69. PubMed: 17525798 MGI: J:122186
Hill GR; Kuns RD; Raffelt NC; Don AL; Olver SD; Markey KA; Wilson YA; Tocker J; Alexander WS; Clouston AD; Roberts AW; MacDonald KP. 2010. SOCS3 regulates graft-versus-host disease. Blood 116(2):287-96. PubMed: 20435883 MGI: J:162796
Hiwatashi K; Tamiya T; Hasegawa E; Fukaya T; Hashimoto M; Kakoi K; Kashiwagi I; Kimura A; Inoue N; Morita R; Yasukawa H; Yoshimura A. 2011. Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction. Cancer Lett 308(2):172-80. PubMed: 21624767 MGI: J:173608
Hodara R; Weiss D; Joseph G; Velasquez-Castano JC; Landazuri N; Han JW; Yoon YS; Taylor WR. 2011. Overexpression of catalase in myeloid cells causes impaired postischemic neovascularization. Arterioscler Thromb Vasc Biol 31(10):2203-9. PubMed: 21799178 MGI: J:191845
Hoeksema MA; Gijbels MJ; Van den Bossche J; van der Velden S; Sijm A; Neele AE; Seijkens T; Stoger JL; Meiler S; Boshuizen MC; Dallinga-Thie GM; Levels JH; Boon L; Mullican SE; Spann NJ; Cleutjens JP; Glass CK; Lazar MA; de Vries CJ; Biessen EA; Daemen MJ; Lutgens E; de Winther MP. 2014. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med 6(9):1124-32. PubMed: 25007801 MGI: J:232468
Holscher C; Arendse B; Schwegmann A; Myburgh E; Brombacher F. 2006. Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice. J Immunol 176(2):1115-21. PubMed: 16394000 MGI: J:126442
Horiguchi N; Wang L; Mukhopadhyay P; Park O; Jeong WI; Lafdil F; Osei-Hyiaman D; Moh A; Fu XY; Pacher P; Kunos G; Gao B. 2008. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134(4):1148-58. PubMed: 18395093 MGI: J:136121
Horiuchi K; Kimura T; Miyamoto T; Takaishi H; Okada Y; Toyama Y; Blobel CP. 2007. Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol 179(5):2686-9. PubMed: 17709479 MGI: J:139846
Horsthemke M; Bachg AC; Groll K; Moyzio S; Muther B; Hemkemeyer SA; Wedlich-Soldner R; Sixt M; Tacke S; Bahler M; Hanley PJ. 2017. Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion. J Biol Chem 292(17):7258-7273. PubMed: 28289096 MGI: J:242502
Hos D; Bucher F; Regenfuss B; Dreisow ML; Bock F; Heindl LM; Eming SA; Cursiefen C. 2016. IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages. Am J Pathol 186(1):159-71. PubMed: 26608451 MGI: J:228206
Hu L; Boesten LS; May P; Herz J; Bovenschen N; Huisman MV; Berbee JF; Havekes LM; van Vlijmen BJ; Tamsma JT. 2006. Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Arterioscler Thromb Vasc Biol 26(12):2710-5. PubMed: 17038633 MGI: J:129557
Hu X; Adebiyi MG; Luo J; Sun K; Le TT; Zhang Y; Wu H; Zhao S; Karmouty-Quintana H; Liu H; Huang A; Wen YE; Zaika OL; Mamenko M; Pochynyuk OM; Kellems RE; Eltzschig HK; Blackburn MR; Walters ET; Huang D; Hu H; Xia Y. 2016. Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction. Cell Rep 16(1):106-19. PubMed: 27320922 MGI: J:238368
Hu X; Chung AY; Wu I; Foldi J; Chen J; Ji JD; Tateya T; Kang YJ; Han J; Gessler M; Kageyama R; Ivashkiv LB. 2008. Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity 29(5):691-703. PubMed: 18976936 MGI: J:143772
Huang G; Wang Y; Vogel P; Kanneganti TD; Otsu K; Chi H. 2012. Signaling via the kinase p38alpha programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol 13(2):152-61. PubMed: 22231518 MGI: J:181211
Huang QQ; Perlman H; Huang Z; Birkett R; Kan L; Agrawal H; Misharin A; Gurbuxani S; Crispino JD; Pope RM. 2010. FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood 116(23):4968-77. PubMed: 20724542 MGI: J:167430
Huen SC; Moeckel GW; Cantley LG. 2013. Macrophage-specific deletion of transforming growth factor-beta1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. Am J Physiol Renal Physiol 305(4):F477-84. PubMed: 23761668 MGI: J:200821
Hui X; Zhang M; Gu P; Li K; Gao Y; Wu D; Wang Y; Xu A. 2017. Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. EMBO Rep 18(4):645-657. PubMed: 28270525 MGI: J:241290
Hui Y; Ricciotti E; Crichton I; Yu Z; Wang D; Stubbe J; Wang M; Pure E; FitzGerald GA. 2010. Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation 121(24):2654-60. PubMed: 20530000 MGI: J:178670
Humeniuk R; Koller R; Bies J; Aplan P; Wolff L. 2014. Brief report: Loss of p15Ink4b accelerates development of myeloid neoplasms in Nup98-HoxD13 transgenic mice. Stem Cells 32(5):1361-6. PubMed: 24449168 MGI: J:211213
Hunt JB Jr; Nash KR; Placides D; Moran P; Selenica ML; Abuqalbeen F; Ratnasamy K; Slouha N; Rodriguez-Ospina S; Savlia M; Ranaweera Y; Reid P; Dickey CA; Uricia R; Yang CG; Sandusky LA; Gordon MN; Morgan D; Lee DC. 2015. Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. J Neurosci 35(44):14842-60. PubMed: 26538654 MGI: J:227049
Hyatt LD; Wasserman GA; Rah YJ; Matsuura KY; Coleman FT; Hilliard KL; Pepper-Cunningham ZA; Ieong M; Stumpo DJ; Blackshear PJ; Quinton LJ; Mizgerd JP; Jones MR. 2014. Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. PLoS One 9(10):e109072. PubMed: 25299049 MGI: J:223460
Idell S; James KK; Levin EG; Schwartz BS; Manchanda N; Maunder RJ; Martin TR; McLarty J; Fair DS. 1989. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest 84(2):695-705. PubMed: 2788176 MGI: J:229737
Ikeda J; Ichiki T; Matsuura H; Inoue E; Kishimoto J; Watanabe A; Sankoda C; Kitamoto S; Tokunou T; Takeda K; Fong GH; Sunagawa K. 2013. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc 2(3):e000178. PubMed: 23778187 MGI: J:199066
Imai Y; Kuba K; Neely GG; Yaghubian-Malhami R; Perkmann T; van Loo G; Ermolaeva M; Veldhuizen R; Leung YH; Wang H; Liu H; Sun Y; Pasparakis M; Kopf M; Mech C; Bavari S; Peiris JS; Slutsky AS; Akira S; Hultqvist M; Holmdahl R; Nicholls J; Jiang C; Binder CJ; Penninger JM. 2008. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133(2):235-49. PubMed: 18423196 MGI: J:145306
Imtiyaz HZ; Williams EP; Hickey MM; Patel SA; Durham AC; Yuan LJ; Hammond R; Gimotty PA; Keith B; Simon MC. 2010. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 120(8):2699-714. PubMed: 20644254 MGI: J:163764
Inoue M; Arikawa T; Chen YH; Moriwaki Y; Price M; Brown M; Perfect JR; Shinohara ML. 2014. T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. Proc Natl Acad Sci U S A 111(14):5295-300. PubMed: 24706909 MGI: J:208867
Ishikawa TO; Oshima M; Herschman HR. 2011. Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis. Carcinogenesis 32(3):417-26. PubMed: 21156970 MGI: J:169324
Ito Y; Ofengeim D; Najafov A; Das S; Saberi S; Li Y; Hitomi J; Zhu H; Chen H; Mayo L; Geng J; Amin P; DeWitt JP; Mookhtiar AK; Florez M; Ouchida AT; Fan JB; Pasparakis M; Kelliher MA; Ravits J; Yuan J. 2016. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science 353(6299):603-8. PubMed: 27493188 MGI: J:234166
Ittner A; Block H; Reichel CA; Varjosalo M; Gehart H; Sumara G; Gstaiger M; Krombach F; Zarbock A; Ricci R. 2012. Regulation of PTEN activity by p38delta-PKD1 signaling in neutrophils confers inflammatory responses in the lung. J Exp Med 209(12):2229-46. PubMed: 23129748 MGI: J:190972
Ivanov SS; Roy CR. 2013. Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR. Nat Immunol 14(12):1219-28. PubMed: 24121838 MGI: J:208652
Iyer SS; Ghaffari AA; Cheng G. 2010. Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages. J Immunol 185(11):6599-607. PubMed: 21041726 MGI: J:166135
Jais A; Einwallner E; Sharif O; Gossens K; Lu TT; Soyal SM; Medgyesi D; Neureiter D; Paier-Pourani J; Dalgaard K; Duvigneau JC; Lindroos-Christensen J; Zapf TC; Amann S; Saluzzo S; Jantscher F; Stiedl P; Todoric J; Martins R; Oberkofler H; Muller S; Hauser-Kronberger C; Kenner L; Casanova E; Sutterluty-Fall H; Bilban M; Miller K; Kozlov AV; Krempler F; Knapp S; Lumeng CN; Patsch W; Wagner O; Pospisilik JA; Esterbauer H. 2014. Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man. Cell 158(1):25-40. PubMed: 24995976 MGI: J:214639
Jakubzick C; Bogunovic M; Bonito AJ; Kuan EL; Merad M; Randolph GJ. 2008. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med 205(12):2839-50. PubMed: 18981237 MGI: J:143220
Jenkins SJ; Ruckerl D; Thomas GD; Hewitson JP; Duncan S; Brombacher F; Maizels RM; Hume DA; Allen JE. 2013. IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. J Exp Med 210(11):2477-91. PubMed: 24101381 MGI: J:204583
Jennewein C; Kuhn AM; Schmidt MV; Meilladec-Jullig V; von Knethen A; Gonzalez FJ; Brune B. 2008. Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. J Immunol 181(8):5646-52. PubMed: 18832723 MGI: J:140756
Jennings RT; Strengert M; Hayes P; El-Benna J; Brakebusch C; Kubica M; Knaus UG. 2014. RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness. Blood 123(23):3635-45. PubMed: 24782506 MGI: J:211293
Jensen KD; Hu K; Whitmarsh RJ; Hassan MA; Julien L; Lu D; Chen L; Hunter CA; Saeij JP. 2013. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun 81(6):2156-67. PubMed: 23545295 MGI: J:199524
Jetten N; Donners MM; Wagenaar A; Cleutjens JP; van Rooijen N; de Winther MP; Post MJ. 2013. Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model. PLoS One 8(7):e68811. PubMed: 23894348 MGI: J:204382
Ji Y; Sun S; Xu A; Bhargava P; Yang L; Lam KS; Gao B; Lee CH; Kersten S; Qi L. 2012. Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J Biol Chem 287(17):13561-71. PubMed: 22396530 MGI: J:184470
Jiang H; Westerterp M; Wang C; Zhu Y; Ai D. 2014. Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice. Diabetologia 57(11):2393-404. PubMed: 25120095 MGI: J:234896
Jiang LI; Sternweis PC; Wang JE. 2013. Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. Mol Immunol 54(1):14-22. PubMed: 23178822 MGI: J:191067
Jiao J; Ishikawa TO; Dumlao DS; Norris PC; Magyar CE; Mikulec C; Catapang A; Dennis EA; Fischer SM; Herschman HR. 2014. Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res 12(11):1677-88. PubMed: 25063587 MGI: J:216703
Jiao J; Mikulec C; Ishikawa TO; Magyar C; Dumlao DS; Dennis EA; Fischer SM; Herschman H. 2014. Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis 35(6):1310-9. PubMed: 24469308 MGI: J:211594
Jin J; Hu H; Li HS; Yu J; Xiao Y; Brittain GC; Zou Q; Cheng X; Mallette FA; Watowich SS; Sun SC. 2014. Noncanonical NF-kappaB pathway controls the production of type I interferons in antiviral innate immunity. Immunity 40(3):342-54. PubMed: 24656046 MGI: J:209992
Jin J; Xiao Y; Hu H; Zou Q; Li Y; Gao Y; Ge W; Cheng X; Sun SC. 2015. Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun 6:5930. PubMed: 25565375 MGI: J:219748
Jin J; Xie X; Xiao Y; Hu H; Zou Q; Cheng X; Sun SC. 2016. Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Nat Immunol 17(3):259-68. PubMed: 26808229 MGI: J:235701
Jin Z; Wei W; Yang M; Du Y; Wan Y. 2014. Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab 20(3):483-98. PubMed: 25130399 MGI: J:215568
Johnnidis JB; Harris MH; Wheeler RT; Stehling-Sun S; Lam MH; Kirak O; Brummelkamp TR; Fleming MD; Camargo FD. 2008. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451(7182):1125-9. PubMed: 18278031 MGI: J:140009
Joshi S; Singh AR; Zulcic M; Durden DL. 2014. A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1alpha and HIF2alpha stability and tumor growth, angiogenesis, and metastasis. Mol Cancer Res 12(10):1520-31. PubMed: 25103499 MGI: J:216067
Jude CD; Climer L; Xu D; Artinger E; Fisher JK; Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3):324-37. PubMed: 18371366 MGI: J:147265
Kallfass C; Lienenklaus S; Weiss S; Staeheli P. 2013. Visualizing the beta interferon response in mice during infection with influenza A viruses expressing or lacking nonstructural protein 1. J Virol 87(12):6925-30. PubMed: 23576514 MGI: J:198349
Kanayama M; Inoue M; Danzaki K; Hammer G; He YW; Shinohara ML. 2015. Autophagy enhances NFkappaB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun 6:5779. PubMed: 25609235 MGI: J:219710
Kang H; Corr M; Mansson R; Welinder E; Hedrick SM; Stone EL. 2015. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis. PLoS One 10(5):e0126728. PubMed: 25969990 MGI: J:235327
Kang J; Jiang MH; Min HJ; Jo EK; Lee S; Karin M; Yune TY; Lee SJ. 2011. IKK-beta-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol 41(5):1266-77. PubMed: 21469085 MGI: J:175413
Kang K; Reilly SM; Karabacak V; Gangl MR; Fitzgerald K; Hatano B; Lee CH. 2008. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab 7(6):485-95. PubMed: 18522830 MGI: J:137033
Kang TB; Ben-Moshe T; Varfolomeev EE; Pewzner-Jung Y; Yogev N; Jurewicz A; Waisman A; Brenner O; Haffner R; Gustafsson E; Ramakrishnan P; Lapidot T; Wallach D. 2004. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173(5):2976-84. PubMed: 15322156 MGI: J:92722
Kang TB; Yang SH; Toth B; Kovalenko A; Wallach D. 2013. Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome. Immunity 38(1):27-40. PubMed: 23260196 MGI: J:192616
Kang YJ; Chen J; Otsuka M; Mols J; Ren S; Wang Y; Han J. 2008. Macrophage Deletion of p38{alpha} Partially Impairs Lipopolysaccharide-Induced Cellular Activation. J Immunol 180(7):5075-82. PubMed: 18354233 MGI: J:133368
Kanisicak O; Khalil H; Ivey MJ; Karch J; Maliken BD; Correll RN; Brody MJ; J Lin SC; Aronow BJ; Tallquist MD; Molkentin JD. 2016. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun 7:12260. PubMed: 27447449 MGI: J:241168
Kanter JE; Kramer F; Barnhart S; Averill MM; Vivekanandan-Giri A; Vickery T; Li LO; Becker L; Yuan W; Chait A; Braun KR; Potter-Perigo S; Sanda S; Wight TN; Pennathur S; Serhan CN; Heinecke JW; Coleman RA; Bornfeldt KE. 2012. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A 109(12):E715-24. PubMed: 22308341 MGI: J:182631
Kanter JE; Tang C; Oram JF; Bornfeldt KE. 2012. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. Biochim Biophys Acta 1821(3):358-64. PubMed: 22020260 MGI: J:182368
Kanters E; Pasparakis M; Gijbels MJ; Vergouwe MN; Partouns-Hendriks I; Fijneman RJ; Clausen BE; Forster I; Kockx MM; Rajewsky K; Kraal G; Hofker MH; de Winther MP. 2003. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest 112(8):1176-85. PubMed: 14561702 MGI: J:86163
Kardakaris R; Gareus R; Xanthoulea S; Pasparakis M. 2011. Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6(6):e21055. PubMed: 21695272 MGI: J:174787
Karlsson MC; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV. 2003. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med 198(2):333-40. PubMed: 12874264 MGI: J:119256
Karlsson T; Glogauer M; Ellen RP; Loitto VM; Magnusson KE; Magalhaes MA. 2011. Aquaporin 9 phosphorylation mediates membrane localization and neutrophil polarization. J Leukoc Biol 90(5):963-73. PubMed: 21873454 MGI: J:178235
Kasorn A; Alcaide P; Jia Y; Subramanian KK; Sarraj B; Li Y; Loison F; Hattori H; Silberstein LE; Luscinskas WF; Luo HR. 2009. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol 183(2):1032-43. PubMed: 19561112 MGI: J:151655
Kasper LH; Fukuyama T; Biesen MA; Boussouar F; Tong C; de Pauw A; Murray PJ; van Deursen JM; Brindle PK. 2006. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26(3):789-809. PubMed: 16428436 MGI: J:105505
Kawakami T; Lichtnekert J; Thompson LJ; Karna P; Bouabe H; Hohl TM; Heinecke JW; Ziegler SF; Nelson PJ; Duffield JS. 2013. Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. J Immunol 191(6):3358-72. PubMed: 23956422 MGI: J:205879
Kawano Y; Nakae J; Watanabe N; Fujisaka S; Iskandar K; Sekioka R; Hayashi Y; Tobe K; Kasuga M; Noda T; Yoshimura A; Onodera M; Itoh H. 2012. Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance. Diabetes 61(8):1935-48. PubMed: 22586579 MGI: J:208461
Kayama H; Ueda Y; Sawa Y; Jeon SG; Ma JS; Okumura R; Kubo A; Ishii M; Okazaki T; Murakami M; Yamamoto M; Yagita H; Takeda K. 2012. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc Natl Acad Sci U S A 109(13):5010-5. PubMed: 22403066 MGI: J:182225
Kenner L; Hoebertz A; Beil T; Keon N; Karreth F; Eferl R; Scheuch H; Szremska A; Amling M; Schorpp-Kistner M; Angel P; Wagner EF. 2004. Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects. J Cell Biol 164(4):613-23. PubMed: 14769860 MGI: J:88126
Kernbauer E; Maier V; Stoiber D; Strobl B; Schneckenleithner C; Sexl V; Reichart U; Reizis B; Kalinke U; Jamieson A; Muller M; Decker T. 2012. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog 8(6):e1002763. PubMed: 22719255 MGI: J:195380
Kew RR; Penzo M; Habiel DM; Marcu KB. 2012. The IKKalpha-Dependent NF-kappaB p52/RelB Noncanonical Pathway Is Essential To Sustain a CXCL12 Autocrine Loop in Cells Migrating in Response to HMGB1. J Immunol 188(5):2380-6. PubMed: 22287708 MGI: J:181251
Khan OM; Akula MK; Skalen K; Karlsson C; Stahlman M; Young SG; Boren J; Bergo MO. 2013. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation 127(7):782-90. PubMed: 23334894 MGI: J:210275
Khan OM; Ibrahim MX; Jonsson IM; Karlsson C; Liu M; Sjogren AK; Olofsson FJ; Brisslert M; Andersson S; Ohlsson C; Hulten LM; Bokarewa M; Bergo MO. 2011. Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. J Clin Invest 121(2):628-39. PubMed: 21266780 MGI: J:171824
Kihira Y; Miyake M; Hirata M; Hoshina Y; Kato K; Shirakawa H; Sakaue H; Yamano N; Izawa-Ishizawa Y; Ishizawa K; Ikeda Y; Tsuchiya K; Tamaki T; Tomita S. 2014. Deletion of hypoxia-inducible factor-1alpha in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PLoS One 9(4):e93856. PubMed: 24705496 MGI: J:215021
Kim C; Sano Y; Todorova K; Carlson BA; Arpa L; Celada A; Lawrence T; Otsu K; Brissette JL; Arthur JS; Park JM. 2008. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol 9(9):1019-27. PubMed: 18677317 MGI: J:140029
Kim HN; Han L; Iyer S; de Cabo R; Zhao H; O'Brien CA; Manolagas SC; Almeida M. 2015. Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs. Mol Endocrinol 29(10):1498-509. PubMed: 26287518 MGI: J:233390
Kimura A; Kinjyo I; Matsumura Y; Mori H; Mashima R; Harada M; Chien KR; Yasukawa H; Yoshimura A. 2004. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem 279(8):6905-10. PubMed: 14699146 MGI: J:88961
Kimura Y; Zhou L; Miwa T; Song WC. 2010. Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury. J Clin Invest 120(10):3545-54. PubMed: 20941861 MGI: J:165497
Kirkland D; Benson A; Mirpuri J; Pifer R; Hou B; Defranco AL; Yarovinsky F. 2012. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage. Immunity 36(2):228-38. PubMed: 22306056 MGI: J:181331
Kiss E; Popovic ZV; Bedke J; Adams J; Bonrouhi M; Babelova A; Schmidt C; Edenhofer F; Zschiedrich I; Domhan S; Abdollahi A; Schafer L; Gretz N; Porubsky S; Grone HJ. 2010. Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage. Am J Pathol 176(5):2150-62. PubMed: 20363918 MGI: J:160750
Kleiman A; Hubner S; Rodriguez Parkitna JM; Neumann A; Hofer S; Weigand MA; Bauer M; Schmid W; Schutz G; Libert C; Reichardt HM; Tuckermann JP. 2012. Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J 26(2):722-9. PubMed: 22042221 MGI: J:180618
Klose R; Krzywinska E; Castells M; Gotthardt D; Putz EM; Kantari-Mimoun C; Chikdene N; Meinecke AK; Schrodter K; Helfrich I; Fandrey J; Sexl V; Stockmann C. 2016. Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia. Nat Commun 7:12528. PubMed: 27538380 MGI: J:241457
Knippenberg S; Brumshagen C; Aschenbrenner F; Welte T; Maus UA. 2015. Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. Eur J Immunol 45(6):1716-26. PubMed: 25789453 MGI: J:229706
Knipper JA; Willenborg S; Brinckmann J; Bloch W; Maass T; Wagener R; Krieg T; Sutherland T; Munitz A; Rothenberg ME; Niehoff A; Richardson R; Hammerschmidt M; Allen JE; Eming SA. 2015. Interleukin-4 Receptor alpha Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair. Immunity 43(4):803-16. PubMed: 26474656 MGI: J:233919
Kobayashi EH; Suzuki T; Funayama R; Nagashima T; Hayashi M; Sekine H; Tanaka N; Moriguchi T; Motohashi H; Nakayama K; Yamamoto M. 2016. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun 7:11624. PubMed: 27211851 MGI: J:239920
Kobayashi H; Gilbert V; Liu Q; Kapitsinou PP; Unger TL; Rha J; Rivella S; Schlondorff D; Haase VH. 2012. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J Immunol 188(10):5106-15. PubMed: 22490864 MGI: J:188688
Kobayashi M; Kweon MN; Kuwata H; Schreiber RD; Kiyono H; Takeda K; Akira S. 2003. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest 111(9):1297-308. PubMed: 12727921 MGI: J:83280
Koh HS; Chang CY; Jeon SB; Yoon HJ; Ahn YH; Kim HS; Kim IH; Jeon SH; Johnson RS; Park EJ. 2015. The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. Nat Commun 6:6340. PubMed: 25790768 MGI: J:221874
Koliaraki V; Roulis M; Kollias G. 2012. Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest 122(11):4231-42. PubMed: 23064365 MGI: J:193546
Kong X; Thimmulappa R; Craciun F; Harvey C; Singh A; Kombairaju P; Reddy SP; Remick D; Biswal S. 2011. Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis. Am J Respir Crit Care Med 184(8):928-38. PubMed: 21799073 MGI: J:207596
Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. PubMed: 12486099 MGI: J:108572
Kossmann S; Hu H; Steven S; Schonfelder T; Fraccarollo D; Mikhed Y; Brahler M; Knorr M; Brandt M; Karbach SH; Becker C; Oelze M; Bauersachs J; Widder J; Munzel T; Daiber A; Wenzel P. 2014. Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II. J Biol Chem 289(40):27540-50. PubMed: 25143378 MGI: J:217069
Kossmann S; Schwenk M; Hausding M; Karbach SH; Schmidgen MI; Brandt M; Knorr M; Hu H; Kroller-Schon S; Schonfelder T; Grabbe S; Oelze M; Daiber A; Munzel T; Becker C; Wenzel P. 2013. Angiotensin II-induced vascular dysfunction depends on interferon-gamma-driven immune cell recruitment and mutual activation of monocytes and NK-cells. Arterioscler Thromb Vasc Biol 33(6):1313-9. PubMed: 23520167 MGI: J:218876
Krabbe G; Minami SS; Etchegaray JI; Taneja P; Djukic B; Davalos D; Le D; Lo I; Zhan L; Reichert MC; Sayed F; Merlini M; Ward ME; Perry DC; Lee SE; Sias A; Parkhurst CN; Gan WB; Akassoglou K; Miller BL; Farese RV Jr; Gan L. 2017. Microglial NFkappaB-TNFalpha hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A 114(19):5029-5034. PubMed: 28438992 MGI: J:242226
Kranc KR; Schepers H; Rodrigues NP; Bamforth S; Villadsen E; Ferry H; Bouriez-Jones T; Sigvardsson M; Bhattacharya S; Jacobsen SE; Enver T. 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5(6):659-65. PubMed: 19951693 MGI: J:155878
Kratochvill F; Gratz N; Qualls JE; Van De Velde LA; Chi H; Kovarik P; Murray PJ. 2015. Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner. Cancer Res 75(15):3054-64. PubMed: 26183929 MGI: J:225584
Kroetz DN; Allen RM; Schaller MA; Cavallaro C; Ito T; Kunkel SL. 2015. Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection. PLoS Pathog 11(12):e1005338. PubMed: 26709698 MGI: J:236763
Kruglov AA; Lampropoulou V; Fillatreau S; Nedospasov SA. 2011. Pathogenic and protective functions of TNF in neuroinflammation are defined by its expression in T lymphocytes and myeloid cells. J Immunol 187(11):5660-70. PubMed: 22058414 MGI: J:179684
Kurihara T; Westenskow PD; Krohne TU; Aguilar E; Johnson RS; Friedlander M. 2011. Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye. J Cell Biol 195(4):689-701. PubMed: 22084310 MGI: J:178823
Kuroda S; Nishio M; Sasaki T; Horie Y; Kawahara K; Sasaki M; Natsui M; Matozaki T; Tezuka H; Ohteki T; Forster I; Mak TW; Nakano T; Suzuki A. 2008. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 38(5):1331-40. PubMed: 18398930 MGI: J:133966
Lacy-Hulbert A; Smith AM; Tissire H; Barry M; Crowley D; Bronson RT; Roes JT; Savill JS; Hynes RO. 2007. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A 104(40):15823-8. PubMed: 17895374 MGI: J:125508
Lai JJ; Lai KP; Chuang KH; Chang P; Yu IC; Lin WJ; Chang C. 2009. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. J Clin Invest 119(12):3739-51. PubMed: 19907077 MGI: J:155101
Lalani AI; Moore CR; Luo C; Kreider BZ; Liu Y; Morse HC 3rd; Xie P. 2015. Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice. J Immunol 194(1):334-48. PubMed: 25422508 MGI: J:230694
Lamacchia C; Palmer G; Bischoff L; Rodriguez E; Talabot-Ayer D; Gabay C. 2010. Distinct Roles of Hepatocyte- and Myeloid Cell-Derived IL-1 Receptor Antagonist during Endotoxemia and Sterile Inflammation in Mice. J Immunol 185(4):2516-24. PubMed: 20639493 MGI: J:162537
Lamacchia C; Palmer G; Seemayer CA; Talabot-Ayer D; Gabay C. 2010. Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist. Arthritis Rheum 62(2):452-62. PubMed: 20112392 MGI: J:162760
Lamothe B; Lai Y; Hur L; Orozco NM; Wang J; Campos AD; Xie M; Schneider MD; Lockworth CR; Jakacky J; Tran D; Ho M; Dawud S; Dong C; Lin HK; Hu P; Estrov Z; Bueso-Ramos CE; Darnay BG. 2012. Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice. PLoS One 7(12):e51228. PubMed: 23251462 MGI: J:195668
Lamothe B; Lai Y; Xie M; Schneider MD; Darnay BG. 2013. TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis. Mol Cell Biol 33(3):582-95. PubMed: 23166301 MGI: J:194222
Lawler C; Tan CS; Simas JP; Stevenson PG. 2016. Type I Interferons and NK Cells Restrict Gammaherpesvirus Lymph Node Infection. J Virol 90(20):9046-57. PubMed: 27466430 MGI: J:236008
Le Moan N; Baeten KM; Rafalski VA; Ryu JK; Rios Coronado PE; Bedard C; Syme C; Davalos D; Akassoglou K. 2015. Hypoxia Inducible Factor-1 in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease eNeuro 2(2):. PubMed: 26213713 MGI: J:229425
Lee B; Qiao L; Kinney B; Feng GS; Shao J. 2014. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One 9(6):e99575. PubMed: 24911652 MGI: J:217326
Lee SC; Miller S; Hyland C; Kauppi M; Lebois M; Di Rago L; Metcalf D; Kinkel SA; Josefsson EC; Blewitt ME; Majewski IJ; Alexander WS. 2015. Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis. Blood 126(2):167-75. PubMed: 26036803 MGI: J:225918
Lefevre L; Authier H; Stein S; Majorel C; Couderc B; Dardenne C; Eddine MA; Meunier E; Bernad J; Valentin A; Pipy B; Schoonjans K; Coste A. 2015. LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARgamma ligand synthesis. Nat Commun 6:6801. PubMed: 25873311 MGI: J:222716
Lefevre L; Lugo-Villarino G; Meunier E; Valentin A; Olagnier D; Authier H; Duval C; Dardenne C; Bernad J; Lemesre JL; Auwerx J; Neyrolles O; Pipy B; Coste A. 2013. The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. Immunity 38(5):1038-49. PubMed: 23684988 MGI: J:203147
Lehmann CHK; Baranska A; Heidkamp GF; Heger L; Neubert K; Luhr JJ; Hoffmann A; Reimer KC; Bruckner C; Beck S; Seeling M; Kiessling M; Soulat D; Krug AB; Ravetch JV; Leusen JHW; Nimmerjahn F; Dudziak D. 2017. DC subset-specific induction of T cell responses upon antigen uptake via Fcgamma receptors in vivo. J Exp Med 214(5):1509-1528. PubMed: 28389502 MGI: J:242013
Leite de Oliveira R; Deschoemaeker S; Henze AT; Debackere K; Finisguerra V; Takeda Y; Roncal C; Dettori D; Tack E; Jonsson Y; Veschini L; Peeters A; Anisimov A; Hofmann M; Alitalo K; Baes M; D'hooge J; Carmeliet P; Mazzone M. 2012. Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. Cancer Cell 22(2):263-77. PubMed: 22897855 MGI: J:191820
Lelu K; Laffont S; Delpy L; Paulet PE; Perinat T; Tschanz SA; Pelletier L; Engelhardt B; Guery JC. 2011. Estrogen receptor alpha signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis. J Immunol 187(5):2386-93. PubMed: 21810607 MGI: J:179128
Letellier E; Kumar S; Sancho-Martinez I; Krauth S; Funke-Kaiser A; Laudenklos S; Konecki K; Klussmann S; Corsini NS; Kleber S; Drost N; Neumann A; Levi-Strauss M; Brors B; Gretz N; Edler L; Fischer C; Hill O; Thiemann M; Biglari B; Karray S; Martin-Villalba A. 2010. CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity 32(2):240-52. PubMed: 20153221 MGI: J:157914
Leung R; Cuddy K; Wang Y; Rommens J; Glogauer M. 2011. Sbds is required for Rac2-mediated monocyte migration and signaling downstream of RANK during osteoclastogenesis. Blood 117(6):2044-53. PubMed: 21084708 MGI: J:169579
Leung R; Wang Y; Cuddy K; Sun C; Magalhaes J; Grynpas M; Glogauer M. 2010. Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis. J Bone Miner Res 25(5):1077-91. PubMed: 19929439 MGI: J:183371
Leveque-El Mouttie L; Vu T; Lineburg KE; Kuns RD; Bagger FO; Teal BE; Lor M; Boyle GM; Bruedigam C; Mintern JD; Hill GR; MacDonald KP; Lane SW. 2015. Autophagy is required for stem cell mobilization by G-CSF. Blood 125(19):2933-6. PubMed: 25788702 MGI: J:222280
Lewis KL; Caton ML; Bogunovic M; Greter M; Grajkowska LT; Ng D; Klinakis A; Charo IF; Jung S; Gommerman JL; Ivanov II; Liu K; Merad M; Reizis B. 2011. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35(5):780-91. PubMed: 22018469 MGI: J:178710
Li B; Alli R; Vogel P; Geiger TL. 2014. IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis. Mucosal Immunol 7(4):869-78. PubMed: 24301657 MGI: J:234754
Li C; Zhang YY; Frieler RA; Zheng XJ; Zhang WC; Sun XN; Yang QZ; Ma SM; Huang B; Berger S; Wang W; Wu Y; Yu Y; Duan SZ; Mortensen RM. 2014. Myeloid mineralocorticoid receptor deficiency inhibits aortic constriction-induced cardiac hypertrophy in mice. PLoS One 9(10):e110950. PubMed: 25354087 MGI: J:223091
Li D; Beisswenger C; Herr C; Hellberg J; Han G; Zakharkina T; Voss M; Wiewrodt R; Bohle RM; Menger MD; Schmid RM; Stockel D; Lenhof HP; Bals R. 2014. Myeloid cell RelA/p65 promotes lung cancer proliferation through Wnt/beta-catenin signaling in murine and human tumor cells. Oncogene 33(10):1239-48. PubMed: 23563178 MGI: J:234001
Li D; Beisswenger C; Herr C; Schmid RM; Gallo RL; Han G; Zakharkina T; Bals R. 2014. Expression of the antimicrobial peptide cathelicidin in myeloid cells is required for lung tumor growth. Oncogene 33(21):2709-16. PubMed: 23812430 MGI: J:234000
Li F; Downing BD; Smiley LC; Mund JA; Distasi MR; Bessler WK; Sarchet KN; Hinds DM; Kamendulis LM; Hingtgen CM; Case J; Clapp DW; Conway SJ; Stansfield BK; Ingram DA Jr. 2014. Neurofibromin-deficient myeloid cells are critical mediators of aneurysm formation in vivo. Circulation 129(11):1213-24. PubMed: 24370551 MGI: J:219312
Li F; Ravetch JV. 2013. Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. Proc Natl Acad Sci U S A 110(48):19501-6. PubMed: 24218606 MGI: J:203058
Li F; Smith P; Ravetch JV. 2014. Inhibitory Fcgamma receptor is required for the maintenance of tolerance through distinct mechanisms. J Immunol 192(7):3021-8. PubMed: 24563255 MGI: J:209892
Li H; Sorenson AL; Poczobutt J; Amin J; Joyal T; Sullivan T; Crossno JT Jr; Weiser-Evans MC; Nemenoff RA. 2011. Activation of PPARgamma in myeloid cells promotes lung cancer progression and metastasis. PLoS One 6(12):e28133. PubMed: 22145026 MGI: J:182274
Li J; Liu Y; Wang B; Xu Y; Ma A; Zhang F; Ge C; Yang Z; Li J; Liu Y. 2013. Myeloid TGF-beta signaling contributes to colitis-associated tumorigenesis in mice. Carcinogenesis 34(9):2099-108. PubMed: 23695722 MGI: J:200523
Li P; Spann NJ; Kaikkonen MU; Lu M; Oh da Y; Fox JN; Bandyopadhyay G; Talukdar S; Xu J; Lagakos WS; Patsouris D; Armando A; Quehenberger O; Dennis EA; Watkins SM; Auwerx J; Glass CK; Olefsky JM. 2013. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell 155(1):200-14. PubMed: 24074869 MGI: J:205151
Li S; Miller CH; Giannopoulou E; Hu X; Ivashkiv LB; Zhao B. 2014. RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis. J Clin Invest 124(11):5057-73. PubMed: 25329696 MGI: J:217698
Li X; Zhang Z; Li L; Gong W; Lazenby AJ; Swanson BJ; Herring LE; Asara JM; Singer JD; Wen H. 2017. Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation. J Exp Med 214(4):1093-1109. PubMed: 28280036 MGI: J:241579
Li Y; Jia Y; Pichavant M; Loison F; Sarraj B; Kasorn A; You J; Robson BE; Umetsu DT; Mizgerd JP; Ye K; Luo HR. 2009. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood 113(20):4930-41. PubMed: 19286998 MGI: J:148947
Liao X; Sharma N; Kapadia F; Zhou G; Lu Y; Hong H; Paruchuri K; Mahabeleshwar GH; Dalmas E; Venteclef N; Flask CA; Kim J; Doreian BW; Lu KQ; Kaestner KH; Hamik A; Clement K; Jain MK. 2011. Kruppel-like factor 4 regulates macrophage polarization. J Clin Invest 121(7):2736-49. PubMed: 21670502 MGI: J:175644
Liao X; Sluimer JC; Wang Y; Subramanian M; Brown K; Pattison JS; Robbins J; Martinez J; Tabas I. 2012. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab 15(4):545-53. PubMed: 22445600 MGI: J:184210
Liehl P; Zuzarte-Luis V; Chan J; Zillinger T; Baptista F; Carapau D; Konert M; Hanson KK; Carret C; Lassnig C; Muller M; Kalinke U; Saeed M; Chora AF; Golenbock DT; Strobl B; Prudencio M; Coelho LP; Kappe SH; Superti-Furga G; Pichlmair A; Vigario AM; Rice CM; Fitzgerald KA; Barchet W; Mota MM. 2014. Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20(1):47-53. PubMed: 24362933 MGI: J:226672
Lillis AP; Greenlee MC; Mikhailenko I; Pizzo SV; Tenner AJ; Strickland DK; Bohlson SS. 2008. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 181(1):364-73. PubMed: 18566402 MGI: J:137404
Lillis AP; Muratoglu SC; Au DT; Migliorini M; Lee MJ; Fried SK; Mikhailenko I; Strickland DK. 2015. LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. PLoS One 10(6):e0128903. PubMed: 26061292 MGI: J:237703
Lin L; Jin Y; Hu K. 2015. Tissue-type Plasminogen Activator (tPA) Promotes M1 Macrophage Survival through p90 Ribosomal S6 Kinase (RSK) and p38 Mitogen-activated Protein Kinase (MAPK) Pathway. J Biol Chem 290(12):7910-7. PubMed: 25670857 MGI: J:220543
Lingrel JB; Pilcher-Roberts R; Basford JE; Manoharan P; Neumann J; Konaniah ES; Srinivasan R; Bogdanov VY; Hui DY. 2012. Myeloid-specific Kruppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circ Res 110(10):1294-302. PubMed: 22474254 MGI: J:212516
Linker RA; Lee DH; Demir S; Wiese S; Kruse N; Siglienti I; Gerhardt E; Neumann H; Sendtner M; Luhder F; Gold R. 2010. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain 133(Pt 8):2248-63. PubMed: 20826430 MGI: J:181017
Linker RA; Lee DH; Flach AC; Litke T; van den Brandt J; Reichardt HM; Lingner T; Bommhardt U; Sendtner M; Gold R; Flugel A; Luhder F. 2015. Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage. Eur J Immunol 45(5):1326-38. PubMed: 25627579 MGI: J:229274
Liu M; Sjogren AK; Karlsson C; Ibrahim MX; Andersson KM; Olofsson FJ; Wahlstrom AM; Dalin M; Yu H; Chen Z; Yang SH; Young SG; Bergo MO. 2010. Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. Proc Natl Acad Sci U S A 107(14):6471-6. PubMed: 20308544 MGI: J:158937
Liu X; Ma B; Malik AB; Tang H; Yang T; Sun B; Wang G; Minshall RD; Li Y; Zhao Y; Ye RD; Xu J. 2012. Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol 13(5):457-64. PubMed: 22447027 MGI: J:185374
Liu X; Yamashita T; Chen Q; Belevych N; Mckim DB; Tarr AJ; Coppola V; Nath N; Nemeth DP; Syed ZW; Sheridan JF; Godbout JP; Zuo J; Quan N. 2015. Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types. J Neurosci 35(7):2860-70. PubMed: 25698726 MGI: J:219864
Liu X; Zhang P; Bao Y; Han Y; Wang Y; Zhang Q; Zhan Z; Meng J; Li Y; Li N; Zhang WJ; Cao X. 2013. Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IkappaBalpha gene transcription. Proc Natl Acad Sci U S A 110(27):11097-102. PubMed: 23776228 MGI: J:219049
Liu Y; Holdbrooks AT; De Sarno P; Rowse AL; Yanagisawa LL; McFarland BC; Harrington LE; Raman C; Sabbaj S; Benveniste EN; Qin H. 2014. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol 192(1):59-72. PubMed: 24323580 MGI: J:207156
Liu Y; Liu X; Hao W; Decker Y; Schomburg R; Fulop L; Pasparakis M; Menger MD; Fassbender K. 2014. IKKbeta deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology. J Neurosci 34(39):12982-99. PubMed: 25253847 MGI: J:216611
Liu Y; Minze LJ; Mumma L; Li XC; Ghobrial RM; Kloc M. 2016. Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3. Exp Cell Res 341(2):225-36. PubMed: 26875770 MGI: J:229535
Liu Z; Dai X; Zhu H; Zhang M; Zou MH. 2015. Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo. J Biol Chem 290(31):19011-7. PubMed: 26070564 MGI: J:224605
Liu Z; Zhang W; Zhang M; Zhu H; Moriasi C; Zou MH. 2015. Liver Kinase B1 Suppresses Lipopolysaccharide-induced Nuclear Factor kappaB (NF-kappaB) Activation in Macrophages. J Biol Chem 290(4):2312-20. PubMed: 25451940 MGI: J:218380
Long L; Deng Y; Yao F; Guan D; Feng Y; Jiang H; Li X; Hu P; Lu X; Wang H; Li J; Gao X; Xie D. 2014. Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling. Immunity 40(4):515-29. PubMed: 24726876 MGI: J:209955
Lu C; Kumar PA; Fan Y; Sperling MA; Menon RK. 2010. A novel effect of growth hormone on macrophage modulates macrophage-dependent adipocyte differentiation. Endocrinology 151(5):2189-99. PubMed: 20185763 MGI: J:160007
Lu C; Kumar PA; Sun J; Aggarwal A; Fan Y; Sperling MA; Lumeng CN; Menon RK. 2013. Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity. J Biol Chem 288(22):15725-35. PubMed: 23595986 MGI: J:199614
Luan B; Goodarzi MO; Phillips NG; Guo X; Chen YD; Yao J; Allison M; Rotter JI; Shaw R; Montminy M. 2014. Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab 19(6):1058-65. PubMed: 24768298 MGI: J:215277
Luan B; Yoon YS; Le Lay J; Kaestner KH; Hedrick S; Montminy M. 2015. CREB pathway links PGE2 signaling with macrophage polarization. Proc Natl Acad Sci U S A 112(51):15642-7. PubMed: 26644581 MGI: J:228308
Lucas T; Waisman A; Ranjan R; Roes J; Krieg T; Muller W; Roers A; Eming SA. 2010. Differential roles of macrophages in diverse phases of skin repair. J Immunol 184(7):3964-77. PubMed: 20176743 MGI: J:160100
Luo B; Wang J; Liu Z; Shen Z; Shi R; Liu YQ; Liu Y; Jiang M; Wu Y; Zhang Z. 2016. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun 7:12177. PubMed: 27397585 MGI: J:240839
Lupfer C; Thomas PG; Anand PK; Vogel P; Milasta S; Martinez J; Huang G; Green M; Kundu M; Chi H; Xavier RJ; Green DR; Lamkanfi M; Dinarello CA; Doherty PC; Kanneganti TD. 2013. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 14(5):480-8. PubMed: 23525089 MGI: J:196443
Luyendyk JP; Flanagan KC; Williams CD; Jaeschke H; Slusser JG; Mackman N; Cantor GH. 2011. Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice. Toxicol Appl Pharmacol 250(3):256-62. PubMed: 21070799 MGI: J:168806
Luyendyk JP; Schabbauer GA; Tencati M; Holscher T; Pawlinski R; Mackman N. 2008. Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages. J Immunol 180(6):4218-26. PubMed: 18322234 MGI: J:132956
Ma CY; Shi GY; Shi CS; Kao YC; Lin SW; Wu HL. 2012. Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol 188(12):6328-37. PubMed: 22573811 MGI: J:188879
Mabrouk I; Buart S; Hasmim M; Michiels C; Connault E; Opolon P; Chiocchia G; Levi-Strauss M; Chouaib S; Karray S. 2008. Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells. Immunity 29(6):922-33. PubMed: 19013083 MGI: J:142793
Mackenzie KF; Clark K; Naqvi S; McGuire VA; Noehren G; Kristariyanto Y; van den Bosch M; Mudaliar M; McCarthy PC; Pattison MJ; Pedrioli PG; Barton GJ; Toth R; Prescott A; Arthur JS. 2013. PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway. J Immunol 190(2):565-77. PubMed: 23241891 MGI: J:191723
Maeda S; Kamata H; Luo JL; Leffert H; Karin M. 2005. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-90. PubMed: 15989949 MGI: J:115107
Maelfait J; Roose K; Bogaert P; Sze M; Saelens X; Pasparakis M; Carpentier I; van Loo G; Beyaert R. 2012. A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS Pathog 8(3):e1002570. PubMed: 22396652 MGI: J:195399
Magez S; Radwanska M; Drennan M; Fick L; Baral TN; Allie N; Jacobs M; Nedospasov S; Brombacher F; Ryffel B; De Baetselier P. 2007. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis 196(6):954-62. PubMed: 17703428 MGI: J:145248
Mahabeleshwar GH; Kawanami D; Sharma N; Takami Y; Zhou G; Shi H; Nayak L; Jeyaraj D; Grealy R; White M; McManus R; Ryan T; Leahy P; Lin Z; Haldar SM; Atkins GB; Wong HR; Lingrel JB; Jain MK. 2011. The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock. Immunity 34(5):715-28. PubMed: 21565532 MGI: J:172120
Majka SM; Fox KE; Psilas JC; Helm KM; Childs CR; Acosta AS; Janssen RC; Friedman JE; Woessner BT; Shade TR; Varella-Garcia M; Klemm DJ. 2010. De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific. Proc Natl Acad Sci U S A 107(33):14781-6. PubMed: 20679227 MGI: J:163704
Malur A; Mccoy AJ; Arce S; Barna BP; Kavuru MS; Malur AG; Thomassen MJ. 2009. Deletion of PPARgamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response. J Immunol 182(9):5816-22. PubMed: 19380830 MGI: J:147703
Mankan AK; Canli O; Schwitalla S; Ziegler P; Tschopp J; Korn T; Greten FR. 2011. TNF-{alpha}-dependent loss of IKK{beta}-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. Proc Natl Acad Sci U S A 108(16):6567-72. PubMed: 21464320 MGI: J:171365
Mantuano E; Brifault C; Lam MS; Azmoon P; Gilder AS; Gonias SL. 2016. LDL receptor-related protein-1 regulates NFkappaB and microRNA-155 in macrophages to control the inflammatory response. Proc Natl Acad Sci U S A 113(5):1369-74. PubMed: 26787872 MGI: J:229967
Martin-Millan M; Almeida M; Ambrogini E; Han L; Zhao H; Weinstein RS; Jilka RL; O'Brien CA; Manolagas SC. 2010. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol 24(2):323-34. PubMed: 20053716 MGI: J:156947
Martinez J; Almendinger J; Oberst A; Ness R; Dillon CP; Fitzgerald P; Hengartner MO; Green DR. 2011. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A 108(42):17396-401. PubMed: 21969579 MGI: J:177449
Martinez J; Cunha LD; Park S; Yang M; Lu Q; Orchard R; Li QZ; Yan M; Janke L; Guy C; Linkermann A; Virgin HW; Green DR. 2016. Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature 533(7601):115-9. PubMed: 27096368 MGI: J:235399
Mathsyaraja H; Thies K; Taffany DA; Deighan C; Liu T; Yu L; Fernandez SA; Shapiro C; Otero J; Timmers C; Lustberg MB; Chalmers J; Leone G; Ostrowski MC. 2015. CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. Oncogene 34(28):3651-61. PubMed: 25241894 MGI: J:222507
Matmati M; Jacques P; Maelfait J; Verheugen E; Kool M; Sze M; Geboes L; Louagie E; Guire CM; Vereecke L; Chu Y; Boon L; Staelens S; Matthys P; Lambrecht BN; Schmidt-Supprian M; Pasparakis M; Elewaut D; Beyaert R; van Loo G. 2011. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 43(9):908-12. PubMed: 21841782 MGI: J:176518
Matsukawa A; Kudo S; Maeda T; Numata K; Watanabe H; Takeda K; Akira S; Ito T. 2005. Stat3 in resident macrophages as a repressor protein of inflammatory response. J Immunol 175(5):3354-9. PubMed: 16116228 MGI: J:113215
Matsumura Y; Kobayashi T; Ichiyama K; Yoshida R; Hashimoto M; Takimoto T; Tanaka K; Chinen T; Shichita T; Wyss-Coray T; Sato K; Yoshimura A. 2007. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J Immunol 179(4):2170-9. PubMed: 17675476 MGI: J:151229
Mauer J; Chaurasia B; Goldau J; Vogt MC; Ruud J; Nguyen KD; Theurich S; Hausen AC; Schmitz J; Bronneke HS; Estevez E; Allen TL; Mesaros A; Partridge L; Febbraio MA; Chawla A; Wunderlich FT; Bruning JC. 2014. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol 15(5):423-30. PubMed: 24681566 MGI: J:209976
McFarland-Mancini MM; Funk HM; Paluch AM; Zhou M; Giridhar PV; Mercer CA; Kozma SC; Drew AF. 2010. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol 184(12):7219-28. PubMed: 20483735 MGI: J:160966
McGeough MD; Pena CA; Mueller JL; Pociask DA; Broderick L; Hoffman HM; Brydges SD. 2012. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol 189(6):2707-11. PubMed: 22904305 MGI: J:189914
McLoed AG; Sherrill TP; Cheng DS; Han W; Saxon JA; Gleaves LA; Wu P; Polosukhin VV; Karin M; Yull FE; Stathopoulos GT; Georgoulias V; Zaynagetdinov R; Blackwell TS. 2016. Neutrophil-Derived IL-1beta Impairs the Efficacy of NF-kappaB Inhibitors against Lung Cancer. Cell Rep 16(1):120-32. PubMed: 27320908 MGI: J:238375
McMahan RS; Riehle KJ; Fausto N; Campbell JS. 2013. A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol 305(1):G25-34. PubMed: 23639813 MGI: J:202784
Meguro K; Nakagomi D; Suzuki K; Hosokawa J; Fukuta T; Yokota M; Maezawa Y; Suto A; Nakajima H. 2016. SOCS3 Expressed in M2 Macrophages Attenuates Contact Hypersensitivity by Suppressing MMP-12 Production. J Invest Dermatol 136(3):649-57. PubMed: 27015453 MGI: J:231144
Meng X; Vander Ark A; Lee P; Hostetter G; Bhowmick NA; Matrisian LM; Williams BO; Miranti CK; Li X. 2016. Myeloid-specific TGF-beta signaling in bone promotes basic-FGF and breast cancer bone metastasis. Oncogene 35(18):2370-8. PubMed: 26279296 MGI: J:234208
Mesa KR; Rompolas P; Zito G; Myung P; Sun TY; Brown S; Gonzalez DG; Blagoev KB; Haberman AM; Greco V. 2015. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature 522(7554):94-7. PubMed: 25849774 MGI: J:226377
Miao H; Ou J; Ma Y; Guo F; Yang Z; Wiggins M; Liu C; Song W; Han X; Wang M; Cao Q; Chung BH; Yang D; Liang H; Xue B; Shi H; Gan L; Yu L. 2014. Macrophage CGI-58 deficiency activates ROS-inflammasome pathway to promote insulin resistance in mice. Cell Rep 7(1):223-35. PubMed: 24703845 MGI: J:211819
Milovanova TN; Bhopale VM; Sorokina EM; Moore JS; Hunt TK; Hauer-Jensen M; Velazquez OC; Thom SR. 2008. Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Mol Cell Biol 28(20):6248-61. PubMed: 18710947 MGI: J:140963
Minami SS; Min SW; Krabbe G; Wang C; Zhou Y; Asgarov R; Li Y; Martens LH; Elia LP; Ward ME; Mucke L; Farese RV Jr; Gan L. 2014. Progranulin protects against amyloid beta deposition and toxicity in Alzheimer's disease mouse models. Nat Med 20(10):1157-64. PubMed: 25261995 MGI: J:227827
Mirza RE; Fang MM; Novak ML; Urao N; Sui A; Ennis WJ; Koh TJ. 2015. Macrophage PPARgamma and impaired wound healing in type 2 diabetes. J Pathol 236(4):433-44. PubMed: 25875529 MGI: J:225544
Miwa T; Sato S; Gullipalli D; Nangaku M; Song WC. 2013. Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice. J Immunol 190(7):3552-9. PubMed: 23427256 MGI: J:194520
Mondal S; Ghosh-Roy S; Loison F; Li Y; Jia Y; Harris C; Williams DA; Luo HR. 2011. PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol 187(11):5783-94. PubMed: 22043008 MGI: J:179722
Mondal S; Subramanian KK; Sakai J; Bajrami B; Luo HR. 2012. Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion. Mol Biol Cell 23(7):1219-30. PubMed: 22323291 MGI: J:196999
Moon JS; Lee S; Park MA; Siempos II; Haslip M; Lee PJ; Yun M; Kim CK; Howrylak J; Ryter SW; Nakahira K; Choi AM. 2015. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest 125(2):665-80. PubMed: 25574840 MGI: J:220392
Moraes-Vieira PM; Yore MM; Dwyer PM; Syed I; Aryal P; Kahn BB. 2014. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab 19(3):512-26. PubMed: 24606904 MGI: J:210633
Morales C; Rachidi S; Hong F; Sun S; Ouyang X; Wallace C; Zhang Y; Garret-Mayer E; Wu J; Liu B; Li Z. 2014. Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res 74(2):446-59. PubMed: 24322981 MGI: J:207908
Moran-Salvador E; Lopez-Parra M; Garcia-Alonso V; Titos E; Martinez-Clemente M; Gonzalez-Periz A; Lopez-Vicario C; Barak Y; Arroyo V; Claria J. 2011. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J 25(8):2538-50. PubMed: 21507897 MGI: J:196866
Morgan EA; Schneider JG; Baroni TE; Uluckan O; Heller E; Hurchla MA; Deng H; Floyd D; Berdy A; Prior JL; Piwnica-Worms D; Teitelbaum SL; Ross FP; Weilbaecher KN. 2010. Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit. FASEB J 24(4):1117-27. PubMed: 19933310 MGI: J:224675
Mori J; Wang YJ; Ellison S; Heising S; Neel BG; Tremblay ML; Watson SP; Senis YA. 2012. Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B. Arterioscler Thromb Vasc Biol 32(12):2956-65. PubMed: 23065825 MGI: J:208313
Morrison AR; Yarovinsky TO; Young BD; Moraes F; Ross TD; Ceneri N; Zhang J; Zhuang ZW; Sinusas AJ; Pardi R; Schwartz MA; Simons M; Bender JR. 2014. Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med 211(10):1957-68. PubMed: 25180062 MGI: J:218700
Mortier E; Advincula R; Kim L; Chmura S; Barrera J; Reizis B; Malynn BA; Ma A. 2009. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity 31(5):811-22. PubMed: 19913445 MGI: J:155298
Mounier R; Theret M; Arnold L; Cuvellier S; Bultot L; Goransson O; Sanz N; Ferry A; Sakamoto K; Foretz M; Viollet B; Chazaud B. 2013. AMPKalpha1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metab 18(2):251-64. PubMed: 23931756 MGI: J:200988
Mukundan L; Odegaard JI; Morel CR; Heredia JE; Mwangi JW; Ricardo-Gonzalez RR; Goh YP; Eagle AR; Dunn SE; Awakuni JU; Nguyen KD; Steinman L; Michie SA; Chawla A. 2009. PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med 15(11):1266-72. PubMed: 19838202 MGI: J:154294
Muller TD; Lee SJ; Jastroch M; Kabra D; Stemmer K; Aichler M; Abplanalp B; Ananthakrishnan G; Bhardwaj N; Collins S; Divanovic S; Endele M; Finan B; Gao Y; Habegger KM; Hembree J; Heppner KM; Hofmann S; Holland J; Kuchler D; Kutschke M; Krishna R; Lehti M; Oelkrug R; Ottaway N; Perez-Tilve D; Raver C; Walch AK; Schriever SC; Speakman J; Tseng YH; Diaz-Meco M; Pfluger PT; Moscat J; Tschop MH. 2013. p62 links beta-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest 123(1):469-78. PubMed: 23257354 MGI: J:194291
Muller U; Stenzel W; Piehler D; Grahnert A; Protschka M; Kohler G; Frey O; Held J; Richter T; Eschke M; Kamradt T; Brombacher F; Alber G. 2013. Abrogation of IL-4 receptor-alpha-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response. Int Immunol 25(8):459-70. PubMed: 23532373 MGI: J:200178
Mullican SE; Gaddis CA; Alenghat T; Nair MG; Giacomin PR; Everett LJ; Feng D; Steger DJ; Schug J; Artis D; Lazar MA. 2011. Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes Dev 25(23):2480-8. PubMed: 22156208 MGI: J:178911
Muratoglu SC; Belgrave S; Lillis AP; Migliorini M; Robinson S; Smith E; Zhang L; Strickland DK. 2011. Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-beta signaling pathway. PLoS One 6(12):e28846. PubMed: 22174911 MGI: J:182253
Murthy A; Li Y; Peng I; Reichelt M; Katakam AK; Noubade R; Roose-Girma M; DeVoss J; Diehl L; Graham RR; van Lookeren Campagne M. 2014. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506(7489):456-62. PubMed: 24553140 MGI: J:206931
Murthy S; Adamcakova-Dodd A; Perry SS; Tephly LA; Keller RM; Metwali N; Meyerholz DK; Wang Y; Glogauer M; Thorne PS; Carter AB. 2009. Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 297(5):L846-55. PubMed: 19684199 MGI: J:154331
Murthy S; Ryan AJ; Carter AB. 2012. SP-1 regulation of MMP-9 expression requires Ser586 in the PEST domain. Biochem J 445(2):229-36. PubMed: 22519702 MGI: J:188079
Nakamura R; Sene A; Santeford A; Gdoura A; Kubota S; Zapata N; Apte RS. 2015. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat Commun 6:7847. PubMed: 26260587 MGI: J:224996
Narasimha AJ; Watanabe J; Ishikawa TO; Priceman SJ; Wu L; Herschman HR; Reddy ST. 2010. Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol 30(2):260-8. PubMed: 19926832 MGI: J:172108
Necela BM; Su W; Thompson EA. 2008. Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages. Immunology 125(3):344-58. PubMed: 18422969 MGI: J:144451
Ng HP; Zhou Y; Song K; Hodges CA; Drumm ML; Wang G. 2014. Neutrophil-mediated phagocytic host defense defect in myeloid Cftr-inactivated mice. PLoS One 9(9):e106813. PubMed: 25184794 MGI: J:223263
Ng RK; Kong CT; So CC; Lui WC; Chan YF; Leung KC; So KC; Tsang HM; Chan LC; Sham MH. 2014. Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model. J Pathol 232(1):65-74. PubMed: 24122813 MGI: J:205605
Nguyen KD; Fentress SJ; Qiu Y; Yun K; Cox JS; Chawla A. 2013. Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science 341(6153):1483-8. PubMed: 23970558 MGI: J:201058
Nguyen KD; Qiu Y; Cui X; Goh YP; Mwangi J; David T; Mukundan L; Brombacher F; Locksley RM; Chawla A. 2011. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480(7375):104-8. PubMed: 22101429 MGI: J:178294
Nieuwenhuizen N; Herbert DR; Lopata AL; Brombacher F. 2007. CD4+ T cell-specific deletion of IL-4 receptor alpha prevents ovalbumin-induced anaphylaxis by an IFN-gamma-dependent mechanism. J Immunol 179(5):2758-65. PubMed: 17709489 MGI: J:151835
Nieuwenhuizen NE; Kirstein F; Jayakumar J; Emedi B; Hurdayal R; Horsnell WG; Lopata AL; Brombacher F. 2012. Allergic airway disease is unaffected by the absence of IL-4Ralpha-dependent alternatively activated macrophages. J Allergy Clin Immunol 130(3):743-750.e8. PubMed: 22552110 MGI: J:190170
Nijboer CH; Heijnen CJ; Willemen HL; Groenendaal F; Dorn GW 2nd; van Bel F; Kavelaars A. 2010. Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice. Brain Behav Immun 24(3):420-6. PubMed: 19932746 MGI: J:222368
Nikolic T; Movita D; Lambers ME; Ribeiro de Almeida C; Biesta P; Kreefft K; de Bruijn MJ; Bergen I; Galjart N; Boonstra A; Hendriks R. 2014. The DNA-binding factor Ctcf critically controls gene expression in macrophages. Cell Mol Immunol 11(1):58-70. PubMed: 24013844 MGI: J:205535
Nishio M; Watanabe K; Sasaki J; Taya C; Takasuga S; Iizuka R; Balla T; Yamazaki M; Watanabe H; Itoh R; Kuroda S; Horie Y; Forster I; Mak TW; Yonekawa H; Penninger JM; Kanaho Y; Suzuki A; Sasaki T. 2007. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol 9(1):36-44. PubMed: 17173042 MGI: J:126426
Novitskiy SV; Pickup MW; Chytil A; Polosukhina D; Owens P; Moses HL. 2012. Deletion of TGF-beta signaling in myeloid cells enhances their anti-tumorigenic properties. J Leukoc Biol 92(3):641-51. PubMed: 22685318 MGI: J:188061
Nunez V; Alameda D; Rico D; Mota R; Gonzalo P; Cedenilla M; Fischer T; Bosca L; Glass CK; Arroyo AG; Ricote M. 2010. Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A 107(23):10626-31. PubMed: 20498053 MGI: J:161295
O'Donnell JA; Kennedy CL; Pellegrini M; Nowell CJ; Zhang JG; O'Reilly LA; Cengia L; Dias S; Masters SL; Hartland EL; Roberts AW; Gerlic M; Croker BA. 2015. Fas regulates neutrophil lifespan during viral and bacterial infection. J Leukoc Biol 97(2):321-6. PubMed: 25473101 MGI: J:220260
Odegaard JI; Ricardo-Gonzalez RR; Goforth MH; Morel CR; Subramanian V; Mukundan L; Eagle AR; Vats D; Brombacher F; Ferrante AW; Chawla A. 2007. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447(7148):1116-20. PubMed: 17515919 MGI: J:122754
Odegaard JI; Ricardo-Gonzalez RR; Red Eagle A; Vats D; Morel CR; Goforth MH; Subramanian V; Mukundan L; Ferrante AW; Chawla A. 2008. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab 7(6):496-507. PubMed: 18522831 MGI: J:137032
Ohshima J; Sasai M; Liu J; Yamashita K; Ma JS; Lee Y; Bando H; Howard JC; Ebisu S; Hayashi M; Takeda K; Standley DM; Frickel EM; Yamamoto M. 2015. RabGDIalpha is a negative regulator of interferon-gamma-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii. Proc Natl Acad Sci U S A 112(33):E4581-90. PubMed: 26240314 MGI: J:226569
Ohtani M; Nagai S; Kondo S; Mizuno S; Nakamura K; Tanabe M; Takeuchi T; Matsuda S; Koyasu S. 2008. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112(3):635-43. PubMed: 18492954 MGI: J:138434
Oikonomou N; Mouratis MA; Tzouvelekis A; Kaffe E; Valavanis C; Vilaras G; Karameris A; Prestwich GD; Bouros D; Aidinis V. 2012. Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol 47(5):566-74. PubMed: 22744859 MGI: J:202085
Ojeda-Fernandez L; Recio-Poveda L; Aristorena M; Lastres P; Blanco FJ; Sanz-Rodriguez F; Gallardo-Vara E; de Las Casas-Engel M; Corbi A; Arthur HM; Bernabeu C; Botella LM. 2016. Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response. PLoS Genet 12(3):e1005935. PubMed: 27010826 MGI: J:232492
Okabe Y; Medzhitov R. 2014. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell 157(4):832-44. PubMed: 24792964 MGI: J:214405
Okuma A; Hoshino K; Ohba T; Fukushi S; Aiba S; Akira S; Ono M; Kaisho T; Muta T. 2013. Enhanced Apoptosis by Disruption of the STAT3-IkappaB-zeta Signaling Pathway in Epithelial Cells Induces Sjogren's Syndrome-like Autoimmune Disease. Immunity 38(3):450-60. PubMed: 23453632 MGI: J:194832
Okuno Y; Nakamura-Ishizu A; Kishi K; Suda T; Kubota Y. 2011. Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. Blood 117(19):5264-72. PubMed: 21411758 MGI: J:173270
Okuno Y; Nakamura-Ishizu A; Otsu K; Suda T; Kubota Y. 2012. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat Med :. PubMed: 22797809 MGI: J:192791
Ori D; Kato H; Sanjo H; Tartey S; Mino T; Akira S; Takeuchi O. 2013. Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs. J Immunol 190(8):4037-45. PubMed: 23509369 MGI: J:195289
Otero K; Shinohara M; Zhao H; Cella M; Gilfillan S; Colucci A; Faccio R; Ross FP; Teitelbaum SL; Takayanagi H; Colonna M. 2012. TREM2 and beta-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis. J Immunol 188(6):2612-21. PubMed: 22312126 MGI: J:181863
Outtz HH; Wu JK; Wang X; Kitajewski J. 2010. Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages. J Immunol 185(7):4363-73. PubMed: 20739676 MGI: J:164219
Overton CD; Yancey PG; Major AS; Linton MF; Fazio S. 2007. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res 100(5):670-7. PubMed: 17303763 MGI: J:133698
Owen KA; Pixley FJ; Thomas KS; Vicente-Manzanares M; Ray BJ; Horwitz AF; Parsons JT; Beggs HE; Stanley ER; Bouton AH. 2007. Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol 179(6):1275-87. PubMed: 18070912 MGI: J:135535
Paglia DN; Yang X; Kalinowski J; Jastrzebski S; Drissi H; Lorenzo J. 2016. Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or Phagocytic Cells in Both Males and Females. Endocrinology 157(8):3058-69. PubMed: 27267711 MGI: J:239758
Panda S; Nilsson JA; Gekara NO. 2015. Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. Immunity 43(4):647-59. PubMed: 26474655 MGI: J:233920
Pang Y; Gara SK; Achyut BR; Li Z; Yan HH; Day CP; Weiss JM; Trinchieri G; Morris JC; Yang L. 2013. TGF-beta signaling in myeloid cells is required for tumor metastasis. Cancer Discov 3(8):936-51. PubMed: 23661553 MGI: J:203558
Panopoulos AD; Zhang L; Snow JW; Jones DM; Smith AM; El Kasmi KC; Liu F; Goldsmith MA; Link DC; Murray PJ; Watowich SS. 2006. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 108(12):3682-90. PubMed: 16888100 MGI: J:133477
Papanicolaou KN; Khairallah RJ; Ngoh GA; Chikando A; Luptak I; O'Shea KM; Riley DD; Lugus JJ; Colucci WS; Lederer WJ; Stanley WC; Walsh K. 2011. Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol 31(6):1309-28. PubMed: 21245373 MGI: J:170619
Park JM; Greten FR; Li ZW; Karin M. 2002. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297(5589):2048-51. PubMed: 12202685 MGI: J:80159
Park JM; Greten FR; Wong A; Westrick RJ; Arthur JS; Otsu K; Hoffmann A; Montminy M; Karin M. 2005. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity 23(3):319-29. PubMed: 16169504 MGI: J:113273
Park MH; Jin HK; Min WK; Lee WW; Lee JE; Akiyama H; Herzog H; Enikolopov GN; Schuchman EH; Bae JS. 2015. Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow. EMBO J 34(12):1648-60. PubMed: 25916827 MGI: J:222788
Park MH; Lee JK; Kim N; Min WK; Lee JE; Kim KT; Akiyama H; Herzog H; Schuchman EH; Jin HK; Bae JS. 2016. Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts. Stem Cells 34(8):2145-56. PubMed: 27090492 MGI: J:238106
Park SH; Park-Min KH; Chen J; Hu X; Ivashkiv LB. 2011. Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol 12(7):607-15. PubMed: 21602809 MGI: J:174318
Park SH; Sui Y; Gizard F; Xu J; Rios-Pilier J; Helsley RN; Han SS; Zhou C. 2012. Myeloid-specific IkappaB kinase beta deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 32(12):2869-76. PubMed: 23023371 MGI: J:207877
Park-Min KH; Serbina NV; Yang W; Ma X; Krystal G; Neel BG; Nutt SL; Hu X; Ivashkiv LB. 2007. FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity 26(1):67-78. PubMed: 17239631 MGI: J:118322
Parsa R; Lund H; Tosevski I; Zhang XM; Malipiero U; Beckervordersandforth J; Merkler D; Prinz M; Gyllenberg A; James T; Warnecke A; Hillert J; Alfredsson L; Kockum I; Olsson T; Fontana A; Suter T; Harris RA. 2016. TGFbeta regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells. Glia 64(11):1925-37. PubMed: 27479807 MGI: J:235622
Pawlinski R; Wang JG; Owens AP 3rd; Williams J; Antoniak S; Tencati M; Luther T; Rowley JW; Low EN; Weyrich AS; Mackman N. 2010. Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood 116(5):806-14. PubMed: 20410508 MGI: J:163510
Pei H; Linden J. 2016. Adenosine influences myeloid cells to inhibit aeroallergen sensitization. Am J Physiol Lung Cell Mol Physiol 310(10):L985-92. PubMed: 27016586 MGI: J:234860
Pelczar P; Zibat A; van Dop WA; Heijmans J; Bleckmann A; Gruber W; Nitzki F; Uhmann A; Guijarro MV; Hernando E; Dittmann K; Wienands J; Dressel R; Wojnowski L; Binder C; Taguchi T; Beissbarth T; Hogendoorn PC; Antonescu CR; Rubin BP; Schulz-Schaeffer W; Aberger F; van den Brink GR; Hahn H. 2013. Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfralpha but not kit. Gastroenterology 144(1):134-144.e6. PubMed: 23041331 MGI: J:221316
Pello OM; Chevre R; Laoui D; De Juan A; Lolo F; Andres-Manzano MJ; Serrano M; Van Ginderachter JA; Andres V. 2012. In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities. PLoS One 7(9):e45399. PubMed: 23028984 MGI: J:192001
Peng M; Falk MJ; Haase VH; King R; Polyak E; Selak M; Yudkoff M; Hancock WW; Meade R; Saiki R; Lunceford AL; Clarke CF; L Gasser D. 2008. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 4(4):e1000061. PubMed: 18437205 MGI: J:136670
Penzo M; Habiel DM; Ramadass M; Kew RR; Marcu KB. 2014. Cell migration to CXCL12 requires simultaneous IKKalpha and IKKbeta-dependent NF-kappaB signaling. Biochim Biophys Acta 1843(9):1796-804. PubMed: 24747690 MGI: J:217042
Penzo M; Molteni R; Suda T; Samaniego S; Raucci A; Habiel DM; Miller F; Jiang HP; Li J; Pardi R; Palumbo R; Olivotto E; Kew RR; Bianchi ME; Marcu KB. 2010. Inhibitor of NK-kappaB kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis. J Immunol 184(8):4497-509. PubMed: 20231695 MGI: J:159873
Perry RJ; Camporez JP; Kursawe R; Titchenell PM; Zhang D; Perry CJ; Jurczak MJ; Abudukadier A; Han MS; Zhang XM; Ruan HB; Yang X; Caprio S; Kaech SM; Sul HS; Birnbaum MJ; Davis RJ; Cline GW; Petersen KF; Shulman GI. 2015. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160(4):745-58. PubMed: 25662011 MGI: J:219885
Pestonjamasp KN; Forster C; Sun C; Gardiner EM; Bohl B; Weiner O; Bokoch GM; Glogauer M. 2006. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood 108(8):2814-20. PubMed: 16809619 MGI: J:139459
Peyssonnaux C; Cejudo-Martin P; Doedens A; Zinkernagel AS; Johnson RS; Nizet V. 2007. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol 178(12):7516-9. PubMed: 17548584 MGI: J:148597
Peyssonnaux C; Datta V; Cramer T; Doedens A; Theodorakis EA; Gallo RL; Hurtado-Ziola N; Nizet V; Johnson RS. 2005. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 115(7):1806-15. PubMed: 16007254 MGI: J:99628
Pfefferkorn C; Kallfass C; Lienenklaus S; Spanier J; Kalinke U; Rieder M; Conzelmann KK; Michiels T; Staeheli P. 2015. Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain. J Virol 90(4):2031-8. PubMed: 26656686 MGI: J:237657
Pilla DM; Hagar JA; Haldar AK; Mason AK; Degrandi D; Pfeffer K; Ernst RK; Yamamoto M; Miao EA; Coers J. 2014. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A 111(16):6046-51. PubMed: 24715728 MGI: J:208845
Pils MC; Pisano F; Fasnacht N; Heinrich JM; Groebe L; Schippers A; Rozell B; Jack RS; Muller W. 2010. Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol 40(2):443-8. PubMed: 19941312 MGI: J:157787
Pinto VI; Senini VW; Wang Y; Kazembe MP; McCulloch CA. 2014. Filamin A protects cells against force-induced apoptosis by stabilizing talin- and vinculin-containing cell adhesions. FASEB J 28(1):453-63. PubMed: 24097310 MGI: J:206618
Pittet LA; Quinton LJ; Yamamoto K; Robson BE; Ferrari JD; Algul H; Schmid RM; Mizgerd JP. 2011. Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia. Am J Respir Cell Mol Biol 45(3):573-81. PubMed: 21216972 MGI: J:190223
Poddar D; Basu A; Baldwin WM 3rd; Kondratov RV; Barik S; Mazumder B. 2013. An extraribosomal function of ribosomal protein l13a in macrophages resolves inflammation. J Immunol 190(7):3600-12. PubMed: 23460747 MGI: J:194920
Polykratis A; van Loo G; Xanthoulea S; Hellmich M; Pasparakis M. 2012. Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of Toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis. Circulation 126(14):1739-51. PubMed: 22935568 MGI: J:202191
Portillo JA; Okenka G; Reed E; Subauste A; Van Grol J; Gentil K; Komatsu M; Tanaka K; Landreth G; Levine B; Subauste CS. 2010. The CD40-autophagy pathway is needed for host protection despite IFN-Gamma-dependent immunity and CD40 induces autophagy via control of P21 levels. PLoS One 5(12):e14472. PubMed: 21217818 MGI: J:168250
Preusch MR; Rattazzi M; Albrecht C; Merle U; Tuckermann J; Schutz G; Blessing E; Zoppellaro G; Pauletto P; Krempien R; Rosenfeld ME; Katus HA; Bea F. 2008. Critical role of macrophages in glucocorticoid driven vascular calcification in a mouse-model of atherosclerosis. Arterioscler Thromb Vasc Biol 28(12):2158-64. PubMed: 18787189 MGI: J:159796
Prigge JR; Hoyt TR; Dobrinen E; Capecchi MR; Schmidt EE; Meissner N. 2015. Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice. J Immunol 195(11):5347-57. PubMed: 26519535 MGI: J:229084
Prinz M; Schmidt H; Mildner A; Knobeloch KP; Hanisch UK; Raasch J; Merkler D; Detje C; Gutcher I; Mages J; Lang R; Martin R; Gold R; Becher B; Bruck W; Kalinke U. 2008. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28(5):675-86. PubMed: 18424188 MGI: J:136301
Proekt I; Miller CN; Jeanne M; Fasano KJ; Moon JJ; Lowell CA; Gould DB; Anderson MS; DeFranco AL. 2016. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest 126(10):3758-3771. PubMed: 27571405 MGI: J:237288
Pruessmeyer J; Hess FM; Alert H; Groth E; Pasqualon T; Schwarz N; Nyamoya S; Kollert J; van der Vorst E; Donners M; Martin C; Uhlig S; Saftig P; Dreymueller D; Ludwig A. 2014. Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space. Blood 123(26):4077-88. PubMed: 24833351 MGI: J:213737
Puttur F; Francozo M; Solmaz G; Bueno C; Lindenberg M; Gohmert M; Swallow M; Tufa D; Jacobs R; Lienenklaus S; Kuhl AA; Borkner L; Cicin-Sain L; Holzmann B; Wagner H; Berod L; Sparwasser T. 2016. Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep 17(4):1113-1127. PubMed: 27760315 MGI: J:240754
Qi B; Cong Q; Li P; Ma G; Guo X; Yeh J; Xie M; Schneider MD; Liu H; Li B. 2014. Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice. Sci Rep 4:7158. PubMed: 25418008 MGI: J:233358
Qi X; Man SM; Malireddi RK; Karki R; Lupfer C; Gurung P; Neale G; Guy CS; Lamkanfi M; Kanneganti TD. 2016. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med 213(10):2081-97. PubMed: 27551156 MGI: J:237236
Qin H; Holdbrooks AT; Liu Y; Reynolds SL; Yanagisawa LL; Benveniste EN. 2012. SOCS3 deficiency promotes M1 macrophage polarization and inflammation. J Immunol 189(7):3439-48. PubMed: 22925925 MGI: J:190360
Qin H; Yeh WI; De Sarno P; Holdbrooks AT; Liu Y; Muldowney MT; Reynolds SL; Yanagisawa LL; Fox TH 3rd; Park K; Harrington LE; Raman C; Benveniste EN. 2012. Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A 109(13):5004-9. PubMed: 22411837 MGI: J:182215
Qiu LQ; Stumpo DJ; Blackshear PJ. 2012. Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype. J Immunol 188(10):5150-9. PubMed: 22491258 MGI: J:188677
Qiu Q; Zheng Z; Chang L; Zhao YS; Tan C; Dandekar A; Zhang Z; Lin Z; Gui M; Li X; Zhang T; Kong Q; Li H; Chen S; Chen A; Kaufman RJ; Yang WL; Lin HK; Zhang D; Perlman H; Thorp E; Zhang K; Fang D. 2013. Toll-like receptor-mediated IRE1alpha activation as a therapeutic target for inflammatory arthritis. EMBO J 32(18):2477-90. PubMed: 23942232 MGI: J:201886
Quinn SR; Mangan NE; Caffrey BE; Gantier MP; Williams BR; Hertzog PJ; McCoy CE; O'Neill LA. 2014. The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10. J Biol Chem 289(7):4316-25. PubMed: 24362029 MGI: J:213032
Rabacal W; Pabbisetty SK; Hoek KL; Cendron D; Guo Y; Maseda D; Sebzda E. 2016. Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival. Proc Natl Acad Sci U S A 113(19):5370-5. PubMed: 27114551 MGI: J:232194
Radigan KA; Morales-Nebreda L; Soberanes S; Nicholson T; Nigdelioglu R; Cho T; Chi M; Hamanaka RB; Misharin AV; Perlman H; Budinger GR; Mutlu GM. 2014. Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. PLoS One 9(9):e108138. PubMed: 25232724 MGI: J:220638
Raetz M; Hwang SH; Wilhelm CL; Kirkland D; Benson A; Sturge CR; Mirpuri J; Vaishnava S; Hou B; Defranco AL; Gilpin CJ; Hooper LV; Yarovinsky F. 2013. Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-gamma-dependent elimination of Paneth cells. Nat Immunol 14(2):136-42. PubMed: 23263554 MGI: J:192614
Ramo K; Sugamura K; Craige S; Keaney JF; Davis RJ. 2016. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife 5:. PubMed: 27504807 MGI: J:235606
Rastegarlari G; Pegon JN; Casari C; Odouard S; Navarrete AM; Saint-Lu N; van Vlijmen BJ; Legendre P; Christophe OD; Denis CV; Lenting PJ. 2012. Macrophage LRP1 contributes to the clearance of von Willebrand factor. Blood 119(9):2126-34. PubMed: 22234691 MGI: J:182558
Rauch A; Seitz S; Baschant U; Schilling AF; Illing A; Stride B; Kirilov M; Mandic V; Takacz A; Schmidt-Ullrich R; Ostermay S; Schinke T; Spanbroek R; Zaiss MM; Angel PE; Lerner UH; David JP; Reichardt HM; Amling M; Schutz G; Tuckermann JP. 2010. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab 11(6):517-31. PubMed: 20519123 MGI: J:160669
Ravishankar B; Liu H; Shinde R; Chaudhary K; Xiao W; Bradley J; Koritzinsky M; Madaio MP; McGaha TL. 2015. The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity. Proc Natl Acad Sci U S A 112(34):10774-9. PubMed: 26261340 MGI: J:226640
Ray BJ; Thomas K; Huang CS; Gutknecht MF; Botchwey EA; Bouton AH. 2012. Regulation of osteoclast structure and function by FAK family kinases. J Leukoc Biol 92(5):1021-8. PubMed: 22941736 MGI: J:190159
Razani B; Feng C; Coleman T; Emanuel R; Wen H; Hwang S; Ting JP; Virgin HW; Kastan MB; Semenkovich CF. 2012. Autophagy links inflammasomes to atherosclerotic progression. Cell Metab 15(4):534-44. PubMed: 22440612 MGI: J:184211
Rebholz B; Haase I; Eckelt B; Paxian S; Flaig MJ; Ghoreschi K; Nedospasov SA; Mailhammer R; Debey-Pascher S; Schultze JL; Weindl G; Forster I; Huss R; Stratis A; Ruzicka T; Rocken M; Pfeffer K; Schmid RM; Rupec RA. 2007. Crosstalk between Keratinocytes and Adaptive Immune Cells in an IkappaBalpha Protein-Mediated Inflammatory Disease of the Skin. Immunity 27(2):296-307. PubMed: 17692539 MGI: J:124343
Redecha P; Tilley R; Tencati M; Salmon JE; Kirchhofer D; Mackman N; Girardi G. 2007. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110(7):2423-31. PubMed: 17536017 MGI: J:147022
Reichardt SD; Weinhage T; Rotte A; Foller M; Oppermann M; Luhder F; Tuckermann JP; Lang F; van den Brandt J; Reichardt HM. 2014. Glucocorticoids induce gastroparesis in mice through depletion of l-arginine. Endocrinology 155(10):3899-908. PubMed: 25057793 MGI: J:218340
Reindl W; Weiss S; Lehr HA; Forster I. 2007. Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice. Immunology 120(1):19-27. PubMed: 17233738 MGI: J:122311
Ren X; Shah TA; Ustiyan V; Zhang Y; Shinn J; Chen G; Whitsett JA; Kalin TV; Kalinichenko VV. 2013. FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Mol Cell Biol 33(2):371-86. PubMed: 23149934 MGI: J:194103
Reutershan J; Cagnina RE; Chang D; Linden J; Ley K. 2007. Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury. J Immunol 179(2):1254-63. PubMed: 17617618 MGI: J:149341
Rhee I; Davidson D; Souza CM; Vacher J; Veillette A. 2013. Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12. Mol Cell Biol 33(12):2458-69. PubMed: 23589331 MGI: J:204493
Ribas V; Drew BG; Le JA; Soleymani T; Daraei P; Sitz D; Mohammad L; Henstridge DC; Febbraio MA; Hewitt SC; Korach KS; Bensinger SJ; Hevener AL. 2011. Myeloid-specific estrogen receptor {alpha} deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A 108(39):16457-62. PubMed: 21900603 MGI: J:176674
Rickard AJ; Morgan J; Tesch G; Funder JW; Fuller PJ; Young MJ. 2009. Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure. Hypertension 54(3):537-43. PubMed: 19635989 MGI: J:164949
Ritprajak P; Hayakawa M; Sano Y; Otsu K; Park JM. 2012. Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. Proc Natl Acad Sci U S A 109(23):9089-94. PubMed: 22615377 MGI: J:184745
Ritter MR; Banin E; Moreno SK; Aguilar E; Dorrell MI; Friedlander M. 2006. Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. J Clin Invest 116(12):3266-76. PubMed: 17111048 MGI: J:117348
Rodriguez-Prados JC; Traves PG; Cuenca J; Rico D; Aragones J; Martin-Sanz P; Cascante M; Bosca L. 2010. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol 185(1):605-14. PubMed: 20498354 MGI: J:161403
Romain M; Taleb S; Dalloz M; Ponnuswamy P; Esposito B; Perez N; Wang Y; Yoshimura A; Tedgui A; Mallat Z. 2013. Overexpression of SOCS3 in T lymphocytes leads to impaired interleukin-17 production and severe aortic aneurysm formation in mice--brief report. Arterioscler Thromb Vasc Biol 33(3):581-4. PubMed: 23329138 MGI: J:216885
Ros-Bernal F; Hunot S; Herrero MT; Parnadeau S; Corvol JC; Lu L; Alvarez-Fischer D; Carrillo-de Sauvage MA; Saurini F; Coussieu C; Kinugawa K; Prigent A; Hoglinger G; Hamon M; Tronche F; Hirsch EC; Vyas S. 2011. Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism. Proc Natl Acad Sci U S A 108(16):6632-7. PubMed: 21467220 MGI: J:171363
Rosas M; Davies LC; Giles PJ; Liao CT; Kharfan B; Stone TC; O'Donnell VB; Fraser DJ; Jones SA; Taylor PR. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184):645-8. PubMed: 24762537 MGI: J:211301
Rosborough BR; Mathews LR; Matta BM; Liu Q; Raich-Regue D; Thomson AW; Turnquist HR. 2014. Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol 192(8):3470-3. PubMed: 24639346 MGI: J:210006
Roszer T; Menendez-Gutierrez MP; Lefterova MI; Alameda D; Nunez V; Lazar MA; Fischer T; Ricote M. 2011. Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency. J Immunol 186(1):621-31. PubMed: 21135166 MGI: J:168799
Roulis M; Nikolaou C; Kotsaki E; Kaffe E; Karagianni N; Koliaraki V; Salpea K; Ragoussis J; Aidinis V; Martini E; Becker C; Herschman HR; Vetrano S; Danese S; Kollias G. 2014. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A 111(43):E4658-67. PubMed: 25316791 MGI: J:216678
Roupe KM; Veerla S; Olson J; Stone EL; Sorensen OE; Hedrick SM; Nizet V. 2014. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One 9(2):e89274. PubMed: 24586650 MGI: J:213755
Rupec RA; Jundt F; Rebholz B; Eckelt B; Weindl G; Herzinger T; Flaig MJ; Moosmann S; Plewig G; Dorken B; Forster I; Huss R; Pfeffer K. 2005. Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity 22(4):479-91. PubMed: 15845452 MGI: J:97945
Ruud J; Wilhelms DB; Nilsson A; Eskilsson A; Tang YJ; Strohle P; Caesar R; Schwaninger M; Wunderlich T; Backhed F; Engblom D; Blomqvist A. 2013. Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. FASEB J 27(5):1973-80. PubMed: 23395911 MGI: J:197842
Ryan J; Ma FY; Han Y; Ozols E; Kanellis J; Tesch GH; Nikolic-Paterson DJ. 2015. Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase. J Pathol :. PubMed: 26251216 MGI: J:227729
Sabio G; Das M; Mora A; Zhang Z; Jun JY; Ko HJ; Barrett T; Kim JK; Davis RJ. 2008. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322(5907):1539-43. PubMed: 19056984 MGI: J:142035
Sachithanandan N; Graham KL; Galic S; Honeyman JE; Fynch SL; Hewitt KA; Steinberg GR; Kay TW. 2011. Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. Diabetes 60(8):2023-31. PubMed: 21646388 MGI: J:186745
Sag D; Cekic C; Wu R; Linden J; Hedrick CC. 2015. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun 6:6354. PubMed: 25724068 MGI: J:221785
Saito K; Horiuchi K; Kimura T; Mizuno S; Yoda M; Morioka H; Akiyama H; Threadgill D; Okada Y; Toyama Y; Sato K. 2013. Conditional inactivation of TNFalpha-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones. PLoS One 8(1):e54853. PubMed: 23349978 MGI: J:195804
Samaniego S; Marcu KB. 2013. IKKbeta in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection. PLoS One 8(1):e54124. PubMed: 23349802 MGI: J:195845
Sanchez M; Galy B; Schwanhaeusser B; Blake J; Bahr-Ivacevic T; Benes V; Selbach M; Muckenthaler MU; Hentze MW. 2011. Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins. Blood 118(22):e168-79. PubMed: 21940823 MGI: J:178884
Sankaran VG; Orkin SH; Walkley CR. 2008. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev 22(4):463-75. PubMed: 18258751 MGI: J:210155
Sarraj B; Massberg S; Li Y; Kasorn A; Subramanian K; Loison F; Silberstein LE; von Andrian U; Luo HR. 2009. Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol 182(11):7190-200. PubMed: 19454716 MGI: J:148853
Sarvestani ST; Stunden HJ; Behlke MA; Forster SC; McCoy CE; Tate MD; Ferrand J; Lennox KA; Latz E; Williams BR; Gantier MP. 2015. Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors. Nucleic Acids Res 43(2):1177-88. PubMed: 25539920 MGI: J:223239
Sasaki M; Knobbe CB; Munger JC; Lind EF; Brenner D; Brustle A; Harris IS; Holmes R; Wakeham A; Haight J; You-Ten A; Li WY; Schalm S; Su SM; Virtanen C; Reifenberger G; Ohashi PS; Barber DL; Figueroa ME; Melnick A; Zuniga-Pflucker JC; Mak TW. 2012. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 488(7413):656-9. PubMed: 22763442 MGI: J:186700
Schabbauer G; Luyendyk J; Crozat K; Jiang Z; Mackman N; Bahram S; Georgel P. 2008. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol Immunol 45(10):2790-6. PubMed: 18339426 MGI: J:134467
Schabbauer G; Matt U; Gunzl P; Warszawska J; Furtner T; Hainzl E; Elbau I; Mesteri I; Doninger B; Binder BR; Knapp S. 2010. Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia. J Immunol 185(1):468-76. PubMed: 20505137 MGI: J:161449
Schaljo B; Kratochvill F; Gratz N; Sadzak I; Sauer I; Hammer M; Vogl C; Strobl B; Muller M; Blackshear PJ; Poli V; Lang R; Murray PJ; Kovarik P. 2009. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183(2):1197-206. PubMed: 19542371 MGI: J:151504
Schallner N; Pandit R; LeBlanc R 3rd; Thomas AJ; Ogilvy CS; Zuckerbraun BS; Gallo D; Otterbein LE; Hanafy KA. 2015. Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J Clin Invest 125(7):2609-25. PubMed: 26011640 MGI: J:224477
Scheerer N; Dehne N; Stockmann C; Swoboda S; Baba HA; Neugebauer A; Johnson RS; Fandrey J. 2013. Myeloid hypoxia-inducible factor-1alpha is essential for skeletal muscle regeneration in mice. J Immunol 191(1):407-14. PubMed: 23729446 MGI: J:205360
Scheller EL; Song J; Dishowitz MI; Hankenson KD; Krebsbach PH. 2012. A potential role for the myeloid lineage in leptin-regulated bone metabolism. Horm Metab Res 44(1):1-5. PubMed: 22205566 MGI: J:231425
Schneider JG; Yang Z; Chakravarthy MV; Lodhi IJ; Wei X; Turk J; Semenkovich CF. 2010. Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosis. J Biol Chem 285(30):23398-409. PubMed: 20479009 MGI: J:165838
Schramm M; Wiegmann K; Schramm S; Gluschko A; Herb M; Utermohlen O; Kronke M. 2014. Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes. Eur J Immunol 44(3):728-41. PubMed: 24272050 MGI: J:209081
Schreiber HA; Loschko J; Karssemeijer RA; Escolano A; Meredith MM; Mucida D; Guermonprez P; Nussenzweig MC. 2013. Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J Exp Med 210(10):2025-39. PubMed: 24043764 MGI: J:202370
Schug TT; Xu Q; Gao H; Peres-da-Silva A; Draper DW; Fessler MB; Purushotham A; Li X. 2010. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol 30(19):4712-21. PubMed: 20647536 MGI: J:164917
Schwab L; Goroncy L; Palaniyandi S; Gautam S; Triantafyllopoulou A; Mocsai A; Reichardt W; Karlsson FJ; Radhakrishnan SV; Hanke K; Schmitt-Graeff A; Freudenberg M; von Loewenich FD; Wolf P; Leonhardt F; Baxan N; Pfeifer D; Schmah O; Schonle A; Martin SF;Mertelsmann R; Duyster J; Finke J; Prinz M; Henneke P; Hacker H; Hildebrandt GC; Hacker G; Zeiser R. 2014. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med 20(6):648-54. PubMed: 24836575 MGI: J:213225
Schwandt T; Schumak B; Gielen GH; Jungerkes F; Schmidbauer P; Klocke K; Staratschek-Jox A; van Rooijen N; Kraal G; Ludwig-Portugall I; Franken L; Wehner S; Kalff JC; Weber O; Kirschning C; Coch C; Kalinke U; Wenzel J; Kurts C; Zawatzky R; Holzmann B; Layland L; Schultze JL; Burgdorf S; den Haan JM; Knolle PA; Limmer A. 2012. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J 31(1):201-13. PubMed: 22036947 MGI: J:180238
Schwarz T; Remer KA; Nahrendorf W; Masic A; Siewe L; Muller W; Roers A; Moll H. 2013. T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine. PLoS Pathog 9(6):e1003476. PubMed: 23825956 MGI: J:213376
Schweingruber N; Haine A; Tiede K; Karabinskaya A; van den Brandt J; Wust S; Metselaar JM; Gold R; Tuckermann JP; Reichardt HM; Luhder F. 2011. Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis. J Immunol 187(8):4310-8. PubMed: 21918186 MGI: J:179309
Schwitalla S; Ziegler PK; Horst D; Becker V; Kerle I; Begus-Nahrmann Y; Lechel A; Rudolph KL; Langer R; Slotta-Huspenina J; Bader FG; Prazeres da Costa O; Neurath MF; Meining A; Kirchner T; Greten FR. 2013. Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell 23(1):93-106. PubMed: 23273920 MGI: J:194357
Scott C; Bonner J; Min D; Boughton P; Stokes R; Cha KM; Walters SN; Maslowski K; Sierro F; Grey ST; Twigg S; McLennan S; Gunton JE. 2014. Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing. Am J Physiol Cell Physiol 307(4):C349-57. PubMed: 24990649 MGI: J:221831
Seillet C; Laffont S; Tremollieres F; Rouquie N; Ribot C; Arnal JF; Douin-Echinard V; Gourdy P; Guery JC. 2012. The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha signaling. Blood 119(2):454-64. PubMed: 22096248 MGI: J:181798
Seimon TA; Obstfeld A; Moore KJ; Golenbock DT; Tabas I. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103(52):19794-9. PubMed: 17167049 MGI: J:118240
Seimon TA; Wang Y; Han S; Senokuchi T; Schrijvers DM; Kuriakose G; Tall AR; Tabas IA. 2009. Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. J Clin Invest 119(4):886-98. PubMed: 19287091 MGI: J:149625
Sekine H; Mimura J; Oshima M; Okawa H; Kanno J; Igarashi K; Gonzalez FJ; Ikuta T; Kawajiri K; Fujii-Kuriyama Y. 2009. Hypersensitivity of aryl hydrocarbon receptor-deficient mice to lipopolysaccharide-induced septic shock. Mol Cell Biol 29(24):6391-400. PubMed: 19822660 MGI: J:155121
Selleck EM; Fentress SJ; Beatty WL; Degrandi D; Pfeffer K; Virgin HW 4th; Macmicking JD; Sibley LD. 2013. Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. PLoS Pathog 9(4):e1003320. PubMed: 23633952 MGI: J:197024
Semba H; Takeda N; Isagawa T; Sugiura Y; Honda K; Wake M; Miyazawa H; Yamaguchi Y; Miura M; Jenkins DM; Choi H; Kim JW; Asagiri M; Cowburn AS; Abe H; Soma K; Koyama K; Katoh M; Sayama K; Goda N; Johnson RS; Manabe I; Nagai R; Komuro I. 2016. HIF-1alpha-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun 7:11635. PubMed: 27189088 MGI: J:239927
Sene A; Khan AA; Cox D; Nakamura RE; Santeford A; Kim BM; Sidhu R; Onken MD; Harbour JW; Hagbi-Levi S; Chowers I; Edwards PA; Baldan A; Parks JS; Ory DS; Apte RS. 2013. Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metab 17(4):549-61. PubMed: 23562078 MGI: J:198972
Serafini N; Dahdah A; Barbet G; Demion M; Attout T; Gautier G; Arcos-Fajardo M; Souchet H; Jouvin MH; Vrtovsnik F; Kinet JP; Benhamou M; Monteiro RC; Launay P. 2012. The TRPM4 channel controls monocyte and macrophage, but not neutrophil, function for survival in sepsis. J Immunol 189(7):3689-99. PubMed: 22933633 MGI: J:190346
Severa M; Islam SA; Waggoner SN; Jiang Z; Kim ND; Ryan G; Kurt-Jones E; Charo I; Caffrey DR; Boyartchuk VL; Luster AD; Fitzgerald KA. 2014. The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J Immunol 192(5):2291-304. PubMed: 24477914 MGI: J:209816
Sha H; Sun S; Francisco AB; Ehrhardt N; Xue Z; Liu L; Lawrence P; Mattijssen F; Guber RD; Panhwar MS; Brenna JT; Shi H; Xue B; Kersten S; Bensadoun A; Peterfy M; Long Q; Qi L. 2014. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab 20(3):458-70. PubMed: 25066055 MGI: J:215786
Shah YM; Morimura K; Gonzalez FJ. 2007. Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. Am J Physiol Gastrointest Liver Physiol 292(2):G657-66. PubMed: 17095756 MGI: J:120606
Shaked I; Hanna RN; Shaked H; Chodaczek G; Nowyhed HN; Tweet G; Tacke R; Basat AB; Mikulski Z; Togher S; Miller J; Blatchley A; Salek-Ardakani S; Darvas M; Kaikkonen MU; Thomas GD; Lai-Wing-Sun S; Rezk A; Bar-Or A; Glass CK; Bandukwala H; Hedrick CC. 2015. Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation. Nat Immunol 16(12):1228-34. PubMed: 26523867 MGI: J:234442
Shankman LS; Gomez D; Cherepanova OA; Salmon M; Alencar GF; Haskins RM; Swiatlowska P; Newman AA; Greene ES; Straub AC; Isakson B; Randolph GJ; Owens GK. 2015. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med 21(6):628-37. PubMed: 25985364 MGI: J:228450
Sharp PE; Martin-Ramirez J; Boross P; Mangsbo SM; Reynolds J; Moss J; Pusey CD; Cook HT; Tarzi RM; Verbeek JS. 2012. Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone. Mol Immunol 50(1-2):49-56. PubMed: 22244885 MGI: J:181363
Shearn AI; Deswaerte V; Gautier EL; Saint-Charles F; Pirault J; Bouchareychas L; Rucker EB 3rd; Beliard S; Chapman J; Jessup W; Huby T; Lesnik P. 2012. Bcl-x inactivation in macrophages accelerates progression of advanced atherosclerotic lesions in Apoe(-/-) mice. Arterioscler Thromb Vasc Biol 32(5):1142-9. PubMed: 22383704 MGI: J:196929
Shen JZ; Morgan J; Tesch GH; Rickard AJ; Chrissobolis S; Drummond GR; Fuller PJ; Young MJ. 2016. Cardiac Tissue Injury and Remodeling Is Dependent Upon MR Regulation of Activation Pathways in Cardiac Tissue Macrophages. Endocrinology 157(8):3213-23. PubMed: 27253999 MGI: J:239763
Shen ZX; Chen XQ; Sun XN; Sun JY; Zhang WC; Zheng XJ; Zhang YY; Shi HJ; Zhang JW; Li C; Wang J; Liu X; Duan SZ. 2017. Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Atherosclerosis by Affecting Foam Cell Formation and Efferocytosis. J Biol Chem 292(3):925-935. PubMed: 27881672 MGI: J:239241
Shi C; Jia T; Mendez-Ferrer S; Hohl TM; Serbina NV; Lipuma L; Leiner I; Li MO; Frenette PS; Pamer EG. 2011. Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity 34(4):590-601. PubMed: 21458307 MGI: J:171379
Shim EJ; Bang BR; Kang SG; Ma J; Otsuka M; Kang J; Stahl M; Han J; Xiao C; Vallance BA; Kang YJ. 2013. Activation of p38alpha in T cells regulates the intestinal host defense against attaching and effacing bacterial infections. J Immunol 191(5):2764-70. PubMed: 23918973 MGI: J:205803
Shin JN; Fattah EA; Bhattacharya A; Ko S; Eissa NT. 2013. Inflammasome activation by altered proteostasis. J Biol Chem 288(50):35886-95. PubMed: 24178293 MGI: J:207202
Shook B; Xiao E; Kumamoto Y; Iwasaki A; Horsley V. 2016. CD301b+ Macrophages Are Essential for Effective Skin Wound Healing. J Invest Dermatol 136(9):1885-91. PubMed: 27287183 MGI: J:235071
Sichien D; Scott CL; Martens L; Vanderkerken M; Van Gassen S; Plantinga M; Joeris T; De Prijck S; Vanhoutte L; Vanheerswynghels M; Van Isterdael G; Toussaint W; Madeira FB; Vergote K; Agace WW; Clausen BE; Hammad H; Dalod M; Saeys Y; Lambrecht BN; Guilliams M. 2016. IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively. Immunity 45(3):626-40. PubMed: 27637148 MGI: J:240512
Siewe L; Bollati-Fogolin M; Wickenhauser C; Krieg T; Muller W; Roers A. 2006. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol 36(12):3248-55. PubMed: 17111348 MGI: J:117122
Sima C; Gastfreund S; Sun C; Glogauer M. 2014. Rac-null leukocytes are associated with increased inflammation-mediated alveolar bone loss. Am J Pathol 184(2):472-82. PubMed: 24269593 MGI: J:205191
Sinclair GB; Jevon G; Colobong KE; Randall DR; Choy FY; Clarke LA. 2007. Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab 90(2):148-56. PubMed: 17079175 MGI: J:117763
Sinha P; Chi HH; Kim HR; Clausen BE; Pederson B; Sercarz EE; Forster I; Moudgil KD. 2004. Mouse lysozyme-M knockout mice reveal how the self-determinant hierarchy shapes the T cell repertoire against this circulating self antigen in wild-type mice. J Immunol 173(3):1763-71. PubMed: 15265906 MGI: J:92024
Sissons JR; Peschon JJ; Schmitz F; Suen R; Gilchrist M; Aderem A. 2012. Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells. J Immunol 189(1):23-7. PubMed: 22661094 MGI: J:188935
Sjogren AK; Andersson KM; Liu M; Cutts BA; Karlsson C; Wahlstrom AM; Dalin M; Weinbaum C; Casey PJ; Tarkowski A; Swolin B; Young SG; Bergo MO. 2007. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest 117(5):1294-304. PubMed: 17476360 MGI: J:122107
Smith MP; Sanchez-Laorden B; O'Brien K; Brunton H; Ferguson J; Young H; Dhomen N; Flaherty KT; Frederick DT; Cooper ZA; Wargo JA; Marais R; Wellbrock C. 2014. The immune microenvironment confers resistance to MAPK pathway inhibitors through macrophage-derived TNFalpha. Cancer Discov 4(10):1214-29. PubMed: 25256614 MGI: J:217894
Smoak KA; Aloor JJ; Madenspacher J; Merrick BA; Collins JB; Zhu X; Cavigiolio G; Oda MN; Parks JS; Fessler MB. 2010. Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Cell Metab 11(6):493-502. PubMed: 20519121 MGI: J:160911
Solanki S; Dube PR; Tano JY; Birnbaumer L; Vazquez G. 2014. Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages. Am J Physiol Cell Physiol 307(6):C521-31. PubMed: 25031020 MGI: J:221823
Solodova E; Jablonska J; Weiss S; Lienenklaus S. 2011. Production of IFN-beta during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage. PLoS One 6(4):e18543. PubMed: 21494554 MGI: J:172226
Sommer J; Engelowski E; Baran P; Garbers C; Floss DM; Scheller J. 2014. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. Int J Mol Med 34(3):651-60. PubMed: 24993179 MGI: J:232158
Son BK; Sawaki D; Tomida S; Fujita D; Aizawa K; Aoki H; Akishita M; Manabe I; Komuro I; Friedman SL; Nagai R; Suzuki T. 2015. Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma. Nat Commun 6:6994. PubMed: 25923510 MGI: J:222781
Sorrells SF; Caso JR; Munhoz CD; Hu CK; Tran KV; Miguel ZD; Chien BY; Sapolsky RM. 2013. Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation. J Neurosci 33(18):7877-89. PubMed: 23637179 MGI: J:197150
Spehlmann ME; Manthey CF; Dann SM; Hanson E; Sandhu SS; Liu LY; Abdelmalak FK; Diamanti MA; Retzlaff K; Scheller J; Rose-John S; Greten FR; Wang JY; Eckmann L. 2013. Trp53 deficiency protects against acute intestinal inflammation. J Immunol 191(2):837-47. PubMed: 23772033 MGI: J:204954
Stadtfeld M; Graf T. 2005. Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development 132(1):203-13. PubMed: 15576407 MGI: J:127936
Stadtfeld M; Ye M; Graf T. 2007. Identification of interventricular septum precursor cells in the mouse embryo. Dev Biol 302(1):195-207. PubMed: 17064678 MGI: J:119953
Stansfield BK; Bessler WK; Mali R; Mund JA; Downing B; Li F; Sarchet KN; Distasi MR; Conway SJ; Kapur R; Ingram DA Jr. 2013. Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway. Hum Mol Genet 22(5):977-88. PubMed: 23197650 MGI: J:192569
Staudt ND; Jo M; Hu J; Bristow JM; Pizzo DP; Gaultier A; Vandenberg SR; Gonias SL. 2013. Myeloid Cell Receptor LRP1/CD91 Regulates Monocyte Recruitment and Angiogenesis in Tumors. Cancer Res 73(13):3902-12. PubMed: 23633492 MGI: J:199015
Steimer DA; Boyd K; Takeuchi O; Fisher JK; Zambetti GP; Opferman JT. 2009. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113(12):2805-15. PubMed: 19064728 MGI: J:146310
Steinckwich N; Myers P; Janardhan KS; Flagler ND; King D; Petranka JG; Putney JW. 2015. Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin. FASEB J 29(7):3003-13. PubMed: 25837581 MGI: J:225467
Stemig M; Astelford K; Emery A; Cho JJ; Allen B; Huang TH; Gopalakrishnan R; Mansky KC; Jensen ED. 2015. Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF. PLoS One 10(4):e0123843. PubMed: 25875108 MGI: J:233501
Stockmann C; Doedens A; Weidemann A; Zhang N; Takeda N; Greenberg JI; Cheresh DA; Johnson RS. 2008. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456(7223):814-8. PubMed: 18997773 MGI: J:143170
Stockmann C; Kerdiles Y; Nomaksteinsky M; Weidemann A; Takeda N; Doedens A; Torres-Collado AX; Iruela-Arispe L; Nizet V; Johnson RS. 2010. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci U S A 107(9):4329-34. PubMed: 20142499 MGI: J:158615
Stoermer KA; Burrack A; Oko L; Montgomery SA; Borst LB; Gill RG; Morrison TE. 2012. Genetic ablation of arginase 1 in macrophages and neutrophils enhances clearance of an arthritogenic alphavirus. J Immunol 189(8):4047-59. PubMed: 22972923 MGI: J:190519
Su X; Esser AK; Amend SR; Xiang J; Xu Y; Ross MH; Fox GC; Kobayashi T; Steri V; Roomp K; Fontana F; Hurchla MA; Knolhoff BL; Meyer MA; Morgan EA; Tomasson JC; Novack JS; Zou W; Faccio R; Novack DV; Robinson SD; Teitelbaum SL; DeNardo DG; Schneider JG; Weilbaecher KN. 2016. Antagonizing Integrin beta3 Increases Immunosuppression in Cancer. Cancer Res 76(12):3484-95. PubMed: 27216180 MGI: J:232703
Subramaniam S; Jurk K; Hobohm L; Jackel S; Saffarzadeh M; Schwierczek K; Wenzel P; Langer F; Reinhardt C; Ruf W. 2017. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood 129(16):2291-2302. PubMed: 28223279 MGI: J:241525
Subramanian KK; Jia Y; Zhu D; Simms BT; Jo H; Hattori H; You J; Mizgerd JP; Luo HR. 2007. Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood 109(9):4028-37. PubMed: 17202315 MGI: J:145331
Sugiyama Y; Kakoi K; Kimura A; Takada I; Kashiwagi I; Wakabayashi Y; Morita R; Nomura M; Yoshimura A. 2012. Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways. Int Immunol 24(4):253-65. PubMed: 22331441 MGI: J:182746
Sun C; Forster C; Nakamura F; Glogauer M. 2013. Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis. PLoS One 8(10):e79009. PubMed: 24205360 MGI: J:209222
Sun CX; Downey GP; Zhu F; Koh AL; Thang H; Glogauer M. 2004. Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood 104(12):3758-65. PubMed: 15308574 MGI: J:94828
Suzuki T; Kelly VP; Motohashi H; Nakajima O; Takahashi S; Nishimura S; Yamamoto M. 2008. Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2. J Biol Chem 283(4):2021-30. PubMed: 18039655 MGI: J:130723
Swain L; Wottawa M; Hillemann A; Beneke A; Odagiri H; Terada K; Endo M; Oike Y; Farhat K; Katschinski DM. 2014. Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions. J Leukoc Biol 96(3):365-75. PubMed: 24626957 MGI: J:218623
Swarnkar G; Karuppaiah K; Mbalaviele G; Chen TH; Abu-Amer Y. 2015. Osteopetrosis in TAK1-deficient mice owing to defective NF-kappaB and NOTCH signaling. Proc Natl Acad Sci U S A 112(1):154-9. PubMed: 25535389 MGI: J:218238
Szanto A; Balint BL; Nagy ZS; Barta E; Dezso B; Pap A; Szeles L; Poliska S; Oros M; Evans RM; Barak Y; Schwabe J; Nagy L. 2010. STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene expression in macrophages and dendritic cells. Immunity 33(5):699-712. PubMed: 21093321 MGI: J:167002
Takahashi H; Ogata H; Nishigaki R; Broide DH; Karin M. 2010. Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKbeta- and JNK1-Dependent Inflammation. Cancer Cell 17(1):89-97. PubMed: 20129250 MGI: J:156928
Takahashi M; Yagyu H; Tazoe F; Nagashima S; Ohshiro T; Okada K; Osuga J; Goldberg IJ; Ishibashi S. 2013. Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity. J Lipid Res 54(4):1124-34. PubMed: 23378601 MGI: J:195158
Takeda K; Clausen BE; Kaisho T; Tsujimura T; Terada N; Forster I ; Akira S. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39-49. PubMed: 10023769 MGI: J:53681
Tamai K; Tanaka N; Nakano T; Kakazu E; Kondo Y; Inoue J; Shiina M; Fukushima K; Hoshino T; Sano K; Ueno Y; Shimosegawa T; Sugamura K. 2010. Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. Biochem Biophys Res Commun 399(3):384-90. PubMed: 20673754 MGI: J:164911
Tang C; Houston BA; Storey C; LeBoeuf RC. 2016. Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages. J Lipid Res 57(5):848-57. PubMed: 26989082 MGI: J:231656
Tang C; Liu Y; Kessler PS; Vaughan AM; Oram JF. 2009. The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. J Biol Chem 284(47):32336-43. PubMed: 19783654 MGI: J:156325
Tang X; Metzger D; Leeman S; Amar S. 2006. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A 103(37):13777-82. PubMed: 16954198 MGI: J:113750
Tao B; Jin W; Xu J; Liang Z; Yao J; Zhang Y; Wang K; Cheng H; Zhang X; Ke Y. 2014. Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. J Immunol 193(6):2801-11. PubMed: 25127857 MGI: J:234895
Taub N; Nairz M; Hilber D; Hess MW; Weiss G; Huber LA. 2012. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J Cell Sci 125(Pt 11):2698-708. PubMed: 22427693 MGI: J:197811
Thomas GD; Hanna RN; Vasudevan NT; Hamers AA; Romanoski CE; McArdle S; Ross KD; Blatchley A; Yoakum D; Hamilton BA; Mikulski Z; Jain MK; Glass CK; Hedrick CC. 2016. Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. Immunity 45(5):975-987. PubMed: 27814941 MGI: J:239509
Thompson AA; Elks PM; Marriott HM; Eamsamarng S; Higgins KR; Lewis A; Williams L; Parmar S; Shaw G; McGrath EE; Formenti F; Van Eeden FJ; Kinnula VL; Pugh CW; Sabroe I; Dockrell DH; Chilvers ER; Robbins PA; Percy MJ; Simon MC; Johnson RS; Renshaw SA; Whyte MK; Walmsley SR. 2014. Hypoxia-inducible factor 2alpha regulates key neutrophil functions in humans, mice, and zebrafish. Blood 123(3):366-76. PubMed: 24196071 MGI: J:207679
Thone J; Ellrichmann G; Seubert S; Peruga I; Lee DH; Conrad R; Hayardeny L; Comi G; Wiese S; Linker RA; Gold R. 2012. Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor. Am J Pathol 180(1):267-74. PubMed: 22152994 MGI: J:180515
Thorp E; Li Y; Bao L; Yao PM; Kuriakose G; Rong J; Fisher EA; Tabas I. 2009. Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2. Arterioscler Thromb Vasc Biol 29(2):169-72. PubMed: 18988889 MGI: J:144243
Tikhanovich I; Zhao J; Olson J; Adams A; Taylor R; Bridges B; Marshall L; Roberts B; Weinman SA. 2017. Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor gamma-dependent macrophage differentiation. J Biol Chem 292(17):6882-6894. PubMed: 28330868 MGI: J:242496
Tsagaratou A; Kontoyiannis DL; Mosialos G. 2011. Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses. PLoS One 6(1):e16397. PubMed: 21283724 MGI: J:169567
Tsuchiya K; Westerterp M; Murphy AJ; Subramanian V; Ferrante AW Jr; Tall AR; Accili D. 2013. Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ Res 112(7):992-1003. PubMed: 23420833 MGI: J:213325
Tsumura H; Ito M; Li XK; Nakamura A; Ohnami N; Fujimoto J; Komada H; Ito Y. 2012. The role of CD98hc in mouse macrophage functions. Cell Immunol 276(1-2):128-34. PubMed: 22624878 MGI: J:188365
Tuckermann JP; Kleiman A; Moriggl R; Spanbroek R; Neumann A; Illing A; Clausen BE; Stride B; Forster I; Habenicht AJ; Reichardt HM; Tronche F; Schmid W; Schutz G. 2007. Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest 117(5):1381-90. PubMed: 17446934 MGI: J:122112
Turpin SM; Nicholls HT; Willmes DM; Mourier A; Brodesser S; Wunderlich CM; Mauer J; Xu E; Hammerschmidt P; Bronneke HS; Trifunovic A; LoSasso G; Wunderlich FT; Kornfeld JW; Bluher M; Kronke M; Bruning JC. 2014. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 20(4):678-86. PubMed: 25295788 MGI: J:215519
Tussiwand R; Everts B; Grajales-Reyes GE; Kretzer NM; Iwata A; Bagaitkar J; Wu X; Wong R; Anderson DA; Murphy TL; Pearce EJ; Murphy KM. 2015. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 42(5):916-28. PubMed: 25992862 MGI: J:229740
Tzima S; Victoratos P; Kranidioti K; Alexiou M; Kollias G. 2009. Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206(5):1167-79. PubMed: 19398754 MGI: J:148498
Ucer S; Iyer S; Bartell SM; Martin-Millan M; Han L; Kim HN; Weinstein RS; Jilka RL; O'Brien CA; Almeida M; Manolagas SC. 2015. The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERalpha Signaling in Osteoblasts and Osteoclasts. J Bone Miner Res 30(7):1138-49. PubMed: 25704845 MGI: J:232760
Ueda Y; Kayama H; Jeon SG; Kusu T; Isaka Y; Rakugi H; Yamamoto M; Takeda K. 2010. Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int Immunol 22(12):953-62. PubMed: 21051439 MGI: J:167353
Usher MG; Duan SZ; Ivaschenko CY; Frieler RA; Berger S; Schutz G; Lumeng CN; Mortensen RM. 2010. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest 120(9):3350-64. PubMed: 20697155 MGI: J:165350
Utomo A; Hirahashi J; Mekala D; Asano K; Glogauer M; Cullere X; Mayadas TN. 2008. Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. J Immunol 180(9):6279-87. PubMed: 18424751 MGI: J:134524
Valledor AF; Arpa L; Sanchez-Tillo E; Comalada M; Casals C; Xaus J; Caelles C; Lloberas J; Celada A. 2008. IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation. Blood 112(8):3274-82. PubMed: 18682602 MGI: J:140209
Valledor AF; Sanchez-Tillo E; Arpa L; Park JM; Caelles C; Lloberas J; Celada A. 2008. Selective Roles of MAPKs during the Macrophage Response to IFN-{gamma}. J Immunol 180(7):4523-9. PubMed: 18354174 MGI: J:132992
Van Hauwermeiren F; Armaka M; Karagianni N; Kranidioti K; Vandenbroucke RE; Loges S; Van Roy M; Staelens J; Puimege L; Palagani A; Berghe WV; Victoratos P; Carmeliet P; Libert C; Kollias G. 2013. Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest 123(6):2590-603. PubMed: 23676465 MGI: J:210950
Van Ziffle JA; Lowell CA. 2009. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114(23):4871-82. PubMed: 19797524 MGI: J:155479
Van den Bossche J; Bogaert P; van Hengel J; Guerin CJ; Berx G; Movahedi K; Van den Bergh R; Pereira-Fernandes A; Geuns JM; Pircher H; Dorny P; Grooten J; De Baetselier P; Van Ginderachter JA. 2009. Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes. Blood 114(21):4664-74. PubMed: 19726720 MGI: J:155503
Vande Walle L; Van Opdenbosch N; Jacques P; Fossoul A; Verheugen E; Vogel P; Beyaert R; Elewaut D; Kanneganti TD; van Loo G; Lamkanfi M. 2014. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature 512(7512):69-73. PubMed: 25043000 MGI: J:217119
Vannella KM; Barron L; Borthwick LA; Kindrachuk KN; Narasimhan PB; Hart KM; Thompson RW; White S; Cheever AW; Ramalingam TR; Wynn TA. 2014. Incomplete deletion of IL-4Ralpha by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. PLoS Pathog 10(9):e1004372. PubMed: 25211233 MGI: J:232460
Varga T; Mounier R; Gogolak P; Poliska S; Chazaud B; Nagy L. 2013. Tissue LyC6- macrophages are generated in the absence of circulating LyC6- monocytes and Nur77 in a model of muscle regeneration. J Immunol 191(11):5695-701. PubMed: 24133167 MGI: J:207030
Vereecke L; Vieira-Silva S; Billiet T; van Es JH; Mc Guire C; Slowicka K; Sze M; van den Born M; De Hertogh G; Clevers H; Raes J; Rutgeerts P; Vermeire S; Beyaert R; van Loo G. 2014. A20 controls intestinal homeostasis through cell-specific activities. Nat Commun 5:5103. PubMed: 25267258 MGI: J:225342
Vettorazzi S; Bode C; Dejager L; Frappart L; Shelest E; Klassen C; Tasdogan A; Reichardt HM; Libert C; Schneider M; Weih F; Henriette Uhlenhaut N; David JP; Graler M; Kleiman A; Tuckermann JP. 2015. Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun 6:7796. PubMed: 26183376 MGI: J:224455
Viader A; Blankman JL; Zhong P; Liu X; Schlosburg JE; Joslyn CM; Liu QS; Tomarchio AJ; Lichtman AH; Selley DE; Sim-Selley LJ; Cravatt BF. 2015. Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. Cell Rep 12(5):798-808. PubMed: 26212325 MGI: J:240386
Vielnascher RM; Hainzl E; Leitner NR; Rammerstorfer M; Popp D; Witalisz A; Rom R; Karaghiosoff M; Kolbe T; Muller S; Rulicke T; Lassnig C; Strobl B; Muller M. 2014. Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance. Transgenic Res 23(3):519-29. PubMed: 24696087 MGI: J:215350
Vujic Spasic M; Kiss J; Herrmann T; Galy B; Martinache S; Stolte J; Grone HJ; Stremmel W; Hentze MW; Muckenthaler MU. 2008. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab 7(2):173-8. PubMed: 18249176 MGI: J:132134
Waddell A; Ahrens R; Tsai YT; Sherrill JD; Denson LA; Steinbrecher KA; Hogan SP. 2013. Intestinal CCL11 and Eosinophilic Inflammation Is Regulated by Myeloid Cell-Specific RelA/p65 in Mice. J Immunol 190(9):4773-85. PubMed: 23562811 MGI: J:195493
Wahlstrom AM; Cutts BA; Liu M; Lindskog A; Karlsson C; Sjogren AK; Andersson KM; Young SG; Bergo MO. 2008. Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease. Blood 112(4):1357-65. PubMed: 18502828 MGI: J:138426
Wallner B; Leitner NR; Vielnascher RM; Kernbauer E; Kolbe T; Karaghiosoff M; Rulicke T; Decker T; Muller M. 2012. Generation of mice with a conditional Stat1 null allele. Transgenic Res 21(1):217-24. PubMed: 21553074 MGI: J:183580
Walmsley SR; Print C; Farahi N; Peyssonnaux C; Johnson RS; Cramer T; Sobolewski A; Condliffe AM; Cowburn AS; Johnson N; Chilvers ER. 2005. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med 201(1):105-15. PubMed: 15630139 MGI: J:95245
Wang H; Park O; Lafdil F; Shen K; Horiguchi N; Yin S; Fu XY; Kunos G; Gao B. 2010. Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology 51(4):1354-62. PubMed: 20041412 MGI: J:174474
Wang J; Kubes P. 2016. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. Cell 165(3):668-78. PubMed: 27062926 MGI: J:234500
Wang J; Wegener JE; Huang TW; Sripathy S; De Jesus-Cortes H; Xu P; Tran S; Knobbe W; Leko V; Britt J; Starwalt R; McDaniel L; Ward CS; Parra D; Newcomb B; Lao U; Nourigat C; Flowers DA; Cullen S; Jorstad NL; Yang Y; Glaskova L; Vigneau S; Kozlitina J; Yetman MJ; Jankowsky JL; Reichardt SD; Reichardt HM; Gartner J; Bartolomei MS; Fang M; Loeb K; Keene CD; Bernstein I; Goodell M; Brat DJ; Huppke P; Neul JL; Bedalov A; Pieper AA. 2015. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature 521(7552):E1-4. PubMed: 25993969 MGI: J:222245
Wang L; Gordon RA; Huynh L; Su X; Park Min KH; Han J; Arthur JS; Kalliolias GD; Ivashkiv LB. 2010. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity 32(4):518-30. PubMed: 20362473 MGI: J:160755
Wang L; Zhang H; Rodriguez S; Cao L; Parish J; Mumaw C; Zollman A; Kamoka MM; Mu J; Chen DZ; Srour EF; Chitteti BR; HogenEsch H; Tu X; Bellido TM; Boswell HS; Manshouri T; Verstovsek S; Yoder MC; Kapur R; Cardoso AA; Carlesso N. 2014. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-kappaB-dependent manner. Cell Stem Cell 15(1):51-65. PubMed: 24996169 MGI: J:218495
Wang QQ; Li H; Oliver T; Glogauer M; Guo J; He YW. 2008. Integrin beta1 regulates phagosome maturation in macrophages through Rac expression. J Immunol 180(4):2419-28. PubMed: 18250451 MGI: J:131992
Wang Y; Koroleva EP; Kruglov AA; Kuprash DV; Nedospasov SA; Fu YX; Tumanov AV. 2010. Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. Immunity 32(3):403-13. PubMed: 20226692 MGI: J:158663
Wang Y; Lebowitz D; Sun C; Thang H; Grynpas MD; Glogauer M. 2008. Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis. J Bone Miner Res 23(2):260-70. PubMed: 17922611 MGI: J:145675
Warszawska JM; Gawish R; Sharif O; Sigel S; Doninger B; Lakovits K; Mesteri I; Nairz M; Boon L; Spiel A; Fuhrmann V; Strobl B; Muller M; Schenk P; Weiss G; Knapp S. 2013. Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest :. PubMed: 23863624 MGI: J:201415
Weber FC; Nemeth T; Csepregi JZ; Dudeck A; Roers A; Ozsvari B; Oswald E; Puskas LG; Jakob T; Mocsai A; Martin SF. 2015. Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity. J Exp Med 212(1):15-22. PubMed: 25512469 MGI: J:219765
Weber S; Wetzel S; Prox J; Lehmann T; Schneppenheim J; Donners M; Saftig P. 2013. Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10). Biochem Biophys Res Commun 442(3-4):234-41. PubMed: 24239882 MGI: J:211494
Wei W; Zeve D; Suh JM; Wang X; Du Y; Zerwekh JE; Dechow PC; Graff JM; Wan Y. 2011. Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by beta-Catenin. Mol Cell Biol 31(23):4706-19. PubMed: 21876000 MGI: J:178340
Wei X; Song H; Yin L; Rizzo MG; Sidhu R; Covey DF; Ory DS; Semenkovich CF. 2016. Fatty acid synthesis configures the plasma membrane for inflammation in diabetes. Nature 539(7628):294-298. PubMed: 27806377 MGI: J:239411
Weigert A; Weichand B; Sekar D; Sha W; Hahn C; Mora J; Ley S; Essler S; Dehne N; Brune B. 2012. HIF-1alpha is a negative regulator of plasmacytoid DC development in vitro and in vivo. Blood 120(15):3001-6. PubMed: 22936665 MGI: J:192921
Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Monch K; Thoren LA; Nielsen FC; Jacobsen SE; Nerlov C; Porse BT. 2008. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev 22(10):1381-96. PubMed: 18483223 MGI: J:134765
Welch JS; Yuan W; Ley TJ. 2011. PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest 121(4):1636-45. PubMed: 21364283 MGI: J:172024
Wenzel P; Knorr M; Kossmann S; Stratmann J; Hausding M; Schuhmacher S; Karbach SH; Schwenk M; Yogev N; Schulz E; Oelze M; Grabbe S; Jonuleit H; Becker C; Daiber A; Waisman A; Munzel T. 2011. Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction. Circulation 124(12):1370-81. PubMed: 21875910 MGI: J:189377
Wermeling F; Anthony RM; Brombacher F; Ravetch JV. 2013. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc Natl Acad Sci U S A 110(33):13487-91. PubMed: 23898202 MGI: J:200690
Westerterp M; Gourion-Arsiquaud S; Murphy AJ; Shih A; Cremers S; Levine RL; Tall AR; Yvan-Charvet L. 2012. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell 11(2):195-206. PubMed: 22862945 MGI: J:190966
Westerterp M; Murphy AJ; Wang M; Pagler TA; Vengrenyuk Y; Kappus MS; Gorman DJ; Nagareddy PR; Zhu X; Abramowicz S; Parks JS; Welch C; Fisher EA; Wang N; Yvan-Charvet L; Tall AR. 2013. Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Circ Res 112(11):1456-65. PubMed: 23572498 MGI: J:213300
White TA; Johnson T; Zarzhevsky N; Tom C; Delacroix S; Holroyd EW; Maroney SA; Singh R; Pan S; Fay WP; van Deursen J; Mast AE; Sandhu GS; Simari RD. 2010. Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood 116(10):1787-94. PubMed: 20516367 MGI: J:164530
Wiig H; Schroder A; Neuhofer W; Jantsch J; Kopp C; Karlsen TV; Boschmann M; Goss J; Bry M; Rakova N; Dahlmann A; Brenner S; Tenstad O; Nurmi H; Mervaala E; Wagner H; Beck FX; Muller DN; Kerjaschki D; Luft FC; Harrison DG; Alitalo K; Titze J. 2013. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. J Clin Invest 123(7):2803-15. PubMed: 23722907 MGI: J:201429
Willemen HL; Campos PM; Lucas E; Morreale A; Gil-Redondo R; Agut J; Gonzalez FV; Ramos P; Heijnen C; Mayor F Jr; Kavelaars A; Murga C. 2014. A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia. Biochem J 459(3):427-39. PubMed: 24517375 MGI: J:212293
Willemen HL; Eijkelkamp N; Wang H; Dantzer R; Dorn GW 2nd; Kelley KW; Heijnen CJ; Kavelaars A. 2010. Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain 150(3):550-60. PubMed: 20609517 MGI: J:214648
Willenborg S; Lucas T; van Loo G; Knipper JA; Krieg T; Haase I; Brachvogel B; Hammerschmidt M; Nagy A; Ferrara N; Pasparakis M; Eming SA. 2012. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120(3):613-25. PubMed: 22577176 MGI: J:189044
Wimmer N; Huber B; Barabas N; Rohrl J; Pfeffer K; Hehlgans T. 2012. Lymphotoxin beta receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands. J Immunol 188(7):3426-33. PubMed: 22357629 MGI: J:183109
Wimmer N; Huber B; Wege AK; Barabas N; Rohrl J; Pfeffer K; Hehlgans T. 2012. Lymphotoxin-beta receptor activation on macrophages ameliorates acute DSS-induced intestinal inflammation in a TRIM30alpha-dependent manner. Mol Immunol 51(2):128-35. PubMed: 22437076 MGI: J:184872
Wolf MJ; Hoos A; Bauer J; Boettcher S; Knust M; Weber A; Simonavicius N; Schneider C; Lang M; Sturzl M; Croner RS; Konrad A; Manz MG; Moch H; Aguzzi A; van Loo G; Pasparakis M; Prinz M; Borsig L; Heikenwalder M. 2012. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22(1):91-105. PubMed: 22789541 MGI: J:191014
Wolford CC; McConoughey SJ; Jalgaonkar SP; Leon M; Merchant AS; Dominick JL; Yin X; Chang Y; Zmuda EJ; O'Toole SA; Millar EK; Roller SL; Shapiro CL; Ostrowski MC; Sutherland RL; Hai T. 2013. Transcription factor ATF3 links host adaptive response to breast cancer metastasis. J Clin Invest 123(7):2893-906. PubMed: 23921126 MGI: J:201626
Wong HL; Jin G; Cao R; Zhang S; Cao Y; Zhou Z. 2016. MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis. Nat Commun 7:10824. PubMed: 26926389 MGI: J:236348
Wong MS; Leisegang MS; Kruse C; Vogel J; Schurmann C; Dehne N; Weigert A; Herrmann E; Brune B; Shah AM; Steinhilber D; Offermanns S; Carmeliet G; Badenhoop K; Schroder K; Brandes RP. 2014. Vitamin D promotes vascular regeneration. Circulation 130(12):976-86. PubMed: 25015343 MGI: J:227457
Wong WW; Vince JE; Lalaoui N; Lawlor KE; Chau D; Bankovacki A; Anderton H; Metcalf D; O'Reilly L; Jost PJ; Murphy JM; Alexander WS; Strasser A; Vaux DL; Silke J. 2014. cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood 123(16):2562-72. PubMed: 24497535 MGI: J:210177
Wu DJ; Gu R; Sarin R; Zavodovskaya R; Chen CP; Christiansen BA; Adamopoulos IE. 2016. Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J Autoimmun 73:73-84. PubMed: 27330028 MGI: J:240245
Wu YH; Kuo WC; Wu YJ; Yang KT; Chen ST; Jiang ST; Gordy C; He YW; Lai MZ. 2014. Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation. Cell Death Differ 21(3):451-61. PubMed: 24270411 MGI: J:229062
Wueest S; Mueller R; Bluher M; Item F; Chin AS; Wiedemann MS; Takizawa H; Kovtonyuk L; Chervonsky AV; Schoenle EJ; Manz MG; Konrad D. 2014. Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance. EMBO Mol Med 6(1):43-56. PubMed: 24203314 MGI: J:232302
Wunderlich CM; Delic D; Behnke K; Meryk A; Strohle P; Chaurasia B; Al-Quraishy S; Wunderlich F; Bruning JC; Wunderlich FT. 2012. Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol 188(9):4141-4. PubMed: 22467660 MGI: J:188445
Wust S; van den Brandt J; Tischner D; Kleiman A; Tuckermann JP; Gold R; Luhder F; Reichardt HM. 2008. Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J Immunol 180(12):8434-43. PubMed: 18523311 MGI: J:137157
Xavier MN; Winter MG; Spees AM; Nguyen K; Atluri VL; Silva TM; Baumler AJ; Muller W; Santos RL; Tsolis RM. 2013. CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function. PLoS Pathog 9(6):e1003454. PubMed: 23818855 MGI: J:213384
Xia P; Wang S; Ye B; Du Y; Huang G; Zhu P; Fan Z. 2015. Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection. Nat Immunol 16(4):366-75. PubMed: 25729924 MGI: J:231647
Xiao C; Wang RH; Lahusen TJ; Park O; Bertola A; Maruyama T; Reynolds D; Chen Q; Xu X; Young HA; Chen WJ; Gao B; Deng CX. 2012. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem 287(50):41903-13. PubMed: 23076146 MGI: J:193418
Xiao Y; Jin J; Chang M; Chang JH; Hu H; Zhou X; Brittain GC; Stansberg C; Torkildsen O; Wang X; Brink R; Cheng X; Sun SC. 2013. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med 19(5):595-602. PubMed: 23603814 MGI: J:198506
Xie M; Yu Y; Kang R; Zhu S; Yang L; Zeng L; Sun X; Yang M; Billiar TR; Wang H; Cao L; Jiang J; Tang D. 2016. PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation. Nat Commun 7:13280. PubMed: 27779186 MGI: J:242646
Xiong L; Jung JU; Wu H; Xia WF; Pan JX; Shen C; Mei L; Xiong WC. 2015. Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption. Proc Natl Acad Sci U S A 112(11):3487-92. PubMed: 25733894 MGI: J:220309
Xiong Y; Lee HJ; Mariko B; Lu YC; Dannenberg AJ; Haka AS; Maxfield FR; Camerer E; Proia RL; Hla T. 2013. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem 288(45):32563-73. PubMed: 24081141 MGI: J:204993
Xiu Y; Xu H; Zhao C; Li J; Morita Y; Yao Z; Xing L; Boyce BF. 2014. Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest 124(1):297-310. PubMed: 24316970 MGI: J:207911
Xu D; Liu X; Yu WM; Meyerson HJ; Guo C; Gerson SL; Qu CK. 2011. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med 208(10):1977-88. PubMed: 21930766 MGI: J:177285
Xu J; Chi F; Guo T; Punj V; Lee WN; French SW; Tsukamoto H. 2015. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest 125(4):1579-90. PubMed: 25798621 MGI: J:222272
Xue J; Sharma V; Hsieh MH; Chawla A; Murali R; Pandol SJ; Habtezion A. 2015. Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat Commun 6:7158. PubMed: 25981357 MGI: J:224933
Yamamoto M; Okamoto T; Takeda K; Sato S; Sanjo H; Uematsu S; Saitoh T; Yamamoto N; Sakurai H; Ishii KJ; Yamaoka S; Kawai T; Matsuura Y; Takeuchi O; Akira S. 2006. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol 7(9):962-70. PubMed: 16862162 MGI: J:112287
Yan C; Ward PA; Wang X; Gao H. 2013. Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein delta pathway. FASEB J 27(8):2967-76. PubMed: 23585399 MGI: J:203576
Yan D; Wang HW; Bowman RL; Joyce JA. 2016. STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1alpha Activation. Cell Rep 16(11):2914-27. PubMed: 27626662 MGI: J:238995
Yanai H; Matsuda A; An J; Koshiba R; Nishio J; Negishi H; Ikushima H; Onoe T; Ohdan H; Yoshida N; Taniguchi T. 2013. Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc Natl Acad Sci U S A 110(51):20699-704. PubMed: 24302768 MGI: J:205499
Yancey PG; Blakemore J; Ding L; Fan D; Overton CD; Zhang Y; Linton MF; Fazio S. 2010. Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arterioscler Thromb Vasc Biol 30(4):787-95. PubMed: 20150557 MGI: J:172263
Yang C; McCoy K; Davis JL; Schmidt-Supprian M; Sasaki Y; Faccio R; Veis Novack D. 2010. NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis. PLoS One 5(11):e15383. PubMed: 21151480 MGI: J:167281
Yang J; Kantrow S; Sai J; Hawkins OE; Boothby M; Ayers GD; Young ED; Demicco EG; Lazar AJ; Lev D; Richmond A. 2012. Ikk4a/Arf inactivation with activation of the NF-kappaB/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma. Cancer Res 72(18):4682-95. PubMed: 22836752 MGI: J:191329
Yang J; Mowry LE; Nejak-Bowen KN; Okabe H; Diegel CR; Lang RA; Williams BO; Monga SP. 2014. beta-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation! Hepatology 60(3):964-76. PubMed: 24700412 MGI: J:225564
Yang Y; Liu B; Dai J; Srivastava PK; Zammit DJ; Lefrancois L; Li Z. 2007. Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages. Immunity 26(2):215-26. PubMed: 17275357 MGI: J:118427
Yang Z; Wang X; He Y; Qi L; Yu L; Xue B; Shi H. 2012. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PLoS One 7(11):e49935. PubMed: 23183898 MGI: J:195014
Yao H; Chung S; Hwang JW; Rajendrasozhan S; Sundar IK; Dean DA; McBurney MW; Guarente L; Gu W; Ronty M; Kinnula VL; Rahman I. 2012. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest 122(6):2032-45. PubMed: 22546858 MGI: J:188297
Yao L; Heuser-Baker J; Herlea-Pana O; Zhang N; Szweda LI; Griffin TM; Barlic-Dicen J. 2014. Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J 28(10):4534-50. PubMed: 25016030 MGI: J:217569
Yasukawa H; Ohishi M; Mori H; Murakami M; Chinen T; Aki D; Hanada T; Takeda K; Akira S; Hoshijima M; Hirano T; Chien KR; Yoshimura A. 2003. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 4(6):551-6. PubMed: 12754507 MGI: J:92040
Ye M; Iwasaki H; Laiosa CV; Stadtfeld M; Xie H; Heck S; Clausen B; Akashi K; Graf T. 2003. Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity 19(5):689-99. PubMed: 14614856 MGI: J:174583
Yiakouvaki A; Dimitriou M; Karakasiliotis I; Eftychi C; Theocharis S; Kontoyiannis DL. 2012. Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest 122(1):48-61. PubMed: 22201685 MGI: J:184388
Yorgan T; Vollersen N; Riedel C; Jeschke A; Peters S; Busse B; Amling M; Schinke T. 2016. Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton. Bone 87:136-46. PubMed: 27102824 MGI: J:235524
York AG; Williams KJ; Argus JP; Zhou QD; Brar G; Vergnes L; Gray EE; Zhen A; Wu NC; Yamada DH; Cunningham CR; Tarling EJ; Wilks MQ; Casero D; Gray DH; Yu AK; Wang ES; Brooks DG; Sun R; Kitchen SG; Wu TT; Reue K; Stetson DB; Bensinger SJ. 2015. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell 163(7):1716-29. PubMed: 26686653 MGI: J:227982
Yoshida Y; Yoshimi R; Yoshii H; Kim D; Dey A; Xiong H; Munasinghe J; Yazawa I; O'Donovan MJ; Maximova OA; Sharma S; Zhu J; Wang H; Morse HC 3rd; Ozato K. 2014. The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation. Immunity 40(2):187-98. PubMed: 24485804 MGI: J:209803
Yoshitaka T; Mukai T; Kittaka M; Alford LM; Masrani S; Ishida S; Yamaguchi K; Yamada M; Mizuno N; Olsen BR; Reichenberger EJ; Ueki Y. 2014. Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism. Cell Rep 8(6):1752-66. PubMed: 25220465 MGI: J:218550
Yu WM; Liu X; Shen J; Jovanovic O; Pohl EE; Gerson SL; Finkel T; Broxmeyer HE; Qu CK. 2013. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell 12(1):62-74. PubMed: 23290137 MGI: J:194929
Yumimoto K; Akiyoshi S; Ueo H; Sagara Y; Onoyama I; Ueo H; Ohno S; Mori M; Mimori K; Nakayama KI. 2015. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest 125(2):621-35. PubMed: 25555218 MGI: J:220397
Zabuawala T; Taffany DA; Sharma SM; Merchant A; Adair B; Srinivasan R; Rosol TJ; Fernandez S; Huang K; Leone G; Ostrowski MC. 2010. An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res 70(4):1323-33. PubMed: 20145133 MGI: J:157608
Zeng MY; Pham D; Bagaitkar J; Liu J; Otero K; Shan M; Wynn TA; Brombacher F; Brutkiewicz RR; Kaplan MH; Dinauer MC. 2013. An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood 121(17):3473-83. PubMed: 23426944 MGI: J:196697
Zhang C; An J; Strickland DK; Yepes M. 2009. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am J Pathol 174(2):586-94. PubMed: 19147818 MGI: J:144185
Zhang D; Tang W; Yao PM; Yang C; Xie B; Jackowski S; Tabas I. 2000. Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. MOLECULAR GENETIC EVIDENCE THAT THE INDUCTION OF PHOSPHATIDYLCHOLINE BIOSYNTHESIS IN FREE CHOLESTEROL-LOADED MACROPHAGES IS AN ADAPTIVE RESPONSE [In Process Citation] J Biol Chem 275(45):35368-76. PubMed: 10944538 MGI: J:65639
Zhang H; Neuhofer P; Song L; Rabe B; Lesina M; Kurkowski MU; Treiber M; Wartmann T; Regner S; Thorlacius H; Saur D; Weirich G; Yoshimura A; Halangk W; Mizgerd JP; Schmid RM; Rose-John S; Algul H. 2013. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest 123(3):1019-31. PubMed: 23426178 MGI: J:196394
Zhang H; Sun C; Glogauer M; Bokoch GM. 2009. Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol 183(4):2718-28. PubMed: 19625648 MGI: J:151789
Zhang J; Modi Y; Yarovinsky T; Yu J; Collinge M; Kyriakides T; Zhu Y; Sessa WC; Pardi R; Bender JR. 2012. Macrophage beta(2) Integrin-Mediated, HuR-Dependent Stabilization of Angiogenic Factor-Encoding mRNAs in Inflammatory Angiogenesis. Am J Pathol 180(4):1751-60. PubMed: 22322302 MGI: J:182000
Zhang JD; Patel MB; Griffiths R; Dolber PC; Ruiz P; Sparks MA; Stegbauer J; Jin H; Gomez JA; Buckley AF; Lefler WS; Chen D; Crowley SD. 2014. Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. J Clin Invest 124(5):2198-203. PubMed: 24743144 MGI: J:212755
Zhang W; Liu H; Liu W; Liu Y; Xu J. 2015. Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-kappaB pathway. Cell Death Differ 22(2):287-97. PubMed: 25215948 MGI: J:230193
Zhang Z; Guo X; Herrera C; Tao Y; Wu Q; Wu A; Wang H; Bartnikas TB; Wang F. 2014. Bmp6 expression can be regulated independently of liver iron in mice. PLoS One 9(1):e84906. PubMed: 24454764 MGI: J:212194
Zhang Z; Zhang F; An P; Guo X; Shen Y; Tao Y; Wu Q; Zhang Y; Yu Y; Ning B; Nie G; Knutson MD; Anderson GJ; Wang F. 2011. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood 118(7):1912-22. PubMed: 21705499 MGI: J:176908
Zhao B; Grimes SN; Li S; Hu X; Ivashkiv LB. 2012. TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. J Exp Med 209(2):319-34. PubMed: 22249448 MGI: J:181699
Zhao C; Irie N; Takada Y; Shimoda K; Miyamoto T; Nishiwaki T; Suda T; Matsuo K. 2006. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab 4(2):111-21. PubMed: 16890539 MGI: J:129733
Zhao H; Roychoudhury J; Doggett TA; Apte RS; Ferguson TA. 2013. Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. Invest Ophthalmol Vis Sci 54(8):5321-31. PubMed: 23821188 MGI: J:214184
Zhao J; Yu H; Liu Y; Gibson SA; Yan Z; Xu X; Gaggar A; Li PK; Li C; Wei S; Benveniste EN; Qin H. 2016. Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 311(5):L868-L880. PubMed: 27638904 MGI: J:237264
Zhao JL; Huang F; He F; Gao CC; Liang SQ; Ma PF; Dong GY; Han H; Qin HY. 2016. Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages. Cancer Res 76(6):1403-15. PubMed: 26759236 MGI: J:231327
Zhong Z; Umemura A; Sanchez-Lopez E; Liang S; Shalapour S; Wong J; He F; Boassa D; Perkins G; Ali SR; McGeough MD; Ellisman MH; Seki E; Gustafsson AB; Hoffman HM; Diaz-Meco MT; Moscat J; Karin M. 2016. NF-kappaB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell 164(5):896-910. PubMed: 26919428 MGI: J:230797
Zhou J; Dehne N; Brune B. 2009. Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med 47(6):741-9. PubMed: 19523512 MGI: J:152571
Zhou S; Xie Y; Tang J; Huang J; Huang Q; Xu W; Wang Z; Luo F; Wang Q; Chen H; Du X; Shen Y; Chen D; Chen L. 2015. FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling. PLoS Genet 11(6):e1005214. PubMed: 26091072 MGI: J:224751
Zhou Y; Mohan A; Moore DC; Lin L; Zhou FL; Cao J; Wu Q; Qin YX; Reginato AM; Ehrlich MG; Yang W. 2015. SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion. FASEB J 29(5):1635-45. PubMed: 25593124 MGI: J:220894
Zhu D; Hattori H; Jo H; Jia Y; Subramanian KK; Loison F; You J; Le Y; Honczarenko M; Silberstein L; Luo HR. 2006. Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A 103(40):14836-41. PubMed: 16988010 MGI: J:114699
Zhu X; Lee JY; Timmins JM; Brown JM; Boudyguina E; Mulya A; Gebre AK; Willingham MC; Hiltbold EM; Mishra N; Maeda N; Parks JS. 2008. Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem 283(34):22930-41. PubMed: 18552351 MGI: J:140263
Zhu X; Owen JS; Wilson MD; Li H; Griffiths GL; Thomas MJ; Hiltbold EM; Fessler MB; Parks JS. 2010. Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res 51(11):3196-206. PubMed: 20650929 MGI: J:179118
Zhu X; Westcott MM; Bi X; Liu M; Gowdy KM; Seo J; Cao Q; Gebre AK; Fessler MB; Hiltbold EM; Parks JS. 2012. Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection. Circ Res 111(11):1398-409. PubMed: 22955730 MGI: J:212623
Zou W; Izawa T; Zhu T; Chappel J; Otero K; Monkley SJ; Critchley DR; Petrich BG; Morozov A; Ginsberg MH; Teitelbaum SL. 2013. Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol 33(4):830-44. PubMed: 23230271 MGI: J:194413
Zou W; Teitelbaum SL. 2015. Absence of Dap12 and the alphavbeta3 integrin causes severe osteopetrosis. J Cell Biol 208(1):125-36. PubMed: 25547154 MGI: J:233352
Zust R; Toh YX; Valdes I; Cerny D; Heinrich J; Hermida L; Marcos E; Guillen G; Kalinke U; Shi PY; Fink K. 2014. Type I interferon signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccines. J Virol 88(13):7276-85. PubMed: 24741106 MGI: J:214416
Zwaferink H; Stockinger S; Reipert S; Decker T. 2008. Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun 76(4):1649-56. PubMed: 18268032 MGI: J:133523
de Aguiar Vallim TQ; Lee E; Merriott DJ; Goulbourne CN; Cheng J; Cheng A; Gonen A; Allen RM; Palladino END; Ford DA; Wang T; Baldan A; Tarling EJ. 2017. ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res 58(5):941-954. PubMed: 28264879 MGI: J:241512
de Almeida L; Khare S; Misharin AV; Patel R; Ratsimandresy RA; Wallin MC; Perlman H; Greaves DR; Hoffman HM; Dorfleutner A; Stehlik C. 2015. The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease. Immunity 43(2):264-76. PubMed: 26275995 MGI: J:233392
van der Merwe M; Abdelsamed HA; Seth A; Ong T; Vogel P; Pillai AB. 2013. Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation. J Immunol 191(11):5764-76. PubMed: 24190658 MGI: J:207149
van der Vorst EP; Jeurissen M; Wolfs IM; Keijbeck A; Theodorou K; Wijnands E; Schurgers L; Weber S; Gijbels MJ; Hamers AA; Dreymueller D; Rose-John S; de Winther MP; Ludwig A; Saftig P; Biessen EA; Donners MM. 2015. Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis. Am J Pathol 185(4):1145-55. PubMed: 25659879 MGI: J:220183
von Bruhl ML; Stark K; Steinhart A; Chandraratne S; Konrad I; Lorenz M; Khandoga A; Tirniceriu A; Coletti R; Kollnberger M; Byrne RA; Laitinen I; Walch A; Brill A; Pfeiler S; Manukyan D; Braun S; Lange P; Riegger J; Ware J; Eckart A; Haidari S; Rudelius M; Schulz C; Echtler K; Brinkmann V; Schwaiger M; Preissner KT; Wagner DD; Mackman N; Engelmann B; Massberg S. 2012. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 209(4):819-35. PubMed: 22451716 MGI: J:183864
von Knethen A; Neb H; Morbitzer V; Schmidt MV; Kuhn AM; Kuchler L; Brune B. 2011. PPARgamma stabilizes HO-1 mRNA in monocytes/macrophages which affects IFN-beta expression. Free Radic Biol Med 51(2):396-405. PubMed: 21571064 MGI: J:174098

Also Known As: LysMcre

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Lyz2tm1(cre)Ifo

Allele Symbol: Lyz2tm1(cre)Ifo

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Genotype: cre related

Genotype: Lyz2tm1(cre)Ifo related

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Genotype: Lyz2tm1(cre)Ifo/Lyz2+involves: 129P2/OlaHsd * C57BL/6

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Lyz2^tm1(cre)Ifo

Allele Symbol: Lyz2^tm1(cre)Ifo

Genotype: Lyz2^tm1(cre)Ifo related

Genotype: Lyz2^tm1(cre)Ifo/*Lyz2⁺
involves: 129P2/OlaHsd C57BL/6

Additional - Lyz2^tm1(cre)Ifo related