These mice carry a spontaneous deletion at the Fam83g locus characterized by rough or matted appearance of their coats.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Fam83g | family with sequence similarity 83, member G |
Mice develop curly hair by 4 weeks of age; whiskers are normal (straight). Giant hair follicles in anagen and a paucity of subdermal fat were found in histology of the skin at 5 weeks of age.
The wooly mutation arose spontaneously in the NOD/LtJ production colony at The Jackson Laboratory in 2001 when that inbred was at F92. The wooly bearing strain has been maintained by sibling breeding and in 2004 reached F20.
Allele Name | wooly |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Fam83g, family with sequence similarity 83, member G |
Gene Synonym(s) | |
Strain of Origin | NOD/ShiLtJ |
Chromosome | 11 |
Molecular Note | A 955 bp deletion removes part of intron 2 and the splice acceptor site at the beginning of exon 3. This results in incorrect splicing and a premature stop codon leading to a truncated protein. The deletion overlaps with intron 10 of Slc5a10 on the opposite strand but does not affect splicing of that gene. |
When using the wooly mouse strain in a publication, please cite the originating article(s) and include JAX stock #004774 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for wly |
Frozen Mouse Embryo | NOD/ShiLtJ-Fam83g<wly>/J | $2595.00 |
Frozen Mouse Embryo | NOD/ShiLtJ-Fam83g<wly>/J | $2595.00 |
Frozen Mouse Embryo | NOD/ShiLtJ-Fam83g<wly>/J | $3373.50 |
Frozen Mouse Embryo | NOD/ShiLtJ-Fam83g<wly>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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