Mice develop curly hair by 4 weeks of age; whiskers are normal (straight). Giant hair follicles in anagen and a paucity of subdermal fat were found in histology of the skin at 5 weeks of age.
The wooly mutation arose spontaneously in the NOD/LtJ production colony at The Jackson Laboratory in 2001 when that inbred was at F92. The wooly bearing strain has been maintained by sibling breeding and in 2004 reached F20.
|Gene Symbol and Name||Fam83g, family with sequence similarity 83, member G|
|Strain of Origin||NOD/ShiLtJ|
|Molecular Note||A 955 bp deletion removes part of intron 2 and the splice acceptor site at the beginning of exon 3. This results in incorrect splicing and a premature stop codon leading to a truncated protein. The deletion overlaps with intron 10 of Slc5a10 on the opposite strand but does not affect splicing of that gene.|
When using the wooly mouse strain in a publication, please cite the originating article(s) and include JAX stock #004774 in your Materials and Methods section.