JAX
Mouse Strain Datasheet - 004696
NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
Also Known As: NOD.TcrLCMV
These NOD.TcrLCMV mice express a transgene containing Tcrα and TcrΒ gene segments.
Donating Investigator
Dr. David Serreze, The Jackson Laboratory
Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Tg(TcrLCMV)327Sdz
| Allele Type |
|---|
| Transgenic (Inserted expressed sequence) |
Development
Zinkernagel et al, established a set of LCMV-specific cytotoxic T-cell clones from lethally irradiated B10.BR/SgSn(H-2K) reconstituted with T-cell depleted C57BL/10Sn ({/i H-2b}) bone marrow cells. The variable beta chain from clone P14, containing Tcrb-V8.1, TcrB-D, TcrB-J2.4 gene segments under the control of the H-2Kb promoter and variable alpha chain from the P14 clone, containing Tcra-V2 and Tcra-J TA31 gene segments under the control of the H-2Kb promoter were co-injected into B6D2F2 fertilized embryos. 10-20 copies of both the alpha and beta transgenes co-integrated on the same chromosome in male founder number 327. Founder 327 was backcrossed to C57BL/6J for one generation prior to being intercrossed to make this a homozygous strain. Serezze, et al. obtained JR2331-B6;D2-Tg(TcrLCMV)327Sdz/J mice, backcrossed to NOD/Lt for 9 generations and then mated Tg/? x Tg/?. A genome scan for NOD derived Idd loci was done as described in J. Exp. Med. 1996 184:2049. This T cell receptor is specific for an LCMV peptide in the context of H2-Db and requires the presence of H2-Dbto be positively selected. (Serreze et al., Diabetes, 2001.) In 2003, the T1DR received NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ from Dr. Serezze. This strain is maintained Tg/? x Tg/?
Expression Data
| Expressed Gene | Tcra, T cell receptor alpha chain, mouse, laboratory |
|---|---|
| Expressed Gene | Tcrb, T cell receptor beta chain, mouse, laboratory |
| Site of Expression |
Control Suggestions
Selected References
- Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 50(9):1992-2000. PubMed: 11522664MGI: J:71050
Tg(TcrLCMV)327Sdz
Allele Symbol: Tg(TcrLCMV)327Sdz
| Allele Name | transgene insertion 327, Birgit Ledermann |
|---|---|
| Allele Type | Transgenic (Inserted expressed sequence) |
| Allele Synonym(s) | P14; P14 TCR; P14 TCR-alphabeta (Valpha2Vbeta8.1); P14 TCRValpha2Vbeta8; P14-TCR; TCR LCMV; TCR P14; TCR-Tg; TgTcr |
| Gene Symbol and Name | Tg(TcrLCMV)327Sdz, transgene insertion 327, Birgit Ledermann |
| Gene Synonym(s) | P14; P14 TCR; P14 TCR-alphabeta (Valpha2Vbeta8.1); P14 TCRValpha2Vbeta8; P14-TCR; TCR LCMV; TCR P14; TCR-Tg; TgTcr |
| Promoter | Tcra, T cell receptor alpha chain, mouse, laboratory |
| Promoter | Tcrb, T cell receptor beta chain, mouse, laboratory |
| Expressed Gene | Tcra, T cell receptor alpha chain, mouse, laboratory |
| Expressed Gene | Tcrb, T cell receptor beta chain, mouse, laboratory |
| Strain of Origin | (C57BL/6 x DBA/2)F2 |
| Chromosome | UN |
| General Note | Transgenic mice carry a T-cell receptor (Tcra-V2, Tcra-J TA31 / Tcrb-V8.1, Tcrb-D, Tcrb-J 2.4) specific for LCMV (lymphocytic choriomeningitis virus), H2-Db. |
| Molecular Note | The transgene carries both Tcra and Tcrb. Ten to twenty copies of the Tcr transgene were reported to have integrated on the same chromosome. At least two transgenic lines are known to exist. Line 327 is the representative line. The second line is 318. |
| Mutations Made By | Dr. Rolf Zinkernagel, University of Zurich |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Immunology, Inflammation and Autoimmunity Research
- T Cell Receptor Transgenics
- Immunology, Inflammation and Autoimmunity Research
Mammalian Phenotype Terms by Genotype
Genotype: Tg(TcrLCMV)327Sdz/Tg(TcrLCMV)327Sdz
NOD.Cg-Tg(TcrLCMV)327Sdz/Dvs
immune system phenotype
- autoimmune response
- the rate and frequency of type 1 diabetes development in transgenic NOD females is the same as that in NOD females lacking the transgene (MGI Ref ID J:71050)
References
- Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 50(9):1992-2000. PubMed: 11522664MGI: J:71050
Additional References
- Pircher H; Burki K; Lang R; Hengartner H; Zinkernagel RM. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342(6249):559-61. PubMed: 2573841MGI: J:77696
Additional - Tg(TcrLCMV)327Sdz related
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