These mice carry a spontaneous mutation at the Lhfpl5 locus characterized by rapid circling and head shaking behavior and deafness.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Null/Knockout) | Lhfpl5 | lipoma HMGIC fusion partner-like 5 |
Mice homozygous for the Lhfpl5hscy mutation circle rapidly, shake their heads from side to side, fail to swim, and are congenitally deaf. Although hair cells appear normal at birth, they degenerate. At 4 months of age, degeneration of the organ of Corti is also found, more pronounced in the basal region of the cochlea than the apex, with loss of inner and outer hair cells and decreased spiral ganglia (Longo-Guess et al., 2005).
The hurry scurry mutation arose spontaneously in 1992 on the B6.MOR-Gusba background in the laboratory of Dr. Gordon Watson at The Jackson Laboratory and was maintained via sibling mating for several generations before being backcrossed three times to C57BL/6, which removed the Gusba allele. This strain was subsequently maintained by sibling mating of primarily heterozygous females with homozygous males. In 2005 this strain reached generation N3F15.
Allele Name | hurry-scurry |
---|---|
Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Lhfpl5, lipoma HMGIC fusion partner-like 5 |
Gene Synonym(s) | |
Strain of Origin | B6.MOR-Gusba |
Chromosome | 17 |
Molecular Note | This spontaneous mutation arose at The Jackson Laboratory. The mutation is a G-to-T transversion in exon 2 that results in a nonconservative amino acid change from cysteine to phenylalanine at amino acid position 161 of the encoded protein (p.C161F). Northern blot analysis demonstrated that a normal sized transcript was expressed from this mutant allele. Histological immunofluorescence analysis confirmed the absence of protein expression in newborn homozygous mice that is normally found in the inner and outer hair cells of the inner ear. |
When using the hurry-scurry mouse strain in a publication, please cite the originating article(s) and include JAX stock #004640 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Tmhs<hscy> |
Frozen Mouse Embryo | B6(MOR)-Lhfpl5<hscy>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6(MOR)-Lhfpl5<hscy>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6(MOR)-Lhfpl5<hscy>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6(MOR)-Lhfpl5<hscy>/J Frozen Embryos | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.