These transgenic mice express the human apolipoprotein E3 isoform (APOE3) under the direction of the human glial fibrillary acidic protein (GFAP) promoter and do not express endogenous mouse apolipoprotein E (APOE). The transgenic isoform expression pattern follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. Cultured astrocytes from transgenic mice secrete APOE3 in lipoproteins that are similar in size to high-density (HDL) plasma lipoproteins. Detergent-soluble APOE3 protein levels in hemizygous mice forebrain tissue and in adult human cortex tissue are similar. Mice that are hemizygous or homozygous for the transgenic insert and homozygous for the targeted allele are viable, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain represents a model that may be useful in studies examining the function of APOE3 in the central nervous system and how APOE3 may contribute to the pathology of Alzheimer's disease. According to the donating investigator, mice that are hemizygous for the transgene and homozygous for the null mutation show dyslipidemia similar to non-transgenic Apoe-null mutant mice (B6.129P2-Apoetm1Unc - Stock No. <a href="https://www.jax.org/strain/002052">002052</a>) in peripheral blood. Although some transgene-derived APOE protein does make it to the periphery, it is not enough to lower peripheral cholesterol significantly.

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These GFAP-apoE3 line 37 mice express a transgene containing human APOE3 and follows the endogenous mouse APOE and GFAP expression patterns in the brain.



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