JAX Mouse Strain Datasheet - 004633

B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/J

Stock No:: 004633 |; GFAP-apoE3 line 37

Cryo Recovery

Overview

Also Known As: GFAP-apoE3 line 37, Tg(GFAP-APOE*3)37Hol

These GFAP-apoE3 line 37 mice express a transgene containing human APOE3 and follows the endogenous mouse APOE and GFAP expression patterns in the brain.

Donating Investigator

Dr. David M. Holtzman, Washington University

Genetic overview

Genetic Background	Generation

Apoe^tm1Unc

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Apoe	apolipoprotein E

Allele Type
Transgenic (Humanized sequence, Inserted expressed sequence)

Research Applications

Cardiovascular Research
Neurobiology Research

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Base Price

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$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

These transgenic mice express the human apolipoprotein E3 isoform (APOE3) under the direction of the human glial fibrillary acidic protein (GFAP) promoter and do not express endogenous mouse apolipoprotein E (APOE). The transgenic isoform expression pattern follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. Cultured astrocytes from transgenic mice secrete APOE3 in lipoproteins that are similar in size to high-density (HDL) plasma lipoproteins. Detergent-soluble APOE3 protein levels in hemizygous mice forebrain tissue and in adult human cortex tissue are similar. Mice that are hemizygous or homozygous for the transgenic insert and homozygous for the targeted allele are viable, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain represents a model that may be useful in studies examining the function of APOE3 in the central nervous system and how APOE3 may contribute to the pathology of Alzheimer's disease.

According to the donating investigator, mice that are hemizygous for the transgene and homozygous for the null mutation show dyslipidemia similar to non-transgenic Apoe-null mutant mice (B6.129P2-Apoe/J - Stock # 002052) in peripheral blood. Although some transgene-derived APOE protein does make it to the periphery, it is not enough to lower peripheral cholesterol significantly.

Development

A transgenic construct containing sequence encoding human apolipoprotein E3 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter was introduced into B6;CBA donor eggs.

Expression Data

Expressed Gene	APOE, apolipoprotein E, human
Site of Expression

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Sun Y; Wu S; Bu G; Onifade MK; Patel SN; LaDu MJ; Fagan AM; Holtzman DM. 1998. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci 18(9):3261-72. PubMed: 9547235 MGI: J:93487

View All References

Genetics

Apoe^tm1Unc

Allele Symbol: Apoe^tm1Unc

Allele Name	targeted mutation 1, University of North Carolina
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	APOE KO; AopE(-); ApoE-KO; Apoe^tm1Un; EKO; apoE-; apoE0; epsilon-; mE^-; mEKO
Gene Symbol and Name	Apoe, apolipoprotein E
Gene Synonym(s)	AD2; AI255918; APO-E; APOEA; ApoE4; LDLCQ5; LPG; expressed sequence AI255918
Strain of Origin	129P2/OlaHsd
Chromosome	7
Molecular Note	Insertion of a neomycin resistance cassette deleted part of exon 3 and part of intron 3 of the Apoe gene. Plasma from homozygous mutant mice gave no detectable immunoprecipitate by the Ouchterlony double immunodiffusion test using a rabbit antibody to rat APOE.
Mutations Made By	Dr. Nobuyo Maeda, University of North Carolina at Chapel Hill

Tg(GFAP-APOE_i3)37Hol

Allele Symbol: Tg(GFAP-APOE_i3)37Hol

Allele Name	transgene insertion 37, David M Holtzman
Allele Type	Transgenic (Humanized sequence, Inserted expressed sequence)
Allele Synonym(s)	GFAP-apoE3 line 37; Tg(GFAP-APOE*3)37Hol; Tg(GFAP-APOE3)37Hol
Gene Symbol and Name	Tg(GFAP-APOE_i3)37Hol, transgene insertion 37, David M Holtzman
Gene Synonym(s)	GFAP-apoE3 line 37; Tg(GFAP-APOE3)37Hol; Tg(GFAP-APOE3)37Hol; Tg(GFAP-APOE3)37Hol; Tg(GFAP-APOE3)37Hol
Promoter	GFAP, glial fibrillary acidic protein, human
Expressed Gene	APOE, apolipoprotein E, human
Strain of Origin	C57BL/6 and CBA
Chromosome	UN
Molecular Note	The transgene contains sequence encoding human apolipoprotein E3 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Two lines were created (lines 2 and 37) with line 37 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice.
Mutations Made By	Dr. David Holtzman, Washington University

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Apoe^tm1Unc related

Cardiovascular Research
- Atherosclerosis
- Hypercholesterolemia

Genotype: Tg(GFAP-APOE_i3)37Hol related

Neurobiology Research
- Alzheimer's Disease
  - APOE mutants

Mammalian Phenotype Terms by Genotype

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i3)37Hol/0
B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/J

nervous system phenotype

abnormal astrocyte physiology
- the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoe^tm1Unc homozygotes

abnormal axon extension
- however, neurite outgrowth rate is equivalent to in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG
- in vitro, neurite length is longer than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons
- in vitro, neuron outgrowth is faster than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons

cellular phenotype

abnormal axon extension
- however, neurite outgrowth rate is equivalent to in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG
- in vitro, neurite length is longer than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons
- in vitro, neuron outgrowth is faster than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i3)37Hol/0
B6.Cg-Apoe^tm1Unc Tg(GFAP-APOE_i3)37Hol

behavior/neurological phenotype

abnormal fear/anxiety-related behavior
- mice exhibit increased protected risk assessment behaviors in an elevated plus maze compared to wild-type mice

abnormal locomotor behavior
- mice spend less time than wild-type mice in the center of an open field

abnormal response to new environment
- mice are less reluctant than wild-type mice to move into an open area
- mice consume food slower in a new environment than Tg(GFAP-APOE_i4)#Hol Apoe^tm1Unc/Apoe^tm1Unc and wild-type mice
- mice require more time to habituate to a novel environment compared to wild-type mice

abnormal spatial learning
- at 14 to 17 months of age, mice perform better than Tg(GFAP-APOE_i4)#Hol Apoe^tm1Unc/Apoe^tm1Unc and wild-type mice in a rotating holeboard test

abnormal stationary movement
- mice exhibit increased numbers of fine movement (not related to ambulation) compared to wild-type mice

decreased startle reflex
- compared to wild-type mice

References

Sun Y; Wu S; Bu G; Onifade MK; Patel SN; LaDu MJ; Fagan AM; Holtzman DM. 1998. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci 18(9):3261-72. PubMed: 9547235 MGI: J:93487

Additional References

Holtzman DM; Bales KR; Tenkova T; Fagan AM; Parsadanian M; Sartorius LJ; Mackey B; Olney J; McKeel D; Wozniak D; Paul SM. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 97(6):2892-7. PubMed: 10694577 MGI: J:61176

Additional - Apoe^tm1Unc related

't Hoen PA; Van der Lans CA; Van Eck M; Bijsterbosch MK; Van Berkel TJ; Twisk J. 2003. Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes. Circ Res 93(3):262-9. PubMed: 12829615 MGI: J:115676
1931790Biswas S; Xin L; Panigrahi S; Zimman A; Wang H; Yakubenko VP; Byzova TV; Salomon RG; Podrez EA. 2016. Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2. Blood 127(21):2618-29. PubMed: 27015965 MGI: J:233074
A-Gonzalez N; Bensinger SJ; Hong C; Beceiro S; Bradley MN; Zelcer N; Deniz J; Ramirez C; Diaz M; Gallardo G; de Galarreta CR; Salazar J; Lopez F; Edwards P; Parks J; Andujar M; Tontonoz P; Castrillo A. 2009. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31(2):245-58. PubMed: 19646905 MGI: J:151872
Abd Alla J; Langer A; Elzahwy SS; Arman-Kalcek G; Streichert T; Quitterer U. 2010. Angiotensin-converting enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 (CCR9)-chemokine ligand 25 (CCL25) axis. J Biol Chem 285(30):23496-505. PubMed: 20504763 MGI: J:165997
Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. PubMed: 10727439 MGI: J:61147
Adachi H; Fujiwara Y; Kondo T; Nishikawa T; Ogawa R; Matsumura T; Ishii N; Nagai R; Miyata K; Tabata M; Motoshima H; Furukawa N; Tsuruzoe K; Kawashima J; Takeya M; Yamashita S; Koh GY; Nagy A; Suda T; Oike Y; Araki E. 2009. Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. Biochem Biophys Res Commun 379(4):806-11. PubMed: 19094966 MGI: J:145171
Agrawal S; Febbraio M; Podrez E; Cathcart MK; Stark GR; Chisolm GM. 2007. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115(23):2939-47. PubMed: 17533179 MGI: J:137115
Ahluwalia N; Lin AY; Tager AM; Pruitt IE; Anderson TJ; Kristo F; Shen D; Cruz AR; Aikawa M; Luster AD; Gerszten RE. 2007. Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol 179(1):691-7. PubMed: 17579092 MGI: J:143153
Aihara K; Azuma H; Akaike M; Ikeda Y; Sata M; Takamori N; Yagi S; Iwase T; Sumitomo Y; Kawano H; Yamada T; Fukuda T; Matsumoto T; Sekine K; Sato T; Nakamichi Y; Yamamoto Y; Yoshimura K; Watanabe T; Nakamura T; Oomizu A; Tsukada M; Hayashi H; Sudo T; KatoS; Matsumoto T. 2007. Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice. J Clin Invest 117(6):1514-26. PubMed: 17549254 MGI: J:122173
Aikawa E; Nahrendorf M; Sosnovik D; Lok VM; Jaffer FA; Aikawa M; Weissleder R. 2007. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115(3):377-86. PubMed: 17224478 MGI: J:130156
Alberts-Grill N; Rezvan A; Son DJ; Qiu H; Kim CW; Kemp ML; Weyand CM; Jo H. 2012. Dynamic immune cell accumulation during flow-induced atherogenesis in mouse carotid artery: an expanded flow cytometry method. Arterioscler Thromb Vasc Biol 32(3):623-32. PubMed: 22247254 MGI: J:195958
Alexander MR; Knowles JW; Nishikimi T; Maeda N. 2003. Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 23(6):1077-82. PubMed: 12702516 MGI: J:103054
Alexander MR; Moehle CW; Johnson JL; Yang Z; Lee JK; Jackson CL; Owens GK. 2012. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 122(1):70-9. PubMed: 22201681 MGI: J:184390
Ali K; Middleton M; Pure E; Rader DJ. 2005. Apolipoprotein E suppresses the type I inflammatory response in vivo. Circ Res 97(9):922-7. PubMed: 16179587 MGI: J:114634
Ali ZA; de Jesus Perez V; Yuan K; Orcholski M; Pan S; Qi W; Chopra G; Adams C; Kojima Y; Leeper NJ; Qu X; Zaleta-Rivera K; Kato K; Yamada Y; Oguri M; Kuchinsky A; Hazen SL; Jukema JW; Ganesh SK; Nabel EG; Channon K; Leon MB; Charest A; Quertermous T; Ashley EA. 2014. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. J Clin Invest 124(12):5159-74. PubMed: 25401476 MGI: J:219378
Alkemade FE; van Vliet P; Henneman P; van Dijk KW; Hierck BP; van Munsteren JC; Scheerman JA; Goeman JJ; Havekes LM; Gittenberger-de Groot AC; van den Elsen PJ; DeRuiter MC. 2010. Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature. Am J Pathol 176(2):542-8. PubMed: 20035052 MGI: J:156605
Alp NJ; McAteer MA; Khoo J; Choudhury RP; Channon KM. 2004. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 24(3):445-50. PubMed: 14707037 MGI: J:102062
Amar S; Wu SC; Madan M. 2009. Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications. J Immunol 182(3):1584-92. PubMed: 19155507 MGI: J:144322
Amigo L; Quinones V; Mardones P; Zanlungo S; Miquel JF; Nervi F; Rigotti A. 2000. Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet. Gastroenterology 118(4):772-9. PubMed: 10734029 MGI: J:107676
Amirbekian S; Long RC Jr; Consolini MA; Suo J; Willett NJ; Fielden SW; Giddens DP; Taylor WR; Oshinski JN. 2009. In vivo assessment of blood flow patterns in abdominal aorta of mice with MRI: implications for AAA localization. Am J Physiol Heart Circ Physiol 297(4):H1290-5. PubMed: 19684182 MGI: J:154334
An G; Miwa T; Song WL; Lawson JA; Rader DJ; Zhang Y; Song WC. 2009. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol 46(8-9):1702-9. PubMed: 19297024 MGI: J:148359
An G; Wang H; Tang R; Yago T; McDaniel JM; McGee S; Huo Y; Xia L. 2008. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 117(25):3227-37. PubMed: 18519846 MGI: J:155081
Anderson DR; Tsutsui JM; Xie F; Radio SJ; Porter TR. 2007. The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque. Cardiovasc Res 73(3):597-606. PubMed: 17196951 MGI: J:119533
Anderson R; Barnes JC; Bliss TV; Cain DP; Cambon K; Davies HA; Errington ML; Fellows LA; Gray RA; Hoh T; Stewart M; Large CH; Higgins GA. 1998. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse. Neuroscience 85(1):93-110. PubMed: 9607706 MGI: J:118390
Anderson R; Higgins GA. 1997. Absence of central cholinergic deficits in ApoE knockout mice. Psychopharmacology (Berl) 132(2):135-44. PubMed: 9266610 MGI: J:127860
Andersson IJ; Jiang YY; Davidge ST. 2009. Maternal stress and development of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring. Am J Physiol Regul Integr Comp Physiol 296(3):R663-71. PubMed: 19129374 MGI: J:145701
Ando Y; Shimizugawa T; Takeshita S; Ono M; Shimamura M; Koishi R; Furukawa H. 2003. A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res 44(6):1216-23. PubMed: 12671033 MGI: J:84022
Andre P; Morooka T; Sim D; Abe K; Lowell C; Nanda N; Delaney S; Siu G; Yan Y; Hollenbach S; Pandey A; Gao H; Wang Y; Nakajima K; Parikh SA; Shi C; Phillips D; Owen W; Sinha U; Simon DI. 2011. Critical role for Syk in responses to vascular injury. Blood 118(18):5000-10. PubMed: 21881044 MGI: J:178801
Andrews-Zwilling Y; Bien-Ly N; Xu Q; Li G; Bernardo A; Yoon SY; Zwilling D; Yan TX; Chen L; Huang Y. 2010. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci 30(41):13707-17. PubMed: 20943911 MGI: J:165492
Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. PubMed: 15485633 MGI: J:93917
Angsana J; Chen J; Smith S; Xiao J; Wen J; Liu L; Haller CA; Chaikof EL. 2015. Syndecan-1 modulates the motility and resolution responses of macrophages. Arterioscler Thromb Vasc Biol 35(2):332-40. PubMed: 25550207 MGI: J:240984
Aono J; Suzuki J; Iwai M; Horiuchi M; Nagai T; Nishimura K; Inoue K; Ogimoto A; Okayama H; Higaki J. 2012. Deletion of the angiotensin II type 1a receptor prevents atherosclerotic plaque rupture in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 32(6):1453-9. PubMed: 22460554 MGI: J:196922
Apostolov EO; Ray D; Savenka AV; Shah SV; Basnakian AG. 2010. Chronic uremia stimulates LDL carbamylation and atherosclerosis. J Am Soc Nephrol 21(11):1852-7. PubMed: 20947625 MGI: J:185898
Aprahamian T; Bonegio R; Rizzo J; Perlman H; Lefer DJ; Rifkin IR; Walsh K. 2006. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol 177(5):3028-34. PubMed: 16920939 MGI: J:139547
Aprahamian T; Bonegio RG; Richez C; Yasuda K; Chiang LK; Sato K; Walsh K; Rifkin IR. 2009. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182(1):340-6. PubMed: 19109165 MGI: J:142895
Aprahamian T; Rifkin I; Bonegio R; Hugel B; Freyssinet JM; Sato K; Castellot JJ Jr; Walsh K. 2004. Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease. J Exp Med 199(8):1121-31. PubMed: 15096538 MGI: J:91058
Arakawa M; Mita T; Azuma K; Ebato C; Goto H; Nomiyama T; Fujitani Y; Hirose T; Kawamori R; Watada H. 2010. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 59(4):1030-7. PubMed: 20068138 MGI: J:164336
Arnold L; Perrin H; de Chanville CB; Saclier M; Hermand P; Poupel L; Guyon E; Licata F; Carpentier W; Vilar J; Mounier R; Chazaud B; Benhabiles N; Boissonnas A; Combadiere B; Combadiere C. 2015. CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production. Nat Commun 6:8972. PubMed: 26632270 MGI: J:228319
Arsenescu V; Arsenescu R; Parulkar M; Karounos M; Zhang X; Baker N; Cassis LA. 2011. Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice. Toxicol Appl Pharmacol 257(1):148-54. PubMed: 21925196 MGI: J:178556
Ashida N; Senbanerjee S; Kodama S; Foo SY; Coggins M; Spencer JA; Zamiri P; Shen D; Li L; Sciuto T; Dvorak A; Gerszten RE; Lin CP; Karin M; Rosenzweig A. 2011. IKKbeta regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun 2:318. PubMed: 21587235 MGI: J:205654
Ason B; van der Hoorn JW; Chan J; Lee E; Pieterman EJ; Nguyen KK; Di M; Shetterly S; Tang J; Yeh WC; Schwarz M; Jukema JW; Scott R; Wasserman SM; Princen HM; Jackson S. 2014. PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE. J Lipid Res 55(11):2370-9. PubMed: 25258384 MGI: J:216603
Atkins GB; Wang Y; Mahabeleshwar GH; Shi H; Gao H; Kawanami D; Natesan V; Lin Z; Simon DI; Jain MK. 2008. Hemizygous deficiency of Kruppel-like factor 2 augments experimental atherosclerosis. Circ Res 103(7):690-3. PubMed: 18757824 MGI: J:155153
Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 294(2):E284-90. PubMed: 18029445 MGI: J:133332
Auger A; Truong TQ; Rhainds D; Lapointe J; Letarte F; Brissette L. 2001. Low and high density lipoprotein metabolism in primary cultures of hepatic cells from normal and apolipoprotein E knockout mice. Eur J Biochem 268(8):2322-30. PubMed: 11298750 MGI: J:115588
Aung HH; Altman R; Nyunt T; Kim J; Nuthikattu S; Budamagunta M; Voss JC; Wilson D; Rutledge JC; Villablanca AC. 2016. Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways. J Lipid Res 57(6):955-68. PubMed: 27087439 MGI: J:233751
Austin SA; Combs CK. 2010. Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice. Neurobiol Aging 31(11):1854-66. PubMed: 19058878 MGI: J:165242
Avraham-Davidi I; Ely Y; Pham VN; Castranova D; Grunspan M; Malkinson G; Gibbs-Bar L; Mayseless O; Allmog G; Lo B; Warren CM; Chen TT; Ungos J; Kidd K; Shaw K; Rogachev I; Wan W; Murphy PM; Farber SA; Carmel L; Shelness GS; Iruela-Arispe ML; Weinstein BM; Yaniv K. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med 18(6):967-73. PubMed: 22581286 MGI: J:187459
Azevedo OG; Bolick DT; Roche JK; Pinkerton RF; Lima AA; Vitek MP; Warren CA; Oria RB; Guerrant RL. 2014. Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. PLoS One 9(2):e89562. PubMed: 24586873 MGI: J:213815
Azuma K; Ichimura K; Mita T; Nakayama S; Jin WL; Hirose T; Fujitani Y; Sumiyoshi K; Shimada K; Daida H; Sakai T; Mitsumata M; Kawamori R; Watada H. 2009. Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta. Biochem Biophys Res Commun 380(3):620-6. PubMed: 19285011 MGI: J:147062
Baba SP; Barski OA; Ahmed Y; O'Toole TE; Conklin DJ; Bhatnagar A; Srivastava S. 2009. Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue. Diabetes 58(11):2486-97. PubMed: 19651811 MGI: J:154389
Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. PubMed: 16380543 MGI: J:121507
Babaev VR; Li L; Shah S; Fazio S; Linton MF; May JM. 2010. Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 30(9):1751-7. PubMed: 20558818 MGI: J:179551
Bagavant H; Scindia Y; Nackiewicz D; Rao Nandula S; Doran A; Cutchins A; Oldham S; Deshmukh U; McNamara C. 2011. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein e-deficient mice a model linking hyperlipidemia and renal disease. Am J Pathol 179(2):651-60. PubMed: 21801865 MGI: J:174603
Bai B; Liang Y; Xu C; Lee MY; Xu A; Wu D; Vanhoutte PM; Wang Y. 2012. Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation 126(6):729-40. PubMed: 22753194 MGI: J:202201
Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. PubMed: 16888235 MGI: J:128048
Bales KR; Liu F; Wu S; Lin S; Koger D; DeLong C; Hansen JC; Sullivan PM; Paul SM. 2009. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. J Neurosci 29(21):6771-9. PubMed: 19474305 MGI: J:149522
Bales KR; Verina T; Cummins DJ; Du Y; Dodel RC; Saura J; Fishman CE; DeLong CA; Piccardo P; Petegnief V; Ghetti B; Paul SM. 1999. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 96(26):15233-8. PubMed: 10611368 MGI: J:59078
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Zeibig S; Li Z; Wagner S; Holthoff HP; Ungerer M; Bultmann A; Uhland K; Vogelmann J; Simmet T; Gawaz M; Munch G. 2011. Effect of the oxLDL binding protein Fc-CD68 on plaque extension and vulnerability in atherosclerosis. Circ Res 108(6):695-703. PubMed: 21293004 MGI: J:183595
Zerbi V; Wiesmann M; Emmerzaal TL; Jansen D; Van Beek M; Mutsaers MP; Beckmann CF; Heerschap A; Kiliaan AJ. 2014. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice. J Neurosci 34(42):13963-75. PubMed: 25319693 MGI: J:217160
Zernecke A; Bot I; Djalali-Talab Y; Shagdarsuren E; Bidzhekov K; Meiler S; Krohn R; Schober A; Sperandio M; Soehnlein O; Bornemann J; Tacke F; Biessen EA; Weber C. 2008. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 102(2):209-17. PubMed: 17991882 MGI: J:145593
Zernecke A; Liehn EA; Fraemohs L; von Hundelshausen P; Koenen RR; Corada M; Dejana E; Weber C. 2006. Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol 26(2):e10-3. PubMed: 16306427 MGI: J:127969
Zernecke A; Liehn EA; Gao JL; Kuziel WA; Murphy PM; Weber C. 2006. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. Blood 107(11):4240-3. PubMed: 16467202 MGI: J:128843
Zernecke A; Schober A; Bot I; von Hundelshausen P; Liehn EA; Mopps B; Mericskay M; Gierschik P; Biessen EA; Weber C. 2005. SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res 96(7):784-91. PubMed: 15761195 MGI: J:137758
Zerr M; Hechler B; Freund M; Magnenat S; Lanois I; Cazenave JP; Leon C; Gachet C. 2011. Major contribution of the P2Y(1)receptor in purinergic regulation of TNFalpha-induced vascular inflammation. Circulation 123(21):2404-13. PubMed: 21576651 MGI: J:184116
Zetterqvist AV; Berglund LM; Blanco F; Garcia-Vaz E; Wigren M; Duner P; Andersson AM; To F; Spegel P; Nilsson J; Bengtsson E; Gomez MF. 2013. Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice. PLoS One 8(6):e65020. PubMed: 23755169 MGI: J:203205
Zhang C; van der Voort D; Shi H; Zhang R; Qing Y; Hiraoka S; Takemoto M; Yokote K; Moxon JV; Norman P; Rittie L; Kuivaniemi H; Atkins GB; Gerson SL; Shi GP; Golledge J; Dong N; Perbal B; Prosdocimo DA; Lin Z. 2016. Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest 126(4):1282-99. PubMed: 26974158 MGI: J:234658
Zhang D; Jiang X; Fang P; Yan Y; Song J; Gupta S; Schafer AI; Durante W; Kruger WD; Yang X; Wang H. 2009. Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation 120(19):1893-902. PubMed: 19858416 MGI: J:168131
Zhang G; Thomas AL; Marshall AL; Kernan KA; Su Y; Zheng Y; Takano J; Saido TC; Eddy AA. 2011. Nicotinic acetylcholine receptor alpha1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy. Lab Invest 91(1):106-23. PubMed: 20661225 MGI: J:167191
Zhang L; Connelly JJ; Peppel K; Brian L; Shah SH; Nelson S; Crosslin DR; Wang T; Allen A; Kraus WE; Gregory SG; Hauser ER; Freedman NJ. 2010. Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. Hum Mol Genet 19(14):2754-66. PubMed: 20421368 MGI: J:161330
Zhang L; Peppel K; Sivashanmugam P; Orman ES; Brian L; Exum ST; Freedman NJ. 2007. Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arterioscler Thromb Vasc Biol 27(5):1087-94. PubMed: 17442899 MGI: J:128059
Zhang S; Picard MH; Vasile E; Zhu Y; Raffai RL; Weisgraber KH; Krieger M. 2005. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation 111(25):3457-64. PubMed: 15967843 MGI: J:114611
Zhang SH; Reddick RL; Burkey B; Maeda N. 1994. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest 94(3):937-45. PubMed: 8083379 MGI: J:20459
Zhang SH; Reddick RL; Piedrahita JA; Maeda N. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258(5081):468-71. PubMed: 1411543 MGI: J:16573
Zhang T; Dai P; Cheng D; Zhang L; Chen Z; Meng X; Zhang F; Han X; Liu J; Pan J; Yang G; Zhang C. 2014. Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. Reproduction 147(2):141-51. PubMed: 24196014 MGI: J:207680
Zhang W; Yancey PG; Su YR; Babaev VR; Zhang Y; Fazio S; Linton MF. 2003. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 108(18):2258-63. PubMed: 14581413 MGI: J:103014
Zhang WJ; Bird KE; McMillen TS; LeBoeuf RC; Hagen TM; Frei B. 2008. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 117(3):421-8. PubMed: 18158360 MGI: J:145089
Zhang X; Thatcher SE; Rateri DL; Bruemmer D; Charnigo R; Daugherty A; Cassis LA. 2012. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res 110(11):e73-85. PubMed: 22539767 MGI: J:212660
Zhang X; Zhu X; Chen B. 2010. Inhibition of collar-induced carotid atherosclerosis by recombinant apoA-I cysteine mutants in apoE-deficient mice. J Lipid Res 51(12):3434-42. PubMed: 20817832 MGI: J:167029
Zhao L; Gottesdiener AJ; Parmar M; Li M; Kaminsky SM; Chiuchiolo MJ; Sondhi D; Sullivan PM; Holtzman DM; Crystal RG; Paul SM. 2016. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. Neurobiol Aging 44:159-72. PubMed: 27318144 MGI: J:239037
Zhao L; Pratico D; Rader DJ; Funk CD. 2005. 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway. Prostaglandins Other Lipid Mediat 78(1-4):185-93. PubMed: 16303615 MGI: J:112785
Zhao Y; Chen X; Yang H; Zhou L; Okoro EU; Guo Z. 2011. A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. PLoS One 6(7):e21453. PubMed: 21779326 MGI: J:223907
Zhao Y; Howatt DA; Gizard F; Nomiyama T; Findeisen HM; Heywood EB; Jones KL; Conneely OM; Daugherty A; Bruemmer D. 2010. Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circ Res 107(4):501-11. PubMed: 20558821 MGI: J:175040
Zhi X; Xu C; Zhang H; Tian D; Li X; Ning Y; Yin L. 2013. Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice. PLoS One 8(4):e60960. PubMed: 23573292 MGI: J:200146
Zhou AX; Wang X; Lin CS; Han J; Yong J; Nadolski MJ; Boren J; Kaufman RJ; Tabas I. 2015. C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circ Res 116(11):1736-43. PubMed: 25872946 MGI: J:233223
Zhou C; King N; Chen KY; Breslow JL. 2009. Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apolipoprotein E deficient mice. J Lipid Res 50:2004-2013. PubMed: 19436068 MGI: J:154141
Zhou J; Dimayuga PC; Zhao X; Yano J; Lio WM; Trinidad P; Honjo T; Cercek B; Shah PK; Chyu KY. 2014. CD8(+)CD25(+) T cells reduce atherosclerosis in apoE(-/-) mice. Biochem Biophys Res Commun 443(3):864-70. PubMed: 24342615 MGI: J:211854
Zhou J; Lee PL; Tsai CS; Lee CI; Yang TL; Chuang HS; Lin WW; Lin TE; Lim SH; Wei SY; Chen YL; Chien S; Chiu JJ. 2012. Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow. Proc Natl Acad Sci U S A 109(20):7770-5. PubMed: 22550179 MGI: J:184788
Zhou J; Lhotak S; Hilditch BA; Austin RC. 2005. Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 111(14):1814-21. PubMed: 15809369 MGI: J:109687
Zhou X; Hansson GK. 1999. Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice. Scand J Immunol 50(1):25-30. PubMed: 10404048 MGI: J:56605
Zhou X; Paulsson G; Stemme S; Hansson GK. 1998. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J Clin Invest 101(8):1717-25. PubMed: 9541503 MGI: J:47027
Zhou X; Robertson AK; Rudling M; Parini P; Hansson GK. 2005. Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis. Circ Res 96(4):427-34. PubMed: 15662027 MGI: J:106869
Zhou X; Stemme S; Hansson GK. 1996. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice [see comments] Am J Pathol 149(2):359-66. PubMed: 8701976 MGI: J:34435
Zhou Y; Cheshire A; Howell LA; Ryan DH; Harris RB. 1999. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice. Brain Res Bull 49(3):173-9. PubMed: 10435780 MGI: J:110915
Zhou Z; Subramanian P; Sevilmis G; Globke B; Soehnlein O; Karshovska E; Megens R; Heyll K; Chun J; Saulnier-Blache JS; Reinholz M; van Zandvoort M; Weber C; Schober A. 2011. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab 13(5):592-600. PubMed: 21531341 MGI: J:175811
Zhu B; Kuhel DG; Witte DP; Hui DY. 2000. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice Am J Pathol 157(6):1839-48. PubMed: 11106557 MGI: J:66130
Zhu J; Chen T; Yang L; Li Z; Wong MM; Zheng X; Pan X; Zhang L; Yan H. 2012. Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10. PLoS One 7(11):e46551. PubMed: 23189122 MGI: J:195455
Zhu L; Zhong M; Elder GA; Sano M; Holtzman DM; Gandy S; Cardozo C; Haroutunian V; Robakis NK; Cai D. 2015. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proc Natl Acad Sci U S A 112(38):11965-70. PubMed: 26372964 MGI: J:226992
Zimmer S; Steinmetz M; Asdonk T; Motz I; Coch C; Hartmann E; Barchet W; Wassmann S; Hartmann G; Nickenig G. 2011. Activation of endothelial toll-like receptor 3 impairs endothelial function. Circ Res 108(11):1358-66. PubMed: 21493895 MGI: J:185699
d'Uscio LV; Baker TA; Mantilla CB; Smith L; Weiler D; Sieck GC; Katusic ZS. 2001. Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 21(6):1017-22. PubMed: 11397713 MGI: J:103189
d'Uscio LV; Katusic ZS. 2006. Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 290(6):H2466-71. PubMed: 16428344 MGI: J:111845
d'Uscio LV; Smith LA; Katusic ZS. 2001. Hypercholesterolemia impairs endothelium-dependent relaxations in common carotid arteries of apolipoprotein e-deficient mice. Stroke 32(11):2658-64. PubMed: 11692031 MGI: J:104001
ten Freyhaus H; Calay ES; Yalcin A; Vallerie SN; Yang L; Calay ZZ; Saatcioglu F; Hotamisligil GS. 2012. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab 16(1):81-9. PubMed: 22704678 MGI: J:187419
van Gils JM; Derby MC; Fernandes LR; Ramkhelawon B; Ray TD; Rayner KJ; Parathath S; Distel E; Feig JL; Alvarez-Leite JI; Rayner AJ; McDonald TO; O'Brien KD; Stuart LM; Fisher EA; Lacy-Hulbert A; Moore KJ. 2012. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 13(2):136-43. PubMed: 22231519 MGI: J:181210
van Haperen R; de Waard M; van Deel E; Mees B; Kutryk M; van Aken T; Hamming J; Grosveld F; Duncker DJ; de Crom R. 2002. Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide. J Biol Chem 277(50):48803-7. PubMed: 12364322 MGI: J:80701
van Meer P; Pfankuch T; Raber J. 2007. Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- mice. J Neurochem 103(1):124-30. PubMed: 17573822 MGI: J:128042
von Dehn G; von Dehn O; Volker W; Langer C; Weinbauer GF; Behre HM; Nieschlag E; Assmann G; von Eckardstein A. 2001. Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones. Horm Metab Res 33(2):110-4. PubMed: 11294492 MGI: J:68906

Additional - Tg(GFAP-APOE_i3)37Hol related

Fagan AM; Holtzman DM; Munson G; Mathur T; Schneider D; Chang LK; Getz GS; Reardon CA; Lukens J; Shah JA; LaDu MJ. 1999. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem 274(42):30001-7. PubMed: 10514484 MGI: J:58019
Fagan AM; Watson M; Parsadanian M; Bales KR; Paul SM; Holtzman DM. 2002. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis 9(3):305-18. PubMed: 11950276 MGI: J:127846
Han X; Cheng H; Fryer JD; Fagan AM; Holtzman DM. 2003. Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content. J Biol Chem 278(10):8043-51. PubMed: 12501252 MGI: J:131491
Hartman RE; Laurer H; Longhi L; Bales KR; Paul SM; McIntosh TK; Holtzman DM. 2002. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci 22(23):10083-7. PubMed: 12451108 MGI: J:133058
Hartman RE; Wozniak DF; Nardi A; Olney JW; Sartorius L; Holtzman DM. 2001. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Exp Neurol 170(2):326-44. PubMed: 11476599 MGI: J:71062
Hayashi H; Campenot RB; Vance DE; Vance JE. 2009. Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin. J Biol Chem 284(43):29605-13. PubMed: 19717566 MGI: J:156971
Holtzman DM; Bales KR; Wu S; Bhat P; Parsadanian M; Fagan AM; Chang LK; Sun Y; Paul SM. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest 103(6):R15-R21. PubMed: 10079115 MGI: J:53613
Jain S; Yoon SY; Leung L; Knoferle J; Huang Y. 2013. Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development. PLoS One 8(3):e59478. PubMed: 23527202 MGI: J:200182
Ji Y; Gong Y; Gan W; Beach T; Holtzman DM; Wisniewski T. 2003. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience 122(2):305-15. PubMed: 14614898 MGI: J:126171
Koistinaho M; Kettunen MI; Holtzman DM; Kauppinen RA; Higgins LS; Koistinaho J. 2002. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Stroke 33(7):1905-10. PubMed: 12105373 MGI: J:133156
Matsuo M; Campenot RB; Vance DE; Ueda K; Vance JE. 2011. Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Biochim Biophys Acta 1811(1):31-8. PubMed: 21040802 MGI: J:170292
Yao J; Petanceska SS; Montine TJ; Holtzman DM; Schmidt SD; Parker CA; Callahan MJ; Lipinski WJ; Bisgaier CL; Turner BA; Nixon RA; Martins RN; Ouimet C; Smith JD; Davies P; Laska E; Ehrlich ME; Walker LC; Mathews PM; Gandy S. 2004. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. J Neurochem 90(4):1011-8. PubMed: 15287908 MGI: J:107867
Zhang HL; Mao XJ; Zhang XM; Li HF; Zheng XY; Adem A; Mix E; Zhu J. 2011. APOE epsilon3 attenuates experimental autoimmune neuritis by modulating T cell, macrophage and Schwann cell functions. Exp Neurol 230(2):197-206. PubMed: 21550340 MGI: J:172657

Also Known As: GFAP-apoE3 line 37, Tg(GFAP-APOE*3)37Hol

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Apoetm1Unc

Allele Symbol: Apoetm1Unc

Tg(GFAP-APOE_i3)37Hol

Allele Symbol: Tg(GFAP-APOE_i3)37Hol

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This mouse can be used to support research in many areas including:

Genotype: Apoetm1Unc related

Genotype: Tg(GFAP-APOE_i3)37Hol related

Mammalian Phenotype Terms by Genotype

Genotype: Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i3)37Hol/0B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/J

nervous system phenotype

cellular phenotype

Genotype: Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i3)37Hol/0B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol

behavior/neurological phenotype

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Additional - Tg(GFAP-APOE_i3)37Hol related

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

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Apoe^tm1Unc

Allele Symbol: Apoe^tm1Unc

Genotype: Apoe^tm1Unc related

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i3)37Hol/0
B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/J

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i3)37Hol/0
B6.Cg-Apoe^tm1Unc Tg(GFAP-APOE_i3)37Hol

Additional - Apoe^tm1Unc related