JAX
Mouse Strain Datasheet - 004623
STOCK Tg(TCF/Lef1-lacZ)34Efu/J
Also Known As: TOPGAL
These TOPGAL transgenic mice express Beta-galactosidase as a reporter in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 mediated signaling pathway and activated Beta-catenin. Beta-galactosidase activity is displayed during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles, This strain represents an effective tool for generating mutants that would be useful in studies of the Wnt signaling pathway.
Donating Investigator
Elaine Fuchs, The Rockefeller University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
|
Gnat2cpfl3
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Gnat2 | guanine nucleotide binding protein, alpha transducing 2 |
Tg(TCF/Lef1-lacZ)34Efu
| Allele Type |
|---|
| Transgenic (Reporter) |
Research Applications
- Cell Biology Research
- Dermatology Research
- Developmental Biology Research
- Research Tools
- Sensorineural Research
Important Note
This strain may be homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.
Detailed Description
These TOPGAL transgenic mice are a reporter strain that express Beta-galactosidase in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 (LEF/TCF) mediated signaling pathway and activated Beta-catenin. The transgene contains the lacZ gene under the control of a regulatory sequence consisting of three consensus LEF/TCF-binding motifs upstream of a minimal c-fos promoter. Transgenic mice display TOPGAL activity (Beta-galactosidase activity) during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles, but not during the next stage of hair follicle development; formation of hair germs. TOPGAL transgene activity reappears in hair follicles at E16.5 and TOPGAL expression is strongly upregulated in the postnatal hair shaft precursor cells in both whisker and body hair anagen follicles (active periods of hair growth). TOPGAL expression ceases during catagen (regression and shortening) and telogen (rest) periods of the postnatal hair growth cycle. Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating mutants that would be useful in studies of the Wnt signaling pathway.
Development
The TOPGAL transgene was designed by Dr. Elaine Fuchs (while at The University of Chicago) with three copies of a T cell specific transcription factor/lymphoid enhancer-binding factor 1 (TCF/Lef1) consensus binding site and the FBJ osteosarcoma oncogene (Fos; c-fos) minimal promoter upstream of the β-galactosidase gene (lacZ). In 2003, TOPGAL mice on a CD-1 genetic background were sent to The Jackson Laboratory Repository as Stock No. 004623. This strain may be homozygous for Gnat2cpfl3 (cone photoreceptor function loss 3), which affects bright light (photopic) vision.
Expression Data
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
|---|---|
| Site of Expression | lacZ expression occurs during early embryonic development in a subset of pluripotent embryonic basel cells of the epithelium and dermis of developing hair follicles. lacZ expression disappears during formation of hair germ and then reappears at E16.5 in hair follicles until 18 days after birth. |
Control Suggestions
Selected References
- DasGupta R; Fuchs E. 1999. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126(20):4557-68. PubMed: 10498690MGI: J:55937
Gnat2cpfl3
Allele Symbol: Gnat2cpfl3
| Allele Name | cone photoreceptor function loss 3 |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | no cones |
| Gene Symbol and Name | Gnat2, guanine nucleotide binding protein, alpha transducing 2 |
| Gene Synonym(s) | ACHM4; AW490837; GNATC; Gnat-2; Gnat-2; Gt-2; Tcalpha; expressed sequence AW490837 |
| Strain of Origin | various |
| Chromosome | 3 |
| General Note | This allele has been detected in the following strains either by genotyping or complementation testing: ALS/LtJ, SENCARA/PtJ, SENCARB/PtJ, SENCARC/PtJ, PN/nBSwUmabJ. (J:122428) The allele has also been reported in NMRI and CD1 (Lluis Montoliu, J:212307) |
| Molecular Note | A single nucleotide substitution of G to A at position 598 in exon 6. This mutation converts codon 200 from aspartic acid to asparagine. |
Tg(TCF/Lef1-lacZ)34Efu
Allele Symbol: Tg(TCF/Lef1-lacZ)34Efu
| Allele Name | transgene insertion 34, Elaine Fuchs |
|---|---|
| Allele Type | Transgenic (Reporter) |
| Allele Synonym(s) | TCF-betagal; TOPGAL; Tg(Fos-lacZ)34Efu; Top-Gal |
| Gene Symbol and Name | Tg(TCF/Lef1-lacZ)34Efu, transgene insertion 34, Elaine Fuchs |
| Gene Synonym(s) | TCF-betagal; TOPGAL; Tg(Fos-lacZ)34Efu; Tg(Fos-lacZ)34Efu; Top-Gal |
| Promoter | Fos, Fos proto-oncogene, AP-1 transcription factor subunit, rat |
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
| Site of Expression | lacZ expression occurs during early embryonic development in a subset of pluripotent embryonic basel cells of the epithelium and dermis of developing hair follicles. lacZ expression disappears during formation of hair germ and then reappears at E16.5 in hair follicles until 18 days after birth. |
| Strain of Origin | Not Specified |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Transgenic mice express beta-galactosidase in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 (LEF1/TCF3) mediated signaling pathway and activated Beta-catenin (CATNB). Transgenic mice display Beta-galactosidase activity during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles. Beta-galactosidase activity is not detected in the next stage of hair follicle development, formation of hair germs. At E16.5, transgene activity reappears in hair follicles and is detectable until 18 days after birth. |
| Molecular Note | The transgene contains the lacZ gene under the control of a promoter consisting of three consensus lymphoid enhancer binding factor 1/transcription factor 3 (LEF/TCF)-binding motifs upstream of a minimal Fos promoter. This allele is responsive to canonical Wnt/beta-catenin signal transduction. |
| Mutations Made By | Elaine Fuchs, The Rockefeller University |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cell Biology Research
- Signal Transduction
- Dermatology Research
- Other
- Developmental Biology Research
- Skin and Hair Texture Defects
- Research Tools
- lacZ Expression
- Dermatology Research
- Developmental Biology Research
- Genetics Research
- Tissue/Cell Markers
Genotype: Gnat2cpfl3 related
- Sensorineural Research
- Eye Defects
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(TCF/Lef1-lacZ)34Efu/0
Not Specified
endocrine/exocrine gland phenotype
- absent sebaceous gland
- sebaceous glands are not detected at P9; however, they are visible in some follicles at P12 (MGI Ref ID J:102493)
integument phenotype
- abnormal epidermal layer morphology
- epidermal differentiation is delayed relative to wild-type (MGI Ref ID J:102493)
- abnormal keratinocyte differentiation
- mice show a decrease in relative number of terminally differentiatied keratinocytes (MGI Ref ID J:102493)
- absent sebaceous gland
- sebaceous glands are not detected at P9; however, they are visible in some follicles at P12 (MGI Ref ID J:102493)
- short hair
- transgenic mice have shorter hair than wild-type (MGI Ref ID J:102493)
- thick epidermis
- (MGI Ref ID J:102493)
cellular phenotype
- abnormal keratinocyte differentiation
- mice show a decrease in relative number of terminally differentiatied keratinocytes (MGI Ref ID J:102493)
References
- DasGupta R; Fuchs E. 1999. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126(20):4557-68. PubMed: 10498690MGI: J:55937
Additional References
- Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. PubMed: 17065522MGI: J:122428
Additional - Gnat2cpfl3 related
- Alexander JJ; Umino Y; Everhart D; Chang B; Min SH; Li Q; Timmers AM; Hawes NL; Pang JJ; Barlow RB; Hauswirth WW. 2007. Restoration of cone vision in a mouse model of achromatopsia. Nat Med 13(6):685-7. PubMed: 17515894MGI: J:121897
- Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. PubMed: 21124780MGI: J:167121
- Altimus CM; Guler AD; Alam NM; Arman AC; Prusky GT; Sampath AP; Hattar S. 2010. Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. Nat Neurosci 13(9):1107-12. PubMed: 20711184MGI: J:165280
- Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. PubMed: 17065522MGI: J:122428
- Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. PubMed: 16332269MGI: J:156373
- Chang B; Hurd R; Wang J; Nishina P. 2013. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci 54(7):4974-81. PubMed: 23800770MGI: J:198916
- Deng WT; Sakurai K; Liu J; Dinculescu A; Li J; Pang J; Min SH; Chiodo VA; Boye SL; Chang B; Kefalov VJ; Hauswirth WW. 2009. Functional interchangeability of rod and cone transducin alpha-subunits. Proc Natl Acad Sci U S A 106(42):17681-6. PubMed: 19815523MGI: J:153749
- IMGC. 2014. Abstracts for the IMGC2014 meeting (October, 2014) :. MGI: J:212307
- Jones RS; Pedisich M; Carroll RC; Nawy S. 2014. Spatial organization of AMPAR subtypes in ON RGCs. J Neurosci 34(2):656-61. PubMed: 24403163MGI: J:205576
- Ke JB; Wang YV; Borghuis BG; Cembrowski MS; Riecke H; Kath WL; Demb JB; Singer JH. 2014. Adaptation to background light enables contrast coding at rod bipolar cell synapses. Neuron 81(2):388-401. PubMed: 24373883MGI: J:250020
- Keenan WT; Rupp AC; Ross RA; Somasundaram P; Hiriyanna S; Wu Z; Badea TC; Robinson PR; Lowell BB; Hattar SS. 2016. A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction. Elife 5:. PubMed: 27669145MGI: J:238084
- Laprell L; Tochitsky I; Kaur K; Manookin MB; Stein M; Barber DM; Schon C; Michalakis S; Biel M; Kramer RH; Sumser MP; Trauner D; Van Gelder RN. 2017. Photopharmacological control of bipolar cells restores visual function in blind mice. J Clin Invest 127(7):2598-2611. PubMed: 28581442MGI: J:244965
- Naarendorp F; Esdaille TM; Banden SM; Andrews-Labenski J; Gross OP; Pugh EN Jr. 2010. Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. J Neurosci 30(37):12495-507. PubMed: 20844144MGI: J:164666
- Nathan J; Reh R; Ankoudinova I; Ankoudinova G; Chang B; Heckenlively J; Hurley JB. 2006. Scotopic and photopic visual thresholds and spatial and temporal discrimination evaluated by behavior of mice in a water maze. Photochem Photobiol 82(6):1489-94. PubMed: 16683905MGI: J:238265
- Nusinowitz S; Ridder WH 3rd; Ramirez J. 2007. Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant mice. Exp Eye Res 84(6):1104-14. PubMed: 17408617MGI: J:126462
- Prigge CL; Yeh PT; Liou NF; Lee CC; You SF; Liu LL; McNeill DS; Chew KS; Hattar S; Chen SK; Zhang DQ. 2016. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. J Neurosci 36(27):7184-97. PubMed: 27383593MGI: J:234637
- Sakami S; Kolesnikov AV; Kefalov VJ; Palczewski K. 2014. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet 23(7):1723-41. PubMed: 24214395MGI: J:207143
- Szikra T; Trenholm S; Drinnenberg A; Juttner J; Raics Z; Farrow K; Biel M; Awatramani G; Clark DA; Sahel JA; da Silveira RA; Roska B. 2014. Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition. Nat Neurosci 17(12):1728-35. PubMed: 25344628MGI: J:219420
- Tikidji-Hamburyan A; Reinhard K; Seitter H; Hovhannisyan A; Procyk CA; Allen AE; Schenk M; Lucas RJ; Munch TA. 2015. Retinal output changes qualitatively with every change in ambient illuminance. Nat Neurosci 18(1):66-74. PubMed: 25485757MGI: J:219606
- Tikidji-Hamburyan A; Reinhard K; Storchi R; Dietter J; Seitter H; Davis KE; Idrees S; Mutter M; Walmsley L; Bedford RA; Ueffing M; Ala-Laurila P; Brown TM; Lucas RJ; Munch TA. 2017. Rods progressively escape saturation to drive visual responses in daylight conditions. Nat Commun 8(1):1813. PubMed: 29180667MGI: J:256237
- Umino Y; Solessio E; Barlow RB. 2008. Speed, spatial, and temporal tuning of rod and cone vision in mouse. J Neurosci 28(1):189-98. PubMed: 18171936MGI: J:131050
- Wang YV; Weick M; Demb JB. 2011. Spectral and temporal sensitivity of cone-mediated responses in mouse retinal ganglion cells. J Neurosci 31(21):7670-81. PubMed: 21613480MGI: J:191557
- Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. PubMed: 21052544MGI: J:166679
- Zhao X; Stafford BK; Godin AL; King WM; Wong KY. 2014. Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells. J Physiol 592(Pt 7):1619-36. PubMed: 24396062MGI: J:219912
Additional - Tg(TCF/Lef1-lacZ)34Efu related
- Ahn Y; Sanderson BW; Klein OD; Krumlauf R. 2010. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 137(19):3221-31. PubMed: 20724449MGI: J:168361
- Ahn Y; Sims C; Logue JM; Weatherbee SD; Krumlauf R. 2013. Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development 140(3):583-93. PubMed: 23293290MGI: J:194074
- Ahrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. PubMed: 19762422MGI: J:153618
- Ahrens MJ; Romereim S; Dudley AT. 2011. A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Dev Dyn 240(9):2060-8. PubMed: 21793100MGI: J:174609
- Aicher A; Kollet O; Heeschen C; Liebner S; Urbich C; Ihling C; Orlandi A; Lapidot T; Zeiher AM; Dimmeler S. 2008. The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche. Circ Res 103(8):796-803. PubMed: 18776043MGI: J:155149
- Aisagbonhi O; Rai M; Ryzhov S; Atria N; Feoktistov I; Hatzopoulos AK. 2011. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis Model Mech 4(4):469-83. PubMed: 21324930MGI: J:174256
- Al Alam D; Green M; Tabatabai Irani R; Parsa S; Danopoulos S; Sala FG; Branch J; El Agha E; Tiozzo C; Voswinckel R; Jesudason EC; Warburton D; Bellusci S. 2011. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One 6(8):e23139. PubMed: 21858009MGI: J:176498
- Aumiller V; Balsara N; Wilhelm J; Gunther A; Konigshoff M. 2013. WNT/beta-catenin signaling induces IL-1beta expression by alveolar epithelial cells in pulmonary fibrosis. Am J Respir Cell Mol Biol 49(1):96-104. PubMed: 23526221MGI: J:221774
- Balli D; Zhang Y; Snyder J; Kalinichenko VV; Kalin TV. 2011. Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer Res 71(1):40-50. PubMed: 21199796MGI: J:167773
- Bazzi H; Anderson KV. 2014. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A 111(15):E1491-500. PubMed: 24706806MGI: J:208632
- Beaudoin GM 3rd; Sisk JM; Coulombe PA; Thompson CC. 2005. Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A 102(41):14653-8. PubMed: 16195376MGI: J:102493
- Bell SM; Schreiner CM; Wert SE; Mucenski ML; Scott WJ; Whitsett JA. 2008. R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development 135(6):1049-58. PubMed: 18256198MGI: J:131960
- Bodmer D; Levine-Wilkinson S; Richmond A; Hirsh S; Kuruvilla R. 2009. Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons. J Neurosci 29(23):7569-81. PubMed: 19515925MGI: J:149814
- Bonnet N; Conway SJ; Ferrari SL. 2012. Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. Proc Natl Acad Sci U S A 109(37):15048-53. PubMed: 22927401MGI: J:190032
- Boras-Granic K; Chang H; Grosschedl R; Hamel PA. 2006. Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol 295(1):219-31. PubMed: 16678815MGI: J:110699
- Brechbuhl HM; Ghosh M; Smith MK; Smith RW; Li B; Hicks DA; Cole BB; Reynolds PR; Reynolds SD. 2011. beta-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination. Am J Pathol 179(1):367-79. PubMed: 21703416MGI: J:173999
- Brown A; Machan JT; Hayes L; Zervas M. 2011. Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo. J Comp Neurol 519(15):2978-3000. PubMed: 21713770MGI: J:176481
- Brown AS; Epstein DJ. 2011. Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development 138(18):3967-76. PubMed: 21831920MGI: J:180898
- Brugmann SA; Allen NC; James AW; Mekonnen Z; Madan E; Helms JA. 2010. A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet 19(8):1577-92. PubMed: 20106874MGI: J:158523
- Burn SF; Webb A; Berry RL; Davies JA; Ferrer-Vaquer A; Hadjantonakis AK; Hastie ND; Hohenstein P. 2011. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol 352(2):288-98. PubMed: 21295565MGI: J:171469
- Cai X; Zhang W; Hu J; Zhang L; Sultana N; Wu B; Cai W; Zhou B; Cai CL. 2013. Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development 140(15):3176-87. PubMed: 23824573MGI: J:198628
- Cambier L; Plate M; Sucov HM; Pashmforoush M. 2014. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development 141(15):2959-71. PubMed: 25053429MGI: J:214093
- Carpenter AC; Rao S; Wells JM; Campbell K; Lang RA. 2010. Generation of mice with a conditional null allele for Wntless. Genesis 48(9):554-8. PubMed: 20614471MGI: J:164701
- Carpenter AC; Smith AN; Wagner H; Cohen-Tayar Y; Rao S; Wallace V; Ashery-Padan R; Lang RA. 2015. Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. Development 142(5):972-82. PubMed: 25715397MGI: J:220323
- Carroll LS; Capecchi MR. 2015. Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/beta-catenin signaling. Development 142(23):4056-67. PubMed: 26459221MGI: J:227707
- Cervantes S; Yamaguchi TP; Hebrok M. 2009. Wnt5a is essential for intestinal elongation in mice. Dev Biol 326(2):285-94. PubMed: 19100728MGI: J:145166
- Chen J; Stahl A; Krah NM; Seaward MR; Dennison RJ; Sapieha P; Hua J; Hatton CJ; Juan AM; Aderman CM; Willett KL; Guerin KI; Mammoto A; Campbell M; Smith LE. 2011. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation 124(17):1871-81. PubMed: 21969016MGI: J:189464
- Chen M; Zhu M; Awad H; Li TF; Sheu TJ; Boyce BF; Chen D; O'Keefe RJ. 2008. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci 121(Pt 9):1455-65. PubMed: 18397998MGI: J:139819
- Cheng SL; Shao JS; Cai J; Sierra OL; Towler DA. 2008. Msx2 exerts bone anabolism via canonical Wnt signaling. J Biol Chem 283(29):20505-22. PubMed: 18487199MGI: J:138745
- Cheng SL; Shao JS; Halstead LR; Distelhorst K; Sierra O; Towler DA. 2010. Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res 107(2):271-82. PubMed: 20489161MGI: J:175050
- Chu EY; Hens J; Andl T; Kairo A; Yamaguchi TP; Brisken C; Glick A; Wysolmerski JJ; Millar SE. 2004. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131(19):4819-29. PubMed: 15342465MGI: J:98338
- Cui CY; Yin M; Sima J; Childress V; Michel M; Piao Y; Schlessinger D. 2014. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development 141(19):3752-60. PubMed: 25249463MGI: J:217500
- Daneman R; Agalliu D; Zhou L; Kuhnert F; Kuo CJ; Barres BA. 2009. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A 106(2):641-6. PubMed: 19129494MGI: J:143865
- Danopoulos S; Krainock M; Toubat O; Thornton M; Grubbs B; Al Alam D. 2016. Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling. Am J Physiol Lung Cell Mol Physiol 311(6):L1036-L1049. PubMed: 27765763MGI: J:237425
- Day TF; Guo X; Garrett-Beal L; Yang Y. 2005. Wnt/beta-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell 8(5):739-50. PubMed: 15866164MGI: J:98427
- De Langhe SP; Carraro G; Tefft D; Li C; Xu X; Chai Y; Minoo P; Hajihosseini MK; Drouin J; Kaartinen V; Bellusci S. 2008. Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS One 3(1):e1516. PubMed: 18231602MGI: J:131535
- De Langhe SP; Carraro G; Warburton D; Hajihosseini MK; Bellusci S. 2006. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299(1):52-62. PubMed: 16989802MGI: J:114396
- Drelon C; Berthon A; Sahut-Barnola I; Mathieu M; Dumontet T; Rodriguez S; Batisse-Lignier M; Tabbal H; Tauveron I; Lefrancois-Martinez AM; Pointud JC; Gomez-Sanchez CE; Vainio S; Shan J; Sacco S; Schedl A; Stratakis CA; Martinez A; Val P. 2016. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development. Nat Commun 7:12751. PubMed: 27624192MGI: J:242183
- Fleming HE; Janzen V; Lo Celso C; Guo J; Leahy KM; Kronenberg HM; Scadden DT. 2008. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2(3):274-83. PubMed: 18371452MGI: J:238121
- Fromel T; Jungblut B; Hu J; Trouvain C; Barbosa-Sicard E; Popp R; Liebner S; Dimmeler S; Hammock BD; Fleming I. 2012. Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proc Natl Acad Sci U S A 109(25):9995-10000. PubMed: 22665795MGI: J:185508
- Fu J; Ivy Yu HM; Maruyama T; Mirando AJ; Hsu W. 2011. Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn 240(2):365-71. PubMed: 21246653MGI: J:167835
- Fuhrmann S; Riesenberg AN; Mathiesen AM; Brown EC; Vetter ML; Brown NL. 2009. Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophthalmol Vis Sci 50(1):432-40. PubMed: 18599572MGI: J:146698
- Gao B; Song H; Bishop K; Elliot G; Garrett L; English MA; Andre P; Robinson J; Sood R; Minami Y; Economides AN; Yang Y. 2011. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell 20(2):163-76. PubMed: 21316585MGI: J:169766
- Gao J; DeRouen MC; Chen CH; Nguyen M; Nguyen NT; Ido H; Harada K; Sekiguchi K; Morgan BA; Miner JH; Oro AE; Marinkovich MP. 2008. Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 22(15):2111-24. PubMed: 18676816MGI: J:139508
- Genander M; Halford MM; Xu NJ; Eriksson M; Yu Z; Qiu Z; Martling A; Greicius G; Thakar S; Catchpole T; Chumley MJ; Zdunek S; Wang C; Holm T; Goff SP; Pettersson S; Pestell RG; Henkemeyer M; Frisen J. 2009. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139(4):679-92. PubMed: 19914164MGI: J:157019
- Giangreco A; Lu L; Vickers C; Teixeira VH; Groot KR; Butler CR; Ilieva EV; George PJ; Nicholson AG; Sage EK; Watt FM; Janes SM. 2012. beta-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol 226(4):575-87. PubMed: 22081448MGI: J:181809
- Glass DA 2nd; Bialek P; Ahn JD; Starbuck M; Patel MS; Clevers H; Taketo MM; Long F; McMahon AP; Lang RA; Karsenty G. 2005. Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8(5):751-64. PubMed: 15866165MGI: J:98430
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