JAX
Mouse Strain Datasheet - 004623
STOCK Tg(TCF/Lef1-lacZ)34Efu/J
Also Known As: TOPGAL
These TOPGAL transgenic mice express Beta-galactosidase as a reporter in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 mediated signaling pathway and activated Beta-catenin. Beta-galactosidase activity is displayed during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles, This strain represents an effective tool for generating mutants that would be useful in studies of the Wnt signaling pathway.
Donating Investigator
Elaine Fuchs, The Rockefeller University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N1F29
|
Gnat2cpfl3
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Gnat2 | guanine nucleotide binding protein, alpha transducing 2 |
Tg(TCF/Lef1-lacZ)34Efu
| Allele Type |
|---|
| Transgenic (Reporter) |
Research Applications
- Cell Biology Research
- Dermatology Research
- Developmental Biology Research
- Research Tools
- Sensorineural Research
Base Price
Starting at:
| $263.00 Domestic price for female |
| $337.00 Domestic price for breeder pair |
Important Note
This strain may be homozygous for Gnat2cpfl3, cone photoreceptor function loss 3, which affects bright light (photopic) vision.
Detailed Description
These TOPGAL transgenic mice are a reporter strain that express Beta-galactosidase in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 (LEF/TCF) mediated signaling pathway and activated Beta-catenin. The transgene contains the lacZ gene under the control of a regulatory sequence consisting of three consensus LEF/TCF-binding motifs upstream of a minimal c-fos promoter. Transgenic mice display TOPGAL activity (Beta-galactosidase activity) during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles, but not during the next stage of hair follicle development; formation of hair germs. TOPGAL transgene activity reappears in hair follicles at E16.5 and TOPGAL expression is strongly upregulated in the postnatal hair shaft precursor cells in both whisker and body hair anagen follicles (active periods of hair growth). TOPGAL expression ceases during catagen (regression and shortening) and telogen (rest) periods of the postnatal hair growth cycle. Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain represents an effective tool for generating mutants that would be useful in studies of the Wnt signaling pathway.
Development
The TOPGAL transgene was designed by Dr. Elaine Fuchs (while at The University of Chicago) with three copies of a T cell specific transcription factor/lymphoid enhancer-binding factor 1 (TCF/Lef1) consensus binding site and the FBJ osteosarcoma oncogene (Fos; c-fos) minimal promoter upstream of the β-galactosidase gene (lacZ). In 2003, TOPGAL mice on a CD-1 genetic background were sent to The Jackson Laboratory Repository as Stock No. 004623. This strain may be homozygous for Gnat2cpfl3 (cone photoreceptor function loss 3), which affects bright light (photopic) vision.
Expression Data
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
|---|---|
| Site of Expression | lacZ expression occurs during early embryonic development in a subset of pluripotent embryonic basel cells of the epithelium and dermis of developing hair follicles. lacZ expression disappears during formation of hair germ and then reappears at E16.5 in hair follicles until 18 days after birth. |
Control Suggestions
Selected References
- DasGupta R; Fuchs E. 1999. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126(20):4557-68. PubMed: 10498690MGI: J:55937
Gnat2cpfl3
Allele Symbol: Gnat2cpfl3
| Allele Name | cone photoreceptor function loss 3 |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | no cones |
| Gene Symbol and Name | Gnat2, guanine nucleotide binding protein, alpha transducing 2 |
| Gene Synonym(s) | ACHM4; AW490837; GNATC; Gnat-2; Gnat-2; Gt-2; Tcalpha; expressed sequence AW490837 |
| Strain of Origin | various |
| Chromosome | 3 |
| General Note | This allele has been detected in the following strains either by genotyping or complementation testing: ALS/LtJ, SENCARA/PtJ, SENCARB/PtJ, SENCARC/PtJ, PN/nBSwUmabJ. (J:122428) The allele has also been reported in NMRI and CD1 (Lluis Montoliu, J:212307) |
| Molecular Note | A single nucleotide substitution of G to A at position 598 in exon 6. This mutation converts codon 200 from aspartic acid to asparagine. |
Tg(TCF/Lef1-lacZ)34Efu
Allele Symbol: Tg(TCF/Lef1-lacZ)34Efu
| Allele Name | transgene insertion 34, Elaine Fuchs |
|---|---|
| Allele Type | Transgenic (Reporter) |
| Allele Synonym(s) | TCF-betagal; TOPGAL; Tg(Fos-lacZ)34Efu; Top-Gal |
| Gene Symbol and Name | Tg(TCF/Lef1-lacZ)34Efu, transgene insertion 34, Elaine Fuchs |
| Gene Synonym(s) | TCF-betagal; TOPGAL; Tg(Fos-lacZ)34Efu; Tg(Fos-lacZ)34Efu; Top-Gal |
| Promoter | Fos, Fos proto-oncogene, AP-1 transcription factor subunit, rat |
| Expressed Gene | lacZ, beta-galactosidase, E. coli |
| Site of Expression | lacZ expression occurs during early embryonic development in a subset of pluripotent embryonic basel cells of the epithelium and dermis of developing hair follicles. lacZ expression disappears during formation of hair germ and then reappears at E16.5 in hair follicles until 18 days after birth. |
| Strain of Origin | Not Specified |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Transgenic mice express beta-galactosidase in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 (LEF1/TCF3) mediated signaling pathway and activated Beta-catenin (CATNB). Transgenic mice display Beta-galactosidase activity during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles. Beta-galactosidase activity is not detected in the next stage of hair follicle development, formation of hair germs. At E16.5, transgene activity reappears in hair follicles and is detectable until 18 days after birth. |
| Molecular Note | The transgene contains the lacZ gene under the control of a promoter consisting of three consensus lymphoid enhancer binding factor 1/transcription factor 3 (LEF/TCF)-binding motifs upstream of a minimal Fos promoter. This allele is responsive to canonical Wnt/beta-catenin signal transduction. |
| Mutations Made By | Elaine Fuchs, The Rockefeller University |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cell Biology Research
- Signal Transduction
- Dermatology Research
- Other
- Developmental Biology Research
- Skin and Hair Texture Defects
- Research Tools
- lacZ Expression
- Dermatology Research
- Developmental Biology Research
- Genetics Research
- Tissue/Cell Markers
Genotype: Gnat2cpfl3 related
- Sensorineural Research
- Eye Defects
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(TCF/Lef1-lacZ)34Efu/0
Not Specified
endocrine/exocrine gland phenotype
- absent sebaceous gland
- sebaceous glands are not detected at P9; however, they are visible in some follicles at P12 (MGI Ref ID J:102493)
integument phenotype
- abnormal epidermal layer morphology
- epidermal differentiation is delayed relative to wild-type (MGI Ref ID J:102493)
- abnormal keratinocyte differentiation
- mice show a decrease in relative number of terminally differentiatied keratinocytes (MGI Ref ID J:102493)
- absent sebaceous gland
- sebaceous glands are not detected at P9; however, they are visible in some follicles at P12 (MGI Ref ID J:102493)
- short hair
- transgenic mice have shorter hair than wild-type (MGI Ref ID J:102493)
- thick epidermis
- (MGI Ref ID J:102493)
cellular phenotype
- abnormal keratinocyte differentiation
- mice show a decrease in relative number of terminally differentiatied keratinocytes (MGI Ref ID J:102493)
References
- DasGupta R; Fuchs E. 1999. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126(20):4557-68. PubMed: 10498690MGI: J:55937
Additional References
- Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. PubMed: 17065522MGI: J:122428
Additional - Gnat2cpfl3 related
- Alexander JJ; Umino Y; Everhart D; Chang B; Min SH; Li Q; Timmers AM; Hawes NL; Pang JJ; Barlow RB; Hauswirth WW. 2007. Restoration of cone vision in a mouse model of achromatopsia. Nat Med 13(6):685-7. PubMed: 17515894MGI: J:121897
- Allen AE; Cameron MA; Brown TM; Vugler AA; Lucas RJ. 2010. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One 5(11):e15063. PubMed: 21124780MGI: J:167121
- Altimus CM; Guler AD; Alam NM; Arman AC; Prusky GT; Sampath AP; Hattar S. 2010. Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. Nat Neurosci 13(9):1107-12. PubMed: 20711184MGI: J:165280
- Chang B; Dacey MS; Hawes NL; Hitchcock PF; Milam AH; Atmaca-Sonmez P; Nusinowitz S; Heckenlively JR. 2006. Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2. Invest Ophthalmol Vis Sci 47(11):5017-21. PubMed: 17065522MGI: J:122428
- Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. PubMed: 16332269MGI: J:156373
- Chang B; Hurd R; Wang J; Nishina P. 2013. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci 54(7):4974-81. PubMed: 23800770MGI: J:198916
- Deng WT; Sakurai K; Liu J; Dinculescu A; Li J; Pang J; Min SH; Chiodo VA; Boye SL; Chang B; Kefalov VJ; Hauswirth WW. 2009. Functional interchangeability of rod and cone transducin alpha-subunits. Proc Natl Acad Sci U S A 106(42):17681-6. PubMed: 19815523MGI: J:153749
- IMGC. 2014. Abstracts for the IMGC2014 meeting (October, 2014) :. MGI: J:212307
- Jones RS; Pedisich M; Carroll RC; Nawy S. 2014. Spatial organization of AMPAR subtypes in ON RGCs. J Neurosci 34(2):656-61. PubMed: 24403163MGI: J:205576
- Keenan WT; Rupp AC; Ross RA; Somasundaram P; Hiriyanna S; Wu Z; Badea TC; Robinson PR; Lowell BB; Hattar SS. 2016. A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction. Elife 5:. PubMed: 27669145MGI: J:238084
- Naarendorp F; Esdaille TM; Banden SM; Andrews-Labenski J; Gross OP; Pugh EN Jr. 2010. Dark light, rod saturation, and the absolute and incremental sensitivity of mouse cone vision. J Neurosci 30(37):12495-507. PubMed: 20844144MGI: J:164666
- Nathan J; Reh R; Ankoudinova I; Ankoudinova G; Chang B; Heckenlively J; Hurley JB. 2006. Scotopic and photopic visual thresholds and spatial and temporal discrimination evaluated by behavior of mice in a water maze. Photochem Photobiol 82(6):1489-94. PubMed: 16683905MGI: J:238265
- Nusinowitz S; Ridder WH 3rd; Ramirez J. 2007. Temporal response properties of the primary and secondary rod-signaling pathways in normal and Gnat2 mutant mice. Exp Eye Res 84(6):1104-14. PubMed: 17408617MGI: J:126462
- Prigge CL; Yeh PT; Liou NF; Lee CC; You SF; Liu LL; McNeill DS; Chew KS; Hattar S; Chen SK; Zhang DQ. 2016. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. J Neurosci 36(27):7184-97. PubMed: 27383593MGI: J:234637
- Sakami S; Kolesnikov AV; Kefalov VJ; Palczewski K. 2014. P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet 23(7):1723-41. PubMed: 24214395MGI: J:207143
- Szikra T; Trenholm S; Drinnenberg A; Juttner J; Raics Z; Farrow K; Biel M; Awatramani G; Clark DA; Sahel JA; da Silveira RA; Roska B. 2014. Rods in daylight act as relay cells for cone-driven horizontal cell-mediated surround inhibition. Nat Neurosci 17(12):1728-35. PubMed: 25344628MGI: J:219420
- Tikidji-Hamburyan A; Reinhard K; Seitter H; Hovhannisyan A; Procyk CA; Allen AE; Schenk M; Lucas RJ; Munch TA. 2015. Retinal output changes qualitatively with every change in ambient illuminance. Nat Neurosci 18(1):66-74. PubMed: 25485757MGI: J:219606
- Umino Y; Solessio E; Barlow RB. 2008. Speed, spatial, and temporal tuning of rod and cone vision in mouse. J Neurosci 28(1):189-98. PubMed: 18171936MGI: J:131050
- Wang YV; Weick M; Demb JB. 2011. Spectral and temporal sensitivity of cone-mediated responses in mouse retinal ganglion cells. J Neurosci 31(21):7670-81. PubMed: 21613480MGI: J:191557
- Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. PubMed: 21052544MGI: J:166679
- Zhao X; Stafford BK; Godin AL; King WM; Wong KY. 2014. Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells. J Physiol 592(Pt 7):1619-36. PubMed: 24396062MGI: J:219912
Additional - Tg(TCF/Lef1-lacZ)34Efu related
- Ahn Y; Sanderson BW; Klein OD; Krumlauf R. 2010. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 137(19):3221-31. PubMed: 20724449MGI: J:168361
- Ahn Y; Sims C; Logue JM; Weatherbee SD; Krumlauf R. 2013. Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development 140(3):583-93. PubMed: 23293290MGI: J:194074
- Ahrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. PubMed: 19762422MGI: J:153618
- Ahrens MJ; Romereim S; Dudley AT. 2011. A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Dev Dyn :. PubMed: 21793100MGI: J:174609
- Aicher A; Kollet O; Heeschen C; Liebner S; Urbich C; Ihling C; Orlandi A; Lapidot T; Zeiher AM; Dimmeler S. 2008. The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche. Circ Res 103(8):796-803. PubMed: 18776043MGI: J:155149
- Aisagbonhi O; Rai M; Ryzhov S; Atria N; Feoktistov I; Hatzopoulos AK. 2011. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis Model Mech 4(4):469-83. PubMed: 21324930MGI: J:174256
- Al Alam D; Green M; Tabatabai Irani R; Parsa S; Danopoulos S; Sala FG; Branch J; El Agha E; Tiozzo C; Voswinckel R; Jesudason EC; Warburton D; Bellusci S. 2011. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One 6(8):e23139. PubMed: 21858009MGI: J:176498
- Aumiller V; Balsara N; Wilhelm J; Gunther A; Konigshoff M. 2013. WNT/beta-catenin signaling induces IL-1beta expression by alveolar epithelial cells in pulmonary fibrosis. Am J Respir Cell Mol Biol 49(1):96-104. PubMed: 23526221MGI: J:221774
- Balli D; Zhang Y; Snyder J; Kalinichenko VV; Kalin TV. 2011. Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer Res 71(1):40-50. PubMed: 21199796MGI: J:167773
- Bazzi H; Anderson KV. 2014. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A 111(15):E1491-500. PubMed: 24706806MGI: J:208632
- Beaudoin GM 3rd; Sisk JM; Coulombe PA; Thompson CC. 2005. Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A 102(41):14653-8. PubMed: 16195376MGI: J:102493
- Bell SM; Schreiner CM; Wert SE; Mucenski ML; Scott WJ; Whitsett JA. 2008. R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development 135(6):1049-58. PubMed: 18256198MGI: J:131960
- Bodmer D; Levine-Wilkinson S; Richmond A; Hirsh S; Kuruvilla R. 2009. Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons. J Neurosci 29(23):7569-81. PubMed: 19515925MGI: J:149814
- Bonnet N; Conway SJ; Ferrari SL. 2012. Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. Proc Natl Acad Sci U S A 109(37):15048-53. PubMed: 22927401MGI: J:190032
- Boras-Granic K; Chang H; Grosschedl R; Hamel PA. 2006. Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol 295(1):219-31. PubMed: 16678815MGI: J:110699
- Brechbuhl HM; Ghosh M; Smith MK; Smith RW; Li B; Hicks DA; Cole BB; Reynolds PR; Reynolds SD. 2011. beta-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination. Am J Pathol 179(1):367-79. PubMed: 21703416MGI: J:173999
- Brown A; Machan JT; Hayes L; Zervas M. 2011. Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo. J Comp Neurol 519(15):2978-3000. PubMed: 21713770MGI: J:176481
- Brown AS; Epstein DJ. 2011. Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development 138(18):3967-76. PubMed: 21831920MGI: J:180898
- Brugmann SA; Allen NC; James AW; Mekonnen Z; Madan E; Helms JA. 2010. A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet 19(8):1577-92. PubMed: 20106874MGI: J:158523
- Burn SF; Webb A; Berry RL; Davies JA; Ferrer-Vaquer A; Hadjantonakis AK; Hastie ND; Hohenstein P. 2011. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol 352(2):288-98. PubMed: 21295565MGI: J:171469
- Cai X; Zhang W; Hu J; Zhang L; Sultana N; Wu B; Cai W; Zhou B; Cai CL. 2013. Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development 140(15):3176-87. PubMed: 23824573MGI: J:198628
- Cambier L; Plate M; Sucov HM; Pashmforoush M. 2014. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development 141(15):2959-71. PubMed: 25053429MGI: J:214093
- Carpenter AC; Rao S; Wells JM; Campbell K; Lang RA. 2010. Generation of mice with a conditional null allele for Wntless. Genesis 48(9):554-8. PubMed: 20614471MGI: J:164701
- Carpenter AC; Smith AN; Wagner H; Cohen-Tayar Y; Rao S; Wallace V; Ashery-Padan R; Lang RA. 2015. Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. Development 142(5):972-82. PubMed: 25715397MGI: J:220323
- Carroll LS; Capecchi MR. 2015. Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/beta-catenin signaling. Development 142(23):4056-67. PubMed: 26459221MGI: J:227707
- Cervantes S; Yamaguchi TP; Hebrok M. 2009. Wnt5a is essential for intestinal elongation in mice. Dev Biol 326(2):285-94. PubMed: 19100728MGI: J:145166
- Chen J; Stahl A; Krah NM; Seaward MR; Dennison RJ; Sapieha P; Hua J; Hatton CJ; Juan AM; Aderman CM; Willett KL; Guerin KI; Mammoto A; Campbell M; Smith LE. 2011. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation 124(17):1871-81. PubMed: 21969016MGI: J:189464
- Chen M; Zhu M; Awad H; Li TF; Sheu TJ; Boyce BF; Chen D; O'Keefe RJ. 2008. Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci 121(Pt 9):1455-65. PubMed: 18397998MGI: J:139819
- Cheng SL; Shao JS; Cai J; Sierra OL; Towler DA. 2008. Msx2 exerts bone anabolism via canonical Wnt signaling. J Biol Chem 283(29):20505-22. PubMed: 18487199MGI: J:138745
- Cheng SL; Shao JS; Halstead LR; Distelhorst K; Sierra O; Towler DA. 2010. Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res 107(2):271-82. PubMed: 20489161MGI: J:175050
- Chu EY; Hens J; Andl T; Kairo A; Yamaguchi TP; Brisken C; Glick A; Wysolmerski JJ; Millar SE. 2004. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131(19):4819-29. PubMed: 15342465MGI: J:98338
- Cui CY; Yin M; Sima J; Childress V; Michel M; Piao Y; Schlessinger D. 2014. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development 141(19):3752-60. PubMed: 25249463MGI: J:217500
- Daneman R; Agalliu D; Zhou L; Kuhnert F; Kuo CJ; Barres BA. 2009. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A 106(2):641-6. PubMed: 19129494MGI: J:143865
- Danopoulos S; Krainock M; Toubat O; Thornton M; Grubbs B; Al Alam D. 2016. Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling. Am J Physiol Lung Cell Mol Physiol 311(6):L1036-L1049. PubMed: 27765763MGI: J:237425
- Day TF; Guo X; Garrett-Beal L; Yang Y. 2005. Wnt/beta-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell 8(5):739-50. PubMed: 15866164MGI: J:98427
- De Langhe SP; Carraro G; Tefft D; Li C; Xu X; Chai Y; Minoo P; Hajihosseini MK; Drouin J; Kaartinen V; Bellusci S. 2008. Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS One 3(1):e1516. PubMed: 18231602MGI: J:131535
- De Langhe SP; Carraro G; Warburton D; Hajihosseini MK; Bellusci S. 2006. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299(1):52-62. PubMed: 16989802MGI: J:114396
- Drelon C; Berthon A; Sahut-Barnola I; Mathieu M; Dumontet T; Rodriguez S; Batisse-Lignier M; Tabbal H; Tauveron I; Lefrancois-Martinez AM; Pointud JC; Gomez-Sanchez CE; Vainio S; Shan J; Sacco S; Schedl A; Stratakis CA; Martinez A; Val P. 2016. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development. Nat Commun 7:12751. PubMed: 27624192MGI: J:242183
- Fleming HE; Janzen V; Lo Celso C; Guo J; Leahy KM; Kronenberg HM; Scadden DT. 2008. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2(3):274-83. PubMed: 18371452MGI: J:238121
- Fromel T; Jungblut B; Hu J; Trouvain C; Barbosa-Sicard E; Popp R; Liebner S; Dimmeler S; Hammock BD; Fleming I. 2012. Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proc Natl Acad Sci U S A 109(25):9995-10000. PubMed: 22665795MGI: J:185508
- Fu J; Ivy Yu HM; Maruyama T; Mirando AJ; Hsu W. 2011. Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn 240(2):365-71. PubMed: 21246653MGI: J:167835
- Fuhrmann S; Riesenberg AN; Mathiesen AM; Brown EC; Vetter ML; Brown NL. 2009. Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophthalmol Vis Sci 50(1):432-40. PubMed: 18599572MGI: J:146698
- Gao B; Song H; Bishop K; Elliot G; Garrett L; English MA; Andre P; Robinson J; Sood R; Minami Y; Economides AN; Yang Y. 2011. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell 20(2):163-76. PubMed: 21316585MGI: J:169766
- Gao J; DeRouen MC; Chen CH; Nguyen M; Nguyen NT; Ido H; Harada K; Sekiguchi K; Morgan BA; Miner JH; Oro AE; Marinkovich MP. 2008. Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev 22(15):2111-24. PubMed: 18676816MGI: J:139508
- Genander M; Halford MM; Xu NJ; Eriksson M; Yu Z; Qiu Z; Martling A; Greicius G; Thakar S; Catchpole T; Chumley MJ; Zdunek S; Wang C; Holm T; Goff SP; Pettersson S; Pestell RG; Henkemeyer M; Frisen J. 2009. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 139(4):679-92. PubMed: 19914164MGI: J:157019
- Giangreco A; Lu L; Vickers C; Teixeira VH; Groot KR; Butler CR; Ilieva EV; George PJ; Nicholson AG; Sage EK; Watt FM; Janes SM. 2012. beta-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol 226(4):575-87. PubMed: 22081448MGI: J:181809
- Glass DA 2nd; Bialek P; Ahn JD; Starbuck M; Patel MS; Clevers H; Taketo MM; Long F; McMahon AP; Lang RA; Karsenty G. 2005. Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8(5):751-64. PubMed: 15866165MGI: J:98430
- Grego-Bessa J; Bloomekatz J; Castel P; Omelchenko T; Baselga J; Anderson KV. 2016. The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife 5:. PubMed: 26809587MGI: J:230653
- Grigoryan T; Stein S; Qi J; Wende H; Garratt AN; Nave KA; Birchmeier C; Birchmeier W. 2013. Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A 110(45):18174-9. PubMed: 24151333MGI: J:202907
- Grisanti L; Revenkova E; Gordon RE; Iomini C. 2016. Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway. Development 143(12):2160-71. PubMed: 27122169MGI: J:235678
- Guo J; Liu M; Yang D; Bouxsein ML; Saito H; Galvin RJ; Kuhstoss SA; Thomas CC; Schipani E; Baron R; Bringhurst FR; Kronenberg HM. 2010. Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab 11(2):161-71. PubMed: 20142103MGI: J:158620
- Hadjantonakis AK; Pisano E; Papaioannou VE. 2008. Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PLoS One 3(6):e2511. PubMed: 18575602MGI: J:137163
- Hagan N; Zervas M. 2012. Wnt1 expression temporally allocates upper rhombic lip progenitors and defines their terminal cell fate in the cerebellum. Mol Cell Neurosci 49(2):217-29. PubMed: 22173107MGI: J:191519
- Hatsell SJ; Cowin P. 2006. Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 133(18):3661-70. PubMed: 16914490MGI: J:112460
- He F; Popkie AP; Xiong W; Li L; Wang Y; Phiel CJ; Chen Y. 2010. Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn 239(12):3235-46. PubMed: 20981831MGI: J:166721
- He F; Xiong W; Wang Y; Li L; Liu C; Yamagami T; Taketo MM; Zhou C; Chen Y. 2011. Epithelial Wnt/beta-catenin signaling regulates palatal shelf fusion through regulation of Tgfbeta3 expression. Dev Biol 350(2):511-9. PubMed: 21185284MGI: J:170579
- He F; Xiong W; Yu X; Espinoza-Lewis R; Liu C; Gu S; Nishita M; Suzuki K; Yamada G; Minami Y; Chen Y. 2008. Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development 135(23):3871-9. PubMed: 18948417MGI: J:144627
- Hiremath M; Dann P; Fischer J; Butterworth D; Boras-Granic K; Hens J; Van Houten J; Shi W; Wysolmerski J. 2012. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development 139(22):4239-49. PubMed: 23034629MGI: J:189075
- Holmberg V; Jalanko A; Isosomppi J; Fabritius AL; Peltonen L; Kopra O. 2004. The mouse ortholog of the neuronal ceroid lipofuscinosis CLN5 gene encodes a soluble lysosomal glycoprotein expressed in the developing brain. Neurobiol Dis 16(1):29-40. PubMed: 15207259MGI: J:91217
- Huang J; Dattilo LK; Rajagopal R; Liu Y; Kaartinen V; Mishina Y; Deng CX; Umans L; Zwijsen A; Roberts AB; Beebe DC. 2009. FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development 136(10):1741-50. PubMed: 19369394MGI: J:148019
- Huang X; Litingtung Y; Chiang C. 2007. Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Hum Mol Genet 16(12):1454-68. PubMed: 17468181MGI: J:125109
- Ip W; Shao W; Chiang YT; Jin T. 2012. The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 303(9):E1166-76. PubMed: 22967502MGI: J:191638
- Iwatsuki K; Liu HX; Gronder A; Singer MA; Lane TF; Grosschedl R; Mistretta CM; Margolskee RF. 2007. Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A 104(7):2253-8. PubMed: 17284610MGI: J:119729
- Jamora C; Lee P; Kocieniewski P; Azhar M; Hosokawa R; Chai Y; Fuchs E. 2005. A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol 3(1):e11. PubMed: 15630473MGI: J:97750
- Jang MH; Bonaguidi MA; Kitabatake Y; Sun J; Song J; Kang E; Jun H; Zhong C; Su Y; Guo JU; Wang MX; Sailor KA; Kim JY; Gao Y; Christian KM; Ming GL; Song H. 2013. Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell 12(2):215-23. PubMed: 23395446MGI: J:195148
- Jin YR; Han XH; Taketo MM; Yoon JK. 2012. Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development 139(10):1821-30. PubMed: 22461561MGI: J:184014
- Jin YR; Turcotte TJ; Crocker AL; Han XH; Yoon JK. 2011. The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol 352(1):1-13. PubMed: 21237142MGI: J:171482
- Johansson PA; Irmler M; Acampora D; Beckers J; Simeone A; Gotz M. 2013. The transcription factor Otx2 regulates choroid plexus development and function. Development 140(5):1055-66. PubMed: 23364326MGI: J:194049
- Joo JH; Taxter TJ; Munguba GC; Kim YH; Dhaduvai K; Dunn NW; Degan WJ; Oh SP; Sugrue SP. 2010. Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis. Dev Biol 345(2):191-203. PubMed: 20637749MGI: J:164807
- Kadzik RS; Cohen ED; Morley MP; Stewart KM; Lu MM; Morrisey EE. 2014. Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape. Proc Natl Acad Sci U S A 111(34):12444-9. PubMed: 25114215MGI: J:213915
- Kahn J; Shwartz Y; Blitz E; Krief S; Sharir A; Breitel DA; Rattenbach R; Relaix F; Maire P; Rountree RB; Kingsley DM; Zelzer E. 2009. Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell 16(5):734-43. PubMed: 19460349MGI: J:148688
- Kamiya N; Kaartinen VM; Mishina Y. 2011. Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1. Biochem Biophys Res Commun 414(2):326-30. PubMed: 21945937MGI: J:178480
- Kamiya N; Kobayashi T; Mochida Y; Yu PB; Yamauchi M; Kronenberg HM; Mishina Y. 2010. Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res 25(2):200-10. PubMed: 19874086MGI: J:179863
- Kamiya N; Ye L; Kobayashi T; Mochida Y; Yamauchi M; Kronenberg HM; Feng JQ; Mishina Y. 2008. BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development 135(22):3801-11. PubMed: 18927151MGI: J:143588
- Kim BM; Buchner G; Miletich I; Sharpe PT; Shivdasani RA. 2005. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell 8(4):611-22. PubMed: 15809042MGI: J:98305
- Kim BM; Mao J; Taketo MM; Shivdasani RA. 2007. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology 133(2):529-38. PubMed: 17681174MGI: J:128278
- Kim BM; Miletich I; Mao J; McMahon AP; Sharpe PA; Shivdasani RA. 2007. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development 134(20):3603-13. PubMed: 17855428MGI: J:128378
- Kousteni S; Almeida M; Han L; Bellido T; Jilka RL; Manolagas SC. 2007. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol 27(4):1516-30. PubMed: 17158928MGI: J:118245
- Kovalovsky D; Yu Y; Dose M; Emmanouilidou A; Konstantinou T; Germar K; Aghajani K; Guo Z; Mandal M; Gounari F. 2009. Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling. J Immunol 183(6):3873-84. PubMed: 19717519MGI: J:152395
- Koyama E; Shibukawa Y; Nagayama M; Sugito H; Young B; Yuasa T; Okabe T; Ochiai T; Kamiya N; Rountree RB; Kingsley DM; Iwamoto M; Enomoto-Iwamoto M; Pacifici M. 2008. A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev Biol 316(1):62-73. PubMed: 18295755MGI: J:135666
- Krutzfeldt J; Stoffel M. 2010. Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice. Diabetologia 53(1):123-7. PubMed: 19898815MGI: J:156548
- Kuhnert F; Mancuso MR; Shamloo A; Wang HT; Choksi V; Florek M; Su H; Fruttiger M; Young WL; Heilshorn SC; Kuo CJ. 2010. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 330(6006):985-9. PubMed: 21071672MGI: J:166127
- Kurosaka H; Trainor PA; Leroux-Berger M; Iulianella A. 2015. Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling. PLoS One 10(3):e0120821. PubMed: 25799573MGI: J:229187
- Lancaster MA; Louie CM; Silhavy JL; Sintasath L; Decambre M; Nigam SK; Willert K; Gleeson JG. 2009. Impaired Wnt-beta-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy. Nat Med 15(9):1046-54. PubMed: 19718039MGI: J:154321
- Leightner AC; Hommerding CJ; Peng Y; Salisbury JL; Gainullin VG; Czarnecki PG; Sussman CR; Harris PC. 2013. The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity. Hum Mol Genet 22(10):2024-40. PubMed: 23393159MGI: J:194966
- Lewis SL; Khoo PL; Andrea De Young R; Bildsoe H; Wakamiya M; Behringer RR; Mukhopadhyay M; Westphal H; Tam PP. 2007. Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mech Dev 124(2):157-165. PubMed: 17127040MGI: J:119933
- Lewis SL; Khoo PL; De Young RA; Steiner K; Wilcock C; Mukhopadhyay M; Westphal H; Jamieson RV; Robb L; Tam PP. 2008. Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development 135(10):1791-801. PubMed: 18403408MGI: J:134688
- Li A; Chan B; Felix JC; Xing Y; Li M; Brody SL; Borok Z; Li C; Minoo P. 2013. Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. PLoS One 8(4):e62215. PubMed: 23646120MGI: J:221024
- Li D; Zhang W; Liu Y; Haneline LS; Shou W. 2012. Lack of plakoglobin in epidermis leads to keratoderma. J Biol Chem 287(13):10435-43. PubMed: 22315228MGI: J:183271
- Li J; Huang X; Xu X; Mayo J; Bringas P Jr; Jiang R; Wang S; Chai Y. 2011. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development 138(10):1977-89. PubMed: 21490069MGI: J:171428
- Li TF; Chen D; Wu Q; Chen M; Sheu TJ; Schwarz EM; Drissi H; Zuscik M; O'Keefe RJ. 2006. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J Biol Chem 281(30):21296-304. PubMed: 16690606MGI: J:116442
- Li Y; Gordon J; Manley NR; Litingtung Y; Chiang C. 2008. Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol 322(1):145-55. PubMed: 18692041MGI: J:142133
- Lien WH; Klezovitch O; Null M; Vasioukhin V. 2008. alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain. J Cell Sci 121(Pt 9):1357-62. PubMed: 18397997MGI: J:139820
- Lin C; Yin Y; Long F; Ma L. 2008. Tissue-specific requirements of beta-catenin in external genitalia development. Development 135(16):2815-25. PubMed: 18635608MGI: J:139251
- Liu F; Chu EY; Watt B; Zhang Y; Gallant NM; Andl T; Yang SH; Lu MM; Piccolo S; Schmidt-Ullrich R; Taketo MM; Morrisey EE; Atit R; Dlugosz AA; Millar SE. 2008. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol 313(1):210-24. PubMed: 18022614MGI: J:130228
- Liu F; Thirumangalathu S; Gallant NM; Yang SH; Stoick-Cooper CL; Reddy ST; Andl T; Taketo MM; Dlugosz AA; Moon RT; Barlow LA; Millar SE. 2007. Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet 39(1):106-12. PubMed: 17128274MGI: J:117476
- Liu H; Fergusson MM; Castilho RM; Liu J; Cao L; Chen J; Malide D; Rovira II; Schimel D; Kuo CJ; Gutkind JS; Hwang PM; Finkel T. 2007. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317(5839):803-6. PubMed: 17690294MGI: J:123536
- Lobov IB; Rao S; Carroll TJ; Vallance JE; Ito M; Ondr JK; Kurup S; Glass DA; Patel MS; Shu W; Morrisey EE; McMahon AP; Karsenty G; Lang RA. 2005. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437(7057):417-21. PubMed: 16163358MGI: J:101493
- Lu TL; Chen CM. 2015. Differential requirements for beta-catenin in murine prostate cancer originating from basal versus luminal cells. J Pathol 236(3):290-301. PubMed: 25712462MGI: J:222750
- Lyubimova A; Garber JJ; Upadhyay G; Sharov A; Anastasoaie F; Yajnik V; Cotsarelis G; Dotto GP; Botchkarev V; Snapper SB. 2010. Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest 120(2):446-56. PubMed: 20071778MGI: J:156678
- Merrill BJ; Pasolli HA; Polak L; Rendl M; Garcia-Garcia MJ; Anderson KV; Fuchs E. 2004. Tcf3: a transcriptional regulator of axis induction in the early embryo. Development 131(2):263-74. PubMed: 14668413MGI: J:90402
- Miller LA; Smith AN; Taketo MM; Lang RA. 2006. Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol 6:14. PubMed: 16539717MGI: J:109351
- Miyagawa S; Harada M; Matsumaru D; Tanaka K; Inoue C; Nakahara C; Haraguchi R; Matsushita S; Suzuki K; Nakagata N; Ng RC; Akita K; Lui VC; Yamada G. 2014. Disruption of the temporally regulated cloaca endodermal beta-catenin signaling causes anorectal malformations. Cell Death Differ 21(6):990-7. PubMed: 24632946MGI: J:210318
- Miyagawa S; Moon A; Haraguchi R; Inoue C; Harada M; Nakahara C; Suzuki K; Matsumaru D; Kaneko T; Matsuo I; Yang L; Taketo MM; Iguchi T; Evans SM; Yamada G. 2009. Dosage-dependent hedgehog signals integrated with Wnt/{beta}-catenin signaling regulate external genitalia formation as an appendicular program. Development 136(23):3969-78. PubMed: 19906864MGI: J:154979
- Munne PM; Tummers M; Jarvinen E; Thesleff I; Jernvall J. 2009. Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction. Development 136(3):393-402. PubMed: 19141669MGI: J:144193
- Nakayama S; Sng N; Carretero J; Welner R; Hayashi Y; Yamamoto M; Tan AJ; Yamaguchi N; Yasuda H; Li D; Soejima K; Soo RA; Costa DB; Wong KK; Kobayashi SS. 2014. beta-catenin contributes to lung tumor development induced by EGFR mutations. Cancer Res 74(20):5891-902. PubMed: 25164010MGI: J:216696
- Narhi K; Tummers M; Ahtiainen L; Itoh N; Thesleff I; Mikkola ML. 2012. Sostdc1 defines the size and number of skin appendage placodes. Dev Biol 364(2):149-61. PubMed: 22509524MGI: J:183911
- Nemeth MJ; Kirby MR; Bodine DM. 2006. Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Proc Natl Acad Sci U S A 103(37):13783-8. PubMed: 16945912MGI: J:113745
- Ng RC; Matsumaru D; Ho AS; Garcia-Barcelo MM; Yuan ZW; Smith D; Kodjabachian L; Tam PK; Yamada G; Lui VC. 2014. Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-beta-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations. Cell Death Differ 21(6):978-89. PubMed: 24632949MGI: J:229809
- Norrmen C; Ivanov KI; Cheng J; Zangger N; Delorenzi M; Jaquet M; Miura N; Puolakkainen P; Horsley V; Hu J; Augustin HG; Yla-Herttuala S; Alitalo K; Petrova TV. 2009. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol 185(3):439-57. PubMed: 19398761MGI: J:149138
- Okubo T; Hogan BL. 2004. Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. J Biol 3(3):11. PubMed: 15186480MGI: J:91317
- Okubo T; Pevny LH; Hogan BL. 2006. Sox2 is required for development of taste bud sensory cells. Genes Dev 20(19):2654-9. PubMed: 17015430MGI: J:112945
- Pan Y; Woodbury A; Esko JD; Grobe K; Zhang X. 2006. Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development 133(24):4933-44. PubMed: 17107998MGI: J:119651
- Paris ND; Coles GL; Ackerman KG. 2015. Wt1 and beta-catenin cooperatively regulate diaphragm development in the mouse. Dev Biol 407(1):40-56. PubMed: 26278035MGI: J:227024
- Pasca di Magliano M; Biankin AV; Heiser PW; Cano DA; Gutierrez PJ; Deramaudt T; Segara D; Dawson AC; Kench JG; Henshall SM; Sutherland RL; Dlugosz A; Rustgi AK; Hebrok M. 2007. Common activation of canonical wnt signaling in pancreatic adenocarcinoma. PLoS One 2(11):e1155. PubMed: 17982507MGI: J:130408
- Pierreux CE; Poll AV; Kemp CR; Clotman F; Maestro MA; Cordi S; Ferrer J; Leyns L; Rousseau GG; Lemaigre FP. 2006. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology 130(2):532-41. PubMed: 16472605MGI: J:125042
- Placencio VR; Sharif-Afshar AR; Li X; Huang H; Uwamariya C; Neilson EG; Shen MM; Matusik RJ; Hayward SW; Bhowmick NA. 2008. Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res 68(12):4709-18. PubMed: 18559517MGI: J:138897
- Plikus MV; Mayer JA; de la Cruz D; Baker RE; Maini PK; Maxson R; Chuong CM. 2008. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451(7176):340-4. PubMed: 18202659MGI: J:131404
- Prochazka J; Pantalacci S; Churava S; Rothova M; Lambert A; Lesot H; Klein O; Peterka M; Laudet V; Peterkova R. 2010. Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A 107(35):15497-502. PubMed: 20709958MGI: J:163666
- Qian L; Mahaffey JP; Alcorn HL; Anderson KV. 2011. Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo. Proc Natl Acad Sci U S A 108(21):8692-7. PubMed: 21555575MGI: J:171894
- Quasnichka H; Slater SC; Beeching CA; Boehm M; Sala-Newby GB; George SJ. 2006. Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ Res 99(12):1329-37. PubMed: 17122440MGI: J:163131
- Qyang Y; Martin-Puig S; Chiravuri M; Chen S; Xu H; Bu L; Jiang X; Lin L; Granger A; Moretti A; Caron L; Wu X; Clarke J; Taketo MM; Laugwitz KL; Moon RT; Gruber P; Evans SM; Ding S; Chien KR. 2007. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell 1(2):165-79. PubMed: 18371348MGI: J:149713
- Rakowiecki S; Epstein DJ. 2013. Divergent roles for Wnt/beta-catenin signaling in epithelial maintenance and breakdown during semicircular canal formation. Development 140(8):1730-9. PubMed: 23487315MGI: J:195122
- Ramkumar N; Harvey BM; Lee JD; Alcorn HL; Silva-Gagliardi NF; McGlade CJ; Bestor TH; Wijnholds J; Haltiwanger RS; Anderson KV. 2015. Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet 11(10):e1005551. PubMed: 26496195MGI: J:227336
- Rao S; Lobov IB; Vallance JE; Tsujikawa K; Shiojima I; Akunuru S; Walsh K; Benjamin LE; Lang RA. 2007. Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development 134(24):4449-58. PubMed: 18039971MGI: J:135278
- Regard JB; Cherman N; Palmer D; Kuznetsov SA; Celi FS; Guettier JM; Chen M; Bhattacharyya N; Wess J; Coughlin SR; Weinstein LS; Collins MT; Robey PG; Yang Y. 2011. Wnt/beta-catenin signaling is differentially regulated by Galpha proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A 108(50):20101-6. PubMed: 22106277MGI: J:180451
- Reynolds SD; Zemke AC; Giangreco A; Brockway BL; Teisanu RM; Drake JA; Mariani T; Di PY; Taketo MM; Stripp BR. 2008. Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells 26(5):1337-46. PubMed: 18356571MGI: J:185114
- Rhee H; Polak L; Fuchs E. 2006. Lhx2 maintains stem cell character in hair follicles. Science 312(5782):1946-9. PubMed: 16809539MGI: J:110119
- Riccomagno MM; Takada S; Epstein DJ. 2005. Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev 19(13):1612-23. PubMed: 15961523MGI: J:99408
- Rognoni E; Widmaier M; Jakobson M; Ruppert R; Ussar S; Katsougkri D; Bottcher RT; Lai-Cheong JE; Rifkin DB; McGrath JA; Fassler R. 2014. Kindlin-1 controls Wnt and TGF-beta availability to regulate cutaneous stem cell proliferation. Nat Med 20(4):350-9. PubMed: 24681597MGI: J:210448
- Romano RA; Smalley K; Liu S; Sinha S. 2010. Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha. Development 137(9):1431-9. PubMed: 20335364MGI: J:168262
- Ruiz-Herguido C; Guiu J; D'Altri T; Ingles-Esteve J; Dzierzak E; Espinosa L; Bigas A. 2012. Hematopoietic stem cell development requires transient Wnt/beta-catenin activity. J Exp Med 209(8):1457-68. PubMed: 22802352MGI: J:189158
- Sakamaki A; Katsuragi Y; Otsuka K; Tomita M; Obata M; Iwasaki T; Abe M; Sato T; Ochiai M; Sakuraba Y; Aoyagi Y; Gondo Y; Sakimura K; Nakagama H; Mishima Y; Kominami R. 2015. Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after gamma-irradiation through Wnt/beta-catenin pathway. Carcinogenesis 36(6):622-31. PubMed: 25827435MGI: J:221957
- Sala FG; Del Moral PM; Tiozzo C; Alam DA; Warburton D; Grikscheit T; Veltmaat JM; Bellusci S. 2011. FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development 138(2):273-82. PubMed: 21148187MGI: J:167739
- Samuel MS; Lopez JI; McGhee EJ; Croft DR; Strachan D; Timpson P; Munro J; Schroder E; Zhou J; Brunton VG; Barker N; Clevers H; Sansom OJ; Anderson KI; Weaver VM; Olson MF. 2011. Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and beta-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth. Cancer Cell 19(6):776-91. PubMed: 21665151MGI: J:173558
- Schaniel C; Sirabella D; Qiu J; Niu X; Lemischka IR; Moore KA. 2011. Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells. Blood 118(9):2420-9. PubMed: 21652676MGI: J:176938
- Shao JS; Cheng SL; Pingsterhaus JM; Charlton-Kachigian N; Loewy AP; Towler DA. 2005. Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest 115(5):1210-20. PubMed: 15841209MGI: J:98092
- Shi F; Hu L; Edge AS. 2013. Generation of hair cells in neonatal mice by beta-catenin overexpression in Lgr5-positive cochlear progenitors. Proc Natl Acad Sci U S A 110(34):13851-6. PubMed: 23918377MGI: J:200672
- Shu W; Guttentag S; Wang Z; Andl T; Ballard P; Lu MM; Piccolo S; Birchmeier W; Whitsett JA; Millar SE; Morrisey EE. 2005. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol 283(1):226-39. PubMed: 15907834MGI: J:99391
- Skah S; Nadjar J; Sirakov M; Plateroti M. 2015. The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium. Exp Cell Res 330(1):56-65. PubMed: 25447442MGI: J:218778
- Smith AN; Miller LA; Song N; Taketo MM; Lang RA. 2005. The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm. Dev Biol 285(2):477-89. PubMed: 16102745MGI: J:101264
- Smith RW; Hicks DA; Reynolds SD. 2012. Roles for beta-catenin and doxycycline in the regulation of respiratory epithelial cell frequency and function. Am J Respir Cell Mol Biol 46(1):115-24. PubMed: 21852686MGI: J:191911
- Song L; Li Y; Wang K; Wang YZ; Molotkov A; Gao L; Zhao T; Yamagami T; Wang Y; Gan Q; Pleasure DE; Zhou CJ. 2009. Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion. Development 136(18):3161-71. PubMed: 19700620MGI: J:152320
- Suomalainen M; Thesleff I. 2009. Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells. Dev Dyn 239(1):364-372. PubMed: 19806668MGI: J:155223
- Takeo M; Chou WC; Sun Q; Lee W; Rabbani P; Loomis C; Taketo MM; Ito M. 2013. Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature 499(7457):228-32. PubMed: 23760480MGI: J:204559
- Taniguchi N; Carames B; Kawakami Y; Amendt BA; Komiya S; Lotz M. 2009. Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway. Proc Natl Acad Sci U S A 106(39):16817-22. PubMed: 19805379MGI: J:153213
- Thirumangalathu S; Barlow LA. 2015. beta-Catenin signaling regulates temporally discrete phases of anterior taste bud development. Development 142(24):4309-17. PubMed: 26525674MGI: J:239947
- Tian Y; Yuan L; Goss AM; Wang T; Yang J; Lepore JJ; Zhou D; Schwartz RJ; Patel V; Cohen ED; Morrisey EE. 2010. Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell 18(2):275-87. PubMed: 20159597MGI: J:158582
- Trowbridge JJ; Scott MP; Bhatia M. 2006. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A 103(38):14134-9. PubMed: 16968775MGI: J:113717
- Tsaousi A; Williams H; Lyon CA; Taylor V; Swain A; Johnson JL; George SJ. 2011. Wnt4/beta-catenin signaling induces VSMC proliferation and is associated with intimal thickening. Circ Res 108(4):427-36. PubMed: 21193738MGI: J:183499
- Ukita K; Hirahara S; Oshima N; Imuta Y; Yoshimoto A; Jang CW; Oginuma M; Saga Y; Behringer RR; Kondoh H; Sasaki H. 2009. Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev 126(10):791-803. PubMed: 19720144MGI: J:153634
- Usongo M; Rizk A; Farookhi R. 2012. beta-Catenin/Tcf signaling in murine oocytes identifies nonovulatory follicles. Reproduction 144(6):669-76. PubMed: 23006471MGI: J:195947
- Ustiyan V; Wang IC; Ren X; Zhang Y; Snyder J; Xu Y; Wert SE; Lessard JL; Kalin TV; Kalinichenko VV. 2009. Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus. Dev Biol 336(2):266-79. PubMed: 19835856MGI: J:154909
- Ustiyan V; Zhang Y; Perl AK; Whitsett JA; Kalin TV; Kalinichenko VV. 2016. beta-catenin and Kras/Foxm1 signaling pathway are critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis. Dev Dyn 245(5):590-604. PubMed: 26869074MGI: J:231302
- Veltmaat JM; Relaix F; Le LT; Kratochwil K; Sala FG; van Veelen W; Rice R; Spencer-Dene B; Mailleux AA; Rice DP; Thiery JP; Bellusci S. 2006. Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133(12):2325-35. PubMed: 16720875MGI: J:109476
- Volckaert T; Campbell A; Dill E; Li C; Minoo P; De Langhe S. 2013. Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development 140(18):3731-42. PubMed: 23924632MGI: J:204465
- Volckaert T; Dill E; Campbell A; Tiozzo C; Majka S; Bellusci S; De Langhe SP. 2011. Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest 121(11):4409-19. PubMed: 21985786MGI: J:178444
- Voutilainen M; Lindfors PH; Lefebvre S; Ahtiainen L; Fliniaux I; Rysti E; Murtoniemi M; Schneider P; Schmidt-Ullrich R; Mikkola ML. 2012. Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-kappaB. Proc Natl Acad Sci U S A 109(15):5744-9. PubMed: 22451941MGI: J:183539
- Voutilainen M; Lindfors PH; Trela E; Lonnblad D; Shirokova V; Elo T; Rysti E; Schmidt-Ullrich R; Schneider P; Mikkola ML. 2015. Ectodysplasin/NF-kappaB Promotes Mammary Cell Fate via Wnt/beta-catenin Pathway. PLoS Genet 11(11):e1005676. PubMed: 26581094MGI: J:231699
- Wang IC; Snyder J; Zhang Y; Lander J; Nakafuku Y; Lin J; Chen G; Kalin TV; Whitsett JA; Kalinichenko VV. 2012. Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Mol Cell Biol 32(19):3838-50. PubMed: 22826436MGI: J:188926
- Wiedau-Pazos M; Wong E; Solomon E; Alarcon M; Geschwind DH. 2009. Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice. Neurobiol Aging 30(1):14-21. PubMed: 17604878MGI: J:145819
- Woo J; Miletich I; Kim BM; Sharpe PT; Shivdasani RA. 2011. Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. PLoS One 6(7):e22493. PubMed: 21799872MGI: J:175765
- Wu X; Tu X; Joeng KS; Hilton MJ; Williams DA; Long F. 2008. Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 133(2):340-53. PubMed: 18423204MGI: J:145305
- Xiong Y; Li W; Shang C; Chen RM; Han P; Yang J; Stankunas K; Wu B; Pan M; Zhou B; Longaker MT; Chang CP. 2013. Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair. Dev Cell 25(2):169-81. PubMed: 23602386MGI: J:196957
- Yan L; Della Coletta L; Powell KL; Shen J; Thames H; Aldaz CM; MacLeod MC. 2011. Activation of the canonical Wnt/beta-catenin pathway in ATF3-induced mammary tumors. PLoS One 6(1):e16515. PubMed: 21304988MGI: J:169544
- Yang J; Zhang X; Wu Y; Zhao B; Liu X; Pan Y; Liu Y; Ding Y; Qiu M; Wang YZ; Zhao G. 2016. Wnt/beta-catenin signaling mediates the seizure-facilitating effect of postischemic reactive astrocytes after pentylenetetrazole-kindling. Glia 64(6):1083-91. PubMed: 27003605MGI: J:232495
- Yang Z; Balic A; Michon F; Juuri E; Thesleff I. 2015. Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10. Stem Cells 33(5):1670-81. PubMed: 25693510MGI: J:224182
- Yu HM; Jerchow B; Sheu TJ; Liu B; Costantini F; Puzas JE; Birchmeier W; Hsu W. 2005. The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development 132(8):1995-2005. PubMed: 15790973MGI: J:98523
- Zemke AC; Teisanu RM; Giangreco A; Drake JA; Brockway BL; Reynolds SD; Stripp BR. 2009. beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. Am J Respir Cell Mol Biol 41(5):535-43. PubMed: 19213872MGI: J:166202
- Zhang Y; Call MK; Yeh LK; Liu H; Kochel T; Wang IJ; Chu PH; Taketo MM; Jester JV; Kao WW; Liu CY. 2010. Aberrant expression of a beta-catenin gain-of-function mutant induces hyperplastic transformation in the mouse cornea. J Cell Sci 123(Pt 8):1285-94. PubMed: 20332116MGI: J:159631
- Zhao J; Kim KA; De Vera J; Palencia S; Wagle M; Abo A. 2009. R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway. Proc Natl Acad Sci U S A 106(7):2331-6. PubMed: 19179402MGI: J:146284
- Zhou CJ; Molotkov A; Song L; Li Y; Pleasure DE; Pleasure SJ; Wang YZ. 2008. Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes. Dev Dyn 237(12):3681-9. PubMed: 18985738MGI: J:143210
- Zhu XJ; Liu Y; Yuan X; Wang M; Zhao W; Yang X; Zhang X; Hsu W; Qiu M; Zhang Z; Zhang Z. 2016. Ectodermal Wnt controls nasal pit morphogenesis through modulation of the BMP/FGF/JNK signaling axis. Dev Dyn 245(3):414-26. PubMed: 26661618MGI: J:229317
- del Moral PM; De Langhe SP; Sala FG; Veltmaat JM; Tefft D; Wang K; Warburton D; Bellusci S. 2006. Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev Biol 293(1):77-89. PubMed: 16494859MGI: J:108388
- van Amerongen R; Fuerer C; Mizutani M; Nusse R. 2012. Wnt5a can both activate and repress Wnt/beta-catenin signaling during mouse embryonic development. Dev Biol 369(1):101-14. PubMed: 22771246MGI: J:187621