| Allele Name | transgene insertion 25, Albee Messing |
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Gfa2-Cre; GFAP-Cre; GFAP-Cre-m; hGFAP::Cre; hGFAPcre; hGFAP-cre; Tg95.2; TgN(GFAPcre)25Mes; TgN25Mes |
| Gene Symbol and Name | Tg(GFAP-cre)25Mes, transgene insertion 25, Albee Messing |
| Gene Synonym(s) | |
| Promoter | GFAP, glial fibrillary acidic protein, human |
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| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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| Site of Expression | primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons; also periportal cells of the liver |
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| Strain of Origin | FVB/N |
| Chromosome | UN |
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Mice that are homozygous for the transgene are not viable. |
| Molecular Note | This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase. |
| Mutations Made By | Dr. Albee Messing, University of Wisconsin-Madison |
