Mice that are homozygous for the targeted mutation are viable, normal in size and do not display any gross physical or behavioral abnormalities. No gene product (protein) is detected by Western blot analysis of bone marrow-derived cell lysates. There is a 65% reduction of splenocyte number. Development of B lymphocytes is arrested at the B220+CD43+ progenitor B cell to B220+CD43- precursor B cell transition stage. The reduced number of mature peripheral B-cells results in diminished serum Ig levels in adult homozygous mice. Peritoneal CD5+IgM+ B-1a B-cell numbers are decreased. This mutant mouse strain may be useful in studies of agammaglobulinemia.

<p>These <em> Blnk</em> knock-out mice exhibit a reduction of splenocyte number and arrest of B lymphocyte development.</p>

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