The C3H/HeJ background strain is homozygous for the retinal degeneration 1 mutation, Pde6brd1.
The snol homozygous mutant phenotype includes a short nose, odd face and body shape, and kinked tail. Most mutants also get malocclusion and two homozygous mutants tested at 49 days of age exhibited intermediate hearing loss ( about 25 dB above normal). The odd shape of the face can be used to distinguish the Homozygotes by 14 days of age. snol has been mapped to Chromosome 4. The most likely gene order places the mutation between D4Mit12 and D4Mit203 in 92 tested meioses. A short nosed mutation, snubnose (sno), maps in this location, but could not be tested for allelism because it is believed to be extinct. The spina bifida occulta reported in sno homozygotes is not seen in snol homozygotes.
The snubnose like mutation arose spontaneously in 1999 in the C3H/HeJ inbred strain at The Jackson Laboratory and has been maintained on this background.
|Gene Symbol and Name||snol, snubnose-like|
|Strain of Origin||C3H/HeJ|
|General Note|| |
A short nosed mutation, snubnose (sno), maps in this location, but could not be allele tested because it is believed to be extinct. The spina bifida occulta reported in sno is not seen in snol.
|Molecular Note||A spontaneous mutation discovered at The Jackson Laboratory.|
When using the C3H/HeJ-snol/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #004476 in your Materials and Methods section.