JAX Mouse Strain Datasheet - 004362

B6;129-Scarb1^tm1Kri Apoe^tm1Unc/J

Stock No:: 004362 |; SR-BI/apoE double KO

Targeted Mutation

Cryo Recovery

Overview

Also Known As: SR-BI/apoE double KO

These SR-BI/apoE double knock-out mice exhibit hypercholesterolemia, low body weights, and early mortality.

Donating Investigator

IMR Colony, The Jackson Laboratory

Genetic overview

Genetic Background	Generation

Apoe^tm1Unc

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Apoe	apolipoprotein E

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Scarb1	scavenger receptor class B, member 1

Research Applications

Cardiovascular Research
Metabolism Research
Reproductive Biology Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

At birth, mice homozygous for both targeted alleles are viable, normal in size and do not display any gross physical or behavioral abnormalities. All double mutants die between 5 to 8 weeks following birth, exhibiting hypercholesterolemia and significantly lower body weights compared to control mice. Mice display an altered appearance several days before death, displaying ruffled fur, an abnormal gate and sometimes labored breathing. Hearts from double mutants are enlarged, exhibit evidence of myocardial infarction and are functionally impaired. Histological examination reveals extensive coronary artery disease characterized by atherosclerotic plaques with evidence of cholesterol clefts and fibrin deposition. As with other Scarb1 homozygous null mutants, females are infertile while the fertility of homozygous males remains intact. This double mutant mouse strain offers a model that may be a useful tool in studies related to coronary heart disease.

Development

Please see strain entries 002052 and 003379 for details regarding the construction of each mutant allele.

Control Suggestions

None Available

Additional Information

Considerations for Choosing Controls

Selected References

Braun A; Trigatti BL; Post MJ; Sato K; Simons M; Edelberg JM; Rosenberg RD; Schrenzel M; Krieger M. 2002. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice.. In: . . MGI: J:109751

View All References

Genetics

Apoe^tm1Unc

Allele Symbol: Apoe^tm1Unc

Allele Name	targeted mutation 1, University of North Carolina
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	APOE KO; AopE(-); ApoE-KO; Apoe^tm1Un; EKO; apoE-; apoE0; epsilon-; mE^-; mEKO
Gene Symbol and Name	Apoe, apolipoprotein E
Gene Synonym(s)	AD2; AI255918; APO-E; APOEA; ApoE4; LDLCQ5; LPG; expressed sequence AI255918
Strain of Origin	129P2/OlaHsd
Chromosome	7
Molecular Note	Insertion of a neomycin resistance cassette deleted part of exon 3 and part of intron 3 of the Apoe gene. Plasma from homozygous mutant mice gave no detectable immunoprecipitate by the Ouchterlony double immunodiffusion test using a rabbit antibody to rat APOE.
Mutations Made By	Dr. Nobuyo Maeda, University of North Carolina at Chapel Hill

Scarb1^tm1Kri

Allele Symbol: Scarb1^tm1Kri

Allele Name	targeted mutation 1, Monty Krieger
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	SR-BI; SR-BI KO; SR-BI^-; Sr-b1^-; srb1-; srbI^-
Gene Symbol and Name	Scarb1, scavenger receptor class B, member 1
Gene Synonym(s)	AI120173; CD36L1; CLA-1; CLA1; Cd36l1; Chohd1; Chohd1; Cla-1; D5Ertd460e; D5Ertd460e; DNA segment, Chr 5, ERATO Doi 460, expressed; HDL QTL 1; HDLQTL6; Hdlq1; Hdlq1; Hlb398; Hlb398; SR-B1; SR-BI; SRB1; SRBI; Srb1; Srb1; dominant hypercholesterolemia 1; expressed sequence AI120173; heart, lung and blood 398; scavenger receptor class B1
Strain of Origin	129S2/SvPas
Chromosome	5
Molecular Note	Replacement of the entire coding region of the first exon and an additional 554 bases of intron 1 with a neomycin cassette.
Mutations Made By	Dr. Monty Krieger, Massachusetts Institute of Technology

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cardiovascular Research
- Heart Abnormalities

Genotype: Apoe^tm1Unc related

Cardiovascular Research
- Atherosclerosis
- Hypercholesterolemia

Genotype: Scarb1^tm1Kri related

Cardiovascular Research
- Hypercholesterolemia
Metabolism Research
- Lipid Metabolism
Reproductive Biology Research
- Fertility Defects
  - females only

Mammalian Phenotype Terms by Genotype

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

hematopoietic system phenotype

abnormal erythrocyte morphology
- intracellular inclusions
- mitochondria present
- non uniform cell populations
- target-like appearance

decreased hematocrit

decreased hemoglobin content

echinocytosis
- often spiculated

hypochromic macrocytic anemia
- abnormally large but with normal cellular hemoglobin levels

macrocytosis

poikilocytosis

reticulocytosis
- a systemic process interferes with reticulocyte maturation
- reticulocytes appear in the circulation

References

Braun A; Trigatti BL; Post MJ; Sato K; Simons M; Edelberg JM; Rosenberg RD; Schrenzel M; Krieger M. 2002. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice.. In: . . MGI: J:109751

Additional References

Zhang SH; Reddick RL; Piedrahita JA; Maeda N. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E.. In: . . MGI: J:16573

Additional - Apoe^tm1Unc related

't Hoen PA; Van der Lans CA; Van Eck M; Bijsterbosch MK; Van Berkel TJ; Twisk J. 2003. Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes.. In: . . MGI: J:115676
A-Gonzalez N; Bensinger SJ; Hong C; Beceiro S; Bradley MN; Zelcer N; Deniz J; Ramirez C; Diaz M; Gallardo G; de Galarreta CR; Salazar J; Lopez F; Edwards P; Parks J; Andujar M; Tontonoz P; Castrillo A. 2009. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.. In: . . MGI: J:151872
Abd Alla J; Langer A; Elzahwy SS; Arman-Kalcek G; Streichert T; Quitterer U. 2010. Angiotensin-converting enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 (CCR9)-chemokine ligand 25 (CCL25) axis.. In: . . MGI: J:165997
Abend A; Shkedi O; Fertouk M; Caspi LH; Kehat I. 2017. Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification.. In: . . MGI: J:243567
Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments]. In: . . MGI: J:61147
Adachi H; Fujiwara Y; Kondo T; Nishikawa T; Ogawa R; Matsumura T; Ishii N; Nagai R; Miyata K; Tabata M; Motoshima H; Furukawa N; Tsuruzoe K; Kawashima J; Takeya M; Yamashita S; Koh GY; Nagy A; Suda T; Oike Y; Araki E. 2009. Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.. In: . . MGI: J:145171
Agrawal S; Febbraio M; Podrez E; Cathcart MK; Stark GR; Chisolm GM. 2007. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development.. In: . . MGI: J:137115
Ahluwalia N; Lin AY; Tager AM; Pruitt IE; Anderson TJ; Kristo F; Shen D; Cruz AR; Aikawa M; Luster AD; Gerszten RE. 2007. Inhibited aortic aneurysm formation in BLT1-deficient mice.. In: . . MGI: J:143153
Aihara K; Azuma H; Akaike M; Ikeda Y; Sata M; Takamori N; Yagi S; Iwase T; Sumitomo Y; Kawano H; Yamada T; Fukuda T; Matsumoto T; Sekine K; Sato T; Nakamichi Y; Yamamoto Y; Yoshimura K; Watanabe T; Nakamura T; Oomizu A; Tsukada M; Hayashi H; Sudo T; KatoS; Matsumoto T. 2007. Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.. In: . . MGI: J:122173
Aikawa E; Nahrendorf M; Sosnovik D; Lok VM; Jaffer FA; Aikawa M; Weissleder R. 2007. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.. In: . . MGI: J:130156
Alam MM; Okazaki K; Nguyen LTT; Ota N; Kitamura H; Murakami S; Shima H; Igarashi K; Sekine H; Motohashi H. 2017. Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.. In: . . MGI: J:242499
Alberts-Grill N; Rezvan A; Son DJ; Qiu H; Kim CW; Kemp ML; Weyand CM; Jo H. 2012. Dynamic immune cell accumulation during flow-induced atherogenesis in mouse carotid artery: an expanded flow cytometry method.. In: . . MGI: J:195958
Alexander MR; Knowles JW; Nishikimi T; Maeda N. 2003. Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice.. In: . . MGI: J:103054
Alexander MR; Moehle CW; Johnson JL; Yang Z; Lee JK; Jackson CL; Owens GK. 2012. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice.. In: . . MGI: J:184390
Ali K; Middleton M; Pure E; Rader DJ. 2005. Apolipoprotein E suppresses the type I inflammatory response in vivo.. In: . . MGI: J:114634
Ali ZA; de Jesus Perez V; Yuan K; Orcholski M; Pan S; Qi W; Chopra G; Adams C; Kojima Y; Leeper NJ; Qu X; Zaleta-Rivera K; Kato K; Yamada Y; Oguri M; Kuchinsky A; Hazen SL; Jukema JW; Ganesh SK; Nabel EG; Channon K; Leon MB; Charest A; Quertermous T; Ashley EA. 2014. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.. In: . . MGI: J:219378
Alkemade FE; van Vliet P; Henneman P; van Dijk KW; Hierck BP; van Munsteren JC; Scheerman JA; Goeman JJ; Havekes LM; Gittenberger-de Groot AC; van den Elsen PJ; DeRuiter MC. 2010. Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature.. In: . . MGI: J:156605
Alp NJ; McAteer MA; Khoo J; Choudhury RP; Channon KM. 2004. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.. In: . . MGI: J:102062
Amar S; Wu SC; Madan M. 2009. Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications.. In: . . MGI: J:144322
Amigo L; Quinones V; Mardones P; Zanlungo S; Miquel JF; Nervi F; Rigotti A. 2000. Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet.. In: . . MGI: J:107676
Amirbekian S; Long RC Jr; Consolini MA; Suo J; Willett NJ; Fielden SW; Giddens DP; Taylor WR; Oshinski JN. 2009. In vivo assessment of blood flow patterns in abdominal aorta of mice with MRI: implications for AAA localization.. In: . . MGI: J:154334
An G; Miwa T; Song WL; Lawson JA; Rader DJ; Zhang Y; Song WC. 2009. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice.. In: . . MGI: J:148359
An G; Wang H; Tang R; Yago T; McDaniel JM; McGee S; Huo Y; Xia L. 2008. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice.. In: . . MGI: J:155081
Anderson DR; Tsutsui JM; Xie F; Radio SJ; Porter TR. 2007. The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque.. In: . . MGI: J:119533
Anderson R; Barnes JC; Bliss TV; Cain DP; Cambon K; Davies HA; Errington ML; Fellows LA; Gray RA; Hoh T; Stewart M; Large CH; Higgins GA. 1998. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse.. In: . . MGI: J:118390
Anderson R; Higgins GA. 1997. Absence of central cholinergic deficits in ApoE knockout mice.. In: . . MGI: J:127860
Andersson IJ; Jiang YY; Davidge ST. 2009. Maternal stress and development of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring.. In: . . MGI: J:145701
Ando Y; Shimizugawa T; Takeshita S; Ono M; Shimamura M; Koishi R; Furukawa H. 2003. A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice.. In: . . MGI: J:84022
Andre P; Morooka T; Sim D; Abe K; Lowell C; Nanda N; Delaney S; Siu G; Yan Y; Hollenbach S; Pandey A; Gao H; Wang Y; Nakajima K; Parikh SA; Shi C; Phillips D; Owen W; Sinha U; Simon DI. 2011. Critical role for Syk in responses to vascular injury.. In: . . MGI: J:178801
Andrews-Zwilling Y; Bien-Ly N; Xu Q; Li G; Bernardo A; Yoon SY; Zwilling D; Yan TX; Chen L; Huang Y. 2010. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.. In: . . MGI: J:165492
Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization.. In: . . MGI: J:93917
Angsana J; Chen J; Smith S; Xiao J; Wen J; Liu L; Haller CA; Chaikof EL. 2015. Syndecan-1 modulates the motility and resolution responses of macrophages.. In: . . MGI: J:240984
Aono J; Suzuki J; Iwai M; Horiuchi M; Nagai T; Nishimura K; Inoue K; Ogimoto A; Okayama H; Higaki J. 2012. Deletion of the angiotensin II type 1a receptor prevents atherosclerotic plaque rupture in apolipoprotein E-/- mice.. In: . . MGI: J:196922
Apostolov EO; Ray D; Savenka AV; Shah SV; Basnakian AG. 2010. Chronic uremia stimulates LDL carbamylation and atherosclerosis.. In: . . MGI: J:185898
Aprahamian T; Bonegio R; Rizzo J; Perlman H; Lefer DJ; Rifkin IR; Walsh K. 2006. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.. In: . . MGI: J:139547
Aprahamian T; Bonegio RG; Richez C; Yasuda K; Chiang LK; Sato K; Walsh K; Rifkin IR. 2009. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin.. In: . . MGI: J:142895
Aprahamian T; Rifkin I; Bonegio R; Hugel B; Freyssinet JM; Sato K; Castellot JJ Jr; Walsh K. 2004. Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease.. In: . . MGI: J:91058
Arakawa M; Mita T; Azuma K; Ebato C; Goto H; Nomiyama T; Fujitani Y; Hirose T; Kawamori R; Watada H. 2010. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4.. In: . . MGI: J:164336
Arnold L; Perrin H; de Chanville CB; Saclier M; Hermand P; Poupel L; Guyon E; Licata F; Carpentier W; Vilar J; Mounier R; Chazaud B; Benhabiles N; Boissonnas A; Combadiere B; Combadiere C. 2015. CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production.. In: . . MGI: J:228319
Arsenescu V; Arsenescu R; Parulkar M; Karounos M; Zhang X; Baker N; Cassis LA. 2011. Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice.. In: . . MGI: J:178556
Ashida N; Senbanerjee S; Kodama S; Foo SY; Coggins M; Spencer JA; Zamiri P; Shen D; Li L; Sciuto T; Dvorak A; Gerszten RE; Lin CP; Karin M; Rosenzweig A. 2011. IKKbeta regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways.. In: . . MGI: J:205654
Ason B; van der Hoorn JW; Chan J; Lee E; Pieterman EJ; Nguyen KK; Di M; Shetterly S; Tang J; Yeh WC; Schwarz M; Jukema JW; Scott R; Wasserman SM; Princen HM; Jackson S. 2014. PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE.. In: . . MGI: J:216603
Atkins GB; Wang Y; Mahabeleshwar GH; Shi H; Gao H; Kawanami D; Natesan V; Lin Z; Simon DI; Jain MK. 2008. Hemizygous deficiency of Kruppel-like factor 2 augments experimental atherosclerosis.. In: . . MGI: J:155153
Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice.. In: . . MGI: J:133332
Auger A; Truong TQ; Rhainds D; Lapointe J; Letarte F; Brissette L. 2001. Low and high density lipoprotein metabolism in primary cultures of hepatic cells from normal and apolipoprotein E knockout mice.. In: . . MGI: J:115588
Aung HH; Altman R; Nyunt T; Kim J; Nuthikattu S; Budamagunta M; Voss JC; Wilson D; Rutledge JC; Villablanca AC. 2016. Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways.. In: . . MGI: J:233751
Austin SA; Combs CK. 2010. Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice.. In: . . MGI: J:165242
Avraham-Davidi I; Ely Y; Pham VN; Castranova D; Grunspan M; Malkinson G; Gibbs-Bar L; Mayseless O; Allmog G; Lo B; Warren CM; Chen TT; Ungos J; Kidd K; Shaw K; Rogachev I; Wan W; Murphy PM; Farber SA; Carmel L; Shelness GS; Iruela-Arispe ML; Weinstein BM; Yaniv K. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.. In: . . MGI: J:187459
Azevedo OG; Bolick DT; Roche JK; Pinkerton RF; Lima AA; Vitek MP; Warren CA; Oria RB; Guerrant RL. 2014. Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.. In: . . MGI: J:213815
Azuma K; Ichimura K; Mita T; Nakayama S; Jin WL; Hirose T; Fujitani Y; Sumiyoshi K; Shimada K; Daida H; Sakai T; Mitsumata M; Kawamori R; Watada H. 2009. Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta.. In: . . MGI: J:147062
Baba SP; Barski OA; Ahmed Y; O'Toole TE; Conklin DJ; Bhatnagar A; Srivastava S. 2009. Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue.. In: . . MGI: J:154389
Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice.. In: . . MGI: J:121507
Babaev VR; Li L; Shah S; Fazio S; Linton MF; May JM. 2010. Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice.. In: . . MGI: J:179551
Bagavant H; Scindia Y; Nackiewicz D; Rao Nandula S; Doran A; Cutchins A; Oldham S; Deshmukh U; McNamara C. 2011. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein e-deficient mice a model linking hyperlipidemia and renal disease.. In: . . MGI: J:174603
Bai B; Liang Y; Xu C; Lee MY; Xu A; Wu D; Vanhoutte PM; Wang Y. 2012. Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis.. In: . . MGI: J:202201
Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.. In: . . MGI: J:128048
Bales KR; Liu F; Wu S; Lin S; Koger D; DeLong C; Hansen JC; Sullivan PM; Paul SM. 2009. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.. In: . . MGI: J:149522
Bales KR; Verina T; Cummins DJ; Du Y; Dodel RC; Saura J; Fishman CE; DeLong CA; Piccardo P; Petegnief V; Ghetti B; Paul SM. 1999. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.. In: . . MGI: J:59078
Bales KR; Verina T; Dodel RC; Du Y; Altstiel L; Bender M; Hyslop P; Johnstone EM; Little SP; Cummins DJ; Piccardo P; Ghetti B; Paul SM. 1997. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [letter] [see comments]. In: . . MGI: J:43845
Baltgalvis KA; White K; Li W; Claypool MD; Lang W; Alcantara R; Singh BK; Friera AM; McLaughlin J; Hansen D; McCaughey K; Nguyen H; Smith IJ; Godinez G; Shaw SJ; Goff D; Singh R; Markovtsov V; Sun TQ; Jenkins Y; Uy G; Li Y; Pan A; Gururaja T; Lau D; ParkG; Hitoshi Y; Payan DG; Kinsella TM. 2014. Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.. In: . . MGI: J:210750
Barajas B; Che N; Yin F; Rowshanrad A; Orozco LD; Gong KW; Wang X; Castellani LW; Reue K; Lusis AJ; Araujo JA. 2011. NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection.. In: . . MGI: J:184195
Barile GR; Pachydaki SI; Tari SR; Lee SE; Donmoyer CM; Ma W; Rong LL; Buciarelli LG; Wendt T; Horig H; Hudson BI; Qu W; Weinberg AD; Yan SF; Schmidt AM. 2005. The RAGE axis in early diabetic retinopathy.. In: . . MGI: J:103714
Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis.. In: . . MGI: J:123530
Barry-Lane PA; Patterson C; van der Merwe M; Hu Z; Holland SM; Yeh ET; Runge MS. 2001. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice.. In: . . MGI: J:111638
Bartelt A; Beil FT; Schinke T; Roeser K; Ruether W; Heeren J; Niemeier A. 2010. Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity.. In: . . MGI: J:165157
Bartelt A; Orlando P; Mele C; Ligresti A; Toedter K; Scheja L; Heeren J; Di Marzo V. 2011. Altered endocannabinoid signalling after a high-fat diet in Apoe (-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.. In: . . MGI: J:178356
Barton M; Haudenschild CC; d'Uscio LV; Shaw S; Munter K; Luscher TF. 1998. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice.. In: . . MGI: J:51282
Basu A; Poddar D; Robinet P; Smith JD; Febbraio M; Baldwin WM 3rd; Mazumder B. 2014. Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation.. In: . . MGI: J:222822
Bates KA; Fonte J; Robertson TA; Martins RN; Harvey AR. 2002. Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein.. In: . . MGI: J:120711
Baumgartl J; Baudler S; Scherner M; Babaev V; Makowski L; Suttles J; McDuffie M; Tobe K; Kadowaki T; Fazio S; Kahn CR; Hotamisligil GS; Krone W; Linton M; Bruning JC. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.. In: . . MGI: J:129654
Beaulieu LM; Clancy L; Tanriverdi K; Benjamin EJ; Kramer CD; Weinberg EO; He X; Mekasha S; Mick E; Ingalls RR; Genco CA; Freedman JE. 2015. Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.. In: . . MGI: J:238389
Bechtholt AJ; Smith R; Raber J; Cunningham CL. 2004. Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe(-/-) mice.. In: . . MGI: J:102259
Becker LE; Koleganova N; Piecha G; Noronha IL; Zeier M; Geldyyev A; Kokeny G; Ritz E; Gross ML. 2011. Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice.. In: . . MGI: J:169320
Beckers L; Heeneman S; Wang L; Burkly L; Rousch M; Davidson N; Gijbels M; de Winther M; Daemen M; Lutgens E. 2007. Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages.. In: . . MGI: J:122864
Beleznai T; Takano H; Hamill C; Yarova P; Douglas G; Channon K; Dora K. 2011. Enhanced K(+)-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE(-/-) mice.. In: . . MGI: J:191707
Bell RD; Winkler EA; Singh I; Sagare AP; Deane R; Wu Z; Holtzman DM; Betsholtz C; Armulik A; Sallstrom J; Berk BC; Zlokovic BV. 2012. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.. In: . . MGI: J:184835
Bengtsson E; To F; Hakansson K; Grubb A; Branen L; Nilsson J; Jovinge S. 2005. Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice.. In: . . MGI: J:114346
Bennett BJ; Scatena M; Kirk EA; Rattazzi M; Varon RM; Averill M; Schwartz SM; Giachelli CM; Rosenfeld ME. 2006. Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice.. In: . . MGI: J:128053
Bennett BJ; Wang SS; Wang X; Wu X; Lusis AJ. 2009. Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.. In: . . MGI: J:159783
Bentzon JF; Sondergaard CS; Kassem M; Falk E. 2007. Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice.. In: . . MGI: J:142997
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Zhou X; Hansson GK. 1999. Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice.. In: . . MGI: J:56605
Zhou X; Paulsson G; Stemme S; Hansson GK. 1998. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice.. In: . . MGI: J:47027
Zhou X; Robertson AK; Rudling M; Parini P; Hansson GK. 2005. Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis.. In: . . MGI: J:106869
Zhou X; Stemme S; Hansson GK. 1996. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice [see comments]. In: . . MGI: J:34435
Zhou Y; Cheshire A; Howell LA; Ryan DH; Harris RB. 1999. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice.. In: . . MGI: J:110915
Zhou Z; Subramanian P; Sevilmis G; Globke B; Soehnlein O; Karshovska E; Megens R; Heyll K; Chun J; Saulnier-Blache JS; Reinholz M; van Zandvoort M; Weber C; Schober A. 2011. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium.. In: . . MGI: J:175811
Zhu B; Kuhel DG; Witte DP; Hui DY. 2000. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice. In: . . MGI: J:66130
Zhu J; Chen T; Yang L; Li Z; Wong MM; Zheng X; Pan X; Zhang L; Yan H. 2012. Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10.. In: . . MGI: J:195455
Zhu L; Zhong M; Elder GA; Sano M; Holtzman DM; Gandy S; Cardozo C; Haroutunian V; Robakis NK; Cai D. 2015. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.. In: . . MGI: J:226992
Zimmer S; Steinmetz M; Asdonk T; Motz I; Coch C; Hartmann E; Barchet W; Wassmann S; Hartmann G; Nickenig G. 2011. Activation of endothelial toll-like receptor 3 impairs endothelial function.. In: . . MGI: J:185699
Zysset D; Weber B; Rihs S; Brasseit J; Freigang S; Riether C; Banz Y; Cerwenka A; Simillion C; Marques-Vidal P; Ochsenbein AF; Saurer L; Mueller C. 2016. TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis.. In: . . MGI: J:242597
d'Uscio LV; Baker TA; Mantilla CB; Smith L; Weiler D; Sieck GC; Katusic ZS. 2001. Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice.. In: . . MGI: J:103189
d'Uscio LV; Katusic ZS. 2006. Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice.. In: . . MGI: J:111845
d'Uscio LV; Smith LA; Katusic ZS. 2001. Hypercholesterolemia impairs endothelium-dependent relaxations in common carotid arteries of apolipoprotein e-deficient mice.. In: . . MGI: J:104001
ten Freyhaus H; Calay ES; Yalcin A; Vallerie SN; Yang L; Calay ZZ; Saatcioglu F; Hotamisligil GS. 2012. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.. In: . . MGI: J:187419
van Gils JM; Derby MC; Fernandes LR; Ramkhelawon B; Ray TD; Rayner KJ; Parathath S; Distel E; Feig JL; Alvarez-Leite JI; Rayner AJ; McDonald TO; O'Brien KD; Stuart LM; Fisher EA; Lacy-Hulbert A; Moore KJ. 2012. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.. In: . . MGI: J:181210
van Haperen R; de Waard M; van Deel E; Mees B; Kutryk M; van Aken T; Hamming J; Grosveld F; Duncker DJ; de Crom R. 2002. Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide.. In: . . MGI: J:80701
van Meer P; Pfankuch T; Raber J. 2007. Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- mice.. In: . . MGI: J:128042
von Dehn G; von Dehn O; Volker W; Langer C; Weinbauer GF; Behre HM; Nieschlag E; Assmann G; von Eckardstein A. 2001. Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones.. In: . . MGI: J:68906

Additional - Scarb1^tm1Kri related

Adorni MP; Zimetti F; Billheimer JT; Wang N; Rader DJ; Phillips MC; Rothblat GH. 2007. The roles of different pathways in the release of cholesterol from macrophages.. In: . . MGI: J:127358
Altmann SW; Davis HR; Yao X; Laverty M; Compton DS; Zhu L; Crona JH; Caplen MA; Hoos LM; Tetzloff G; Priestley T; Burnett DA; Strader CD; Graziano MP. 2002. The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.. In: . . MGI: J:75435
Annema W; Dikkers A; Freark de Boer J; Gautier T; Rensen PC; Rader DJ; Tietge UJ. 2012. ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.. In: . . MGI: J:184916
Baranova IN; Vishnyakova TG; Bocharov AV; Leelahavanichkul A; Kurlander R; Chen Z; Souza AC; Yuen PS; Star RA; Csako G; Patterson AP; Eggerman TL. 2012. Class B scavenger receptor types I and II and CD36 mediate bacterial recognition and proinflammatory signaling induced by Escherichia coli, lipopolysaccharide, and cytosolic chaperonin 60.. In: . . MGI: J:180755
Braun A; Zhang S; Miettinen HE; Ebrahim S; Holm TM; Vasile E; Post MJ; Yoerger DM; Picard MH; Krieger JL; Andrews NC; Simons M; Krieger M. 2003. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse.. In: . . MGI: J:83785
Bravo I; Amigo L; Cohen DE; Nervi F; Rigotti A; Francone O; Zanlungo S. 2007. Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse.. In: . . MGI: J:121757
Brodeur MR; Luangrath V; Bourret G; Falstrault L; Brissette L. 2005. Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice.. In: . . MGI: J:98578
Brundert M; Heeren J; Bahar-Bayansar M; Ewert A; Moore KJ; Rinninger F. 2006. Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI.. In: . . MGI: J:147399
Cai L; Ji A; de Beer FC; Tannock LR; van der Westhuyzen DR. 2008. SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance.. In: . . MGI: J:130849
Cai L; Wang Z; Meyer JM; Ji A; van der Westhuyzen DR. 2012. Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages.. In: . . MGI: J:186565
Callow MJ; Dudoit S; Gong EL; Speed TP; Rubin EM. 2000. Microarray expression profiling identifies genes with altered expression in HDL-deficient mice.. In: . . MGI: J:115384
Chang EH; Rigotti A; Huerta PT. 2009. Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition.. In: . . MGI: J:145814
Cuchel M; Lund-Katz S; de la Llera-Moya M; Millar JS; Chang D; Fuki I; Rothblat GH; Phillips MC; Rader DJ. 2010. Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages.. In: . . MGI: J:172105
Dole VS; Matuskova J; Vasile E; Yesilaltay A; Bergmeier W; Bernimoulin M; Wagner DD; Krieger M. 2008. Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice.. In: . . MGI: J:149018
Dorner M; Horwitz JA; Robbins JB; Barry WT; Feng Q; Mu K; Jones CT; Schoggins JW; Catanese MT; Burton DR; Law M; Rice CM; Ploss A. 2011. A genetically humanized mouse model for hepatitis C virus infection.. In: . . MGI: J:173453
Drover VA; Nguyen DV; Bastie CC; Darlington YF; Abumrad NA; Pessin JE; London E; Sahoo D; Phillips MC. 2008. CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice.. In: . . MGI: J:137082
Feng H; Guo L; Wang D; Gao H; Hou G; Zheng Z; Ai J; Foreman O; Daugherty A; Li XA. 2011. Deficiency of scavenger receptor BI leads to impaired lymphocyte homeostasis and autoimmune disorders in mice.. In: . . MGI: J:191836
Guo L; Song Z; Li M; Wu Q; Wang D; Feng H; Bernard P; Daugherty A; Huang B; Li XA. 2009. Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response.. In: . . MGI: J:152734
Guo L; Zheng Z; Ai J; Howatt DA; Mittelstadt PR; Thacker S; Daugherty A; Ashwell JD; Remaley AT; Li XA. 2014. Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.. In: . . MGI: J:222905
Harder C; Lau P; Meng A; Whitman SC; McPherson R. 2007. Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice.. In: . . MGI: J:128221
Hildebrand RB; Lammers B; Meurs I; Korporaal SJ; De Haan W; Zhao Y; Kruijt JK; Pratico D; Schimmel AW; Holleboom AG; Hoekstra M; Kuivenhoven JA; Van Berkel TJ; Rensen PC; Van Eck M. 2010. Restoration of high-density lipoprotein levels by cholesteryl ester transfer protein expression in scavenger receptor class B type I (SR-BI) knockout mice does not normalize pathologies associated with SR-BI deficiency.. In: . . MGI: J:180862
Hoekstra M; Meurs I; Koenders M; Out R; Hildebrand RB; Kruijt JK; Van Eck M; Van Berkel TJ. 2008. Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting.. In: . . MGI: J:133584
Hoekstra M; Ye D; Hildebrand RB; Zhao Y; Lammers B; Stitzinger M; Kuiper J; Van Berkel TJ; Van Eck M. 2009. Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production.. In: . . MGI: J:149859
Hoekstra M; van der Sluis RJ; Van Eck M; Van Berkel TJ. 2013. Adrenal-specific scavenger receptor BI deficiency induces glucocorticoid insufficiency and lowers plasma very-low-density and low-density lipoprotein levels in mice.. In: . . MGI: J:216909
Holm TM; Braun A; Trigatti BL; Brugnara C; Sakamoto M; Krieger M; Andrews NC. 2002. Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI.. In: . . MGI: J:75090
Ji A; Wroblewski JM; Cai L; de Beer MC; Webb NR; van der Westhuyzen DR. 2012. Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI.. In: . . MGI: J:183126
Jimenez LM; Binelli M; Bertolin K; Pelletier RM; Murphy BD. 2010. Scavenger receptor-B1 and luteal function in mice.. In: . . MGI: J:162944
Karackattu SL; Picard MH; Krieger M. 2005. Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice.. In: . . MGI: J:110023
Karackattu SL; Trigatti B; Krieger M. 2006. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice.. In: . . MGI: J:127979
Kocher O; Yesilaltay A; Shen CH; Zhang S; Daniels K; Pal R; Chen J; Krieger M. 2008. Influence of PDZK1 on lipoprotein metabolism and atherosclerosis.. In: . . MGI: J:136729
Korporaal SJ; Meurs I; Hauer AD; Hildebrand RB; Hoekstra M; Cate HT; Pratico D; Akkerman JW; Van Berkel TJ; Kuiper J; Van Eck M. 2011. Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol.. In: . . MGI: J:184188
Lee JY; Badeau RM; Mulya A; Boudyguina E; Gebre AK; Smith TL; Parks JS. 2007. Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice.. In: . . MGI: J:121837
Lee WR; Sacharidou A; Behling-Kelly E; Oltmann SC; Zhu W; Ahmed M; Gerard RD; Hui DY; Abe J; Shaul PW; Mineo C. 2015. PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.. In: . . MGI: J:233480
Leelahavanichkul A; Bocharov AV; Kurlander R; Baranova IN; Vishnyakova TG; Souza AC; Hu X; Doi K; Vaisman B; Amar M; Sviridov D; Chen Z; Remaley AT; Csako G; Patterson AP; Yuen PS; Star RA; Eggerman TL. 2012. Class B Scavenger Receptor Types I and II and CD36 Targeting Improves Sepsis Survival and Acute Outcomes in Mice.. In: . . MGI: J:181845
Li XA; Guo L; Asmis R; Nikolova-Karakashian M; Smart EJ. 2006. Scavenger receptor BI prevents nitric oxide-induced cytotoxicity and endotoxin-induced death.. In: . . MGI: J:121399
Li XA; Guo L; Dressman JL; Asmis R; Smart EJ. 2005. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein.. In: . . MGI: J:99934
Liao J; Gao M; Wang M; Guo X; Huang W; Liu G. 2015. Spontaneous and diet-aggravated hemolysis and its correction by probucol in SR-BI knockout mice with LDL-R deficiency.. In: . . MGI: J:228451
Lim HY; Thiam CH; Yeo KP; Bisoendial R; Hii CS; McGrath KC; Tan KW; Heather A; Alexander JS; Angeli V. 2013. Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL.. In: . . MGI: J:199273
Lindegaard ML; Wassif CA; Vaisman B; Amar M; Wasmuth EV; Shamburek R; Nielsen LB; Remaley AT; Porter FD. 2008. Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome.. In: . . MGI: J:141147
Lino M; Farr S; Baker C; Fuller M; Trigatti B; Adeli K. 2015. Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states.. In: . . MGI: J:228657
Lockett AD; Petrusca DN; Justice MJ; Poirier C; Serban KA; Rush NI; Kamocka M; Predescu D; Predescu S; Petrache I. 2015. Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells.. In: . . MGI: J:232528
Luangrath V; Brodeur MR; Rhainds D; Brissette L. 2008. Mouse CD36 has opposite effects on LDL and oxidized LDL metabolism in vivo.. In: . . MGI: J:159812
Ma K; Forte T; Otvos JD; Chan L. 2005. Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models.. In: . . MGI: J:109812
Ma Y; Ashraf MZ; Podrez EA. 2010. Scavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia.. In: . . MGI: J:164537
Mardones P; Quinones V; Amigo L; Moreno M; Miquel JF; Schwarz M; Miettinen HE; Trigatti B; Krieger M; VanPatten S; Cohen DE; Rigotti A. 2001. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice.. In: . . MGI: J:68352
Mardones P; Strobel P; Miranda S; Leighton F; Quinones V; Amigo L; Rozowski J; Krieger M; Rigotti A. 2002. Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice.. In: . . MGI: J:75363
Martineau C; Kevorkova O; Brissette L; Moreau R. 2014. Scavenger receptor class B, type I (Scarb1) deficiency promotes osteoblastogenesis but stunts terminal osteocyte differentiation.. In: . . MGI: J:228774
Martineau C; Martin-Falstrault L; Brissette L; Moreau R. 2014. Gender- and region-specific alterations in bone metabolism in Scarb1-null female mice.. In: . . MGI: J:233229
Martineau C; Martin-Falstrault L; Brissette L; Moreau R. 2014. The atherogenic Scarb1 null mouse model shows a high bone mass phenotype.. In: . . MGI: J:208381
Meurs I; Hoekstra M; van Wanrooij EJ; Hildebrand RB; Kuiper J; Kuipers F; Hardeman MR; Van Berkel TJ; Van Eck M. 2005. HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes.. In: . . MGI: J:102414
Miettinen HE; Rayburn H; Krieger M. 2001. Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice.. In: . . MGI: J:73138
Minahk C; Kim KW; Nelson R; Trigatti B; Lehner R; Vance DE. 2008. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes.. In: . . MGI: J:133757
Nakagawa-Toyama Y; Zhang S; Krieger M. 2012. Dietary manipulation and social isolation alter disease progression in a murine model of coronary heart disease.. In: . . MGI: J:192296
Nakaoka H; Nakagawa-Toyama Y; Nishida M; Okada T; Kawase R; Yamashita T; Yuasa-Kawase M; Nakatani K; Masuda D; Ohama T; Sonobe T; Shirai M; Komuro I; Yamashita S. 2013. Establishment of a novel murine model of ischemic cardiomyopathy with multiple diffuse coronary lesions.. In: . . MGI: J:204930
Nguyen DV; Drover VA; Knopfel M; Dhanasekaran P; Hauser H; Phillips MC. 2009. Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption.. In: . . MGI: J:154959
Nijstad N; Wiersma H; Gautier T; van der Giet M; Maugeais C; Tietge UJ. 2009. Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase.. In: . . MGI: J:147892
Out R; Hoekstra M; Spijkers JA; Kruijt JK; van Eck M; Bos IS; Twisk J; Van Berkel TJ. 2004. Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice.. In: . . MGI: J:94153
Out R; Kruijt JK; Rensen PC; Hildebrand RB; de Vos P; Van Eck M; Van Berkel TJ. 2004. Scavenger receptor BI plays a role in facilitating chylomicron metabolism.. In: . . MGI: J:124241
Panigrahi S; Ma Y; Hong L; Gao D; West XZ; Salomon RG; Byzova TV; Podrez EA. 2013. Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.. In: . . MGI: J:212876
Pei Y; Chen X; Aboutouk D; Fuller MT; Dadoo O; Yu P; White EJ; Igdoura SA; Trigatti BL. 2013. SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction.. In: . . MGI: J:204436
Provost AC; Vede L; Bigot K; Keller N; Tailleux A; Jais JP; Savoldelli M; Ameqrane I; Lacassagne E; Legeais JM; Staels B; Menasche M; Mallat Z; Behar-Cohen F; Abitbol M. 2009. Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet.. In: . . MGI: J:154505
Rigotti A; Trigatti BL; Penman M; Rayburn H; Herz J; Krieger M. 1997. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.. In: . . MGI: J:44187
Santander NG; Contreras-Duarte S; Awad MF; Lizama C; Passalacqua I; Rigotti A; Busso D. 2013. Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.. In: . . MGI: J:193292
Schafer G; Guler R; Murray G; Brombacher F; Brown GD. 2009. The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model.. In: . . MGI: J:155946
Seetharam D; Mineo C; Gormley AK; Gibson LL; Vongpatanasin W; Chambliss KL; Hahner LD; Cummings ML; Kitchens RL; Marcel YL; Rader DJ; Shaul PW. 2006. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I.. In: . . MGI: J:118063
Tanigawa H; Billheimer JT; Tohyama J; Zhang Y; Rothblat G; Rader DJ. 2007. Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.. In: . . MGI: J:139845
Tao H; Yancey PG; Babaev VR; Blakemore JL; Zhang Y; Ding L; Fazio S; Linton MF. 2015. Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis.. In: . . MGI: J:224390
Thacker SG; Rousset X; Esmail S; Zarzour A; Jin X; Collins HL; Sampson M; Stonik J; Demosky S; Malide DA; Freeman L; Vaisman BL; Kruth HS; Adelman SJ; Remaley AT. 2015. Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.. In: . . MGI: J:224937
Thanopoulou K; Fragkouli A; Stylianopoulou F; Georgopoulos S. 2010. Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model.. In: . . MGI: J:167168
Trigatti B; Rayburn H; Vinals M; Braun A; Miettinen H; Penman M; Hertz M; Schrenzel M; Amigo L; Rigotti A; Krieger M. 1999. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology.. In: . . MGI: J:105226
Tsukamoto K; Mani DR; Shi J; Zhang S; Haagensen DE; Otsuka F; Guan J; Smith JD; Weng W; Liao R; Kolodgie FD; Virmani R; Krieger M. 2013. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease.. In: . . MGI: J:201999
Van Eck M; Bos IS; Hildebrand RB; Van Rij BT; Van Berkel TJ. 2004. Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development.. In: . . MGI: J:92320
Van Eck M; Hoekstra M; Hildebrand RB; Yaong Y; Stengel D; Kruijt JK; Sattler W; Tietge UJ; Ninio E; Van Berkel TJ; Pratico D. 2007. Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL.. In: . . MGI: J:134874
Van Eck M; Hoekstra M; Out R; Bos IS; Kruijt JK; Hildebrand RB; Van Berkel TJ. 2008. Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo.. In: . . MGI: J:130302
Van Eck M; Twisk J; Hoekstra M; Van Rij BT; Van der Lans CA; Bos IS; Kruijt JK; Kuipers F; Van Berkel TJ. 2003. Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver.. In: . . MGI: J:84112
Vishnyakova TG; Kurlander R; Bocharov AV; Baranova IN; Chen Z; Abu-Asab MS; Tsokos M; Malide D; Basso F; Remaley A; Csako G; Eggerman TL; Patterson AP. 2006. CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells.. In: . . MGI: J:117112
Vrins CL; Ottenhoff R; van den Oever K; de Waart DR; Kruyt JK; Zhao Y; van Berkel TJ; Havekes LM; Aerts JM; van Eck M; Rensen PC; Groen AK. 2012. Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.. In: . . MGI: J:188045
Wang J; Bie J; Ghosh S. 2016. Intracellular cholesterol transport proteins enhance hydrolysis of HDL-CEs and facilitate elimination of cholesterol into bile.. In: . . MGI: J:235221
Wang MD; Kiss RS; Franklin V; McBride HM; Whitman SC; Marcel YL. 2007. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways.. In: . . MGI: J:120283
Wang X; Collins HL; Ranalletta M; Fuki IV; Billheimer JT; Rothblat GH; Tall AR; Rader DJ. 2007. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.. In: . . MGI: J:123959
West XZ; Malinin NL; Merkulova AA; Tischenko M; Kerr BA; Borden EC; Podrez EA; Salomon RG; Byzova TV. 2010. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands.. In: . . MGI: J:165559
Widjaja-Adhi MA; Lobo GP; Golczak M; Von Lintig J. 2015. A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption.. In: . . MGI: J:221145
Williams DL; Wong JS; Hamilton RL. 2002. SR-BI is required for microvillar channel formation and the localization of HDL particles to the surface of adrenocortical cells in vivo.. In: . . MGI: J:75696
Xie C; Richardson JA; Turley SD; Dietschy JM. 2006. Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.. In: . . MGI: J:109000
Yamamoto S; Tanigawa H; Li X; Komaru Y; Billheimer JT; Rader DJ. 2011. Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport.. In: . . MGI: J:189383
Yancey PG; Jerome WG; Yu H; Griffin EE; Cox BE; Babaev VR; Fazio S; Linton MF. 2007. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI.. In: . . MGI: J:121848
Yang XP; Amar MJ; Vaisman B; Bocharov AV; Vishnyakova TG; Freeman LA; Kurlander RJ; Patterson AP; Becker LC; Remaley AT. 2013. Scavenger receptor-BI is a receptor for lipoprotein(a).. In: . . MGI: J:200770
Yesilaltay A; Dokshin GA; Busso D; Wang L; Galiani D; Chavarria T; Vasile E; Quilaqueo L; Orellana JA; Walzer D; Shalgi R; Dekel N; Albertini DF; Rigotti A; Page DC; Krieger M. 2014. Excess cholesterol induces mouse egg activation and may cause female infertility.. In: . . MGI: J:216748
Yesilaltay A; Kocher O; Pal R; Leiva A; Quinones V; Rigotti A; Krieger M. 2006. PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function.. In: . . MGI: J:116925
Yu H; Zhang W; Yancey PG; Koury MJ; Zhang Y; Fazio S; Linton MF. 2006. Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice.. In: . . MGI: J:127962
Yuan Q; Bie J; Wang J; Ghosh SS; Ghosh S. 2013. Cooperation between hepatic cholesteryl ester hydrolase and scavenger receptor BI for hydrolysis of HDL-CE.. In: . . MGI: J:203432
Yvan-Charvet L; Pagler TA; Wang N; Senokuchi T; Brundert M; Li H; Rinninger F; Tall AR. 2008. SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL.. In: . . MGI: J:130277
Zhang S; Picard MH; Vasile E; Zhu Y; Raffai RL; Weisgraber KH; Krieger M. 2005. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.. In: . . MGI: J:114611
Zhang W; Yancey PG; Su YR; Babaev VR; Zhang Y; Fazio S; Linton MF. 2003. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice.. In: . . MGI: J:103014
Zhang Y; Da Silva JR; Reilly M; Billheimer JT; Rothblat GH; Rader DJ. 2005. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo.. In: . . MGI: J:101524
Zhang Y; Yin L; Anderson J; Ma H; Gonzalez FJ; Willson TM; Edwards PA. 2010. Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.. In: . . MGI: J:159763
Zhao B; Song J; Ghosh S. 2008. Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport.. In: . . MGI: J:142768
Zhao Y; Pennings M; Hildebrand RB; Ye D; Calpe-Berdiel L; Out R; Kjerrulf M; Hurt-Camejo E; Groen AK; Hoekstra M; Jessup W; Chimini G; Van Berkel TJ; Van Eck M. 2010. Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet.. In: . . MGI: J:178508
van der Veen JN; Lingrell S; Vance DE. 2012. The membrane lipid phosphatidylcholine is an unexpected source of triacylglycerol in the liver.. In: . . MGI: J:188367
van der Velde AE; Vrins CL; van den Oever K; Seemann I; Oude Elferink RP; van Eck M; Kuipers F; Groen AK. 2008. Regulation of direct transintestinal cholesterol excretion in mice.. In: . . MGI: J:137834

Also Known As: SR-BI/apoE double KO

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Apoetm1Unc

Allele Symbol: Apoetm1Unc

Scarb1tm1Kri

Allele Symbol: Scarb1tm1Kri

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Apoetm1Unc related

Genotype: Scarb1tm1Kri related

Mammalian Phenotype Terms by Genotype

Genotype: Apoetm1Unc/Apoetm1Unc Scarb1tm1Kri/Scarb1tm1Kriinvolves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

hematopoietic system phenotype

References

Additional References

Additional - Apoetm1Unc related

Additional - Scarb1tm1Kri related

Genotyping Protocols

Breeding Considerations

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

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Apoe^tm1Unc

Allele Symbol: Apoe^tm1Unc

Scarb1^tm1Kri

Allele Symbol: Scarb1^tm1Kri

Genotype: Apoe^tm1Unc related

Genotype: Scarb1^tm1Kri related

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Additional - Apoe^tm1Unc related

Additional - Scarb1^tm1Kri related