This NOD/MrkTac congenic strain, commonly referred to as NOD.B10-Idd9, line R905 contains a 31Mb genomic segment from the diabetes resistant strain C57BL/10SnJ (Stock No. <a href="https://www.jax.org/strain/000666">000666</a>) introgressed into chromosome 4 and is defined within markers D4Mit258 (119Mb) and D4Mit42 (150Mb). The C57BL/10SnJ genomic segment includes Idd9.1, Idd9.2 and Idd59.3. Line 905 replaces and exhibits the same phenotype as line R28, which had a slight larger congenic interval. Congenic females and males are significantly protected from diabetes (less than 10% diabetic by 220 days of age), yet histological evaluation of 3 and 7 to9-month old females and males showed mild to extensive insulitis and were indistinguishable from the pancreas of NOD controls. When compared with NOD controls, insulin autoantibodies (IAA) are essentially the same at 13-15 weeks of age. 
This strain may be useful for positional mapping of the Idd9 sub-loci and studying candidate genes within the Idd9 region.

This chromosome 4 congenic stock, commonly referred to as NOD.B10-Idd9, Line 905, contains the C57BL/10SnJ derived Idd9 region, 119Mb through 150Mb, introgressed into the NOD/MrkTac background and exhibits significantly reduced diabetes incidence. This strain may be useful for positional mapping of the Idd9 sub-loci and studying candidate genes within the Idd9 region.

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