JAX
Mouse Strain Datasheet - 004321
B6.129S2-Mapk9tm1Flv/J
Also Known As: JNK2 KO
Th1 cell differentiation is impaired in these mice. Primary murine embryonic fibroblasts prepared from mutant embryos have decreased viability and increased genomic DNA fragmentation with UV irradiation. This mutant mouse strain represents a model that may be useful in studies related to signal transduction.
Donating Investigator
Dr. Richard A. Flavell, Yale University School of Medicine
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N5+N1F1
|
Mapk9tm1Flv
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Mapk9 | mitogen-activated protein kinase 9 |
Research Applications
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
Mice that are homozygous for the targeted mutation are viable, normal in size and do not display any gross physical or behavioral abnormalities. No gene product, mRNA or protein, is detected. Mutant mice have normal T cell and B cell development, ratio of CD4+ and CD8+ T cells in the spleen, and numbers of peripheral B cells. Although differentiation of precursor CD4+ T cells into effector Th2 cells is normal, Th1 cell differentiation is impaired. Treatment with IFN-gamma and IL-12 during precursor CD4+ T cell differentiation results in normal Th1 cell development. Primary murine embryonic fibroblasts prepared from mutant embryos have decreased viability and increased genomic DNA fragmentation with UV irradiation. This mutant mouse strain represents a model that may be useful in studies related to signal transduction.
Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt three exons encoding the protein subdomains VIII and IX (amino acids residues 151-229). The construct was electroporated into 129S2/SvPas derived D3M embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The donating investigator reports that the resulting chimeric animals were backcrossed to C57BL/6 mice (see SNP note below).
A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, at least 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Control Suggestions
Approximate Controls
- 000664 C57BL/6J, (A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, at least 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.)
- 005304 C57BL/6NJ, (A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, at least 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.)
Additional Information
Selected References
- Yang DD; Conze D; Whitmarsh AJ; Barrett T; Davis RJ; Rincon M; Flavell RA. 1998. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 9(4):575-85. PubMed: 9806643MGI: J:50628
Mapk9tm1Flv
Allele Symbol: Mapk9tm1Flv
| Allele Name | targeted mutation 1, Richard Flavell |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | Jnk2 KO; Jnk2- |
| Gene Symbol and Name | Mapk9, mitogen-activated protein kinase 9 |
| Gene Synonym(s) | AI851083; JNK-55; JNK/SAPK alpha; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; Prkm9; Prkm9; SAPK; SAPK1a; c-Jun N-terminal kinase; expressed sequence AI851083; p54a; p54aSAPK; protein kinase, mitogen-activated 9 |
| Strain of Origin | 129S2/SvPas |
| Chromosome | 11 |
| Molecular Note | A neomycin selection cassette replaced a genomic fragment containing three coding exons containing sequences required for protein kinase activity. RT-PCR analysis on RNA derived from thymus of homozygous mice confirmed that no detectable transcript is produced from this allele. Western blot analysis on brain, thymocyte and T cells derived from homozygous mice confirmed that no protein was expressed from this allele. |
| Mutations Made By | Dr. Richard Flavell, Yale University School of Medicine |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Mapk9tm1Flv related
- Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
- specific T cell deficiency
- Immunodeficiency
Mammalian Phenotype Terms by Genotype
Genotype: Mapk9tm1Flv/Mapk9tm1Flv
B6.129S2-Mapk9tm1Flv
integument phenotype
- abnormal keratinocyte morphology
- exhibit greater number of keratinocyte stem cells in skin (MGI Ref ID J:93433)
- epidermal hyperplasia
- keratinocyte hyperplasia, resulting in an increased number of epithelial cell layers (MGI Ref ID J:93433)
- increased keratohyalin granule number
- keratohyalin granules, markers of epidermal differentiation, are increased in the stratum granulosum (MGI Ref ID J:93433)
- thick epidermis
- (MGI Ref ID J:93433)
Genotype: Mapk9tm1Flv/Mapk9tm1Flv
B6.129S2-Mapk9tm1Flv/J
mortality/aging
- decreased sensitivity to induced morbidity/mortality
- mortality from galactosamine/lipopolysaccharide (GalN/LPS)-induced liver injury is markedly decreased compared to wild-type (MGI Ref ID J:113452)
liver/biliary system phenotype
- abnormal liver physiology
- exhibit protection from galactosamine/lipopolysaccharide (GalN/LPS)-induced liver injury, showing decreased injury, mortality, and blockage of the TNF death pathway and mitochondrial death pathway (decrease in Bid cleavage, mitochondrial translocation, and cytochrome c release)d cytochrome c release) (MGI Ref ID J:113452)
homeostasis/metabolism phenotype
- decreased susceptibility to injury
- exhibit protection from GalN/LPS-induced liver injury (MGI Ref ID J:113452)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Mapk9tm1Flv/Mapk9tm1Flv
involves: 129P2/OlaHsd * C57BL/6
homeostasis/metabolism phenotype
- abnormal enzyme/coenzyme activity
- upon UV irradiation, mutant MEFs (mouse embryonic fibroblasts) show decreased JNK activity compared to wild-type or Mapk8-null MEFs (MGI Ref ID J:112737)
Genotype: Mapk9tm1Flv/Mapk9tm1Flv
involves: 129S2/SvPas
cardiovascular system phenotype
- cardiovascular system phenotype
immune system phenotype
- abnormal T-helper 1 cell differentiation
- IFN-gamma production is reduced in effector Th1 cells; impairment of IFN-gamma production in Th1 cells is caused by insufficient IL-12 stimulated differentiation of the precursor CD4+ T cells into effector Th1 cells (MGI Ref ID J:50628)
- even in the presence of IL-2, precursor CD4+ T cells fail to differentiate into Th1 cells that produce large amounts of the effector cytokine IFN-gamma (MGI Ref ID J:50628)
- exhibit impaired differentiation of precursor CD4+ T cells into effector T helper 1 cells but not T helper 2 cells (MGI Ref ID J:50628)
hematopoietic system phenotype
- abnormal T-helper 1 cell differentiation
- IFN-gamma production is reduced in effector Th1 cells; impairment of IFN-gamma production in Th1 cells is caused by insufficient IL-12 stimulated differentiation of the precursor CD4+ T cells into effector Th1 cells (MGI Ref ID J:50628)
- even in the presence of IL-2, precursor CD4+ T cells fail to differentiate into Th1 cells that produce large amounts of the effector cytokine IFN-gamma (MGI Ref ID J:50628)
- exhibit impaired differentiation of precursor CD4+ T cells into effector T helper 1 cells but not T helper 2 cells (MGI Ref ID J:50628)
References
- Yang DD; Conze D; Whitmarsh AJ; Barrett T; Davis RJ; Rincon M; Flavell RA. 1998. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 9(4):575-85. PubMed: 9806643MGI: J:50628
Additional - Mapk9tm1Flv related
- Abdelli S; Puyal J; Bielmann C; Buchillier V; Abderrahmani A; Clarke PG; Beckmann JS; Bonny C. 2009. JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52(9):1871-80. PubMed: 19609503MGI: J:154878
- Alcorn JF; Guala AS; van der Velden J; McElhinney B; Irvin CG; Davis RJ; Janssen-Heininger YM. 2008. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci 121(Pt 7):1036-45. PubMed: 18334556MGI: J:138475
- Anbalagan M; Sabapathy K. 2012. JNK1 and JNK2 play redundant functions in Myc-induced B cell lymphoma formation. Int J Cancer 130(8):1967-9. PubMed: 21630260MGI: J:181076
- Barnat M; Enslen H; Propst F; Davis RJ; Soares S; Nothias F. 2010. Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration. J Neurosci 30(23):7804-16. PubMed: 20534829MGI: J:160890
- Bi X; Pohl NM; Yin Z; Yang W. 2011. Loss of JNK2 increases intestinal tumor susceptibility in Apc1638+/- mice with dietary modulation. Carcinogenesis 32(4):584-8. PubMed: 21183606MGI: J:170586
- Bonnesen B; Orskov C; Rasmussen S; Holst PJ; Christensen JP; Eriksen KW; Qvortrup K; Odum N; Labuda T. 2005. MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver. Blood 106(10):3396-404. PubMed: 16081685MGI: J:124072
- Bourdi M; Korrapati MC; Chakraborty M; Yee SB; Pohl LR. 2008. Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury. Biochem Biophys Res Commun 374(1):6-10. PubMed: 18586006MGI: J:139164
- Brecht S; Kirchhof R; Chromik A; Willesen M; Nicolaus T; Raivich G; Wessig J; Waetzig V; Goetz M; Claussen M; Pearse D; Kuan CY; Vaudano E; Behrens A; Wagner E; Flavell RA; Davis RJ; Herdegen T. 2005. Specific pathophysiological functions of JNK isoforms in the brain. Eur J Neurosci 21(2):363-77. PubMed: 15673436MGI: J:100808
- Cellurale C; Girnius N; Jiang F; Cavanagh-Kyros J; Lu S; Garlick DS; Mercurio AM; Davis RJ. 2012. Role of JNK in mammary gland development and breast cancer. Cancer Res 72(2):472-81. PubMed: 22127926MGI: J:181146
- Cellurale C; Sabio G; Kennedy NJ; Das M; Barlow M; Sandy P; Jacks T; Davis RJ. 2011. Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation. Mol Cell Biol 31(7):1565-76. PubMed: 21282468MGI: J:170101
- Cellurale C; Weston CR; Reilly J; Garlick DS; Jerry DJ; Sluss HK; Davis RJ. 2010. Role of JNK in a Trp53-dependent mouse model of breast cancer. PLoS One 5(8):. PubMed: 20814571MGI: J:163993
- Chen N; Nomura M; She QB; Ma WY; Bode AM; Wang L; Flavell RA; Dong Z. 2001. Suppression of Skin Tumorigenesis in c-Jun NH(2)-Terminal Kinase-2-Deficient Mice. Cancer Res 61(10):3908-12. PubMed: 11358804MGI: J:69188
- Choi HS; Bode AM; Shim JH; Lee SY; Dong Z. 2009. c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer. Mol Cell Biol 29(8):2168-80. PubMed: 19204086MGI: J:147767
- Chromik AM; Muller AM; Korner J; Belyaev O; Holland-Letz T; Schmitz F; Herdegen T; Uhl W; Mittelkotter U. 2007. Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice. J Invest Surg 20(1):23-33. PubMed: 17365404MGI: J:130576
- Chung HK; Rao JN; Zou T; Liu L; Xiao L; Gu H; Turner DJ; Yang P; Wang JY. 2014. Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1. Am J Physiol Cell Physiol 306(12):C1167-75. PubMed: 24740539MGI: J:213244
- Conze D; Krahl T; Kennedy N; Weiss L; Lumsden J; Hess P; Flavell RA; Le Gros G; Davis RJ; Rincon M. 2002. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med 195(7):811-23. PubMed: 11927626MGI: J:124416
- Das M; Garlick DS; Greiner DL; Davis RJ. 2011. The role of JNK in the development of hepatocellular carcinoma. Genes Dev 25(6):634-45. PubMed: 21406557MGI: J:171040
- Das M; Jiang F; Sluss HK; Zhang C; Shokat KM; Flavell RA; Davis RJ. 2007. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A 104(40):15759-64. PubMed: 17893331MGI: J:131766
- Das M; Sabio G; Jiang F; Rincon M; Flavell RA; Davis RJ. 2009. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-60. PubMed: 19167327MGI: J:147632
- Denninger K; Rasmussen S; Larsen JM; Orskov C; Seier Poulsen S; Sorensen P; Christensen JP; Illges H; Odum N; Labuda T. 2011. JNK1, but Not JNK2, Is Required in Two Mechanistically Distinct Models of Inflammatory Arthritis. Am J Pathol 179(4):1884-93. PubMed: 21839715MGI: J:176299
- Dong C; Yang DD; Tournier C; Whitmarsh AJ; Xu J; Davis RJ; Flavell RA. 2000. JNK is required for effector T-cell function but not for T-cell activation. Nature 405(6782):91-4. PubMed: 10811224MGI: J:61895
- Fernandes KA; Harder JM; John SW; Shrager P; Libby RT. 2014. DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury. Neurobiol Dis 69:108-16. PubMed: 24878510MGI: J:214369
- Fujii N; Boppart MD; Dufresne SD; Crowley PF; Jozsi AC; Sakamoto K; Yu H; Aschenbach WG; Kim S; Miyazaki H; Rui L; White MF; Hirshman MF; Goodyear LJ. 2004. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. Am J Physiol Cell Physiol 287(1):C200-8. PubMed: 15013949MGI: J:95346
- Gao Z; Zhang J; Kheterpal I; Kennedy N; Davis RJ; Ye J. 2011. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem 286(25):22227-34. PubMed: 21540183MGI: J:174806
- Heinonen KM; Vanegas JR; Lew D; Krosl J; Perreault C. 2011. Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS One 6(4):e19279. PubMed: 21541287MGI: J:172379
- Hu D; Bi X; Fang W; Han A; Yang W. 2009. GSK3beta is involved in JNK2-mediated beta-catenin inhibition. PLoS One 4(8):e6640. PubMed: 19675674MGI: J:223636
- Hubner A; Barrett T; Flavell RA; Davis RJ. 2008. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell 30(4):415-25. PubMed: 18498746MGI: J:137061
- Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. PubMed: 22753496MGI: J:186492
- Hunot S; Vila M; Teismann P; Davis RJ; Hirsch EC; Przedborski S; Rakic P; Flavell RA. 2004. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 101(2):665-70. PubMed: 14704277MGI: J:87428
- Ijaz A; Tejada T; Catanuto P; Xia X; Elliot SJ; Lenz O; Jauregui A; Saenz MO; Molano RD; Pileggi A; Ricordi C; Fornoni A. 2009. Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes. Kidney Int 75(4):381-8. PubMed: 18971923MGI: J:162711
- Jaeschke A; Karasarides M; Ventura JJ; Ehrhardt A; Zhang C; Flavell RA; Shokat KM; Davis RJ. 2006. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 23(6):899-911. PubMed: 16973441MGI: J:112737
- Jaeschke A; Rincon M; Doran B; Reilly J; Neuberg D; Greiner DL; Shultz LD; Rossini AA; Flavell RA; Davis RJ. 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A 102(19):6931-5. PubMed: 15867147MGI: J:99056
- Joetham A; Ohnishi H; Okamoto M; Takeda K; Schedel M; Domenico J; Dakhama A; Gelfand EW. 2012. Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation. J Biol Chem 287(21):17100-8. PubMed: 22461627MGI: J:185623
- Kelkar N; Delmotte MH; Weston CR; Barrett T; Sheppard BJ; Flavell RA; Davis RJ. 2003. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A 100(17):9843-8. PubMed: 12897243MGI: J:85160
- Keramaris E; Ruzhynsky VA; Callaghan SM; Wong E; Davis RJ; Flavell R; Slack RS; Park DS. 2008. Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. J Biol Chem 283(1):405-15. PubMed: 17984095MGI: J:130256
- Keramaris E; Vanderluit JL; Bahadori M; Mousavi K; Davis RJ; Flavell R; Slack RS; Park DS. 2005. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. J Biol Chem 280(2):1132-41. PubMed: 15528206MGI: J:96192
- Kim L; Del Rio L; Butcher BA; Mogensen TH; Paludan SR; Flavell RA; Denkers EY. 2005. p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection. J Immunol 174(7):4178-84. PubMed: 15778378MGI: J:97936
- Kodama Y; Taura K; Miura K; Schnabl B; Osawa Y; Brenner DA. 2009. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology 136(4):1423-34. PubMed: 19249395MGI: J:148191
- Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. PubMed: 12486099MGI: J:108572
- Kuan CY; Whitmarsh AJ; Yang DD; Liao G; Schloemer AJ; Dong C; Bao J; Banasiak KJ; Haddad GG; Flavell RA; Davis RJ; Rakic P. 2003. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A 100(25):15184-9. PubMed: 14657393MGI: J:86985
- Kuan CY; Yang DD; Samanta Roy DR; Davis RJ; Rakic P; Flavell RA. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22(4):667-76. PubMed: 10230788MGI: J:54653
- Li X; Weng H; Xu C; Reece EA; Yang P. 2012. Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy. Diabetes 61(8):2084-92. PubMed: 22688338MGI: J:208533
- Li X; Xu C; Yang P. 2013. c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes 62(2):599-608. PubMed: 22961085MGI: J:208480
- Lu L; Ma J; Wang X; Wang J; Zhang F; Yu J; He G; Xu B; Brand DD; Horwitz DA; Shi W; Zheng SG. 2010. Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg. Eur J Immunol 40(1):142-52. PubMed: 19943263MGI: J:155683
- Lu L; Wang J; Zhang F; Chai Y; Brand D; Wang X; Horwitz DA; Shi W; Zheng SG. 2010. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol 184(8):4295-306. PubMed: 20304828MGI: J:159864
- Melief EJ; Miyatake M; Bruchas MR; Chavkin C. 2010. Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proc Natl Acad Sci U S A 107(25):11608-13. PubMed: 20534436MGI: J:161284
- Molinero LL; Cubre A; Mora-Solano C; Wang Y; Alegre ML. 2012. T cell receptor/CARMA1/NF-kappaB signaling controls T-helper (Th) 17 differentiation. Proc Natl Acad Sci U S A 109(45):18529-34. PubMed: 23091043MGI: J:191230
- Nagelin MH; Srinivasan S; Nadler JL; Hedrick CC. 2009. Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. J Biol Chem 284(45):31303-14. PubMed: 19713213MGI: J:156345
- Ni HM; Chen X; Ding WX; Schuchmann M; Yin XM. 2008. Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol 173(4):962-72. PubMed: 18772342MGI: J:139659
- Ni HM; Chen X; Shi YH; Liao Y; Beg AA; Fan J; Yin XM. 2009. Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice. J Biol Chem 284(7):4373-82. PubMed: 19060338MGI: J:147600
- Nicolson K; Freland S; Weir C; Delahunt B; Flavell RA; Backstrom BT. 2002. Induction of experimental autoimmune encephalomyelitis in the absence of c-Jun N-terminal kinase 2. Int Immunol 14(8):849-56. PubMed: 12147621MGI: J:113540
- Noh H; Lee H; Park E; Park S. 2016. Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development 143(3):461-72. PubMed: 26839344MGI: J:240082
- Norseen J; Hosooka T; Hammarstedt A; Yore MM; Kant S; Aryal P; Kiernan UA; Phillips DA; Maruyama H; Kraus BJ; Usheva A; Davis RJ; Smith U; Kahn BB. 2012. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol 32(10):2010-9. PubMed: 22431523MGI: J:185736
- Osto E; Matter CM; Kouroedov A; Malinski T; Bachschmid M; Camici GG; Kilic U; Stallmach T; Boren J; Iliceto S; Luscher TF; Cosentino F. 2008. c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative stress. Circulation 118(20):2073-80. PubMed: 18955669MGI: J:165619
- Otterbein LE; Otterbein SL; Ifedigbo E; Liu F; Morse DE; Fearns C; Ulevitch RJ; Knickelbein R; Flavell RA; Choi AM. 2003. MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. Am J Pathol 163(6):2555-63. PubMed: 14633627MGI: J:86602
- Papa S; Zazzeroni F; Fu YX; Bubici C; Alvarez K; Dean K; Christiansen PA; Anders RA; Franzoso G. 2008. Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J Clin Invest 118(5):1911-23. PubMed: 18382767MGI: J:136146
- Pedra JH; Mattner J; Tao J; Kerfoot SM; Davis RJ; Flavell RA; Askenase PW; Yin Z; Fikrig E. 2008. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infect Immun 76(1):308-16. PubMed: 17998313MGI: J:130174
- Pelegrino FS; Pflugfelder SC; De Paiva CS. 2012. Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. Exp Eye Res 94(1):150-6. PubMed: 22166618MGI: J:191525
- Ramo K; Sugamura K; Craige S; Keaney JF; Davis RJ. 2016. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife 5:. PubMed: 27504807MGI: J:235606
- Reinecke K; Herdegen T; Eminel S; Aldenhoff JB; Schiffelholz T. 2013. Knockout of c-Jun N-terminal kinases 1, 2 or 3 isoforms induces behavioural changes. Behav Brain Res 245:88-95. PubMed: 23428746MGI: J:197459
- Ricci R; Sumara G; Sumara I; Rozenberg I; Kurrer M; Akhmedov A; Hersberger M; Eriksson U; Eberli FR; Becher B; Boren J; Chen M; Cybulsky MI; Moore KJ; Freeman MW; Wagner EF; Matter CM; Luscher TF. 2004. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science 306(5701):1558-61. PubMed: 15567863MGI: J:94044
- Ries V; Silva RM; Oo TF; Cheng HC; Rzhetskaya M; Kholodilov N; Flavell RA; Kuan CY; Rakic P; Burke RE. 2008. JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. J Neurochem 107(6):1578-88. PubMed: 19014392MGI: J:144751
- Ruff CA; Staak N; Patodia S; Kaswich M; Rocha-Ferreira E; Da Costa C; Brecht S; Makwana M; Fontana X; Hristova M; Rumajogee P; Galiano M; Bohatschek M; Herdegen T; Behrens A; Raivich G. 2012. Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate. J Neurochem 121(4):607-18. PubMed: 22372722MGI: J:184366
- Sabio G; Cavanagh-Kyros J; Ko HJ; Jung DY; Gray S; Jun JY; Barrett T; Mora A; Kim JK; Davis RJ. 2009. Prevention of steatosis by hepatic JNK1. Cell Metab 10(6):491-8. PubMed: 19945406MGI: J:155978
- Samak G; Suzuki T; Bhargava A; Rao RK. 2010. c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 299(3):G572-84. PubMed: 20595622MGI: J:163330
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