These mice carry the ALR H2gx complex and insulin dependent diabetes susceptibility locus 16, Idd16aALR from ALR/LtJ and exhibit suppression of diabetes incidence.
Dr. Edward Leiter, The Jackson Laboratory
|Allele Type||Gene Symbol||Gene Name|
|QTL||Idd16.1||insulin dependent diabetes susceptibility 16.1|
|Marker Symbol||Marker Name|
|Idd1||insulin dependent diabetes susceptibility 1|
|D17Mit16||DNA segment, Chr 17, Massachusetts Institute of Technology 16|
|H2-D||histocompatibility 2, D region|
This allelic congenic strain commonly called D.R2, carries a defined segment of Chr 17 that includes the ALR H2gx complex and insulin dependent diabetes susceptibility locus 16, Idd16aALR. At 35 weeks of age diabetes incidence in this NOD.ALR strain is significantly suppressed with 50% of the females and almost 15% the males diabetic as compared to NOD/ShiLt in which 100% of the females and nearly 70% of the males were diabetic. Similar to Stock No. 004309 pancreatic histological examination of pre-diabetic 8-week old males show lower mean insulitis scores than controls.
This strain is useful for identifying candidate genes and dissecting the role of Idd16a in autoimmune diabetes.
ALR/LtJ-derived portions of the Idd16 locus were introgressed onto the genetic background of NOD/LtJ. Parental strain ALR/LtJ is resistant to insulin-dependent (type 1) diabetes whereas parental strain NOD/LtJ is susceptible. This strain, similar to Stock No. 004309, but with a shorter congenic interval, was produced by mating mice from NOD/ShiLt to ALR/Lt followed by 10 additional crosses to NOD/ShiLt with selection for H2gx complex at each generation. Siblings carrying the ALR/Lt derived D17Mit16 through H2-D were intercrossed to make homozygous. In 2007, the T1DR received this strain at generation N10F15.
|Gene Symbol and Name||Idd16.1, insulin dependent diabetes susceptibility 16.1|
|Strain of Origin||ALR/LtJ|
|General Note||This allele confers slower insulitis progression.|
|Molecular Note||This allele confers resistance to type I diabetes mellitus compared to NOD/LtJ.|