mammalian phenotype

• cardiovascular system phenotype
  • Normal - at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition
  (MGI Ref ID J:80537)

mortality/aging

• premature death
  • male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates
  (MGI Ref ID J:44497)

cardiovascular system phenotype

• hemorrhage
  • male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads
  (MGI Ref ID J:44497)
  • at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature
  (MGI Ref ID J:44497)
  • intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed
  (MGI Ref ID J:44497)

• internal hemorrhage
  • male hemizygotes display fatal internal hemorrhage after normal fighting with littermates
  (MGI Ref ID J:44497)

growth/size/body region phenotype

• enlarged spleen
  • male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
  (MGI Ref ID J:44497)

hematopoietic system phenotype

• enlarged spleen
  • male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
  (MGI Ref ID J:44497)

homeostasis/metabolism phenotype

• abnormal blood coagulation
  • male hemizygotes display a severe hemophilia B phenotype with reduced plasma clotting activity although an 8% residual activity is observed
  (MGI Ref ID J:44497)
  • when their tails are cut, male hemizygotes bleed and die if the wound is not cauterized
  (MGI Ref ID J:44497)

immune system phenotype

• enlarged spleen
  • male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
  (MGI Ref ID J:44497)

hematopoietic system phenotype

• decreased hematocrit
  • following bleeding experiments
  (MGI Ref ID J:166332)

homeostasis/metabolism phenotype

• increased bleeding time
  • mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice
  (MGI Ref ID J:166332)

• abnormal blood coagulation
  • rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
  (MGI Ref ID J:166332)

mortality/aging

• increased sensitivity to induced morbidity/mortality
  • rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
  (MGI Ref ID J:166332)

hematopoietic system phenotype

• decreased hematocrit
  • following bleeding experiments
  (MGI Ref ID J:166332)

homeostasis/metabolism phenotype

• increased bleeding time
  • mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice
  (MGI Ref ID J:166332)

• abnormal blood coagulation
  • rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
  (MGI Ref ID J:166332)

mortality/aging

• increased sensitivity to induced morbidity/mortality
  • rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
  (MGI Ref ID J:166332)