JAX Mouse Strain Datasheet - 004257

NOD.Cg-Prkdc^scid Tg(TcrLCMV)327Sdz/DvsJ

Stock No:: 004257

Cryo Recovery

Overview

These mice do not develop diabetes; The presence of the T cell receptor expressing transgene does not alter the resistance to type 1 diabetes conferred to the NOD background by homozygosity for the scid mutation.

Genetic overview

Genetic Background	Generation

Prkdc^scid

Allele Type	Gene Symbol	Gene Name
Spontaneous	Prkdc	protein kinase, DNA activated, catalytic polypeptide

Tg(TcrLCMV)327Sdz

Allele Type
Transgenic (Inserted expressed sequence)

View Genetics

Research Applications

Diabetes and Obesity Research
Immunology, Inflammation and Autoimmunity Research
Research Tools
Internal/Organ Research
Virology Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

Development

Strains B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ (#004694) and NOD.CB17-Prkdc^scid/J (#001303) served as progenitors for NOD.Cg-Prkdc^scid Tg(TcrLCMV)327Sdz/Dvs. (Serreze DV et al 2001 Diabetes 50(9):1992)

Expression Data

Expressed Gene	Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene	Tcrb, T cell receptor beta chain, mouse, laboratory
Site of Expression

Selected References

Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 50(9):1992-2000. PubMed: 11522664 MGI: J:71050

View All References

Genetics

Prkdc^scid

Allele Symbol: Prkdc^scid

Allele Name	severe combined immunodeficiency
Allele Type	Spontaneous
Allele Synonym(s)	SCID; scid
Gene Symbol and Name	Prkdc, protein kinase, DNA activated, catalytic polypeptide
Gene Synonym(s)	AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip
Site of Expression	T and B lymphocytes.
Strain of Origin	C.B-17
Chromosome	16
Molecular Note	A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon.

Tg(TcrLCMV)327Sdz

Allele Symbol: Tg(TcrLCMV)327Sdz

Allele Name	transgene insertion 327, Birgit Ledermann
Allele Type	Transgenic (Inserted expressed sequence)
Allele Synonym(s)	P14; P14 TCR; P14 TCR-alphabeta (Valpha2Vbeta8.1); P14 TCRValpha2Vbeta8; P14-TCR; TCR LCMV; TCR P14; TCR-Tg; TgTcr
Gene Symbol and Name	Tg(TcrLCMV)327Sdz, transgene insertion 327, Birgit Ledermann
Gene Synonym(s)	P14; P14 TCR; P14 TCR-alphabeta (Valpha2Vbeta8.1); P14 TCRValpha2Vbeta8; P14-TCR; TCR LCMV; TCR P14; TCR-Tg; TgTcr
Promoter	Tcra, T cell receptor alpha chain, mouse, laboratory
Promoter	Tcrb, T cell receptor beta chain, mouse, laboratory
Expressed Gene	Tcra, T cell receptor alpha chain, mouse, laboratory
Expressed Gene	Tcrb, T cell receptor beta chain, mouse, laboratory
Strain of Origin	(C57BL/6 x DBA/2)F2
Chromosome	UN
General Note	Transgenic mice carry a T-cell receptor (Tcra-V2, Tcra-J TA31 / Tcrb-V8.1, Tcrb-D, Tcrb-J 2.4) specific for LCMV (lymphocytic choriomeningitis virus), H2-D^b.
Molecular Note	The transgene carries both Tcra and Tcrb. Ten to twenty copies of the Tcr transgene were reported to have integrated on the same chromosome. At least two transgenic lines are known to exist. Line 327 is the representative line. The second line is 318.
Mutations Made By	Dr. Rolf Zinkernagel, University of Zurich

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
  - Type 1 Diabetes
Research Tools
- Diabetes and Obesity Research
- Immunology, Inflammation and Autoimmunity Research
  - T Cell Receptor Transgenics

Genotype: Prkdc^scid related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Research Tools
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
- Toxicology Research
  - xenograft/transplant host
Virology Research
- B and T Cell Deficiency
  - AIDS research tool

Mammalian Phenotype Terms by Genotype

Genotype: Prkdc^scid/Prkdc^scid Tg(TcrLCMV)327Sdz/?
NOD.Cg-Prkdc^scid Tg(TcrLCMV)327Sdz/DvsJ

immune system phenotype

immune system phenotype
- the presence of the T cell receptor transgene does not increase susceptibility to type 1 diabetes, even in the presence of this transgene NOD mice homozygous for the scid mutation do not develop type 1 diabetes

References

Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 50(9):1992-2000. PubMed: 11522664 MGI: J:71050

Additional - Prkdc^scid related

Accardi R; Gruffat H; Sirand C; Fusil F; Gheit T; Hernandez-Vargas H; Le Calvez-Kelm F; Traverse-Glehen A; Cosset FL; Manet E; Wild CP; Tommasino M. 2015. The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models. Carcinogenesis 36(11):1440-51. PubMed: 26424750 MGI: J:226625
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Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. PubMed: 18688847 MGI: J:142410
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Alba A; Puertas MC; Carrillo J; Planas R; Ampudia R; Pastor X; Bosch F; Pujol-Borrell R; Verdaguer J; Vives-Pi M. 2004. IFNbeta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice. J Immunol 173(11):6667-75. PubMed: 15557158 MGI: J:94366
Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A 105(47):18366-71. PubMed: 19017790 MGI: J:142215
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Prkdcscid

Allele Symbol: Prkdcscid

Tg(TcrLCMV)327Sdz

Allele Symbol: Tg(TcrLCMV)327Sdz

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Genotype: Prkdcscid related

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Genotype: Prkdcscid/Prkdcscid Tg(TcrLCMV)327Sdz/?NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ

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Additional - Tg(TcrLCMV)327Sdz related

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Prkdc^scid

Allele Symbol: Prkdc^scid

Genotype: Prkdc^scid related

Genotype: Prkdc^scid/Prkdc^scid Tg(TcrLCMV)327Sdz/?
NOD.Cg-Prkdc^scid Tg(TcrLCMV)327Sdz/DvsJ

Additional - Prkdc^scid related