NOD.129S1(B6)-Ifngr2^tm1Pbro/Dvs

Stock number: 004229
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

This strain has been cryopreserved as Stock No. 004352.

Detailed description

The Ifngr2 allele was made in W9.5 ES cells (129S1/Sv-p⁺ Tyr⁺ Kitl^Sl-J/+ background) and was imported into The Jackson Laboratory from Paul Rothman on a B6,129 segregating background. It was backcrossed onto NOD/Lt and a genome scan was run to select for NOD/Lt markers at Idd1 through Idd15 (performed as described in Serreze et al., J Exp Med, 1996). This strain was then fixed homozygous at N8. It is maintained by sibling breeding homozygotes. (Serreze et al., 2000, Lu et al., 1998.)

Allele

Symbol: Ifngr2^tm1Pbro
Name: targeted mutation 1, Paul B Rothman
MGI accession ID: MGI:1930965
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Ifngr2
Marker name: interferon gamma receptor 2
Chromosome: 16
Strain of origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺
Molecular note: Replacement of the second coding exon with a neomycin gene.