Mouse Strain Datasheet - 004194
Mouse Strain Datasheet - 004194
These OT-II transgenic mice express the mouse alpha-chain and beta-chain T cell receptor that pairs with the CD4 co-receptor and is specific for chicken ovalbumin 323-339 peptide in the context of I-Ab (CD4 co-receptor interaction with MHC class II). This results in CD4+ T cells that primarily recognize ovalbumin peptide residues 323-339 when presented by the MHC class II molecule. In these mice there is a four-fold increase in the CD4+ to CD8+ peripheral T cell ratio, and lymph node T cells demonstrate a dose-dependent proliferative response to the specific ovalbumin peptide (OVA323-339). Immune response dynamics can be studied by direct administration of ovalbumin. These transgenic mice are useful for studying in vivo T cell biology such as TCR-ligand interactions, T cell activation, thymic selection, cross-presentation of antigens, and central and peripheral T cell tolerance and induction. Like most TCR transgenics, these mice are somewhat immunodeficient.
Frank Carbone, University of Melbourne
| Genetic Background | Generation |
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Contact Technical Support
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| Allele Type |
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| Transgenic (Inserted expressed sequence) |
| Service | Genotype | Price |
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| Hemizygous for Tg(TcraTcrb)425Cbn |
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
