Male mice with this Tg(Wap-HRAS)69Lln transgene on a segregating B6;SJL background develop multiple tumors of the mammary and salivary glands by 1 year of age, and on the FVB/N background they develop multiple mammary tumors by age 6-8 weeks. The tumor phenotype has not been characterized on the B6;FVB segregating background, but some males of the Edaraddcr-3J bearing stock developed visible mammary gland tumors and became moribund between 4 and 8 months of age (LR Donahue, personal communication). The transgene can be eliminated from the stock by crossing a female homozygous for Edaraddcr-3J with a wild-type male mouse, which will replace the transgene-bearing Y Chromosome with that of the wild-type strain.

These mice are characterized by the development of multiple tumors of the mammary and salivary glands.

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