Mice homozygous for this targeted allele are viable, fertile and normal in size. No <i>Fgf7</i> transcript is detected. By two months of age, the hair coat takes on a matted/greasy appearance that becomes more prominent with age. Homozygote kidneys are markedly smaller and possess structural anomalies. Morphometric analyses indicate a reduction (~30% of wildtype) in the total number of nephrons present. Kidney development appears to be effected as early as embryonic day 16.5. This mutant mouse strain represents a model that may be useful in studies related to kidney disease.

KGF knockout mice are fibroblast growth factor 7 deficient, and may be useful in studying kidney disease as well as spleen hypoplasia, abnormal synaptic vesicle clustering and miniature inhibitory postsynaptic currents, increased susceptibility to drug-induced seizures, and impaired thymic recovery after injury.

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