These mice possess loxP sites located in introns 1 and 6 of the targeted gene. Mice that are homozygous for this floxed allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
When bred to a strain expressing Cre recombinase in chrondocytes (see Stock No. 003554 for example), this mutant mouse strain may be useful in studies of chrondocyte differentiation.
When bred to a strain expressing Cre recombinase in heart(see Stock No. 005650 or 005657 for example), this mutant mouse strain may be useful in studies of cardiovascular disease.
When bred to a strain expressing Cre recombinase in midbrain/dorsal spinal cord (see Stock No. 007807 or 009107 for example), this mutant mouse strain may be useful in studies of brain malformation and craniofacial development.
When bred to a strain expressing Cre recombinase in the distal posterior region of the embryo (see Stock No. 005622 for example), this mutant mouse strain may be useful in studies of lung development.
When bred to a strain expressing Cre recombinase in palate (see Stock No. 009388 for example), this mutant mouse strain may be useful in studies of tooth development.
When bred to a strain expressing Cre recombinase in early limb bud mesenchyme and a subset of craniofacial mesenchyme (see Stock No. 005584 for example), this mutant mouse strain may be useful in studies of bone development.
When bred to mice carrying Tg(Krt1-15-cre/PGR)22Cot (Stock No. 005249), RU 486-induced Cre recombinase expression in the epithelial and hair follicle results in altered hair growth.
When bred to mice carrying Tg(KRT14-cre/ERT)20Efu (Stock No. 005107), tamoxifen-inducible Cre recombinase expression in the epidermis results in increased cell proliferation and increased numbers of mast cells.
