At birth, mice homozygous for the targeted allele are viable, and do not display any gross physical or behavioral abnormalities. No <i>App</i> gene product (mRNA or protein) is detected. Body weight is 15-20% less than that observed in wildtype age-matched control mice. By 14 weeks of age the mice exhibit evidence of reactive gliosis. Neurological evaluation reveals significantly reduced forelimb grip strength and decreased locomotor activity. This mutant strain offers a model useful in studies related to Alzheimer's disease.

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Homozygous <i>App</i> mice weigh 15%-20% less than age-matched wild-type controls, and exhibit decreased locomotor activity and forelimb grip strength. Reactive gliosis is seen in some homozygous mice at 14 weeks of age. This  beta-amyloid precursor protein (APP) knock-out strain offers a model useful in studies related to Alzheimer's disease.


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