JAX Mouse Strain Datasheet - 004126

C.Cg-Cd19^tm1(cre)Cgn Igh^b/J

Stock No:: 004126 |; CD19Cre

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Overview

Also Known As: CD19Cre

Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM.

Donating Investigator

Robert Rickert, The Burnham Institute

Genetic overview

Genetic Background	Generation
	N13F?+N2F9 (19-SEP-16)

Cd19^tm1(cre)Cgn

Allele Type	Gene Symbol	Gene Name
Targeted (Recombinase-expressing)	Cd19	CD19 antigen

Marker(s)

	Marker Symbol	Marker Name
	Igh	immunoglobulin heavy chain complex

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Research Applications

Research Tools
Hematological Research
Immunology, Inflammation and Autoimmunity Research

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Base Price

Starting at:

$263.00 Domestic price for female

$526.00 Domestic price for breeder pair

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Details

Detailed Description

The Cd19 promoter specifically directs expression at the earliest stages and throughout B-lymphocyte development and differentiation. A Cre cassette is inserted into the Cd19 exon 2, functionally disrupting the gene. Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Mice that are homozygous deficient for Cd19 are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers.

Because the targeted mutation was generated on 129P2-derived embryonic stem cells, and the Cd19 locus is near the Tyr locus on chromosome 7, the these CD19-deficient mice may be albino (white coat color/pink eyes) or light-agouti coat color with dark eyes.

View cre expression characterization.

Development

A targeting vector containing Cre recombinase, rabbit beta-globin intron /poly A signal sequence, and an FRT-flanked neomycin resistance gene, was used to disrupt exon 2 of the Cd19 gene. Herpes simplex virus thymidine kinase gene was placed 3' of the Cd19 sequence to allow for the selection against random integration. The construct was transfected into 129P2/OlaHsd-derived E14-1 embryonic stem cells. Correctly targeted ES cells were injected into 129/Sv blastocysts. This strain was backrossed to C.BKa-Igh^b/IcrSmnJ (commonly known as C.B-17) for a minimum of 13 generations before being made homozygous.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	B cells

Control Suggestions

000651 BALB/cJ

Additional Information

Considerations for Choosing Controls

Selected References

Rickert RC; Roes J; Rajewsky K. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice.. In: . . MGI: J:67676

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Genetics

Cd19^tm1(cre)Cgn

Allele Symbol: Cd19^tm1(cre)Cgn

Allele Name	targeted mutation 1, University of Cologne
Allele Type	Targeted (Recombinase-expressing)
Allele Synonym(s)	B-Cre; CD19-; CD19-Cre; CD19-KO; Cd19^Cre; Cd19cre
Gene Symbol and Name	Cd19, CD19 antigen
Gene Synonym(s)	AW495831; B4; CVID3; expressed sequence AW495831
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	B cells
Strain of Origin	129P2/OlaHsd
Chromosome	7
Molecular Note	In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development.
Mutations Made By	Robert Rickert, The Burnham Institute

Igh

Marker Symbol: Igh

Marker Synonym(s)
Chromosome(s)	12

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Cre-lox System
  - Cre Recombinase Expression
- Developmental Biology Research
  - Cre-lox System

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Genotype: Cd19^tm1(cre)Cgn related

Hematological Research
- Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Immunodeficiency
  - B cell defects
Research Tools
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn
involves: 129P2/OlaHsd

immune system phenotype

abnormal B cell differentiation

abnormal B cell physiology
- impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate

abnormal immunoglobulin level
- failure of affinity maturation of serum antibodies

absent spleen germinal center
- failure of germinal center formation

decreased B-1 B cell number
- reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo)

decreased IgE level

decreased IgG1 level
- absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate

decreased IgM level
- reduction in serum IgM

hematopoietic system phenotype

abnormal B cell differentiation

abnormal B cell physiology
- impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate

abnormal immunoglobulin level
- failure of affinity maturation of serum antibodies

absent spleen germinal center
- failure of germinal center formation

decreased B-1 B cell number
- reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo)

decreased IgE level

decreased IgG1 level
- absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate

decreased IgM level
- reduction in serum IgM

References

Rickert RC; Roes J; Rajewsky K. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice.. In: . . MGI: J:67676

Additional References

Rickert RC; Rajewsky K; Roes J. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.. In: . . MGI: J:27463

Additional - Cd19^tm1(cre)Cgn related

Adams CM; Eischen CM. 2014. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.. In: . . MGI: J:213117
Allende ML; Tuymetova G; Lee BG; Bonifacino E; Wu YP; Proia RL. 2010. S1P1 receptor directs the release of immature B cells from bone marrow into blood.. In: . . MGI: J:161236
Altuwaijri S; Chuang KH; Lai KP; Lai JJ; Lin HY; Young FM; Bottaro A; Tsai MY; Zeng WP; Chang HC; Yeh S; Chang C. 2009. Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells.. In: . . MGI: J:146896
An L; Wang Y; Liu Y; Yang X; Liu C; Hu Z; He W; Song W; Hang H. 2010. Rad9 is required for B cell proliferation and immunoglobulin class switch recombination.. In: . . MGI: J:166880
Anderson LJ; Longnecker R. 2009. Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo.. In: . . MGI: J:144258
Anz D; Thaler R; Stephan N; Waibler Z; Trauscheid MJ; Scholz C; Kalinke U; Barchet W; Endres S; Bourquin C. 2009. Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus.. In: . . MGI: J:148244
Anzelon AN; Wu H; Rickert RC. 2003. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.. In: . . MGI: J:83213
Arana E; Vehlow A; Harwood NE; Vigorito E; Henderson R; Turner M; Tybulewicz VL; Batista FD. 2008. Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.. In: . . MGI: J:131150
Archambault AS; Carrero JA; Barnett LG; McGee NG; Sim J; Wright JO; Raabe T; Chen P; Ding H; Allenspach EJ; Dragatsis I; Laufer TM; Wu GF. 2013. Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses.. In: . . MGI: J:204951
Arcipowski KM; Stunz LL; Bishop GA. 2014. TRAF6 is a critical regulator of LMP1 functions in vivo.. In: . . MGI: J:207011
Arrate MP; Vincent T; Odvody J; Kar R; Jones SN; Eischen CM. 2010. MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.. In: . . MGI: J:162464
Audzevich T; Bashford-Rogers R; Mabbott NA; Frampton D; Freeman TC; Potocnik A; Kellam P; Gilroy DW. 2017. Pre/pro-B cells generate macrophage populations during homeostasis and inflammation.. In: . . MGI: J:242211
Bagislar S; Sabo A; Kress TR; Doni M; Nicoli P; Campaner S; Amati B. 2016. Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.. In: . . MGI: J:240508
Bai L; Constantinides MG; Thomas SY; Reboulet R; Meng F; Koentgen F; Teyton L; Savage PB; Bendelac A. 2012. Distinct APCs explain the cytokine bias of alpha-galactosylceramide variants in vivo.. In: . . MGI: J:183087
Bai L; Deng S; Reboulet R; Mathew R; Teyton L; Savage PB; Bendelac A. 2013. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides.. In: . . MGI: J:201141
Ballon G; Chen K; Perez R; Tam W; Cesarman E. 2011. Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice.. In: . . MGI: J:172031
Barnett LG; Simkins HM; Barnett BE; Korn LL; Johnson AL; Wherry EJ; Wu GF; Laufer TM. 2014. B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation.. In: . . MGI: J:209996
Baschant U; Frappart L; Rauchhaus U; Bruns L; Reichardt HM; Kamradt T; Brauer R; Tuckermann JP. 2011. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.. In: . . MGI: J:180395
Beisner DR; Ch'en IL; Kolla RV; Hoffmann A; Hedrick SM. 2005. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.. In: . . MGI: J:116713
Belver L; de Yebenes VG; Ramiro AR. 2010. MicroRNAs prevent the generation of autoreactive antibodies.. In: . . MGI: J:167003
Benhamou D; Labi V; Novak R; Dai I; Shafir-Alon S; Weiss A; Gaujoux R; Arnold R; Shen-Orr SS; Rajewsky K; Melamed D. 2016. A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency.. In: . . MGI: J:238518
Benhamron S; Hadar R; Iwawaky T; So JS; Lee AH; Tirosh B. 2014. Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells.. In: . . MGI: J:209089
Benhamron S; Pattanayak SP; Berger M; Tirosh B. 2015. mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.. In: . . MGI: J:224314
Bertossi A; Aichinger M; Sansonetti P; Lech M; Neff F; Pal M; Wunderlich FT; Anders HJ; Klein L; Schmidt-Supprian M. 2011. Loss of Roquin induces early death and immune deregulation but not autoimmunity.. In: . . MGI: J:177784
Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.. In: . . MGI: J:152307
Bolduc A; Long E; Stapler D; Cascalho M; Tsubata T; Koni PA; Shimoda M. 2010. Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.. In: . . MGI: J:161444
Bothmer A; Rommel PC; Gazumyan A; Polato F; Reczek CR; Muellenbeck MF; Schaetzlein S; Edelmann W; Chen PL; Brosh RM Jr; Casellas R; Ludwig T; Baer R; Nussenzweig A; Nussenzweig MC; Robbiani DF. 2013. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.. In: . . MGI: J:194603
Bowman-Colin C; Xia B; Bunting S; Klijn C; Drost R; Bouwman P; Fineman L; Chen X; Culhane AC; Cai H; Rodig SJ; Bronson RT; Jonkers J; Nussenzweig A; Kanellopoulou C; Livingston DM. 2013. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.. In: . . MGI: J:197442
Brockschnieder D; Lappe-Siefke C; Goebbels S; Boesl MR; Nave KA; Riethmacher D. 2004. Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination.. In: . . MGI: J:92789
Broske AM; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SE; Rosenbauer F. 2009. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.. In: . . MGI: J:155126
Browne CD; Del Nagro CJ; Cato MH; Dengler HS; Rickert RC. 2009. Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.. In: . . MGI: J:155314
Browne CD; Hoefer MM; Chintalapati SK; Cato MH; Wallez Y; Ostertag DV; Pasquale EB; Rickert RC. 2010. SHEP1 partners with CasL to promote marginal zone B-cell maturation.. In: . . MGI: J:166239
Browne EP. 2011. Toll-like receptor 7 controls the anti-retroviral germinal center response.. In: . . MGI: J:183184
Bruscoli S; Biagioli M; Sorcini D; Frammartino T; Cimino M; Sportoletti P; Mazzon E; Bereshchenko O; Riccardi C. 2015. Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice.. In: . . MGI: J:230683
Buch T; Heppner FL; Tertilt C; Heinen TJ; Kremer M; Wunderlich FT; Jung S; Waisman A. 2005. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.. In: . . MGI: J:131076
Cantor J; Browne CD; Ruppert R; Feral CC; Fassler R; Rickert RC; Ginsberg MH. 2009. CD98hc facilitates B cell proliferation and adaptive humoral immunity.. In: . . MGI: J:148000
Capitini CM; Nasholm NM; Chien CD; Larabee SM; Qin H; Song YK; Klover PJ; Hennighausen L; Khan J; Fry TJ. 2014. Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD.. In: . . MGI: J:214606
Caro-Maldonado A; Wang R; Nichols AG; Kuraoka M; Milasta S; Sun LD; Gavin AL; Abel ED; Kelsoe G; Green DR; Rathmell JC. 2014. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.. In: . . MGI: J:210231
Cazac BB; Roes J. 2000. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo.. In: . . MGI: J:90558
Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection.. In: . . MGI: J:143484
Chaimowitz NS; Martin RK; Cichy J; Gibb DR; Patil P; Kang DJ; Farnsworth J; Butcher EC; McCright B; Conrad DH. 2011. A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture.. In: . . MGI: J:179629
Chan TD; Wood K; Hermes JR; Butt D; Jolly CJ; Basten A; Brink R. 2012. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.. In: . . MGI: J:190871
Chandra A; van Maldegem F; Andrews S; Neuberger MS; Rada C. 2013. Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice.. In: . . MGI: J:232010
Chen J; Limon JJ; Blanc C; Peng SL; Fruman DA. 2010. Foxo1 regulates marginal zone B-cell development.. In: . . MGI: J:165926
Chen M; Hong MJ; Sun H; Wang L; Shi X; Gilbert BE; Corry DB; Kheradmand F; Wang J. 2014. Essential role for autophagy in the maintenance of immunological memory against influenza infection.. In: . . MGI: J:213239
Chen S; Miyazaki M; Chandra V; Fisch KM; Chang AN; Murre C. 2016. Id3 Orchestrates Germinal Center B Cell Development.. In: . . MGI: J:236307
Chiang YJ; Difilippantonio MJ; Tessarollo L; Morse HC; Hodes RJ. 2012. Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas.. In: . . MGI: J:195018
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Choi J; Jeon S; Choi S; Park K; Seong RH. 2015. The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression.. In: . . MGI: J:220000
Chung EY; Psathas JN; Yu D; Li Y; Weiss MJ; Thomas-Tikhonenko A. 2012. CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.. In: . . MGI: J:188298
Ci X; Kuraoka M; Wang H; Carico Z; Hopper K; Shin J; Deng X; Qiu Y; Unniraman S; Kelsoe G; Zhong XP. 2015. TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.. In: . . MGI: J:235410
Cinamon G; Zachariah MA; Lam OM; Foss FW Jr; Cyster JG. 2008. Follicular shuttling of marginal zone B cells facilitates antigen transport.. In: . . MGI: J:130200
Cobaleda C; Jochum W; Busslinger M. 2007. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.. In: . . MGI: J:126362
Coffey F; Manser T. 2010. Expression of cellular FLIP by B cells is required for their participation in an immune response.. In: . . MGI: J:160481
Coles MC; Veiga-Fernandes H; Foster KE; Norton T; Pagakis SN; Seddon B; Kioussis D. 2006. Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.. In: . . MGI: J:112903
Cooley LF; Martin RK; Zellner HB; Irani AM; Uram-Tuculescu C; El Shikh ME; Conrad DH. 2015. Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.. In: . . MGI: J:235248
Cooper CL; Hardy RR; Reth M; Desiderio S. 2012. Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors.. In: . . MGI: J:188661
Cronshaw DG; Nie Y; Waite J; Zou YR. 2010. An essential role of the cytoplasmic tail of CXCR4 in g-protein signaling and organogenesis.. In: . . MGI: J:167314
Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.. In: . . MGI: J:152690
Cunningham JT; Moreno MV; Lodi A; Ronen SM; Ruggero D. 2014. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.. In: . . MGI: J:214383
Dai X; Chen Y; Di L; Podd A; Li G; Bunting KD; Hennighausen L; Wen R; Wang D. 2007. Stat5 is essential for early B cell development but not for B cell maturation and function.. In: . . MGI: J:143004
Dai X; James RG; Habib T; Singh S; Jackson S; Khim S; Moon RT; Liggitt D; Wolf-Yadlin A; Buckner JH; Rawlings DJ. 2013. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.. In: . . MGI: J:201448
Daly J; Bebenek K; Watt DL; Richter K; Jiang C; Zhao ML; Ray M; McGregor WG; Kunkel TA; Diaz M. 2012. Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase zeta activity.. In: . . MGI: J:188723
De Silva NS; Anderson MM; Carette A; Silva K; Heise N; Bhagat G; Klein U. 2016. Transcription factors of the alternative NF-kappaB pathway are required for germinal center B-cell development.. In: . . MGI: J:235291
De Silva NS; Silva K; Anderson MM; Bhagat G; Klein U. 2016. Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-kappaB Transcription Factors RELB and NF-kappaB2 in B Cells.. In: . . MGI: J:233743
Del Nagro CJ; Kolla RV; Rickert RC. 2005. A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis.. In: . . MGI: J:119107
Delogu A; Schebesta A; Sun Q; Aschenbrenner K; Perlot T; Busslinger M. 2006. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.. In: . . MGI: J:113322
Demircik F; Buch T; Waisman A. 2013. Efficient B cell depletion via diphtheria toxin in CD19-Cre/iDTR mice.. In: . . MGI: J:200172
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Donahue AC; Hess KL; Ng KL; Fruman DA. 2004. Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85{alpha}. In: . . MGI: J:94022
Dougan SK; Hu CC; Paquet ME; Greenblatt MB; Kim J; Lilley BN; Watson N; Ploegh HL. 2011. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes.. In: . . MGI: J:170650
Duque-Afonso J; Feng J; Scherer F; Lin CH; Wong SH; Wang Z; Iwasaki M; Cleary ML. 2015. Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.. In: . . MGI: J:226241
Duque-Afonso J; Lin CH; Han K; Wei MC; Feng J; Kurzer JH; Schneidawind C; Wong SH; Bassik MC; Cleary ML. 2016. E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia.. In: . . MGI: J:238007
Ellinghaus U; Rupec RA; Pabst O; Ignatius R; Forster R; Dorken B; Jundt F. 2008. IkappaBalpha is required for marginal zone B cell lineage development.. In: . . MGI: J:138198
Fagone P; Gunter C; Sage CR; Gunn KE; Brewer JW; Jackowski S. 2009. CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination.. In: . . MGI: J:148370
Fahl SP; Crittenden RB; Allman D; Bender TP. 2009. c-Myb is required for pro-B cell differentiation.. In: . . MGI: J:156796
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Feldhahn N; Ferretti E; Robbiani DF; Callen E; Deroubaix S; Selleri L; Nussenzweig A; Nussenzweig MC. 2012. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.. In: . . MGI: J:190019
Feng J; Wang H; Shin DM; Masiuk M; Qi CF; Morse HC 3rd. 2011. IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools.. In: . . MGI: J:168923
Fernandez D; Ortiz M; Rodriguez L; Garcia A; Martinez D; Moreno de Alboran I. 2013. The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination.. In: . . MGI: J:204835
Fleige A; Alberti S; Grobe L; Frischmann U; Geffers R; Muller W; Nordheim A; Schippers A. 2007. Serum response factor contributes selectively to lymphocyte development.. In: . . MGI: J:124767
Folgosa L; Zellner HB; El Shikh ME; Conrad DH. 2013. Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-alpha shedding.. In: . . MGI: J:207127
Fornek JL; Tygrett LT; Waldschmidt TJ; Poli V; Rickert RC; Kansas GS. 2006. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.. In: . . MGI: J:127212
Forster N; Gallinat S; Jablonska J; Weiss S; Elsasser HP; Lutz W. 2007. p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice.. In: . . MGI: J:147840
Freitas do Rosario AP; Lamb T; Spence P; Stephens R; Lang A; Roers A; Muller W; O'Garra A; Langhorne J. 2012. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.. In: . . MGI: J:180758
Frommer F; Heinen TJ; Wunderlich FT; Yogev N; Buch T; Roers A; Bettelli E; Muller W; Anderton SM; Waisman A. 2008. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion.. In: . . MGI: J:140751
Fujiwara Y; Piemontese M; Liu Y; Thostenson JD; Xiong J; O'Brien CA. 2016. RANKL (Receptor Activator of NFkappaB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice.. In: . . MGI: J:237636
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Teichmann LL; Kashgarian M; Weaver CT; Roers A; Muller W; Shlomchik MJ. 2012. B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.. In: . . MGI: J:181124
Thomas MD; Kremer CS; Ravichandran KS; Rajewsky K; Bender TP. 2005. c-Myb is critical for B cell development and maintenance of follicular B cells.. In: . . MGI: J:113271
Thompson BJ; Bhansali R; Diebold L; Cook DE; Stolzenburg L; Casagrande AS; Besson T; Leblond B; Desire L; Malinge S; Crispino JD. 2015. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.. In: . . MGI: J:223138
Todd DJ; McHeyzer-Williams LJ; Kowal C; Lee AH; Volpe BT; Diamond B; McHeyzer-Williams MG; Glimcher LH. 2009. XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development.. In: . . MGI: J:153424
Tokoyoda K; Egawa T; Sugiyama T; Choi BI; Nagasawa T. 2004. Cellular niches controlling B lymphocyte behavior within bone marrow during development.. In: . . MGI: J:109147
Tsai CM; Chiu YK; Hsu TL; Lin IY; Hsieh SL; Lin KI. 2008. Galectin-1 promotes immunoglobulin production during plasma cell differentiation.. In: . . MGI: J:141296
Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.. In: . . MGI: J:205347
Tsalavos S; Segklia K; Passa O; Petryk A; O'Connor MB; Graf D. 2011. Involvement of twisted gastrulation in T cell-independent plasma cell production.. In: . . MGI: J:175484
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Vanoaica L; Richman L; Jaworski M; Darshan D; Luther SA; Kuhn LC. 2014. Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations.. In: . . MGI: J:213756
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Wermeling F; Lind SM; Jordo ED; Cardell SL; Karlsson MC. 2010. Invariant NKT cells limit activation of autoreactive CD1d-positive B cells.. In: . . MGI: J:160933
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Winslow MM; Gallo EM; Neilson JR; Crabtree GR. 2006. The calcineurin phosphatase complex modulates immunogenic B cell responses.. In: . . MGI: J:113318
Wirtz T; Weber T; Kracker S; Sommermann T; Rajewsky K; Yasuda T. 2016. Mouse model for acute Epstein-Barr virus infection.. In: . . MGI: J:239093
Xie P; Poovassery J; Stunz LL; Smith SM; Schultz ML; Carlin LE; Bishop GA. 2011. Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes.. In: . . MGI: J:178855
Xie P; Stunz LL; Larison KD; Yang B; Bishop GA. 2007. Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.. In: . . MGI: J:124329
Xing C; Ma N; Xiao H; Wang X; Zheng M; Han G; Chen G; Hou C; Shen B; Li Y; Wang R. 2015. Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis.. In: . . MGI: J:219596
Xu D; Liu X; Yu WM; Meyerson HJ; Guo C; Gerson SL; Qu CK. 2011. Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.. In: . . MGI: J:177285
Xu H; Chaudhri VK; Wu Z; Biliouris K; Dienger-Stambaugh K; Rochman Y; Singh H. 2015. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8.. In: . . MGI: J:233874
Xu HC; Huang J; Khairnar V; Duhan V; Pandyra AA; Grusdat M; Shinde P; McIlwain DR; Maney SK; Gommerman J; Lohning M; Ohashi PS; Mak TW; Pieper K; Sic H; Speletas M; Eibel H; Ware CF; Tumanov AV; Kruglov AA; Nedospasov SA; Haussinger D; Recher M; Lang KS;Lang PA. 2015. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.. In: . . MGI: J:222881
Xu LS; Sokalski KM; Hotke K; Christie DA; Zarnett O; Piskorz J; Thillainadesan G; Torchia J; DeKoter RP. 2012. Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.. In: . . MGI: J:190544
Xu S; Ou X; Huo J; Lim K; Huang Y; Chee S; Lam KP. 2015. Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c.. In: . . MGI: J:222711
Xu W; Fukuyama T; Ney PA; Wang D; Rehg J; Boyd K; van Deursen JM; Brindle PK. 2006. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells.. In: . . MGI: J:123532
Xu Y; Beavitt SJ; Harder KW; Hibbs ML; Tarlinton DM. 2002. The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent.. In: . . MGI: J:118420
Yabe D; Fukuda H; Aoki M; Yamada S; Takebayashi S; Shinkura R; Yamamoto N; Honjo T. 2007. Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.. In: . . MGI: J:121523
Yagi T; Giallourakis C; Mohanty S; Scheidig C; Shen J; Zheng H; Xavier RJ; Shaw AC. 2008. Defective signal transduction in B lymphocytes lacking presenilin proteins.. In: . . MGI: J:131284
Yamamoto K; Lee BJ; Li C; Dubois RL; Hobeika E; Bhagat G; Zha S. 2015. Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice.. In: . . MGI: J:221968
Yamamoto M; Okamoto T; Takeda K; Sato S; Sanjo H; Uematsu S; Saitoh T; Yamamoto N; Sakurai H; Ishii KJ; Yamaoka S; Kawai T; Matsuura Y; Takeuchi O; Akira S. 2006. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.. In: . . MGI: J:112287
Yang Z; Robinson MJ; Chen X; Smith GA; Taunton J; Liu W; Allen CD. 2016. Regulation of B cell fate by chronic activity of the IgE B cell receptor.. In: . . MGI: J:239451
Yang Z; Sullivan BM; Allen CD. 2012. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition.. In: . . MGI: J:187336
Ye M; Iwasaki H; Laiosa CV; Stadtfeld M; Xie H; Heck S; Clausen B; Akashi K; Graf T. 2003. Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential.. In: . . MGI: J:174583
Yoon HS; Scharer CD; Majumder P; Davis CW; Butler R; Zinzow-Kramer W; Skountzou I; Koutsonanos DG; Ahmed R; Boss JM. 2012. ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.. In: . . MGI: J:189853
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You Y; Zhao H; Wang Y; Carter RH. 2009. Cutting edge: Primary and secondary effects of CD19 deficiency on cells of the marginal zone.. In: . . MGI: J:149307
Yu Q; Quinn WJ 3rd; Salay T; Crowley JE; Cancro MP; Sen JM. 2008. Role of beta-catenin in B cell development and function.. In: . . MGI: J:139115
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Also Known As: CD19Cre

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Cd19tm1(cre)Cgn

Allele Symbol: Cd19tm1(cre)Cgn

Igh

Marker Symbol: Igh

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Genotype: Cd19tm1(cre)Cgn related

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Genotype: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgninvolves: 129P2/OlaHsd

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Cd19^tm1(cre)Cgn

Allele Symbol: Cd19^tm1(cre)Cgn

Genotype: Cd19^tm1(cre)Cgn related

Genotype: Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn
involves: 129P2/OlaHsd

Additional - Cd19^tm1(cre)Cgn related