JAX Mouse Strain Datasheet - 004126

C.Cg-Cd19^tm1(cre)Cgn Igh^b/J

Stock No:: 004126 |; CD19Cre

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Overview

Also Known As: CD19Cre

Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM.

Donating Investigator

Robert Rickert, The Burnham Institute

Genetic overview

Genetic Background	Generation
	N13F?+N2F9 (19-SEP-16)

Cd19^tm1(cre)Cgn

Allele Type	Gene Symbol	Gene Name
Targeted (Recombinase-expressing)	Cd19	CD19 antigen

Marker(s)

	Marker Symbol	Marker Name
	Igh	immunoglobulin heavy chain complex

View Genetics

Research Applications

Research Tools
Hematological Research
Immunology, Inflammation and Autoimmunity Research

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Base Price

Starting at:

$263.00 Domestic price for female

$526.00 Domestic price for breeder pair

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Details

Detailed Description

The Cd19 promoter specifically directs expression at the earliest stages and throughout B-lymphocyte development and differentiation. A Cre cassette is inserted into the Cd19 exon 2, functionally disrupting the gene. Homozygous mice are Cd19-deficient, whereas heterozygous mice are phenotypically normal and can be used for specific deletion of floxed targets in B-lymphocytes. Mice that are homozygous deficient for Cd19 are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. A deficiency in the B-1 subset of B-lymphocytes is observed along with a concomitant reduction in serum IgM. Homozygous mice are severely impaired in their ability to respond to T-cell-dependent antigens and fail to form splenic germinal centers.

Because the targeted mutation was generated on 129P2-derived embryonic stem cells, and the Cd19 locus is near the Tyr locus on chromosome 7, the these CD19-deficient mice may be albino (white coat color/pink eyes) or light-agouti coat color with dark eyes.

View cre expression characterization.

Development

A targeting vector containing Cre recombinase, rabbit beta-globin intron /poly A signal sequence, and an FRT-flanked neomycin resistance gene, was used to disrupt exon 2 of the Cd19 gene. Herpes simplex virus thymidine kinase gene was placed 3' of the Cd19 sequence to allow for the selection against random integration. The construct was transfected into 129P2/OlaHsd-derived E14-1 embryonic stem cells. Correctly targeted ES cells were injected into 129/Sv blastocysts. This strain was backrossed to C.BKa-Igh^b/IcrSmnJ (commonly known as C.B-17) for a minimum of 13 generations before being made homozygous.

Expression Data

Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	B cells

Control Suggestions

000651 BALB/cJ

Additional Information

Considerations for Choosing Controls

Selected References

Rickert RC; Roes J; Rajewsky K. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res 25(6):1317-8. PubMed: 9092650 MGI: J:67676

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Genetics

Cd19^tm1(cre)Cgn

Allele Symbol: Cd19^tm1(cre)Cgn

Allele Name	targeted mutation 1, University of Cologne
Allele Type	Targeted (Recombinase-expressing)
Allele Synonym(s)	B-Cre; CD19-; CD19-Cre; CD19-KO; Cd19^Cre; Cd19cre
Gene Symbol and Name	Cd19, CD19 antigen
Gene Synonym(s)	AW495831; B4; CVID3; expressed sequence AW495831
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	B cells
Strain of Origin	129P2/OlaHsd
Chromosome	7
Molecular Note	In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development.
Mutations Made By	Robert Rickert, The Burnham Institute

Igh

Marker Symbol: Igh

Marker Synonym(s)
Chromosome(s)	12

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- Cre-lox System
  - Cre Recombinase Expression
- Developmental Biology Research
  - Cre-lox System

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Genotype: Cd19^tm1(cre)Cgn related

Hematological Research
- Hematopoietic Defects
Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers
- Immunodeficiency
  - B cell defects
Research Tools
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn
involves: 129P2/OlaHsd

immune system phenotype

abnormal B cell differentiation

abnormal B cell physiology
- impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate

abnormal immunoglobulin level
- failure of affinity maturation of serum antibodies

absent spleen germinal center
- failure of germinal center formation

decreased B-1 B cell number
- reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo)

decreased IgE level

decreased IgG1 level
- absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate

decreased IgM level
- reduction in serum IgM

hematopoietic system phenotype

abnormal B cell differentiation

abnormal B cell physiology
- impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate

abnormal immunoglobulin level
- failure of affinity maturation of serum antibodies

absent spleen germinal center
- failure of germinal center formation

decreased B-1 B cell number
- reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo)

decreased IgE level

decreased IgG1 level
- absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate

decreased IgM level
- reduction in serum IgM

References

Rickert RC; Roes J; Rajewsky K. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res 25(6):1317-8. PubMed: 9092650 MGI: J:67676

Additional References

Rickert RC; Rajewsky K; Roes J. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376(6538):352-5. PubMed: 7543183 MGI: J:27463

Additional - Cd19^tm1(cre)Cgn related

Adams CM; Eischen CM. 2014. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer. Cancer Res 74(14):3923-34. PubMed: 24840646 MGI: J:213117
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Anderson LJ; Longnecker R. 2009. Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo. Blood 113(1):108-16. PubMed: 18815281 MGI: J:144258
Anz D; Thaler R; Stephan N; Waibler Z; Trauscheid MJ; Scholz C; Kalinke U; Barchet W; Endres S; Bourquin C. 2009. Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol 182(10):6044-50. PubMed: 19414755 MGI: J:148244
Anzelon AN; Wu H; Rickert RC. 2003. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol 4(3):287-94. PubMed: 12563260 MGI: J:83213
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Also Known As: CD19Cre

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Cd19tm1(cre)Cgn

Allele Symbol: Cd19tm1(cre)Cgn

Igh

Marker Symbol: Igh

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This mouse can be used to support research in many areas including:

Genotype: cre related

Genotype: Cd19tm1(cre)Cgn related

Mammalian Phenotype Terms by Genotype

Genotype: Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgninvolves: 129P2/OlaHsd

immune system phenotype

hematopoietic system phenotype

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Additional - Cd19tm1(cre)Cgn related

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Cd19^tm1(cre)Cgn

Allele Symbol: Cd19^tm1(cre)Cgn

Genotype: Cd19^tm1(cre)Cgn related

Genotype: Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn
involves: 129P2/OlaHsd

Additional - Cd19^tm1(cre)Cgn related