JAX
Mouse Strain Datasheet - 004077
B6;129-Gt(ROSA)26Sortm2Sho/J
Also Known As: ROSA26-EGFPf
These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in cre-expressing tissues. The expression level in this reporter strain is suitable for applications involving FACS but is too low for histological applications.
Donating Investigator
Stuart H Orkin, Harvard University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+35
|
Gt(ROSA)26Sortm2Sho
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), Reporter) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Detailed Description
These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. Expression of the EGFP gene is blocked by a loxP-flanked STOP fragment placed between the EGFP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in cre-expressing tissues. Mice that are homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The donating investigator indicates that the EGFP expression level in this reporter strain is suitable for applications involving FACS but is too low for histological applications.
Development
A targeting vector containing the mouse phosphoglycerate kinase promoter driving cytosine deaminase and puromycin genes, a STOP fragment, an EGFP cDNA and a Bgeo gene (not expressed), was inserted into the Gt(ROSA)26Sor locus. Located immediately 5' of the puromycin gene, the stop fragment, and the EGFP cDNA are loxP sites. A herpes simplex viral thymidine kinase cassette was used as a negative selection marker. The construct was electroporated into ROSA26 ES cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric animals were backcrossed to C57BL/6J mice.
Expression Data
| Expressed Gene | GFP, Green Fluorescent Protein, |
|---|---|
| Site of Expression | when crossed to a cre recombinase-expressing strain, Enhanced Green Fluorescent Protein expression is observed in the cre-expressing tissues |
Control Suggestions
Selected References
- Mao X; Fujiwara Y; Chapdelaine A; Yang H; Orkin SH. 2001. Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain. In: . . MGI: J:66742
Gt(ROSA)26Sortm2Sho
Allele Symbol: Gt(ROSA)26Sortm2Sho
| Allele Name | targeted mutation 2, Stuart Orkin |
|---|---|
| Allele Type | Targeted (Conditional ready (e.g. floxed), Reporter) |
| Allele Synonym(s) | R26-GFP; R26floxGFP; ROSA-GFP; ROSA-loxP-stop-loxP-GFP loxP-GFP; ROSA26-EGFP; ROSA26-EGFTf; ROSA26-flox-STOP-flox-GFP; Rosa26LOXPEGFP; Rosa26R-eGFP; RosaC |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | when crossed to a cre recombinase-expressing strain, Enhanced Green Fluorescent Protein expression is observed in the cre-expressing tissues |
| Strain of Origin | 129S4/SvJaeSor |
| Chromosome | 6 |
| Molecular Note | These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. Expression of the EGFP gene is blocked by a loxP-flanked STOP fragment placed between the EGFP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in Cre-expressing tissues. |
| Mutations Made By | Dr. Xiaohong Mao, Novartis |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- loxP-flanked Sequences
- loxP-flanked Sequences: Test/Reporter
- Fluorescent Proteins
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Cre-lox System
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
References
- Mao X; Fujiwara Y; Chapdelaine A; Yang H; Orkin SH. 2001. Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain. In: . . MGI: J:66742
Additional References
- Ohyama T; Groves AK. 2004. Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome.. In: . . MGI: J:89784
Additional - Gt(ROSA)26Sortm2Sho related
- Albert V; Cornu M; Hall MN. 2015. mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior.. In: . . MGI: J:228766
- Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells.. In: . . MGI: J:106155
- Arenkiel BR; Gaufo GO; Capecchi MR. 2003. Hoxb1 neural crest preferentially form glia of the PNS.. In: . . MGI: J:84448
- Babwah AV; Navarro VM; Ahow M; Pampillo M; Nash C; Fayazi M; Calder M; Elbert A; Urbanski HF; Wettschureck N; Offermanns S; Carroll RS; Bhattacharya M; Tobet SA; Kaiser UB. 2015. GnRH Neuron-Specific Ablation of Galphaq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Galphaq/11-Independent GnRH Secretion.. In: . . MGI: J:226397
- Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure.. In: . . MGI: J:115192
- Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network.. In: . . MGI: J:152688
- Brzezinski JA 4th; Prasov L; Glaser T. 2012. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle.. In: . . MGI: J:184871
- Campbell AL; Shih HP; Xu J; Gross MK; Kioussi C. 2012. Regulation of motility of myogenic cells in filling limb muscle anlagen by Pitx2.. In: . . MGI: J:187280
- Carhuatanta KA; Demuro G; Tschop MH; Pfluger PT; Benoit SC; Obici S. 2011. Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity.. In: . . MGI: J:174884
- Castrop H; Oppermann M; Weiss Y; Huang Y; Mizel D; Lu H; Germain S; Schweda F; Theilig F; Bachmann S; Briggs J; Kurtz A; Schnermann J. 2006. Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene.. In: . . MGI: J:144009
- Charles MA; Mortensen AH; Potok MA; Camper SA. 2008. Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility.. In: . . MGI: J:142726
- Chee MJ; Price CJ; Statnick MA; Colmers WF. 2011. Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus.. In: . . MGI: J:189408
- Chen ZL; Yao Y; Norris EH; Kruyer A; Jno-Charles O; Akhmerov A; Strickland S. 2013. Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.. In: . . MGI: J:201512
- Danielson LS; Reavie L; Coussens M; Davalos V; Castillo-Martin M; Guijarro MV; Coffre M; Cordon-Cardo C; Aifantis I; Ibrahim S; Liu C; Koralov SB; Hernando E. 2015. Limited miR-17-92 overexpression drives hematologic malignancies.. In: . . MGI: J:232684
- Dessaud E; Ribes V; Balaskas N; Yang LL; Pierani A; Kicheva A; Novitch BG; Briscoe J; Sasai N. 2010. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.. In: . . MGI: J:161598
- Dodd GT; Worth AA; Nunn N; Korpal AK; Bechtold DA; Allison MB; Myers MG Jr; Statnick MA; Luckman SM. 2014. The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.. In: . . MGI: J:215557
- Duggan CD; Demaria S; Baudhuin A; Stafford D; Ngai J. 2008. Foxg1 is required for development of the vertebrate olfactory system.. In: . . MGI: J:136319
- Eberl G; Littman DR. 2004. Thymic origin of intestinal alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells.. In: . . MGI: J:91566
- Fogarty M; Grist M; Gelman D; Marin O; Pachnis V; Kessaris N. 2007. Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex.. In: . . MGI: J:125700
- Fogarty M; Richardson WD; Kessaris N. 2005. A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord.. In: . . MGI: J:101712
- Fogarty MH. 2006. Fate-mapping the mouse neural tube by Cre-loxP transgenesis. In: . . MGI: J:186011
- Frazao R; Cravo RM; Donato J Jr; Ratra DV; Clegg DJ; Elmquist JK; Zigman JM; Williams KW; Elias CF. 2013. Shift in Kiss1 cell activity requires estrogen receptor alpha.. In: . . MGI: J:194265
- Garfield AS; Patterson C; Skora S; Gribble FM; Reimann F; Evans ML; Myers MG Jr; Heisler LK. 2012. Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract.. In: . . MGI: J:191291
- Gerfen CR; Paletzki R; Heintz N. 2013. GENSAT BAC Cre-Recombinase Driver Lines to Study the Functional Organization of Cerebral Cortical and Basal Ganglia Circuits.. In: . . MGI: J:203555
- Ghiaur G; Ferkowicz MJ; Milsom MD; Bailey J; Witte D; Cancelas JA; Yoder MC; Williams DA. 2008. Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells.. In: . . MGI: J:133470
- Gong L; Yao F; Hockman K; Heng HH; Morton GJ; Takeda K; Akira S; Low MJ; Rubinstein M; MacKenzie RG. 2008. Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.. In: . . MGI: J:145370
- Guijarro MV; Dahiya S; Danielson LS; Segura MF; Vales-Lara FM; Menendez S; Popiolek D; Mittal K; Wei JJ; Zavadil J; Cordon-Cardo C; Pandolfi PP; Hernando E. 2013. Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.. In: . . MGI: J:199111
- Haws ME; Jaramillo TC; Espinosa F; Widman AJ; Stuber GD; Sparta DR; Tye KM; Russo SJ; Parada LF; Stavarache M; Kaplitt M; Bonci A; Powell CM. 2014. PTEN knockdown alters dendritic spine/protrusion morphology, not density.. In: . . MGI: J:208826
- Heffner CS; Herbert Pratt C; Babiuk RP; Sharma Y; Rockwood SF; Donahue LR; Eppig JT; Murray SA. 2012. Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource.. In: . . MGI: J:226227
- Heldt SA; Ressler KJ. 2009. The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors.. In: . . MGI: J:210657
- Herndon MK; Nilson JH. 2015. Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones.. In: . . MGI: J:235339
- High FA; Zhang M; Proweller A; Tu L; Parmacek MS; Pear WS; Epstein JA. 2007. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.. In: . . MGI: J:118039
- Hill JW; Williams KW; Ye C; Luo J; Balthasar N; Coppari R; Cowley MA; Cantley LC; Lowell BB; Elmquist JK. 2008. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.. In: . . MGI: J:136147
- Hlady RA; Novakova S; Opavska J; Klinkebiel D; Peters SL; Bies J; Hannah J; Iqbal J; Anderson KM; Siebler HM; Smith LM; Greiner TC; Bastola D; Joshi S; Lockridge O; Simpson MA; Felsher DW; Wagner KU; Chan WC; Christman JK; Opavsky R. 2012. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.. In: . . MGI: J:184415
- Irani BG; Donato J Jr; Olson DP; Lowell BB; Sacktor TC; Reyland ME; Tolson KP; Zinn AR; Ueta Y; Sakata I; Zigman JM; Elias CF; Clegg DJ. 2010. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus.. In: . . MGI: J:166797
- Jakubzick C; Bogunovic M; Bonito AJ; Kuan EL; Merad M; Randolph GJ. 2008. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes.. In: . . MGI: J:143220
- Jeon D; Kim S; Chetana M; Jo D; Ruley HE; Lin SY; Rabah D; Kinet JP; Shin HS. 2010. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC.. In: . . MGI: J:159698
- Jeselsohn R; Brown NE; Arendt L; Klebba I; Hu MG; Kuperwasser C; Hinds PW. 2010. Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis.. In: . . MGI: J:156929
- Johnson JA; Calo S; Nair L; IglayReger HB; Greenwald-Yarnell M; Skorupski J; Myers MG Jr; Bodary PF. 2012. Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity.. In: . . MGI: J:190163
- Kaplan DH; Li MO; Jenison MC; Shlomchik WD; Flavell RA; Shlomchik MJ. 2007. Autocrine/paracrine TGF{beta}1 is required for the development of epidermal Langerhans cells.. In: . . MGI: J:126147
- Kessaris N; Fogarty M; Iannarelli P; Grist M; Wegner M; Richardson WD. 2006. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage.. In: . . MGI: J:105334
- Kim HJ; Kobayashi M; Sasaki T; Kikuchi O; Amano K; Kitazumi T; Lee YS; Yokota-Hashimoto H; Susanti VY; Kitamura YI; Nakae J; Kitamura T. 2012. Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance.. In: . . MGI: J:181720
- Knauf JA; Sartor MA; Medvedovic M; Lundsmith E; Ryder M; Salzano M; Nikiforov YE; Giordano TJ; Ghossein RA; Fagin JA. 2011. Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFbeta signaling.. In: . . MGI: J:174636
- Kong JH; Yang L; Dessaud E; Chuang K; Moore DM; Rohatgi R; Briscoe J; Novitch BG. 2015. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.. In: . . MGI: J:221657
- Lam DD; Leinninger GM; Louis GW; Garfield AS; Marston OJ; Leshan RL; Scheller EL; Christensen L; Donato J Jr; Xia J; Evans ML; Elias C; Dalley JW; Burdakov DI; Myers MG Jr; Heisler LK. 2011. Leptin does not directly affect CNS serotonin neurons to influence appetite.. In: . . MGI: J:175812
- Leinninger GM; Jo YH; Leshan RL; Louis GW; Yang H; Barrera JG; Wilson H; Opland DM; Faouzi MA; Gong Y; Jones JC; Rhodes CJ; Chua S Jr; Diano S; Horvath TL; Seeley RJ; Becker JB; Munzberg H; Myers MG Jr. 2009. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding.. In: . . MGI: J:151971
- Leinninger GM; Opland DM; Jo YH; Faouzi M; Christensen L; Cappellucci LA; Rhodes CJ; Gnegy ME; Becker JB; Pothos EN; Seasholtz AF; Thompson RC; Myers MG Jr. 2011. Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance.. In: . . MGI: J:176657
- Leshan RL; Louis GW; Jo YH; Rhodes CJ; Munzberg H; Myers MG Jr. 2009. Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus.. In: . . MGI: J:147070
- Leshan RL; Opland DM; Louis GW; Leinninger GM; Patterson CM; Rhodes CJ; Munzberg H; Myers MG Jr. 2010. Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala.. In: . . MGI: J:159836
- Li Z; Frey JL; Wong GW; Faugere MC; Wolfgang MJ; Kim JK; Riddle RC; Clemens TL. 2016. Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts.. In: . . MGI: J:240554
- Liao CP; Zhong C; Saribekyan G; Bading J; Park R; Conti PS; Moats R; Berns A; Shi W; Zhou Z; Nikitin AY; Roy-Burman P. 2007. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence.. In: . . MGI: J:123911
- Lin HV; Ren H; Samuel VT; Lee HY; Lu TY; Shulman GI; Accili D. 2011. Diabetes in mice with selective impairment of insulin action in glut4-expressing tissues.. In: . . MGI: J:169404
- Liu Z; Dearman JA; Cox BC; Walters BJ; Zhang L; Ayrault O; Zindy F; Gan L; Roussel MF; Zuo J. 2012. Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by Atoh1 ectopic expression.. In: . . MGI: J:184850
- Louis GW; Leinninger GM; Rhodes CJ; Myers MG Jr. 2010. Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.. In: . . MGI: J:163528
- Lu F; Kar D; Gruenig N; Zhang ZW; Cousins N; Rodgers HM; Swindell EC; Jamrich M; Schuurmans C; Mathers PH; Kurrasch DM. 2013. Rax is a selector gene for mediobasal hypothalamic cell types.. In: . . MGI: J:193919
- Lu J; Sun Y; Nombela-Arrieta C; Du KP; Park SY; Chai L; Walkley C; Luo HR; Silberstein LE. 2012. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion.. In: . . MGI: J:191529
- Luccardini C; Hennekinne L; Viou L; Yanagida M; Murakami F; Kessaris N; Ma X; Adelstein RS; Mege RM; Metin C. 2013. N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration.. In: . . MGI: J:204170
- Luche H; Weber O; Nageswara Rao T; Blum C; Fehling HJ. 2007. Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies.. In: . . MGI: J:117041
- Matsuki T; Nomiyama M; Takahira H; Hirashima N; Kunita S; Takahashi S; Yagami K; Kilduff TS; Bettler B; Yanagisawa M; Sakurai T. 2009. Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.. In: . . MGI: J:146778
- Mayne CG; Spanier JA; Relland LM; Williams CB; Hayes CE. 2011. 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis.. In: . . MGI: J:175424
- Mikedis MM; Downs KM. 2017. PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.. In: . . MGI: J:237427
- Moldrich RX; Gobius I; Pollak T; Zhang J; Ren T; Brown L; Mori S; De Juan Romero C; Britanova O; Tarabykin V; Richards LJ. 2010. Molecular regulation of the developing commissural plate.. In: . . MGI: J:196051
- Morgans CW; Zhang J; Jeffrey BG; Nelson SM; Burke NS; Duvoisin RM; Brown RL. 2009. TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells.. In: . . MGI: J:154776
- Mukhopadhyay A; McGuire T; Peng CY; Kessler JA. 2009. Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation.. In: . . MGI: J:158140
- Muller AJ; Filipe-Santos O; Eberl G; Aebischer T; Spath GF; Bousso P. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation.. In: . . MGI: J:187413
- Murray SA; Oram KF; Gridley T. 2007. Multiple functions of Snail family genes during palate development in mice.. In: . . MGI: J:121243
- Nern C; Wolff I; Macas J; von Randow J; Scharenberg C; Priller J; Momma S. 2009. Fusion of hematopoietic cells with Purkinje neurons does not lead to stable heterokaryon formation under noninvasive conditions.. In: . . MGI: J:158171
- Ohinata Y; Payer B; O'Carroll D; Ancelin K; Ono Y; Sano M; Barton SC; Obukhanych T; Nussenzweig M; Tarakhovsky A; Saitou M; Surani MA. 2005. Blimp1 is a critical determinant of the germ cell lineage in mice.. In: . . MGI: J:99994
- Opavsky R; Wang SH; Trikha P; Raval A; Huang Y; Wu YZ; Rodriguez B; Keller B; Liyanarachchi S; Wei G; Davuluri RV; Weinstein M; Felsher D; Ostrowski M; Leone G; Plass C. 2007. CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.. In: . . MGI: J:130029
- Padilla SL; Carmody JS; Zeltser LM. 2010. Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits.. In: . . MGI: J:159306
- Park SY; Wolfram P; Canty K; Harley B; Nombela-Arrieta C; Pivarnik G; Manis J; Beggs HE; Silberstein LE. 2013. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.. In: . . MGI: J:192606
- Patterson CM; Leshan RL; Jones JC; Myers MG Jr. 2011. Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells.. In: . . MGI: J:240530
- Peng CY; Mukhopadhyay A; Jarrett JC; Yoshikawa K; Kessler JA. 2012. BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior.. In: . . MGI: J:193055
- Pepper M; Pagan AJ; Igyarto BZ; Taylor JJ; Jenkins MK. 2011. Opposing signals from the bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.. In: . . MGI: J:177635
- Peters SL; Hlady RA; Opavska J; Klinkebiel D; Novakova S; Smith LM; Lewis RE; Karpf AR; Simpson MA; Wu L; Opavsky R. 2013. Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.. In: . . MGI: J:205419
- Peters SL; Hlady RA; Opavska J; Klinkebiel D; Pirruccello SJ; Talmon GA; Sharp JG; Wu L; Jaenisch R; Simpson MA; Karpf AR; Opavsky R. 2014. Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis.. In: . . MGI: J:209078
- Petracca YL; Sartoretti MM; Di Bella DJ; Marin-Burgin A; Carcagno AL; Schinder AF; Lanuza GM. 2016. The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord.. In: . . MGI: J:240080
- Plum L; Lin HV; Dutia R; Tanaka J; Aizawa KS; Matsumoto M; Kim AJ; Cawley NX; Paik JH; Loh YP; DePinho RA; Wardlaw SL; Accili D. 2009. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.. In: . . MGI: J:154300
- Provenzano PP; Cuevas C; Chang AE; Goel VK; Von Hoff DD; Hingorani SR. 2012. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.. In: . . MGI: J:189345
- Qiu X; Dao H; Wang M; Heston A; Garcia KM; Sangal A; Dowling AR; Faulkner LD; Molitor SC; Elias CF; Hill JW. 2015. Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.. In: . . MGI: J:235348
- Quante M; Marrache F; Goldenring JR; Wang TC. 2010. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa.. In: . . MGI: J:198266
- Ren H; Plum-Morschel L; Gutierrez-Juarez R; Lu TY; Kim-Muller JY; Heinrich G; Wardlaw SL; Silver R; Accili D. 2013. Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons.. In: . . MGI: J:208948
- Rezai-Zadeh K; Yu S; Jiang Y; Laque A; Schwartzenburg C; Morrison CD; Derbenev AV; Zsombok A; Munzberg H. 2014. Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake.. In: . . MGI: J:234889
- Ridder K; Keller S; Dams M; Rupp AK; Schlaudraff J; Turco DD; Starmann J; Macas J; Karpova D; Devraj K; Depboylu C; Landfried B; Arnold B; Plate KH; Hoglinger G; Sultmann H; Altevogt P; Momma S. 2014. Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation.. In: . . MGI: J:213802
- Rossi J; Balthasar N; Olson D; Scott M; Berglund E; Lee CE; Choi MJ; Lauzon D; Lowell BB; Elmquist JK. 2011. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis.. In: . . MGI: J:169562
- Rubin AN; Alfonsi F; Humphreys MP; Choi CK; Rocha SF; Kessaris N. 2010. The germinal zones of the basal ganglia but not the septum generate GABAergic interneurons for the cortex.. In: . . MGI: J:164291
- Rubin AN; Kessaris N. 2013. PROX1: a lineage tracer for cortical interneurons originating in the lateral/caudal ganglionic eminence and preoptic area.. In: . . MGI: J:209095
- Schaefer A; O'Carroll D; Tan CL; Hillman D; Sugimori M; Llinas R; Greengard P. 2007. Cerebellar neurodegeneration in the absence of microRNAs.. In: . . MGI: J:125878
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