JAX
Mouse Strain Datasheet - 004077
B6;129-Gt(ROSA)26Sortm2Sho/J
Also Known As: ROSA26-EGFPf
These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in cre-expressing tissues. The expression level in this reporter strain is suitable for applications involving FACS but is too low for histological applications.
Donating Investigator
Stuart H Orkin, Harvard University
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+36
|
Gt(ROSA)26Sortm2Sho
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), Reporter) | Gt(ROSA)26Sor | gene trap ROSA 26, Philippe Soriano |
Detailed Description
These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. Expression of the EGFP gene is blocked by a loxP-flanked STOP fragment placed between the EGFP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in cre-expressing tissues. Mice that are homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The donating investigator indicates that the EGFP expression level in this reporter strain is suitable for applications involving FACS but is too low for histological applications.
Development
A targeting vector containing the mouse phosphoglycerate kinase promoter driving cytosine deaminase and puromycin genes, a STOP fragment, an EGFP cDNA and a Bgeo gene (not expressed), was inserted into the Gt(ROSA)26Sor locus. Located immediately 5' of the puromycin gene, the stop fragment, and the EGFP cDNA are loxP sites. A herpes simplex viral thymidine kinase cassette was used as a negative selection marker. The construct was electroporated into ROSA26 ES cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric animals were backcrossed to C57BL/6J mice.
Expression Data
| Expressed Gene | GFP, Green Fluorescent Protein, |
|---|---|
| Site of Expression | when crossed to a cre recombinase-expressing strain, Enhanced Green Fluorescent Protein expression is observed in the cre-expressing tissues |
Control Suggestions
Selected References
- Mao X; Fujiwara Y; Chapdelaine A; Yang H; Orkin SH. 2001. Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain Blood 97(1):324-6. PubMed: 11133778MGI: J:66742
Gt(ROSA)26Sortm2Sho
Allele Symbol: Gt(ROSA)26Sortm2Sho
| Allele Name | targeted mutation 2, Stuart Orkin |
|---|---|
| Allele Type | Targeted (Conditional ready (e.g. floxed), Reporter) |
| Allele Synonym(s) | R26-GFP; R26floxGFP; ROSA-GFP; ROSA-loxP-stop-loxP-GFP loxP-GFP; ROSA26-EGFP; ROSA26-EGFTf; ROSA26-flox-STOP-flox-GFP; Rosa26LOXPEGFP; Rosa26R-eGFP; RosaC |
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano |
| Gene Synonym(s) | AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26 |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | when crossed to a cre recombinase-expressing strain, Enhanced Green Fluorescent Protein expression is observed in the cre-expressing tissues |
| Strain of Origin | 129S4/SvJaeSor |
| Chromosome | 6 |
| Molecular Note | These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted into the Gt(ROSA)26Sor locus. Expression of the EGFP gene is blocked by a loxP-flanked STOP fragment placed between the EGFP sequence and the Gt(ROSA)26Sor promoter. This strain serves as a reporter strain, with successful Cre excision being indicated by EGFP expression in Cre-expressing tissues. |
| Mutations Made By | Dr. Xiaohong Mao, Novartis |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- loxP-flanked Sequences
- loxP-flanked Sequences: Test/Reporter
- Fluorescent Proteins
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Cre-lox System
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
References
- Mao X; Fujiwara Y; Chapdelaine A; Yang H; Orkin SH. 2001. Activation of EGFP expression by cre-mediated excision in a new ROSA26 reporter mouse strain Blood 97(1):324-6. PubMed: 11133778MGI: J:66742
Additional References
- Ohyama T; Groves AK. 2004. Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis 38(4):195-9. PubMed: 15083520MGI: J:89784
Additional - Gt(ROSA)26Sortm2Sho related
- Albert V; Cornu M; Hall MN. 2015. mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior. Biochem Biophys Res Commun 464(2):480-6. PubMed: 26159924MGI: J:228766
- Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235(3):759-67. PubMed: 16450386MGI: J:106155
- Arenkiel BR; Gaufo GO; Capecchi MR. 2003. Hoxb1 neural crest preferentially form glia of the PNS. Dev Dyn 227(3):379-86. PubMed: 12815623MGI: J:84448
- Babwah AV; Navarro VM; Ahow M; Pampillo M; Nash C; Fayazi M; Calder M; Elbert A; Urbanski HF; Wettschureck N; Offermanns S; Carroll RS; Bhattacharya M; Tobet SA; Kaiser UB. 2015. GnRH Neuron-Specific Ablation of Galphaq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Galphaq/11-Independent GnRH Secretion. J Neurosci 35(37):12903-16. PubMed: 26377475MGI: J:226397
- Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505. PubMed: 16269339MGI: J:115192
- Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. PubMed: 19733489MGI: J:152688
- Brzezinski JA 4th; Prasov L; Glaser T. 2012. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol 365(2):395-413. PubMed: 22445509MGI: J:184871
- Campbell AL; Shih HP; Xu J; Gross MK; Kioussi C. 2012. Regulation of motility of myogenic cells in filling limb muscle anlagen by Pitx2. PLoS One 7(4):e35822. PubMed: 22558231MGI: J:187280
- Carhuatanta KA; Demuro G; Tschop MH; Pfluger PT; Benoit SC; Obici S. 2011. Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology 152(7):2655-64. PubMed: 21586558MGI: J:174884
- Castrop H; Oppermann M; Weiss Y; Huang Y; Mizel D; Lu H; Germain S; Schweda F; Theilig F; Bachmann S; Briggs J; Kurtz A; Schnermann J. 2006. Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene. Physiol Genomics 25(2):277-85. PubMed: 16418317MGI: J:144009
- Charles MA; Mortensen AH; Potok MA; Camper SA. 2008. Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility. Genesis 46(10):507-14. PubMed: 18802953MGI: J:142726
- Chee MJ; Price CJ; Statnick MA; Colmers WF. 2011. Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus. J Physiol 589(Pt 13):3103-14. PubMed: 21502286MGI: J:189408
- Chen ZL; Yao Y; Norris EH; Kruyer A; Jno-Charles O; Akhmerov A; Strickland S. 2013. Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke. J Cell Biol 202(2):381-95. PubMed: 23857767MGI: J:201512
- Danielson LS; Reavie L; Coussens M; Davalos V; Castillo-Martin M; Guijarro MV; Coffre M; Cordon-Cardo C; Aifantis I; Ibrahim S; Liu C; Koralov SB; Hernando E. 2015. Limited miR-17-92 overexpression drives hematologic malignancies. Leuk Res 39(3):335-41. PubMed: 25597017MGI: J:232684
- Dessaud E; Ribes V; Balaskas N; Yang LL; Pierani A; Kicheva A; Novitch BG; Briscoe J; Sasai N. 2010. Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS Biol 8(6):e1000382. PubMed: 20532235MGI: J:161598
- Dodd GT; Worth AA; Nunn N; Korpal AK; Bechtold DA; Allison MB; Myers MG Jr; Statnick MA; Luckman SM. 2014. The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab 20(4):639-49. PubMed: 25176149MGI: J:215557
- Duggan CD; Demaria S; Baudhuin A; Stafford D; Ngai J. 2008. Foxg1 is required for development of the vertebrate olfactory system. J Neurosci 28(20):5229-39. PubMed: 18480279MGI: J:136319
- Eberl G; Littman DR. 2004. Thymic origin of intestinal alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells. Science 305(5681):248-51. PubMed: 15247480MGI: J:91566
- Fogarty M; Grist M; Gelman D; Marin O; Pachnis V; Kessaris N. 2007. Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex. J Neurosci 27(41):10935-46. PubMed: 17928435MGI: J:125700
- Fogarty M; Richardson WD; Kessaris N. 2005. A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord. Development 132(8):1951-9. PubMed: 15790969MGI: J:101712
- Fogarty MH. 2006. Fate-mapping the mouse neural tube by Cre-loxP transgenesis Doctoral Thesis, University of London :. MGI: J:186011
- Frazao R; Cravo RM; Donato J Jr; Ratra DV; Clegg DJ; Elmquist JK; Zigman JM; Williams KW; Elias CF. 2013. Shift in Kiss1 cell activity requires estrogen receptor alpha. J Neurosci 33(7):2807-20. PubMed: 23407940MGI: J:194265
- Garfield AS; Patterson C; Skora S; Gribble FM; Reimann F; Evans ML; Myers MG Jr; Heisler LK. 2012. Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology 153(10):4600-7. PubMed: 22869346MGI: J:191291
- Gerfen CR; Paletzki R; Heintz N. 2013. GENSAT BAC Cre-Recombinase Driver Lines to Study the Functional Organization of Cerebral Cortical and Basal Ganglia Circuits. Neuron 80(6):1368-83. PubMed: 24360541MGI: J:203555
- Ghiaur G; Ferkowicz MJ; Milsom MD; Bailey J; Witte D; Cancelas JA; Yoder MC; Williams DA. 2008. Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood 111(7):3313-21. PubMed: 18083846MGI: J:133470
- Gong L; Yao F; Hockman K; Heng HH; Morton GJ; Takeda K; Akira S; Low MJ; Rubinstein M; MacKenzie RG. 2008. Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology 149(7):3346-54. PubMed: 18403487MGI: J:145370
- Guijarro MV; Dahiya S; Danielson LS; Segura MF; Vales-Lara FM; Menendez S; Popiolek D; Mittal K; Wei JJ; Zavadil J; Cordon-Cardo C; Pandolfi PP; Hernando E. 2013. Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling. Am J Pathol 182(6):2015-27. PubMed: 23708211MGI: J:199111
- Haws ME; Jaramillo TC; Espinosa F; Widman AJ; Stuber GD; Sparta DR; Tye KM; Russo SJ; Parada LF; Stavarache M; Kaplitt M; Bonci A; Powell CM. 2014. PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol 522(5):1171-90. PubMed: 24264880MGI: J:208826
- Heffner CS; Herbert Pratt C; Babiuk RP; Sharma Y; Rockwood SF; Donahue LR; Eppig JT; Murray SA. 2012. Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource. Nat Commun 3:1218. PubMed: 23169059MGI: J:226227
- Heldt SA; Ressler KJ. 2009. The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors. Front Mol Neurosci 2:22. PubMed: 20011219MGI: J:210657
- Herndon MK; Nilson JH. 2015. Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones. PLoS One 10(5):e0126527. PubMed: 25955311MGI: J:235339
- High FA; Zhang M; Proweller A; Tu L; Parmacek MS; Pear WS; Epstein JA. 2007. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest 117(2):353-363. PubMed: 17273555MGI: J:118039
- Hill JW; Williams KW; Ye C; Luo J; Balthasar N; Coppari R; Cowley MA; Cantley LC; Lowell BB; Elmquist JK. 2008. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest 118(5):1796-805. PubMed: 18382766MGI: J:136147
- Hlady RA; Novakova S; Opavska J; Klinkebiel D; Peters SL; Bies J; Hannah J; Iqbal J; Anderson KM; Siebler HM; Smith LM; Greiner TC; Bastola D; Joshi S; Lockridge O; Simpson MA; Felsher DW; Wagner KU; Chan WC; Christman JK; Opavsky R. 2012. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest 122(1):163-77. PubMed: 22133874MGI: J:184415
- Irani BG; Donato J Jr; Olson DP; Lowell BB; Sacktor TC; Reyland ME; Tolson KP; Zinn AR; Ueta Y; Sakata I; Zigman JM; Elias CF; Clegg DJ. 2010. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus. Neuroscience 170(4):1065-79. PubMed: 20691763MGI: J:166797
- Jakubzick C; Bogunovic M; Bonito AJ; Kuan EL; Merad M; Randolph GJ. 2008. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med 205(12):2839-50. PubMed: 18981237MGI: J:143220
- Jeon D; Kim S; Chetana M; Jo D; Ruley HE; Lin SY; Rabah D; Kinet JP; Shin HS. 2010. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat Neurosci 13(4):482-8. PubMed: 20190743MGI: J:159698
- Jeselsohn R; Brown NE; Arendt L; Klebba I; Hu MG; Kuperwasser C; Hinds PW. 2010. Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis. Cancer Cell 17(1):65-76. PubMed: 20129248MGI: J:156929
- Johnson JA; Calo S; Nair L; IglayReger HB; Greenwald-Yarnell M; Skorupski J; Myers MG Jr; Bodary PF. 2012. Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity. J Steroid Biochem Mol Biol 132(3-5):212-9. PubMed: 22750459MGI: J:190163
- Kaplan DH; Li MO; Jenison MC; Shlomchik WD; Flavell RA; Shlomchik MJ. 2007. Autocrine/paracrine TGF{beta}1 is required for the development of epidermal Langerhans cells. J Exp Med 204(11):2545-52. PubMed: 17938236MGI: J:126147
- Kessaris N; Fogarty M; Iannarelli P; Grist M; Wegner M; Richardson WD. 2006. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat Neurosci 9(2):173-9. PubMed: 16388308MGI: J:105334
- Kim HJ; Kobayashi M; Sasaki T; Kikuchi O; Amano K; Kitazumi T; Lee YS; Yokota-Hashimoto H; Susanti VY; Kitamura YI; Nakae J; Kitamura T. 2012. Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance. Endocrinology 153(2):659-71. PubMed: 22186407MGI: J:181720
- Knauf JA; Sartor MA; Medvedovic M; Lundsmith E; Ryder M; Salzano M; Nikiforov YE; Giordano TJ; Ghossein RA; Fagin JA. 2011. Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFbeta signaling. Oncogene 30(28):3153-62. PubMed: 21383698MGI: J:174636
- Kong JH; Yang L; Dessaud E; Chuang K; Moore DM; Rohatgi R; Briscoe J; Novitch BG. 2015. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell 33(4):373-87. PubMed: 25936505MGI: J:221657
- Lam DD; Leinninger GM; Louis GW; Garfield AS; Marston OJ; Leshan RL; Scheller EL; Christensen L; Donato J Jr; Xia J; Evans ML; Elias C; Dalley JW; Burdakov DI; Myers MG Jr; Heisler LK. 2011. Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab 13(5):584-91. PubMed: 21531340MGI: J:175812
- Leinninger GM; Jo YH; Leshan RL; Louis GW; Yang H; Barrera JG; Wilson H; Opland DM; Faouzi MA; Gong Y; Jones JC; Rhodes CJ; Chua S Jr; Diano S; Horvath TL; Seeley RJ; Becker JB; Munzberg H; Myers MG Jr. 2009. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab 10(2):89-98. PubMed: 19656487MGI: J:151971
- Leinninger GM; Opland DM; Jo YH; Faouzi M; Christensen L; Cappellucci LA; Rhodes CJ; Gnegy ME; Becker JB; Pothos EN; Seasholtz AF; Thompson RC; Myers MG Jr. 2011. Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance. Cell Metab 14(3):313-23. PubMed: 21907138MGI: J:176657
- Leshan RL; Louis GW; Jo YH; Rhodes CJ; Munzberg H; Myers MG Jr. 2009. Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci 29(10):3138-47. PubMed: 19279251MGI: J:147070
- Leshan RL; Opland DM; Louis GW; Leinninger GM; Patterson CM; Rhodes CJ; Munzberg H; Myers MG Jr. 2010. Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci 30(16):5713-23. PubMed: 20410123MGI: J:159836
- Li Z; Frey JL; Wong GW; Faugere MC; Wolfgang MJ; Kim JK; Riddle RC; Clemens TL. 2016. Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts. Endocrinology 157(11):4094-4103. PubMed: 27689415MGI: J:240554
- Liao CP; Zhong C; Saribekyan G; Bading J; Park R; Conti PS; Moats R; Berns A; Shi W; Zhou Z; Nikitin AY; Roy-Burman P. 2007. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res 67(15):7525-33. PubMed: 17671224MGI: J:123911
- Lin HV; Ren H; Samuel VT; Lee HY; Lu TY; Shulman GI; Accili D. 2011. Diabetes in mice with selective impairment of insulin action in glut4-expressing tissues. Diabetes 60(3):700-9. PubMed: 21266328MGI: J:169404
- Liu Z; Dearman JA; Cox BC; Walters BJ; Zhang L; Ayrault O; Zindy F; Gan L; Roussel MF; Zuo J. 2012. Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by Atoh1 ectopic expression. J Neurosci 32(19):6600-10. PubMed: 22573682MGI: J:184850
- Louis GW; Leinninger GM; Rhodes CJ; Myers MG Jr. 2010. Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci 30(34):11278-87. PubMed: 20739548MGI: J:163528
- Lu F; Kar D; Gruenig N; Zhang ZW; Cousins N; Rodgers HM; Swindell EC; Jamrich M; Schuurmans C; Mathers PH; Kurrasch DM. 2013. Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci 33(1):259-72. PubMed: 23283339MGI: J:193919
- Lu J; Sun Y; Nombela-Arrieta C; Du KP; Park SY; Chai L; Walkley C; Luo HR; Silberstein LE. 2012. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol 40(4):307-17.e3. PubMed: 22155722MGI: J:191529
- Luccardini C; Hennekinne L; Viou L; Yanagida M; Murakami F; Kessaris N; Ma X; Adelstein RS; Mege RM; Metin C. 2013. N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration. J Neurosci 33(46):18149-60. PubMed: 24227724MGI: J:204170
- Luche H; Weber O; Nageswara Rao T; Blum C; Fehling HJ. 2007. Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol 37(1):43-53. PubMed: 17171761MGI: J:117041
- Matsuki T; Nomiyama M; Takahira H; Hirashima N; Kunita S; Takahashi S; Yagami K; Kilduff TS; Bettler B; Yanagisawa M; Sakurai T. 2009. Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A 106(11):4459-64. PubMed: 19246384MGI: J:146778
- Mayne CG; Spanier JA; Relland LM; Williams CB; Hayes CE. 2011. 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol 41(3):822-32. PubMed: 21287548MGI: J:175424
- Mikedis MM; Downs KM. 2017. PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula. Dev Dyn 246(1):50-71. PubMed: 27696611MGI: J:237427
- Moldrich RX; Gobius I; Pollak T; Zhang J; Ren T; Brown L; Mori S; De Juan Romero C; Britanova O; Tarabykin V; Richards LJ. 2010. Molecular regulation of the developing commissural plate. J Comp Neurol 518(18):3645-61. PubMed: 20653027MGI: J:196051
- Morgans CW; Zhang J; Jeffrey BG; Nelson SM; Burke NS; Duvoisin RM; Brown RL. 2009. TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Proc Natl Acad Sci U S A 106(45):19174-8. PubMed: 19861548MGI: J:154776
- Mukhopadhyay A; McGuire T; Peng CY; Kessler JA. 2009. Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation. Development 136(15):2633-42. PubMed: 19592576MGI: J:158140
- Muller AJ; Filipe-Santos O; Eberl G; Aebischer T; Spath GF; Bousso P. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity 37(1):147-57. PubMed: 22727490MGI: J:187413
- Murray SA; Oram KF; Gridley T. 2007. Multiple functions of Snail family genes during palate development in mice. Development 134(9):1789-97. PubMed: 17376812MGI: J:121243
- Nern C; Wolff I; Macas J; von Randow J; Scharenberg C; Priller J; Momma S. 2009. Fusion of hematopoietic cells with Purkinje neurons does not lead to stable heterokaryon formation under noninvasive conditions. J Neurosci 29(12):3799-807. PubMed: 19321776MGI: J:158171
- Ohinata Y; Payer B; O'Carroll D; Ancelin K; Ono Y; Sano M; Barton SC; Obukhanych T; Nussenzweig M; Tarakhovsky A; Saitou M; Surani MA. 2005. Blimp1 is a critical determinant of the germ cell lineage in mice. Nature 436(7048):207-13. PubMed: 15937476MGI: J:99994
- Opavsky R; Wang SH; Trikha P; Raval A; Huang Y; Wu YZ; Rodriguez B; Keller B; Liyanarachchi S; Wei G; Davuluri RV; Weinstein M; Felsher D; Ostrowski M; Leone G; Plass C. 2007. CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet 3(9):1757-69. PubMed: 17907813MGI: J:130029
- Padilla SL; Carmody JS; Zeltser LM. 2010. Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat Med 16(4):403-5. PubMed: 20348924MGI: J:159306
- Park SY; Wolfram P; Canty K; Harley B; Nombela-Arrieta C; Pivarnik G; Manis J; Beggs HE; Silberstein LE. 2013. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol 190(3):1094-102. PubMed: 23264658MGI: J:192606
- Patterson CM; Leshan RL; Jones JC; Myers MG Jr. 2011. Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res 1378:18-28. PubMed: 21237139MGI: J:240530
- Peng CY; Mukhopadhyay A; Jarrett JC; Yoshikawa K; Kessler JA. 2012. BMP receptor 1A regulates development of hypothalamic circuits critical for feeding behavior. J Neurosci 32(48):17211-24. PubMed: 23197713MGI: J:193055
- Pepper M; Pagan AJ; Igyarto BZ; Taylor JJ; Jenkins MK. 2011. Opposing signals from the bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35(4):583-95. PubMed: 22018468MGI: J:177635
- Peters SL; Hlady RA; Opavska J; Klinkebiel D; Novakova S; Smith LM; Lewis RE; Karpf AR; Simpson MA; Wu L; Opavsky R. 2013. Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Mol Cell Biol 33(21):4321-33. PubMed: 24001767MGI: J:205419
- Peters SL; Hlady RA; Opavska J; Klinkebiel D; Pirruccello SJ; Talmon GA; Sharp JG; Wu L; Jaenisch R; Simpson MA; Karpf AR; Opavsky R. 2014. Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. Leukemia 28(5):1138-42. PubMed: 24292811MGI: J:209078
- Petracca YL; Sartoretti MM; Di Bella DJ; Marin-Burgin A; Carcagno AL; Schinder AF; Lanuza GM. 2016. The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord. Development 143(5):880-91. PubMed: 26839365MGI: J:240080
- Plum L; Lin HV; Dutia R; Tanaka J; Aizawa KS; Matsumoto M; Kim AJ; Cawley NX; Paik JH; Loh YP; DePinho RA; Wardlaw SL; Accili D. 2009. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med 15(10):1195-201. PubMed: 19767734MGI: J:154300
- Provenzano PP; Cuevas C; Chang AE; Goel VK; Von Hoff DD; Hingorani SR. 2012. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21(3):418-29. PubMed: 22439937MGI: J:189345
- Qiu X; Dao H; Wang M; Heston A; Garcia KM; Sangal A; Dowling AR; Faulkner LD; Molitor SC; Elias CF; Hill JW. 2015. Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. PLoS One 10(5):e0121974. PubMed: 25946091MGI: J:235348
- Quante M; Marrache F; Goldenring JR; Wang TC. 2010. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology 139(6):2018-2027.e2. PubMed: 20708616MGI: J:198266
- Ren H; Plum-Morschel L; Gutierrez-Juarez R; Lu TY; Kim-Muller JY; Heinrich G; Wardlaw SL; Silver R; Accili D. 2013. Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons. Diabetes 62(10):3373-83. PubMed: 23835335MGI: J:208948
- Rezai-Zadeh K; Yu S; Jiang Y; Laque A; Schwartzenburg C; Morrison CD; Derbenev AV; Zsombok A; Munzberg H. 2014. Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake. Mol Metab 3(7):681-93. PubMed: 25352997MGI: J:234889
- Ridder K; Keller S; Dams M; Rupp AK; Schlaudraff J; Turco DD; Starmann J; Macas J; Karpova D; Devraj K; Depboylu C; Landfried B; Arnold B; Plate KH; Hoglinger G; Sultmann H; Altevogt P; Momma S. 2014. Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS Biol 12(6):e1001874. PubMed: 24893313MGI: J:213802
- Rossi J; Balthasar N; Olson D; Scott M; Berglund E; Lee CE; Choi MJ; Lauzon D; Lowell BB; Elmquist JK. 2011. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 13(2):195-204. PubMed: 21284986MGI: J:169562
- Rubin AN; Alfonsi F; Humphreys MP; Choi CK; Rocha SF; Kessaris N. 2010. The germinal zones of the basal ganglia but not the septum generate GABAergic interneurons for the cortex. J Neurosci 30(36):12050-62. PubMed: 20826668MGI: J:164291
- Rubin AN; Kessaris N. 2013. PROX1: a lineage tracer for cortical interneurons originating in the lateral/caudal ganglionic eminence and preoptic area. PLoS One 8(10):e77339. PubMed: 24155945MGI: J:209095
- Schaefer A; O'Carroll D; Tan CL; Hillman D; Sugimori M; Llinas R; Greengard P. 2007. Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med 204(7):1553-8. PubMed: 17606634MGI: J:125878
- Scheller EL; Leinninger GM; Hankenson KD; Myers MG Jr; Krebsbach PH. 2011. Ectopic expression of Col2.3 and Col3.6 promoters in the brain and association with leptin signaling. Cells Tissues Organs 194(2-4):268-73. PubMed: 21555864MGI: J:196049
- Stefater MA; MacLennan AJ; Lee N; Patterson CM; Haller A; Sorrell J; Myers M; Woods SC; Seeley RJ. 2012. The anorectic effect of CNTF does not require action in leptin-responsive neurons. Endocrinology 153(6):2647-54. PubMed: 22518062MGI: J:188659
- Stratigopoulos G; Martin Carli JF; O'Day DR; Wang L; Leduc CA; Lanzano P; Chung WK; Rosenbaum M; Egli D; Doherty DA; Leibel RL. 2014. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab 19(5):767-79. PubMed: 24807221MGI: J:215262
- Su H; Marcheva B; Meng S; Liang FA; Kohsaka A; Kobayashi Y; Xu AW; Bass J; Wang X. 2010. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol 339(1):38-50. PubMed: 20025866MGI: J:157958
- Sugrue ML; Vella KR; Morales C; Lopez ME; Hollenberg AN. 2010. The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo. Endocrinology 151(2):793-801. PubMed: 20032051MGI: J:162058
- Talchai C; Xuan S; Kitamura T; DePinho RA; Accili D. 2012. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet 44(4):406-12, S1. PubMed: 22406641MGI: J:183890
- Tavazoie SF; Alvarez VA; Ridenour DA; Kwiatkowski DJ; Sabatini BL. 2005. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8(12):1727-34. PubMed: 16286931MGI: J:103933
- Torsoni MA; Borges BC; Cote JL; Allen SJ; Mahany E; Garcia-Galiano D; Elias CF. 2016. AMPKalpha2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female Mice. Endocrinology 157(12):4803-4816. PubMed: 27732087MGI: J:240776
- Vallespinos M; Fernandez D; Rodriguez L; Alvaro-Blanco J; Baena E; Ortiz M; Dukovska D; Martinez D; Rojas A; Campanero MR; Moreno de Alboran I. 2011. B Lymphocyte commitment program is driven by the proto-oncogene c-Myc. J Immunol 186(12):6726-36. PubMed: 21572027MGI: J:175485
- Vidali L; Chen F; Cicchetti G; Ohta Y; Kwiatkowski DJ. 2006. Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell 17(5):2377-90. PubMed: 16525021MGI: J:112526
- Villanueva EC; Munzberg H; Cota D; Leshan RL; Kopp K; Ishida-Takahashi R; Jones JC; Fingar DC; Seeley RJ; Myers MG Jr. 2009. Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology 150(10):4541-51. PubMed: 19628573MGI: J:157328
- Xu L; Scheenen WJ; Leshan RL; Patterson CM; Elias CF; Bouwhuis S; Roubos EW; Myers MG Jr; Kozicz T. 2011. Leptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic Edinger-Westphal nucleus. Endocrinology 152(3):979-88. PubMed: 21209012MGI: J:173887
- Yang L; Jung Y; Omenetti A; Witek RP; Choi S; Vandongen HM; Huang J; Alpini GD; Diehl AM. 2008. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells 26(8):2104-13. PubMed: 18511600MGI: J:201713
- Yang ZJ; Ellis T; Markant SL; Read TA; Kessler JD; Bourboulas M; Schuller U; Machold R; Fishell G; Rowitch DH; Wainwright BJ; Wechsler-Reya RJ. 2008. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14(2):135-45. PubMed: 18691548MGI: J:139573
- Yi L; Domyan ET; Lewandoski M; Sun X. 2008. Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn 238(1):123-137. PubMed: 19097117MGI: J:142646
- Young KM; Mitsumori T; Pringle N; Grist M; Kessaris N; Richardson WD. 2010. An Fgfr3-iCreER(T2) transgenic mouse line for studies of neural stem cells and astrocytes. Glia 58(8):943-53. PubMed: 20155815MGI: J:159164
- Yuan TL; Choi HS; Matsui A; Benes C; Lifshits E; Luo J; Frangioni JV; Cantley LC. 2008. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A 105(28):9739-44. PubMed: 18621722MGI: J:137878
- Zaman T; Zhou X; Pandey NR; Qin Z; Keyhanian K; Wen K; Courtney RD; Stewart AF; Chen HH. 2014. LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia. J Neurosci 34(1):140-8. PubMed: 24381275MGI: J:205589
- Zeng H; Yang K; Cloer C; Neale G; Vogel P; Chi H. 2013. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499(7459):485-90. PubMed: 23812589MGI: J:204754
- Zhang J; Zhong W; Cui T; Yang M; Hu X; Xu K; Xie C; Xue C; Gibbons GH; Liu C; Li L; Chen YE. 2006. Generation of an adult smooth muscle cell-targeted Cre recombinase mouse model. Arterioscler Thromb Vasc Biol 26(3):e23-4. PubMed: 16484601MGI: J:119865
- Zhou J; Feigenbaum L; Yee C; Song H; Yates C. 2013. Mouse prostate epithelial luminal cells lineage originate in the basal layer where the primitive stem/early progenitor cells reside: implications for identifying prostate cancer stem cells. Biomed Res Int 2013:913179. PubMed: 23819124MGI: J:232002
- Zhou W; Zhang Y; Li Y; Wei YS; Liu G; Liu DP; Pleasure SJ; Xie W; Zhao C. 2010. A transgenic Cre mouse line for the study of cortical and hippocampal development. Genesis 48(5):343-50. PubMed: 20143346MGI: J:160192
- Zhou X; Xue HH. 2012. Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1. J Immunol 189(6):2722-6. PubMed: 22875805MGI: J:189838