Mice that are homozygous null for the <i>Crebbp</i> gene are embryonic lethal, dying at about embryonic day 10.5 exhibiting open neural tube defects. Heterozygous mice though viable and fertile, are subject to early growth retardation, craniofacial abnormalities and often fail to thrive. Heterozygous mice are also subject to age-dependent splenomegaly and irregular hematopoiesis. By three months of age, the abundance of all hematopoietic cell types is significantly diminished. Older mice (10-21 months) are more prone to develop hematologic malignancies than wildtype mice.

These <i> Crebbp </i> knock-out mice exhibit embryonic lethality and heterozygotes show growth retardation, craniofacial abnormalities and failure to thrive. They may be useful in applications related to signal transduction pathways and studies of Rubinstein-Taybi syndrome (RTS) in humans.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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