This model of X-linked dominant hypophosphatemic rickets does not display degeneration of the organ of Corti or hearing loss.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Phex | phosphate regulating endopeptidase homolog, X-linked |
Heterozygous females and hemizygous males have a square shaped trunk, shortened tail, and shortened hind limbs. Hemizygous males weigh approximately 25% less than wildtype male controls and the skull has a smaller length and width than normal with a lower areal bone mineral density and larger inner canthal distance. Hemizygous males have hypocalcemia, decreased serum PO4 and Ca2+, undermineralized bone, thickened and irregular growth plates of the knees, and higher lean body mass. Unlike Phex
Allele Name | hypophosphatemia 2 Jackson |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Phex, phosphate regulating endopeptidase homolog, X-linked |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | X |
Molecular Note | A deletion of at least 7.3 kb containing exon 15 of the Phex gene was identified and confirmed by RT-PCR, genomic PCR and Southern blot analysis |
When using the hypophosphatemia 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #003950 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
X linked - Heterozygous Females and Wild-type males for Phex<Hyp-2J> |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.