Heterozygous females and hemizygous males have a square shaped trunk, shortened tail, and shortened hind limbs. Hemizygous males weigh approximately 25% less than wildtype male controls and the skull has a smaller length and width than normal with a lower areal bone mineral density and larger inner canthal distance. Hemizygous males have hypocalcemia, decreased serum PO4 and Ca2+, undermineralized bone, thickened and irregular growth plates of the knees, and higher lean body mass. Unlike Phex
|Allele Name||hypophosphatemia 2 Jackson|
|Gene Symbol and Name||Phex, phosphate regulating endopeptidase homolog, X-linked|
|Strain of Origin||C57BL/6J|
|Molecular Note||A deletion of at least 7.3 kb containing exon 15 of the Phex gene was identified and confirmed by RT-PCR, genomic PCR and Southern blot analysis|
When using the hypophosphatemia 2 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #003950 in your Materials and Methods section.