Overview

Also Known As:scrambler 2 Jackson

This strain has been discontinued. Please see Stock No. 021430

Dab1^scm-2J is a remutation to Dab1^scm. Mice homozygous for the scrambler spontaneous mutation (Dab1^scm) are recognized by an unstable gait and whole-body tremor. The cerebella of 30-day-old scrambler homozygotes are hypoplastic and devoid of folia; however, neither seizures nor abnormal brain wave patterns have been observed. Scrambler is similar to the reeler mutation in phenotype and pathology and, like reeler, probably results from defective neuronal migration.

Genetic overview

Genetic Background	Generation

Dab1^scm-2J

Allele Type	Gene Symbol	Gene Name
Spontaneous (Not Specified)	Dab1	disabled 1

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Research Applications

Neurobiology Research
Developmental Biology Research

View All Research Applications

Details

Detailed Description

Dab1^scm-2J is a remutation to Dab1^scm by a direct test for allelism (see STOCK A/A-Dab1^scm/J, #002043).

See MRL/MpJ (#000486) for important information on the MRL/MpJ background.

Development

Scrambler 2 Jackson (Dab1^scm-2J), a new remutation to scrambler in the Dab1 gene, was discovered at The Jackson Laboratory and reported in 2001.

Control Suggestions

Heterozygote from the colony
+/? from the colony

Additional Information

Considerations for Choosing Controls

Selected References

Clark LD; Clark RK; Heber-Katz E. 1998. A new murine model for mammalian wound repair and regeneration. Clin Immunol Immunopathol 88(1):35-45PubMed: 9683548 MGI: J:48937
Kench JA; Russell DM; Fadok VA; Young SK; Worthen GS; Jones-Carson J; Henson JE; Henson PM; Nemazee D. 1999. Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse. Clin Immunol 92(3):300-10PubMed: 10479535 MGI: J:57718
Leferovich JM; Bedelbaeva K; Samulewicz S; Zhang XM; Zwas D; Lankford EB; Heber-Katz E. 2001. Heart regeneration in adult MRL mice. Proc Natl Acad Sci U S A 98(17):9830-5PubMed: 11493713 MGI: J:109867
Li X; Mohan S; Gu W; Baylink DJ. 2001. Analysis of gene expression in the wound repair/regeneration process. Mamm Genome 12(1):52-9PubMed: 11178744 MGI: J:68684
Li X; Mohan S; Gu W; Miyakoshi N; Baylink DJ. 2000. Differential protein profile in the ear-punched tissue of regeneration and non-regeneration strains of mice: a novel approach to explore the candidate genes for soft-tissue regeneration Biochim Biophys Acta 1524(2-3):102-9PubMed: 11113556 MGI: J:66437
McBrearty BA; Clark LD; Zhang XM; Blankenhorn EP; Heber-Katz E. 1998. Genetic analysis of a mammalian wound-healing trait. Proc Natl Acad Sci U S A 95(20):11792-7PubMed: 9751744 MGI: J:50111
Sweet HO; Bronson RT; Johnson KR; Cook SA; Davisson MT. 1996. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome 7(11):798-802PubMed: 8875886 MGI: J:37166

View All References

Genetics

Dab1^scm-2J

Allele Symbol: Dab1^scm-2J

Allele Name	scrambler 2 Jackson
Allele Type	Spontaneous (Not Specified)
Allele Synonym(s)
Gene Symbol and Name	Dab1, disabled 1
Gene Synonym(s)
Strain of Origin	MRL.129P2(B6)-B2m^tm1Unc/Dcr
Chromosome	4
Molecular Note	Dab1^scm-2J is a remutation to Dab1^scm by a direct test for allelism.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Dab1^scm-2J related

Neurobiology Research
- Cerebellar Defects
- Cortical Defects
- Neurodevelopmental Defects
- Tremor Defects
- Ataxia (Movement) Defects
Developmental Biology Research
- Neurodevelopmental Defects

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Dab1^scm-2J/Dab1^scm-2J
MRL.129P2(B6)-B2m/Dcr

behavior/neurological phenotype

tremors
- mice are shaky

growth/size/body region phenotype

cachexia
- mice exhibit wasting

mortality/aging

prenatal lethality, incomplete penetrance
- fewer than expected mice are born

postnatal lethality, incomplete penetrance
- mice may die prior to weaning

References

Clark LD; Clark RK; Heber-Katz E. 1998. A new murine model for mammalian wound repair and regeneration. Clin Immunol Immunopathol 88(1):35-45PubMed: 9683548 MGI: J:48937
Kench JA; Russell DM; Fadok VA; Young SK; Worthen GS; Jones-Carson J; Henson JE; Henson PM; Nemazee D. 1999. Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse. Clin Immunol 92(3):300-10PubMed: 10479535 MGI: J:57718
Leferovich JM; Bedelbaeva K; Samulewicz S; Zhang XM; Zwas D; Lankford EB; Heber-Katz E. 2001. Heart regeneration in adult MRL mice. Proc Natl Acad Sci U S A 98(17):9830-5PubMed: 11493713 MGI: J:109867
Li X; Mohan S; Gu W; Baylink DJ. 2001. Analysis of gene expression in the wound repair/regeneration process. Mamm Genome 12(1):52-9PubMed: 11178744 MGI: J:68684
Li X; Mohan S; Gu W; Miyakoshi N; Baylink DJ. 2000. Differential protein profile in the ear-punched tissue of regeneration and non-regeneration strains of mice: a novel approach to explore the candidate genes for soft-tissue regeneration Biochim Biophys Acta 1524(2-3):102-9PubMed: 11113556 MGI: J:66437
McBrearty BA; Clark LD; Zhang XM; Blankenhorn EP; Heber-Katz E. 1998. Genetic analysis of a mammalian wound-healing trait. Proc Natl Acad Sci U S A 95(20):11792-7PubMed: 9751744 MGI: J:50111
Sweet HO; Bronson RT; Johnson KR; Cook SA; Davisson MT. 1996. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm Genome 7(11):798-802PubMed: 8875886 MGI: J:37166

Additional - Dab1^scm-2J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Breeding Considerations

Due to the heightened healing which occurs in mice with the MRL genetic background, ear punch is not a good method for individual mouse identification in this strain.
- Additional Breeding and Husbandry Support
Appearance
- albino
  Related Genotype: a/a Tyr^c/Tyr^c

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Also Known As:scrambler 2 Jackson

Genetic overview

Research Applications

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Dab1scm-2J

Allele Symbol: Dab1scm-2J

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Dab1scm-2J related

Mammalian Phenotype Terms by Genotype

Genotype: Dab1scm-2J/Dab1scm-2JMRL.129P2(B6)-B2m/Dcr

behavior/neurological phenotype

growth/size/body region phenotype

mortality/aging

References

Additional - Dab1scm-2J related

Genotyping Protocols

Breeding Considerations

Appearance

Terms Of Use

Licensing Information

Dab1^scm-2J

Allele Symbol: Dab1^scm-2J

Genotype: Dab1^scm-2J related

Genotype: Dab1^scm-2J/Dab1^scm-2J
MRL.129P2(B6)-B2m/Dcr

Additional - Dab1^scm-2J related