MRL(Cg)-Dab1^scm-2J/J

Stock number: 003925
Product name: scrambler 2 Jackson
Research areas: Developmental Biology Research, Neurobiology Research

Description

This strain has been discontinued. Please see Stock No. 021430

Dab1^scm-2J is a remutation to Dab1^scm. Mice homozygous for the scrambler spontaneous mutation (Dab1^scm) are recognized by an unstable gait and whole-body tremor. The cerebella of 30-day-old scrambler homozygotes are hypoplastic and devoid of folia; however, neither seizures nor abnormal brain wave patterns have been observed. Scrambler is similar to the reeler mutation in phenotype and pathology and, like reeler, probably results from defective neuronal migration.

Detailed description

Dab1^scm-2J is a remutation to Dab1^scm by a direct test for allelism (see STOCK A/A-Dab1^scm/J, #002043).

See MRL/MpJ (#000486) for important information on the MRL/MpJ background.

Development

Scrambler 2 Jackson (Dab1^scm-2J), a new remutation to scrambler in the Dab1 gene, was discovered at The Jackson Laboratory and reported in 2001.

Allele

Symbol: Dab1^scm-2J
Name: scrambler 2 Jackson
MGI accession ID: MGI:2136961
Generation method: Spontaneous
Attributes: Not Specified
Marker symbol: Dab1
Marker name: disabled 1
Marker synonyms: C630028C02Rik; SCA37
Chromosome: 4
Strain of origin: MRL.129P2(B6)-B2m^tm1Unc/Dcr
Molecular note: Dab1^scm-2J is a remutation to Dab1^scm by a direct test for allelism.