Mice that are homozygous null for the Irs3 gene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The inactivation of Irs3 appears not to perturb glucose homeostasis with the possible exception of young (9-13 weeks, postnatal) homozygous males. These mice exhibit a fasting plasma insulin level 60% that of wildtype controls. The difference is not observed in female or older (6 months) homozygous null mice.

These Irs3 knock-out mice exhibit a reduction in fasting plasma insulin level.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.