|Allele Type||Gene Symbol||Gene Name|
|QTL||Idd5||insulin dependent diabetes susceptibility 5|
|Marker Symbol||Marker Name|
|D1Mit15||DNA segment, Chr 1, Massachusetts Institute of Technology 15|
|D1Mit5.1||DNA segment, Chr 1, Massachusetts Institute of Technology 5.1|
This strain is congenic for a 47 cM segment of Chr 1 extending from D1Mit5 through D1Mit15 that includes Idd5 (insulin dependent diabetes susceptibility 5). The name given this segment in the primary reference is c1t. Upon histologic examination of the pancreas, a significantly higher percentage of B6.NOD-D1Mit5-D1Mit15 congenic mice than of C57BL/6J control mice were found to exhibit periinsulitis, and more extensive mononuclear cell infiltrates were observed in the pancreata of these mice. The pancreatic infiltrates were not associated specifically with the islets. Insulitis (intraislet infiltration) was extremely rare, and no more than one affected islet was observed in a single animal, even in cases where extensive perivascular/periductal infiltrates existed. Female B6.NOD-D1Mit5-D1Mit15 mice exhibited pancreatic infiltration at twice the frequency of males; female NOD mice are more susceptible than males to both insulitis and diabetes.
Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate homozygotes for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest. As evidence suggested the existence of multiple loci on Chr 1 that affect susceptibility to IDD and/or insulitis, two congenic lines were generated carrying overlapping segments of Chr 1, each including the diabetes susceptibility locus and one insulitis susceptibility locus.
|Allele Synonym(s)||NOD; Idd5NOD|
|Gene Symbol and Name||Idd5, insulin dependent diabetes susceptibility 5|
|Gene Synonym(s)||Idd-5; Idd-5|
|Strain of Origin||NOD|
|Molecular Note||This allele confers susceptibility to insulin dependent diabetes compared to C57BL/10.|
|Marker Synonym(s)||D1Mit5; DNA segment, Chr 1, Massachusetts Institute of Technology 5; D1Mit5|
|Homozygous, 1 pair minimum|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
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