|Allele Type||Gene Symbol||Gene Name|
|QTL||Idd5||insulin dependent diabetes susceptibility 5|
|Marker Symbol||Marker Name|
|D1Mit15||DNA segment, Chr 1, Massachusetts Institute of Technology 15|
|D1Mit5.1||DNA segment, Chr 1, Massachusetts Institute of Technology 5.1|
This strain is congenic for a 47 cM segment of Chr 1 extending from D1Mit5 through D1Mit15 that includes Idd5 (insulin dependent diabetes susceptibility 5). The name given this segment in the primary reference is c1t. Upon histologic examination of the pancreas, a significantly higher percentage of B6.NOD-D1Mit5-D1Mit15 congenic mice than of C57BL/6J control mice were found to exhibit periinsulitis, and more extensive mononuclear cell infiltrates were observed in the pancreata of these mice. The pancreatic infiltrates were not associated specifically with the islets. Insulitis (intraislet infiltration) was extremely rare, and no more than one affected islet was observed in a single animal, even in cases where extensive perivascular/periductal infiltrates existed. Female B6.NOD-D1Mit5-D1Mit15 mice exhibited pancreatic infiltration at twice the frequency of males; female NOD mice are more susceptible than males to both insulitis and diabetes.
Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate homozygotes for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest. As evidence suggested the existence of multiple loci on Chr 1 that affect susceptibility to IDD and/or insulitis, two congenic lines were generated carrying overlapping segments of Chr 1, each including the diabetes susceptibility locus and one insulitis susceptibility locus.
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