|Allele Type||Gene Symbol||Gene Name|
|Not Applicable||H2||histocompatibility-2, MHC|
|Marker Symbol||Marker Name|
|D17Mit30||DNA segment, Chr 17, Massachusetts Institute of Technology 30|
|D17Mit123||DNA segment, Chr 17, Massachusetts Institute of Technology 123|
This congenic strain carries the H2 major histocompatibility complex from NOD/Lt on a background that is otherwise, statistically, 99.9% of ALR/Lt origin. The introgessed chromosomal segment from NOD/Lt in this strain, previously called ALR.NOD-H2g7, has been defined by microsatellite analysis and the strain renamed accordingly. The most proximal marker identified within the NOD-derived segment is D17Mit30, at 16.4 cM just 3.6 cM from the most proximal gene in the H2 complex. The introgressed segment includes all of the H2 complex and extends 33.7 cM distally from it.
This strain was derived from an initial cross between mice of strains ALR/Lt and NOD/Lt followed by a series of 9 backcrosses to ARL/Lt with selection of progeny for each subsequent backcross that were heterozygous for markers in the region of the H2 major histocompatibility complex. Following the last backcross (at N10), mice heterozygous at the H2 region were intercrossed, and progeny homozygous for NOD/Lt markers were selected to initiate a homozygous congenic strain.
|Allele Name||g7 variant|
|Allele Type||Not Applicable|
|Allele Synonym(s)||H-2g7; H-2g7|
|Gene Symbol and Name||H2, histocompatibility-2, MHC|
|Strain of Origin||Not Applicable|
|General Note||The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2g7|
When using the ALR.NOD-(D17Mit30-D17Mit123)/Lt mouse strain in a publication, please cite the originating article(s) and include JAX stock #003851 in your Materials and Methods section.