ALR.NOD-(D17Mit30-D17Mit123)/Lt

Stock number: 003851
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

This congenic strain carries a chromosomal segment from the NOD/Lt strain that includes H2^g7.

Detailed description

This congenic strain carries the H2 major histocompatibility complex from NOD/Lt on a background that is otherwise, statistically, 99.9% of ALR/Lt origin. The introgessed chromosomal segment from NOD/Lt in this strain, previously called ALR.NOD-H2^g7, has been defined by microsatellite analysis and the strain renamed accordingly. The most proximal marker identified within the NOD-derived segment is D17Mit30, at 16.4 cM just 3.6 cM from the most proximal gene in the H2 complex. The introgressed segment includes all of the H2 complex and extends 33.7 cM distally from it.

Development

This strain was derived from an initial cross between mice of strains ALR/Lt and NOD/Lt followed by a series of 9 backcrosses to ARL/Lt with selection of progeny for each subsequent backcross that were heterozygous for markers in the region of the H2 major histocompatibility complex. Following the last backcross (at N10), mice heterozygous at the H2 region were intercrossed, and progeny homozygous for NOD/Lt markers were selected to initiate a homozygous congenic strain.

Allele

Symbol: H2^g7
Name: g7 variant
MGI accession ID: MGI:3579321
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Chromosome: 17
Strain of origin: Not Applicable
General note: The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2^g7

Allele

MGI accession ID: MGI:90763
Marker symbol: D17Mit123
Marker name: DNA segment, Chr 17, Massachusetts Institute of Technology 123
Chromosome: 17

Allele

MGI accession ID: MGI:90819
Marker symbol: D17Mit30
Marker name: DNA segment, Chr 17, Massachusetts Institute of Technology 30
Chromosome: 17