JAX Mouse Strain Datasheet - 003829

STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J

Stock No:: 003829 |; Wnt-1/GAL4/cre-11

Transgenic

Repository Live

Overview

Also Known As: Wnt-1/GAL4/cre-11

These Wnt-1/GAL4/cre-11 transgenic mice have expression of both Cre recombinase and the GAL4 transcriptional activator directed to midbrain and developing neural tube by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre-mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.

Donating Investigator

David H. Rowitch, University of California, San Francisco

Genetic overview

Genetic Background	Generation
	F?+F39 (27-AUG-17)

Tg(Wnt1-GAL4)11Rth

Allele Type
Transgenic (Inserted expressed sequence)

Tg(Wnt1-cre)11Rth

Allele Type
Transgenic (Recombinase-expressing)

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Research Applications

Developmental Biology Research
Research Tools

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Base Price

Starting at:

$263.00 Domestic price for female

$337.00 Domestic price for breeder pair

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Details

Detailed Description

When homozygous for both co-injected transgenes, Wnt-1/GAL4/cre-11 transgenic mice are viable and fertile. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. Cre recombinase activity is detected in the Wnt1 pattern of expression: in the midbrain by 8.5 dpc and, after neural tube closure, in the dorsal and ventral midlines of the midbrain and caudal diencephalon, midbrain-hindbrain junction and dorsal spinal cord. Double transgenic mice exhibit psychiatric disorder-related behavioral abnormalities. Males, specifically, exhibit increased locomotor activity, increased anxiety, and decreased social interaction, while females exhibit impaired short-term spatial memory and nesting behavior. Both sexes have disordered cholinergic and glutamatergic fiber tracts from the medial habenula neurons in the interpeduncular nucleus.

Transgenic mice exhibit ectopic transgene expression and midbrain enlargement (Lewis et al. 2013 Dev Biol 379:229).

When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre-mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.

Development

The transgenic line Wnt-1/GAL4/cre-11 was created by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University). These mice resulted from co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre) into pronuclei of B6CBAF1/J (C57BL/6JxCBA/J) zygotes. Double transgenic mice from founder line 11 were obtained and bred with Swiss albino outbred mice. Double transgenic albino mice were sent to The Jackson Laboratory Repository in 2000 (as Stock No. 003829). Upon arrival, mice were bred together to establish the colony. The description of each transgene is below.

The pWEXP2-GAL4 transgene (Wnt1-GAL4) was designed by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University) with the mouse Wnt1 promoter/enhancer elements upstream of a sequence encoding the full-length yeast GAL4 gene. Specifically, the Wnt1-GAL4 transgene was created by inserting a sequence encoding the full-length yeast GAL4 gene into a 10 kbp modified mouse Wnt1 genomic sequence at a polylinker site between the promoter and enhancer (the Wnt1 genomic sequence spans from approximately 1 kbp upstream of the translation initiation codon to approximately 5.5 kbp downstream of the polyA signal, and is modified with a polylinker that disrupts the translational start site and a reverse-oriented neo cassette in 3' UTR of exon 4).

The pWEXP3C-cre transgene (Wnt1-Cre) was designed by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University) with the mouse Wnt1 promoter/enhancer elements upstream of a Cre recombinase cDNA sequence. Specifically, the Wnt1-Cre transgene was created by inserting the Cre recombinase cDNA into a 10 kbp modified mouse Wnt1 genomic sequence at a polylinker site between the promoter and enhancer (the Wnt1 genomic sequence spans from approximately 1 kbp upstream of the translation initiation codon to approximately 5.5 kbp downstream of the polyA signal, and is modified with a polylinker that disrupts the translational start site and a reverse-oriented neo cassette in 3' UTR of exon 4).

Expression Data

Expressed Gene	GAL4, transcriptional activator GAL4, yeast
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord

Control Suggestions

Noncarrier

Additional Information

Considerations for Choosing Controls

Selected References

Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. PubMed: 9843687 MGI: J:69326

View All References

Genetics

Tg(Wnt1-GAL4)11Rth

Allele Symbol: Tg(Wnt1-GAL4)11Rth

Allele Name	transgene insertion 11, David H Rowitch
Allele Type	Transgenic (Inserted expressed sequence)
Allele Synonym(s)	WEXP-GAL4; Wnt-1/GAL4
Gene Symbol and Name	Tg(Wnt1-GAL4)11Rth, transgene insertion 11, David H Rowitch
Gene Synonym(s)	WEXP-GAL4; Wnt-1/GAL4
Promoter	Wnt1, wingless-type MMTV integration site family, member 1, mouse, laboratory
Expressed Gene	GAL4, transcriptional activator GAL4, yeast
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord
Strain of Origin	(C57BL/6J x CBA/J)F1
Chromosome	UN
General Note	Six lines were generated. Homozygous transgenic mice that are also homozygous for Tg(Wnt1-cre)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of Wnt1 regulatory sequences. Regulated expression initially occurs in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction, and in the dorsal spinal cord.
Molecular Note	The transgene contains the yeast GAL4 gene directed by Wnt1 promoter/enhancer sequences. Expression of the transgene matches that of the endogenous Wnt1.
Mutations Made By	David Rowitch, University of California, San Francisco

Tg(Wnt1-cre)11Rth

Allele Symbol: Tg(Wnt1-cre)11Rth

Allele Name	transgene insertion 11, David H Rowitch
Allele Type	Transgenic (Recombinase-expressing)
Allele Synonym(s)	Wnt1-Cre; Wnt1::Cre; Wnt1^Cre; Wnt1cre
Gene Symbol and Name	Tg(Wnt1-cre)11Rth, transgene insertion 11, David H Rowitch
Gene Synonym(s)	Wnt1-Cre; Wnt1::Cre; Wnt1cre
Promoter	Wnt1, wingless-type MMTV integration site family, member 1, mouse, laboratory
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord
Strain of Origin	(C57BL/6J x CBA/J)F1/J
Chromosome	UN
General Note	Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
Molecular Note	The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord.
Mutations Made By	David Rowitch, University of California, San Francisco

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Developmental Biology Research
- Craniofacial and Palate Defects
  - Orofacial clefting-specific cre expression
Research Tools
- Cre-lox System
  - Cre Recombinase Expression
- GAL4-UAS System
  - GAL4 transcriptional activator

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Genotype: GAL4 related

Research Tools
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: transcriptional activation

References

Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. PubMed: 9843687 MGI: J:69326

Additional References

Pietri T; Eder O; Blanche M; Thiery JP; Dufour S. 2003. The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev Biol 259(1):176-87. PubMed: 12812797 MGI: J:92369

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Additional - Tg(Wnt1-GAL4)11Rth related

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Avetisyan M; Wang H; Schill EM; Bery S; Grider JR; Hassell JA; Stappenbeck T; Heuckeroth RO. 2015. Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. J Neurosci 35(33):11543-58. PubMed: 26290232 MGI: J:226097
Baydyuk M; Xie Y; Tessarollo L; Xu B. 2013. Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci 33(8):3363-9. PubMed: 23426664 MGI: J:194255
Brault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. PubMed: 11262227 MGI: J:67966
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. PubMed: 14975722 MGI: J:88826
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. PubMed: 10725243 MGI: J:61091
Cornell B; Toyo-oka K. 2016. Deficiency of 14-3-3epsilon and 14-3-3zeta by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects. BMC Res Notes 9:180. PubMed: 27001213 MGI: J:242528
Fleming MS; Li JJ; Ramos D; Li T; Talmage DA; Abe SI; Arber S; Luo W. 2016. A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. J Neurosci 36(40):10337-10355. PubMed: 27707970 MGI: J:235934
Funato N; Nakamura M; Richardson JA; Srivastava D; Yanagisawa H. 2015. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet 24(2):424-35. PubMed: 25209980 MGI: J:217210
Garrington TP; Ishizuka T; Papst PJ; Chayama K; Webb S; Yujiri T; Sun W; Sather S; Russell DM; Gibson SB; Keller G; Gelfand EW; Johnson GL. 2000. MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells. EMBO J 19(20):5387-95. PubMed: 11032806 MGI: J:193674
Hancock ML; Preitner N; Quan J; Flanagan JG. 2014. MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension. J Neurosci 34(1):66-78. PubMed: 24381269 MGI: J:205590
Inman KE; Purcell P; Kume T; Trainor PA. 2013. Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia. PLoS Genet 9(12):e1003949. PubMed: 24385915 MGI: J:223126
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Kurosaka H; Wang Q; Sandell L; Yamashiro T; Trainor PA. 2017. Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia. Hum Mol Genet 26(7):1268-1279. PubMed: 28169399 MGI: J:241377
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Nakajima M; Mori H; Nishikawa C; Tsuruta M; Okuyama S; Furukawa Y. 2013. Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice. J Neurochem 124(2):241-9. PubMed: 23134367 MGI: J:192250
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Passman JN; Dong XR; Wu SP; Maguire CT; Hogan KA; Bautch VL; Majesky MW. 2008. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A 105(27):9349-54. PubMed: 18591670 MGI: J:137825
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Also Known As: Wnt-1/GAL4/cre-11

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Tg(Wnt1-GAL4)11Rth

Allele Symbol: Tg(Wnt1-GAL4)11Rth

Tg(Wnt1-cre)11Rth

Allele Symbol: Tg(Wnt1-cre)11Rth

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Genotype: cre related

Genotype: GAL4 related

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