JAX Mouse Strain Datasheet - 003829

STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J

Stock No:: 003829 |; Wnt-1/GAL4/cre-11

Transgenic

Repository Live

Overview

Also Known As: Wnt-1/GAL4/cre-11

These Wnt-1/GAL4/cre-11 transgenic mice have expression of both Cre recombinase and the GAL4 transcriptional activator directed to midbrain and developing neural tube by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre-mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.

Donating Investigator

David H. Rowitch, University of California, San Francisco

Genetic overview

Genetic Background	Generation
	F?+F32 (17-JUN-15)

Tg(Wnt1-GAL4)11Rth

Allele Type
Transgenic (Inserted expressed sequence)

Tg(Wnt1-cre)11Rth

Allele Type
Transgenic (Recombinase-expressing)

View Genetics

Research Applications

Developmental Biology Research
Research Tools

View All Research Applications

Base Price

Starting at:

$263.00 Domestic price for female

$337.00 Domestic price for breeder pair

View Price List

Details

Detailed Description

When homozygous for both co-injected transgenes, Wnt-1/GAL4/cre-11 transgenic mice are viable and fertile. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. Cre recombinase activity is detected in the Wnt1 pattern of expression: in the midbrain by 8.5 dpc and, after neural tube closure, in the dorsal and ventral midlines of the midbrain and caudal diencephalon, midbrain-hindbrain junction and dorsal spinal cord. Double transgenic mice exhibit psychiatric disorder-related behavioral abnormalities. Males, specifically, exhibit increased locomotor activity, increased anxiety, and decreased social interaction, while females exhibit impaired short-term spatial memory and nesting behavior. Both sexes have disordered cholinergic and glutamatergic fiber tracts from the medial habenula neurons in the interpeduncular nucleus.

Transgenic mice exhibit ectopic transgene expression and midbrain enlargement (Lewis et al. 2013 Dev Biol 379:229).

When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre-mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.

Development

The transgenic line Wnt-1/GAL4/cre-11 was created by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University). These mice resulted from co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre) into pronuclei of B6CBAF1/J (C57BL/6JxCBA/J) zygotes. Double transgenic mice from founder line 11 were obtained and bred with Swiss albino outbred mice. Double transgenic albino mice were sent to The Jackson Laboratory Repository in 2000 (as Stock No. 003829). Upon arrival, mice were bred together to establish the colony. The description of each transgene is below.

The pWEXP2-GAL4 transgene (Wnt1-GAL4) was designed by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University) with the mouse Wnt1 promoter/enhancer elements upstream of a sequence encoding the full-length yeast GAL4 gene. Specifically, the Wnt1-GAL4 transgene was created by inserting a sequence encoding the full-length yeast GAL4 gene into a 10 kbp modified mouse Wnt1 genomic sequence at a polylinker site between the promoter and enhancer (the Wnt1 genomic sequence spans from approximately 1 kbp upstream of the translation initiation codon to approximately 5.5 kbp downstream of the polyA signal, and is modified with a polylinker that disrupts the translational start site and a reverse-oriented neo cassette in 3' UTR of exon 4).

The pWEXP3C-cre transgene (Wnt1-Cre) was designed by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University) with the mouse Wnt1 promoter/enhancer elements upstream of a Cre recombinase cDNA sequence. Specifically, the Wnt1-Cre transgene was created by inserting the Cre recombinase cDNA into a 10 kbp modified mouse Wnt1 genomic sequence at a polylinker site between the promoter and enhancer (the Wnt1 genomic sequence spans from approximately 1 kbp upstream of the translation initiation codon to approximately 5.5 kbp downstream of the polyA signal, and is modified with a polylinker that disrupts the translational start site and a reverse-oriented neo cassette in 3' UTR of exon 4).

Expression Data

Expressed Gene	GAL4, transcriptional activator GAL4, yeast
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord

Control Suggestions

Noncarrier

Additional Information

Considerations for Choosing Controls

Selected References

Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. PubMed: 9843687 MGI: J:69326

View All References

Genetics

Tg(Wnt1-GAL4)11Rth

Allele Symbol: Tg(Wnt1-GAL4)11Rth

Allele Name	transgene insertion 11, David H Rowitch
Allele Type	Transgenic (Inserted expressed sequence)
Allele Synonym(s)	WEXP-GAL4; Wnt-1/GAL4
Gene Symbol and Name	Tg(Wnt1-GAL4)11Rth, transgene insertion 11, David H Rowitch
Gene Synonym(s)	WEXP-GAL4; Wnt-1/GAL4
Promoter	Wnt1, wingless-type MMTV integration site family, member 1, mouse, laboratory
Expressed Gene	GAL4, transcriptional activator GAL4, yeast
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord
Strain of Origin	(C57BL/6J x CBA/J)F1
Chromosome	UN
General Note	Six lines were generated. Homozygous transgenic mice that are also homozygous for Tg(Wnt1-cre)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Both Cre recombinase and the GAL4 transcriptional activator are expressed under the direction of Wnt1 regulatory sequences. Regulated expression initially occurs in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction, and in the dorsal spinal cord.
Molecular Note	The transgene contains the yeast GAL4 gene directed by Wnt1 promoter/enhancer sequences. Expression of the transgene matches that of the endogenous Wnt1.
Mutations Made By	David Rowitch, University of California, San Francisco

Tg(Wnt1-cre)11Rth

Allele Symbol: Tg(Wnt1-cre)11Rth

Allele Name	transgene insertion 11, David H Rowitch
Allele Type	Transgenic (Recombinase-expressing)
Allele Synonym(s)	Wnt1-Cre; Wnt1::Cre; Wnt1^Cre; Wnt1cre
Gene Symbol and Name	Tg(Wnt1-cre)11Rth, transgene insertion 11, David H Rowitch
Gene Synonym(s)	Wnt1-Cre; Wnt1::Cre; Wnt1cre
Promoter	Wnt1, wingless-type MMTV integration site family, member 1, mouse, laboratory
Expressed Gene	cre, cre recombinase, bacteriophage P1
Site of Expression	embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord
Strain of Origin	(C57BL/6J x CBA/J)F1/J
Chromosome	UN
General Note	Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
Molecular Note	The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord.
Mutations Made By	David Rowitch, University of California, San Francisco

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Developmental Biology Research
- Craniofacial and Palate Defects
  - Orofacial clefting-specific cre expression
Research Tools
- Cre-lox System
  - Cre Recombinase Expression
- GAL4-UAS System
  - GAL4 transcriptional activator

Genotype: cre related

Research Tools
- Cre-lox System
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System

Genotype: GAL4 related

Research Tools
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: transcriptional activation

References

Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. PubMed: 9843687 MGI: J:69326

Additional References

Pietri T; Eder O; Blanche M; Thiery JP; Dufour S. 2003. The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev Biol 259(1):176-87. PubMed: 12812797 MGI: J:92369

Additional - Tg(Wnt1-cre)11Rth related

Aanhaanen WT; Boukens BJ; Sizarov A; Wakker V; de Gier-de Vries C; van Ginneken AC; Moorman AF; Coronel R; Christoffels VM. 2011. Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. J Clin Invest 121(2):534-44. PubMed: 21266775 MGI: J:171828
Abdo H; Li L; Lallemend F; Bachy I; Xu XJ; Rice FL; Ernfors P. 2011. Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci 34(10):1529-41. PubMed: 22103411 MGI: J:184160
Achim K; Peltopuro P; Lahti L; Tsai HH; Zachariah A; Astrand M; Salminen M; Rowitch D; Partanen J. 2013. The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors. Biol Open 2(10):990-7. PubMed: 24167708 MGI: J:203421
Adameyko I; Lallemend F; Furlan A; Zinin N; Aranda S; Kitambi SS; Blanchart A; Favaro R; Nicolis S; Lubke M; Muller T; Birchmeier C; Suter U; Zaitoun I; Takahashi Y; Ernfors P. 2012. Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development 139(2):397-410. PubMed: 22186729 MGI: J:178973
Agarwal P; Verzi MP; Nguyen T; Hu J; Ehlers ML; McCulley DJ; Xu SM; Dodou E; Anderson JP; Wei ML; Black BL. 2011. The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development 138(12):2555-65. PubMed: 21610032 MGI: J:173609
Aggarwal VS; Carpenter C; Freyer L; Liao J; Petti M; Morrow BE. 2010. Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol 344(2):669-81. PubMed: 20501333 MGI: J:163487
Almaidhan A; Cesario J; Landin Malt A; Zhao Y; Sharma N; Choi V; Jeong J. 2014. Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation. BMC Dev Biol 14:3. PubMed: 24433583 MGI: J:208345
Anderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. PubMed: 16894609 MGI: J:111609
Anthwal N; Chai Y; Tucker AS. 2008. The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn 237(6):1604-13. PubMed: 18498113 MGI: J:136394
Aoki H; Hara A; Kunisada T. 2015. White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage. Genes Cells 20(5):439-49. PubMed: 25818501 MGI: J:230341
Aoki H; Hara A; Oomori Y; Shimizu Y; Yamada Y; Kunisada T. 2014. Neonatal lethality of neural crest cell-specific Rest knockout mice is associated with gastrointestinal distension caused by aberrations of myenteric plexus. Genes Cells 19(10):723-42. PubMed: 25135772 MGI: J:230224
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. PubMed: 19251646 MGI: J:147154
Arenkiel BR; Tvrdik P; Gaufo GO; Capecchi MR. 2004. Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev 18(13):1539-52. PubMed: 15198977 MGI: J:91364
Arnold TD; Zang K; Vallejo-Illarramendi A. 2013. Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality. Dis Model Mech 6(5):1205-12. PubMed: 23744273 MGI: J:201332
Avetisyan M; Wang H; Schill EM; Bery S; Grider JR; Hassell JA; Stappenbeck T; Heuckeroth RO. 2015. Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. J Neurosci 35(33):11543-58. PubMed: 26290232 MGI: J:226097
Baek WY; Kim YJ; de Crombrugghe B; Kim JE. 2013. Osterix is required for cranial neural crest-derived craniofacial bone formation. Biochem Biophys Res Commun 432(1):188-92. PubMed: 23313488 MGI: J:198072
Bain VE; Gordon J; O'Neil JD; Ramos I; Richie ER; Manley NR. 2016. Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development 143(21):4027-4037. PubMed: 27633995 MGI: J:237523
Bankhead EJ; Colasanto MP; Dyorich KM; Jamrich M; Murtaugh LC; Fuhrmann S. 2015. Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis. Am J Pathol 185(1):197-213. PubMed: 25451153 MGI: J:218165
Baquet ZC; Bickford PC; Jones KR. 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25(26):6251-9. PubMed: 15987955 MGI: J:99291
Barbosa AC; Funato N; Chapman S; McKee MD; Richardson JA; Olson EN; Yanagisawa H. 2007. Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol 310(1):154-68. PubMed: 17764670 MGI: J:128020
Barnes RM; Firulli BA; Vandusen NJ; Morikawa Y; Conway SJ; Cserjesi P; Vincentz JW; Firulli AB. 2011. Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res 108(8):940-9. PubMed: 21350214 MGI: J:171088
Barraud P; Seferiadis AA; Tyson LD; Zwart MF; Szabo-Rogers HL; Ruhrberg C; Liu KJ; Baker CV. 2010. Neural crest origin of olfactory ensheathing glia. Proc Natl Acad Sci U S A 107(49):21040-5. PubMed: 21078992 MGI: J:167161
Barron F; Woods C; Kuhn K; Bishop J; Howard MJ; Clouthier DE. 2011. Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development 138(11):2249-59. PubMed: 21558373 MGI: J:173619
Baydyuk M; Xie Y; Tessarollo L; Xu B. 2013. Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci 33(8):3363-9. PubMed: 23426664 MGI: J:194255
Becker L; Kulkarni S; Tiwari G; Micci MA; Pasricha PJ. 2012. Divergent fate and origin of neurosphere-like bodies from different layers of the gut. Am J Physiol Gastrointest Liver Physiol 302(9):G958-65. PubMed: 22361728 MGI: J:187487
Behr B; Longaker MT; Quarto N. 2010. Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosis. Dev Biol 344(2):922-40. PubMed: 20547147 MGI: J:163650
Behr B; Panetta NJ; Longaker MT; Quarto N. 2010. Different endogenous threshold levels of Fibroblast Growth Factor-ligands determine the healing potential of frontal and parietal bones. Bone 47(2):281-94. PubMed: 20472108 MGI: J:163361
Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. PubMed: 19409885 MGI: J:150767
Bhattaram P; Penzo-Mendez A; Sock E; Colmenares C; Kaneko KJ; Vassilev A; Depamphilis ML; Wegner M; Lefebvre V. 2010. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1:9. PubMed: 20596238 MGI: J:175338
Billmyre KK; Klingensmith J. 2015. Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. Dev Dyn 244(4):564-76. PubMed: 25626636 MGI: J:220864
Boczonadi V; Gillespie R; Keenan I; Ramsbottom SA; Donald-Wilson C; Al Nazer M; Humbert P; Schwarz RJ; Chaudhry B; Henderson DJ. 2014. Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium. Cardiovasc Res 104(1):103-15. PubMed: 25139745 MGI: J:230220
Bogenmann E; Thomas PS; Li Q; Kim J; Yang LT; Pierchala B; Kaartinen V. 2011. Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene. Genesis 49(11):862-9. PubMed: 21413144 MGI: J:178666
Bonilla-Claudio M; Wang J; Bai Y; Klysik E; Selever J; Martin JF. 2012. Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Development 139(4):709-19. PubMed: 22219353 MGI: J:181229
Bourane S; Garces A; Venteo S; Pattyn A; Hubert T; Fichard A; Puech S; Boukhaddaoui H; Baudet C; Takahashi S; Valmier J; Carroll P. 2009. Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron 64(6):857-70. PubMed: 20064392 MGI: J:157721
Bradshaw L; Chaudhry B; Hildreth V; Webb S; Henderson DJ. 2009. Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H). J Anat 214(2):245-57. PubMed: 19207986 MGI: J:150613
Brault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. PubMed: 11262227 MGI: J:67966
Breau MA; Pietri T; Stemmler MP; Thiery JP; Weston JA. 2008. A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme. Proc Natl Acad Sci U S A 105(22):7750-5. PubMed: 18515427 MGI: J:175963
Brewer JR; Molotkov A; Mazot P; Hoch RV; Soriano P. 2015. Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev 29(17):1863-74. PubMed: 26341559 MGI: J:226497
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. PubMed: 14975722 MGI: J:88826
Brown CB; Feiner L; Lu MM; Li J; Ma X; Webber AL; Jia L; Raper JA; Epstein JA. 2001. PlexinA2 and semaphorin signaling during cardiac neural crest development. Development 128(16):3071-80. PubMed: 11688557 MGI: J:71241
Brugmann SA; Allen NC; James AW; Mekonnen Z; Madan E; Helms JA. 2010. A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet 19(8):1577-92. PubMed: 20106874 MGI: J:158523
Buchmann-Moller S; Miescher I; John N; Krishnan J; Deng CX; Sommer L. 2009. Multiple lineage-specific roles of Smad4 during neural crest development. Dev Biol 330(2):329-38. PubMed: 19361496 MGI: J:149223
Cao H; Wang J; Li X; Florez S; Huang Z; Venugopalan SR; Elangovan S; Skobe Z; Margolis HC; Martin JF; Amendt BA. 2010. MicroRNAs play a critical role in tooth development. J Dent Res 89(8):779-84. PubMed: 20505045 MGI: J:227896
Carpenter AC; Rao S; Wells JM; Campbell K; Lang RA. 2010. Generation of mice with a conditional null allele for Wntless. Genesis 48(9):554-8. PubMed: 20614471 MGI: J:164701
Carpenter AC; Smith AN; Wagner H; Cohen-Tayar Y; Rao S; Wallace V; Ashery-Padan R; Lang RA. 2015. Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. Development 142(5):972-82. PubMed: 25715397 MGI: J:220323
Cases O; Joseph A; Obry A; Santin MD; Ben-Yacoub S; Paques M; Amsellem-Levera S; Bribian A; Simonutti M; Augustin S; Debeir T; Sahel JA; Christ A; de Castro F; Lehericy S; Cosette P; Kozyraki R. 2015. Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. PLoS One 10(6):e0129518. PubMed: 26107939 MGI: J:238249
Causeret F; Ensini M; Teissier A; Kessaris N; Richardson WD; Lucas de Couville T; Pierani A. 2011. Dbx1-expressing cells are necessary for the survival of the Mammalian anterior neural and craniofacial structures. PLoS One 6(4):e19367. PubMed: 21552538 MGI: J:172360
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. PubMed: 10725243 MGI: J:61091
Chandler RL; Magnuson T. 2016. The SWI/SNF BAF-A complex is essential for neural crest development. Dev Biol 411(1):15-24. PubMed: 26806701 MGI: J:231470
Chang CP; Stankunas K; Shang C; Kao SC; Twu KY; Cleary ML. 2008. Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 135(21):3577-86. PubMed: 18849531 MGI: J:141111
Chapnik E; Sasson V; Blelloch R; Hornstein E. 2012. Dgcr8 controls neural crest cells survival in cardiovascular development. Dev Biol 362(1):50-6. PubMed: 22138056 MGI: J:180151
Charron F; Stein E; Jeong J; McMahon AP; Tessier-Lavigne M. 2003. The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance. Cell 113(1):11-23. PubMed: 12679031 MGI: J:82736
Chen AI; Nguyen CN; Copenhagen DR; Badurek S; Minichiello L; Ranscht B; Reichardt LF. 2011. TrkB (Tropomyosin-Related Kinase B) Controls the Assembly and Maintenance of GABAergic Synapses in the Cerebellar Cortex. J Neurosci 31(8):2769-80. PubMed: 21414899 MGI: J:169866
Chen CL; Broom DC; Liu Y; de Nooij JC; Li Z; Cen C; Samad OA; Jessell TM; Woolf CJ; Ma Q. 2006. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron 49(3):365-77. PubMed: 16446141 MGI: J:106971
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. PubMed: 17693261 MGI: J:132329
Chen H; Zhang W; Sun X; Yoshimoto M; Chen Z; Zhu W; Liu J; Shen Y; Yong W; Li D; Zhang J; Lin Y; Li B; Vandusen NJ; Snider P; Schwartz RJ; Conway SJ; Field LJ; Yoder MC; Firulli AB; Carlesso N; Towbin JA; Shou W. 2013. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development 140(9):1946-57. PubMed: 23571217 MGI: J:195489
Chen J; Tu X; Esen E; Joeng KS; Lin C; Arbeit JM; Ruegg MA; Hall MN; Ma L; Long F. 2014. WNT7B promotes bone formation in part through mTORC1. PLoS Genet 10(1):e1004145. PubMed: 24497849 MGI: J:208766
Chen L; Zhao P; Wells L; Amemiya CT; Condie BG; Manley NR. 2010. Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function. Proc Natl Acad Sci U S A 107(23):10555-60. PubMed: 20498049 MGI: J:161296
Chen Q; Zhang H; Liu Y; Adams S; Eilken H; Stehling M; Corada M; Dejana E; Zhou B; Adams RH. 2016. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun 7:12422. PubMed: 27516371 MGI: J:236848
Chen YH; Ishii M; Sun J; Sucov HM; Maxson RE Jr. 2007. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308(2):421-37. PubMed: 17601530 MGI: J:124119
Cheng Z; Sundberg-Smith LJ; Mangiante LE; Sayers RL; Hakim ZS; Musunuri S; Maguire CT; Majesky MW; Zhou Z; Mack CP; Taylor JM. 2011. Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature. Arterioscler Thromb Vasc Biol 31(10):2193-202. PubMed: 21757658 MGI: J:191848
Cheret C; Willem M; Fricker FR; Wende H; Wulf-Goldenberg A; Tahirovic S; Nave KA; Saftig P; Haass C; Garratt AN; Bennett DL; Birchmeier C. 2013. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. EMBO J 32(14):2015-28. PubMed: 23792428 MGI: J:199150
Choe Y; Kozlova A; Graf D; Pleasure SJ. 2013. Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci 33(16):6766-75. PubMed: 23595735 MGI: J:196652
Choi M; Stottmann RW; Yang YP; Meyers EN; Klingensmith J. 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res 100(2):220-8. PubMed: 17218603 MGI: J:133691
Chojnowski JL; Masuda K; Trau HA; Thomas K; Capecchi M; Manley NR. 2014. Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development 141(19):3697-708. PubMed: 25249461 MGI: J:217502
Chojnowski JL; Trau HA; Masuda K; Manley NR. 2016. Temporal and spatial requirements for Hoxa3 in mouse embryonic development. Dev Biol 415(1):33-45. PubMed: 27178667 MGI: J:234117
Choudhary B; Ito Y; Makita T; Sasaki T; Chai Y; Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289(2):420-9. PubMed: 16332365 MGI: J:104325
Choudhary B; Zhou J; Li P; Thomas S; Kaartinen V; Sucov HM. 2009. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis 47(2):115-21. PubMed: 19165826 MGI: J:147389
Cimadamore F; Amador-Arjona A; Chen C; Huang CT; Terskikh AV. 2013. SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors. Proc Natl Acad Sci U S A 110(32):E3017-26. PubMed: 23884650 MGI: J:200697
Colak D; Ji SJ; Porse BT; Jaffrey SR. 2013. Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay. Cell 153(6):1252-65. PubMed: 23746841 MGI: J:198412
Connerney J; Andreeva V; Leshem Y; Muentener C; Mercado MA; Spicer DB. 2006. Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn 235(5):1334-46. PubMed: 16502419 MGI: J:108218
Coppola E; Rallu M; Richard J; Dufour S; Riethmacher D; Guillemot F; Goridis C; Brunet JF. 2010. Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A 107(5):2066-71. PubMed: 20133851 MGI: J:157532
D'Autreaux F; Morikawa Y; Cserjesi P; Gershon MD. 2007. Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia. Development 134(12):2237-49. PubMed: 17507395 MGI: J:135127
Dai J; Kuang Y; Fang B; Gong H; Lu S; Mou Z; Sun H; Dong Y; Lu J; Zhang W; Zhang J; Wang Z; Wang X; Shen G. 2013. The effect of overexpression of Dlx2 on the migration, proliferation and osteogenic differentiation of cranial neural crest stem cells. Biomaterials 34(8):1898-910. PubMed: 23246068 MGI: J:231270
Davy A; Aubin J; Soriano P. 2004. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18(5):572-83. PubMed: 15037550 MGI: J:89008
Degenhardt KR; Milewski RC; Padmanabhan A; Miller M; Singh MK; Lang D; Engleka KA; Wu M; Li J; Zhou D; Antonucci N; Li L; Epstein JA. 2010. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol 339(2):519-27. PubMed: 20045680 MGI: J:159124
Delalande JM; Natarajan D; Vernay B; Finlay M; Ruhrberg C; Thapar N; Burns AJ. 2014. Vascularisation is not necessary for gut colonisation by enteric neural crest cells. Dev Biol 385(2):220-9. PubMed: 24262984 MGI: J:205408
Dennis JF; Kurosaka H; Iulianella A; Pace J; Thomas N; Beckham S; Williams T; Trainor PA. 2012. Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. PLoS Genet 8(10):e1002927. PubMed: 23055936 MGI: J:190013
Di Bonito M; Narita Y; Avallone B; Sequino L; Mancuso M; Andolfi G; Franze AM; Puelles L; Rijli FM; Studer M. 2013. Assembly of the auditory circuitry by a Hox genetic network in the mouse brainstem. PLoS Genet 9(2):e1003249. PubMed: 23408898 MGI: J:197162
Di Meglio T; Kratochwil CF; Vilain N; Loche A; Vitobello A; Yonehara K; Hrycaj SM; Roska B; Peters AH; Eichmann A; Wellik D; Ducret S; Rijli FM. 2013. Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons. Science 339(6116):204-7. PubMed: 23307742 MGI: J:193244
Dietrich P; Shanmugasundaram R; Shuyu E; Dragatsis I. 2009. Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages. Hum Mol Genet 18(1):142-50. PubMed: 18838463 MGI: J:143295
Dilg D; Saleh RN; Phelps SE; Rose Y; Dupays L; Murphy C; Mohun T; Anderson RH; Scambler PJ; Chapgier AL. 2016. HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3. PLoS One 11(8):e0161096. PubMed: 27518902 MGI: J:236915
Downs AM; Bond CE; Hoover DB. 2014. Localization of alpha7 nicotinic acetylcholine receptor mRNA and protein within the cholinergic anti-inflammatory pathway. Neuroscience 266:178-85. PubMed: 24561218 MGI: J:210336
Druckenbrod NR; Epstein ML. 2009. Age-dependent changes in the gut environment restrict the invasion of the hindgut by enteric neural progenitors. Development 136(18):3195-203. PubMed: 19700623 MGI: J:152317
Druckenbrod NR; Powers PA; Bartley CR; Walker JW; Epstein ML. 2008. Targeting of endothelin receptor-B to the neural crest. Genesis 46(8):396-400. PubMed: 18693272 MGI: J:140320
Dudas M; Kim J; Li WY; Nagy A; Larsson J; Karlsson S; Chai Y; Kaartinen V. 2006. Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol 296(2):298-314. PubMed: 16806156 MGI: J:119289
Dudas M; Sridurongrit S; Nagy A; Okazaki K; Kaartinen V. 2004. Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech Dev 121(2):173-82. PubMed: 15037318 MGI: J:90453
Dulauroy S; Di Carlo SE; Langa F; Eberl G; Peduto L. 2012. Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat Med :. PubMed: 22842476 MGI: J:188912
Dupe V; Pellerin I. 2009. Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells. Dev Dyn 238(10):2701-2711. PubMed: 19777591 MGI: J:152832
Dupuis LE; McCulloch DR; McGarity JD; Bahan A; Wessels A; Weber D; Diminich AM; Nelson CM; Apte SS; Kern CB. 2011. Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease. Dev Biol 357(1):152-64. PubMed: 21749862 MGI: J:175544
Duverger O; Isaac J; Zah A; Hwang J; Berdal A; Lian JB; Morasso MI. 2013. In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones. J Cell Physiol 228(3):654-64. PubMed: 22886599 MGI: J:225092
Duverger O; Zah A; Isaac J; Sun HW; Bartels AK; Lian JB; Berdal A; Hwang J; Morasso MI. 2012. Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp. J Biol Chem 287(15):12230-40. PubMed: 22351765 MGI: J:184287
Dykes IM; Tempest L; Lee SI; Turner EE. 2011. Brn3a and islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci 31(27):9789-99. PubMed: 21734270 MGI: J:174563
Dykes IM; van Bueren KL; Ashmore RJ; Floss T; Wurst W; Szumska D; Bhattacharya S; Scambler PJ. 2014. HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res 115(1):23-31. PubMed: 24748541 MGI: J:225226
El Robrini N; Etchevers HC; Ryckebusch L; Faure E; Eudes N; Niederreither K; Zaffran S; Bertrand N. 2016. Cardiac outflow morphogenesis depends on effects of retinoic acid signaling on multiple cell lineages. Dev Dyn 245(3):388-401. PubMed: 26442704 MGI: J:229170
Engelhard C; Sarsfield S; Merte J; Wang Q; Li P; Beppu H; Kolodkin AL; Sucov HM; Ginty DD. 2013. MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife 2:e01160. PubMed: 24052814 MGI: J:206541
Engleka KA; Wu M; Zhang M; Antonucci NB; Epstein JA. 2007. Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol 311(2):524-37. PubMed: 17927973 MGI: J:127545
Erickson CS; Zaitoun I; Haberman KM; Gosain A; Druckenbrod NR; Epstein ML. 2012. Sacral neural crest-derived cells enter the aganglionic colon of Ednrb-/- mice along extrinsic nerve fibers. J Comp Neurol 520(3):620-32. PubMed: 21858821 MGI: J:187343
Etheridge SL; Ray S; Li S; Hamblet NS; Lijam N; Tsang M; Greer J; Kardos N; Wang J; Sussman DJ; Chen P; Wynshaw-Boris A. 2008. Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet 4(11):e1000259. PubMed: 19008950 MGI: J:142392
Evans AL; Gage PJ. 2005. Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet 14(22):3347-59. PubMed: 16203745 MGI: J:104125
Falk S; Joosten E; Kaartinen V; Sommer L. 2014. Smad4 and Trim33/Tif1gamma redundantly regulate neural stem cells in the developing cortex. Cereb Cortex 24(11):2951-63. PubMed: 23765158 MGI: J:226378
Fantauzzo KA; Soriano P. 2016. PDGFRbeta regulates craniofacial development through homodimers and functional heterodimers with PDGFRalpha. Genes Dev 30(21):2443-2458. PubMed: 27856617 MGI: J:237202
Farago AF; Awatramani RB; Dymecki SM. 2006. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron 50(2):205-18. PubMed: 16630833 MGI: J:133039
Feng Y; Chen MH; Moskowitz IP; Mendonza AM; Vidali L; Nakamura F; Kwiatkowski DJ; Walsh CA. 2006. Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A 103(52):19836-41. PubMed: 17172441 MGI: J:118252
Ferretti E; Li B; Zewdu R; Wells V; Hebert JM; Karner C; Anderson MJ; Williams T; Dixon J; Dixon MJ; Depew MJ; Selleri L. 2011. A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell 21(4):627-41. PubMed: 21982646 MGI: J:178316
Finelli MJ; Murphy KJ; Chen L; Zou H. 2013. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep 3(5):1592-606. PubMed: 23665221 MGI: J:198483
Firulli BA; Fuchs RK; Vincentz JW; Clouthier DE; Firulli AB. 2014. Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development 141(15):3050-61. PubMed: 25053435 MGI: J:214092
Fleming MS; Li JJ; Ramos D; Li T; Talmage DA; Abe SI; Arber S; Luo W. 2016. A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. J Neurosci 36(40):10337-10355. PubMed: 27707970 MGI: J:235934
Forni PE; Taylor-Burds C; Melvin VS; Williams T; Wray S. 2011. Neural Crest and Ectodermal Cells Intermix in the Nasal Placode to Give Rise to GnRH-1 Neurons, Sensory Neurons, and Olfactory Ensheathing Cells. J Neurosci 31(18):6915-27. PubMed: 21543621 MGI: J:171903
Foster K; Sheridan J; Veiga-Fernandes H; Roderick K; Pachnis V; Adams R; Blackburn C; Kioussis D; Coles M. 2008. Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol 180(5):3183-9. PubMed: 18292542 MGI: J:131558
Foster KE; Gordon J; Cardenas K; Veiga-Fernandes H; Makinen T; Grigorieva E; Wilkinson DG; Blackburn CC; Richie E; Manley NR; Adams RH; Kioussis D; Coles MC. 2010. EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci U S A 107(30):13414-9. PubMed: 20616004 MGI: J:162413
Frank DU; Fotheringham LK; Brewer JA; Muglia LJ; Tristani-Firouzi M; Capecchi MR; Moon AM. 2002. An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development 129(19):4591-603. PubMed: 12223415 MGI: J:78685
Freem LJ; Escot S; Tannahill D; Druckenbrod NR; Thapar N; Burns AJ. 2010. The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice. J Anat 217(6):651-64. PubMed: 20840354 MGI: J:179040
Fu J; Ivy Yu HM; Maruyama T; Mirando AJ; Hsu W. 2011. Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn 240(2):365-71. PubMed: 21246653 MGI: J:167835
Fuchs S; Herzog D; Sumara G; Buchmann-Moller S; Civenni G; Wu X; Chrostek-Grashoff A; Suter U; Ricci R; Relvas JB; Brakebusch C; Sommer L. 2009. Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell 4(3):236-47. PubMed: 19265663 MGI: J:149918
Fujita M; Sakabe M; Ioka T; Watanabe Y; Kinugasa-Katayama Y; Tsuchihashi T; Utset MF; Yamagishi H; Nakagawa O. 2016. Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev 139:65-73. PubMed: 26577899 MGI: J:229950
Fukuhara K; Imai F; Ladle DR; Katayama K; Leslie JR; Arber S; Jessell TM; Yoshida Y. 2013. Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling. Cell Rep 5(3):748-58. PubMed: 24210822 MGI: J:205528
Funato N; Nakamura M; Richardson JA; Srivastava D; Yanagisawa H. 2015. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet 24(2):424-35. PubMed: 25209980 MGI: J:217210
Funato N; Nakamura M; Richardson JA; Srivastava D; Yanagisawa H. 2012. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet 21(11):2524-37. PubMed: 22371266 MGI: J:183770
Furlan A; La Manno G; Lubke M; Haring M; Abdo H; Hochgerner H; Kupari J; Usoskin D; Airaksinen MS; Oliver G; Linnarsson S; Ernfors P. 2016. Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nat Neurosci 19(10):1331-40. PubMed: 27571008 MGI: J:238230
Furlan A; Lubke M; Adameyko I; Lallemend F; Ernfors P. 2013. The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification. EMBO J 32(11):1613-25. PubMed: 23591430 MGI: J:198834
Gaborit N; Sakuma R; Wylie JN; Kim KH; Zhang SS; Hui CC; Bruneau BG. 2012. Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development 139(21):4007-19. PubMed: 22992950 MGI: J:189007
Gage PJ; Qian M; Wu D; Rosenberg KI. 2008. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol 317(1):310-24. PubMed: 18367164 MGI: J:136041
Gascon E; Gaillard S; Malapert P; Liu Y; Rodat-Despoix L; Samokhvalov IM; Delmas P; Helmbacher F; Maina F; Moqrich A. 2010. Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci 30(37):12414-23. PubMed: 20844136 MGI: J:164668
Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :. MGI: J:193672
George L; Chaverra M; Wolfe L; Thorne J; Close-Davis M; Eibs A; Riojas V; Grindeland A; Orr M; Carlson GA; Lefcort F. 2013. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A 110(46):18698-703. PubMed: 24173031 MGI: J:202989
Geyer CB; Inselman AL; Sunman JA; Bornstein S; Handel MA; Eddy EM. 2009. A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Dev Biol 330(1):142-52. PubMed: 19341723 MGI: J:149233
Gitler AD; Zhu Y; Ismat FA; Lu MM; Yamauchi Y; Parada LF; Epstein JA. 2003. Nf1 has an essential role in endothelial cells. Nat Genet 33(1):75-9. PubMed: 12469121 MGI: J:80323
Goddeeris MM; Schwartz R; Klingensmith J; Meyers EN. 2007. Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development 134(8):1593-604. PubMed: 17344228 MGI: J:135134
Gosain A; Barlow-Anacker AJ; Erickson CS; Pierre JF; Heneghan AF; Epstein ML; Kudsk KA. 2015. Impaired Cellular Immunity in the Murine Neural Crest Conditional Deletion of Endothelin Receptor-B Model of Hirschsprung's Disease. PLoS One 10(6):e0128822. PubMed: 26061883 MGI: J:233811
Goudy S; Angel P; Jacobs B; Hill C; Mainini V; Smith AL; Kousa YA; Caprioli R; Prince LS; Baldwin S; Schutte BC. 2013. Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. PLoS One 8(2):e56270. PubMed: 23451037 MGI: J:199408
Gregoire D; Kmita M. 2008. Recombination between inverted loxP sites is cytotoxic for proliferating cells and provides a simple tool for conditional cell ablation. Proc Natl Acad Sci U S A 105(38):14492-6. PubMed: 18787116 MGI: J:198909
Greif DM; Kumar M; Lighthouse JK; Hum J; An A; Ding L; Red-Horse K; Espinoza FH; Olson L; Offermanns S; Krasnow MA. 2012. Radial construction of an arterial wall. Dev Cell 23(3):482-93. PubMed: 22975322 MGI: J:189012
Grifone R; Jarry T; Dandonneau M; Grenier J; Duprez D; Kelly RG. 2008. Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos. Dev Dyn 237(10):3071-3078. PubMed: 18816853 MGI: J:139636
Grossmann KS; Wende H; Paul FE; Cheret C; Garratt AN; Zurborg S; Feinberg K; Besser D; Schulz H; Peles E; Selbach M; Birchmeier W; Birchmeier C. 2009. The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A 106(39):16704-9. PubMed: 19805360 MGI: J:153219
Gu S; Wei N; Yu L; Fei J; Chen Y. 2008. Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev 125(8):729-42. PubMed: 18514492 MGI: J:138379
Gu S; Wei N; Yu X; Jiang Y; Fei J; Chen Y. 2008. Mice with an anterior cleft of the palate survive neonatal lethality. Dev Dyn 237(5):1509-16. PubMed: 18393307 MGI: J:134348
Guo C; Qiu HY; Huang Y; Chen H; Yang RQ; Chen SD; Johnson RL; Chen ZF; Ding YQ. 2007. Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development 134(2):317-25. PubMed: 17166916 MGI: J:117035
Haberland M; Mokalled MH; Montgomery RL; Olson EN. 2009. Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev 23(14):1625-30. PubMed: 19605684 MGI: J:150709
Hadjab S; Franck MC; Wang Y; Sterzenbach U; Sharma A; Ernfors P; Lallemend F. 2013. A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. J Neurosci 33(45):17656-66. PubMed: 24198358 MGI: J:204192
Hahm K; Sum EY; Fujiwara Y; Lindeman GJ; Visvader JE; Orkin SH. 2004. Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol 24(5):2074-82. PubMed: 14966286 MGI: J:88168
Han A; Zhao H; Li J; Pelikan R; Chai Y. 2014. ALK5-mediated transforming growth factor beta signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol 34(16):3120-31. PubMed: 24912677 MGI: J:224277
Han D; Zhao H; Parada C; Hacia JG; Bringas P Jr; Chai Y. 2012. A TGFbeta-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development 139(9):1640-50. PubMed: 22438570 MGI: J:184019
Han J; Ishii M; Bringas P Jr; Maas RL; Maxson RE Jr; Chai Y. 2007. Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev 124(9-10):729-45. PubMed: 17693062 MGI: J:125119
Han J; Ito Y; Yeo JY; Sucov HM; Maas R; Chai Y. 2003. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol 261(1):183-96. PubMed: 12941628 MGI: J:85296
Hancock ML; Preitner N; Quan J; Flanagan JG. 2014. MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension. J Neurosci 34(1):66-78. PubMed: 24381269 MGI: J:205590
Hari L; Brault V; Kleber M; Lee HY; Ille F; Leimeroth R; Paratore C; Suter U; Kemler R; Sommer L. 2002. Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol 159(5):867-80. PubMed: 12473692 MGI: J:80757
Hari L; Miescher I; Shakhova O; Suter U; Chin L; Taketo M; Richardson WD; Kessaris N; Sommer L. 2012. Temporal control of neural crest lineage generation by Wnt/beta-catenin signaling. Development 139(12):2107-17. PubMed: 22573620 MGI: J:185553
Harlow DE; Yang H; Williams T; Barlow LA. 2011. Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn 240(2):309-23. PubMed: 21246648 MGI: J:167838
Harmon AW; Nakano A. 2013. Nkx2-5 lineage tracing visualizes the distribution of second heart field-derived aortic smooth muscle. Genesis 51(12):862-9. PubMed: 24133047 MGI: J:204970
He F; Soriano P. 2013. A Critical Role for PDGFRalpha Signaling in Medial Nasal Process Development. PLoS Genet 9(9):e1003851. PubMed: 24086166 MGI: J:202450
Heanue TA; Pachnis V. 2011. Prospective identification and isolation of enteric nervous system progenitors using Sox2. Stem Cells 29(1):128-40. PubMed: 21280162 MGI: J:180118
Hendershot TJ; Liu H; Clouthier DE; Shepherd IT; Coppola E; Studer M; Firulli AB; Pittman DL; Howard MJ. 2008. Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. Dev Biol 319(2):179-91. PubMed: 18501887 MGI: J:137726
Hendershot TJ; Liu H; Sarkar AA; Giovannucci DR; Clouthier DE; Abe M; Howard MJ. 2007. Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn 236(1):93-105. PubMed: 17075884 MGI: J:138032
Heuze Y; Singh N; Basilico C; Jabs EW; Holmes G; Richtsmeier JT. 2014. Morphological comparison of the craniofacial phenotypes of mouse models expressing the Apert FGFR2 S252W mutation in neural crest- or mesoderm-derived tissues. Bone 63:101-9. PubMed: 24632501 MGI: J:207963
High FA; Zhang M; Proweller A; Tu L; Parmacek MS; Pear WS; Epstein JA. 2007. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest 117(2):353-363. PubMed: 17273555 MGI: J:118039
Hill CR; Yuasa M; Schoenecker J; Goudy SL. 2014. Jagged1 is essential for osteoblast development during maxillary ossification. Bone 62:10-21. PubMed: 24491691 MGI: J:207974
Hisatsune C; Miyamoto H; Hirono M; Yamaguchi N; Sugawara T; Ogawa N; Ebisui E; Ohshima T; Yamada M; Hensch TK; Hattori M; Mikoshiba K. 2013. IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice. Front Neural Circuits 7:156. PubMed: 24109434 MGI: J:202815
Ho AT; Hayashi S; Brohl D; Aurade F; Rattenbach R; Relaix F. 2011. Neural Crest Cell Lineage Restricts Skeletal Muscle Progenitor Cell Differentiation through Neuregulin1-ErbB3 Signaling. Dev Cell 21(2):273-87. PubMed: 21782525 MGI: J:175786
Ho HY; Susman MW; Bikoff JB; Ryu YK; Jonas AM; Hu L; Kuruvilla R; Greenberg ME. 2012. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A 109(11):4044-51. PubMed: 22343533 MGI: J:182150
Ho TV; Iwata J; Ho HA; Grimes WC; Park S; Sanchez-Lara PA; Chai Y. 2015. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol 400(2):180-90. PubMed: 25722190 MGI: J:221137
Hodge LK; Klassen MP; Han BX; Yiu G; Hurrell J; Howell A; Rousseau G; Lemaigre F; Tessier-Lavigne M; Wang F. 2007. Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 55(4):572-86. PubMed: 17698011 MGI: J:126770
Holler KL; Hendershot TJ; Troy SE; Vincentz JW; Firulli AB; Howard MJ. 2010. Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol 341(1):291-304. PubMed: 20144608 MGI: J:160022
Holmes G; Basilico C. 2012. Mesodermal expression of Fgfr2(S252W) is necessary and sufficient to induce craniosynostosis in a mouse model of Apert syndrome. Dev Biol 368(2):283-93. PubMed: 22664175 MGI: J:186558
Hosokawa R; Oka K; Yamaza T; Iwata J; Urata M; Xu X; Bringas P Jr; Nonaka K; Chai Y. 2010. TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol 341(1):186-95. PubMed: 20193675 MGI: J:160001
Hou B; Kolpakova-Hart E; Fukai N; Wu K; Olsen BR. 2009. The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice. Bone 44(6):1121-33. PubMed: 19264154 MGI: J:150386
Hsu W; Mirando AJ; Yu HM. 2009. Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev Dyn 239(1):338-345. PubMed: 19653308 MGI: J:155252
Hu H; Li J; Gagen CS; Gray NW; Zhang Z; Qi Y; Zhang P. 2011. Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol 519(7):1320-37. PubMed: 21452199 MGI: J:179356
Hu J; Verzi MP; Robinson AS; Tang PL; Hua LL; Xu SM; Kwok PY; Black BL. 2015. Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway. Development 142(16):2775-80. PubMed: 26160899 MGI: J:224213
Hu ZL; Shi M; Huang Y; Zheng MH; Pei Z; Chen JY; Han H; Ding YQ. 2011. The role of the transcription factor Rbpj in the development of dorsal root ganglia. Neural Dev 6:14. PubMed: 21510873 MGI: J:173761
Hua ZL; Emiliani FE; Nathans J. 2015. Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems. Neural Dev 10(1):21. PubMed: 26395878 MGI: J:226479
Hua ZL; Smallwood PM; Nathans J. 2013. Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons. Elife 2:e01482. PubMed: 24347548 MGI: J:207894
Huang EJ; Li H; Tang AA; Wiggins AK; Neve RL; Zhong W; Jan LY; Jan YN. 2005. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev 19(1):138-51. PubMed: 15598981 MGI: J:95688
Huang J; Cheng L; Li J; Chen M; Zhou D; Lu MM; Proweller A; Epstein JA; Parmacek MS. 2008. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest 118(2):515-25. PubMed: 18188448 MGI: J:131288
Huang S; O'Donovan KJ; Turner EE; Zhong J; Ginty DD. 2015. Extrinsic and intrinsic signals converge on the Runx1/CBFbeta transcription factor for nonpeptidergic nociceptor maturation. Elife 4:. PubMed: 26418744 MGI: J:226826
Huang T; Liu Y; Huang M; Zhao X; Cheng L. 2010. Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice. J Mol Cell Biol 2(3):152-63. PubMed: 20457670 MGI: J:162791
Huang X; Bringas P Jr; Slavkin HC; Chai Y. 2009. Fate of HERS during tooth root development. Dev Biol 334(1):22-30. PubMed: 19576204 MGI: J:153568
Huang X; Goudy SL; Ketova T; Litingtung Y; Chiang C. 2008. Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn 237(10):3079-3087. PubMed: 18816854 MGI: J:139635
Huang X; Ketova T; Fleming JT; Wang H; Dey SK; Litingtung Y; Chiang C. 2009. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development 136(15):2535-43. PubMed: 19570847 MGI: J:152851
Huang X; Liu J; Ketova T; Fleming JT; Grover VK; Cooper MK; Litingtung Y; Chiang C. 2010. Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A 107(18):8422-7. PubMed: 20400693 MGI: J:160335
Huang ZP; Chen JF; Regan JN; Maguire CT; Tang RH; Dong XR; Majesky MW; Wang DZ. 2010. Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol 30(12):2575-86. PubMed: 20884876 MGI: J:182094
Huh SH; Ornitz DM. 2010. Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development 137(7):1137-47. PubMed: 20215350 MGI: J:158677
Humphreys R; Zheng W; Prince LS; Qu X; Brown C; Loomes K; Huppert SS; Baldwin S; Goudy S. 2012. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet 21(6):1374-83. PubMed: 22156581 MGI: J:181120
Inman KE; Purcell P; Kume T; Trainor PA. 2013. Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia. PLoS Genet 9(12):e1003949. PubMed: 24385915 MGI: J:223126
Ito Y; Yeo JY; Chytil A; Han J; Bringas P Jr; Nakajima A; Shuler CF; Moses HL; Chai Y. 2003. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development 130(21):5269-80. PubMed: 12975342 MGI: J:86042
Iulianella A; Sharma M; Vanden Heuvel GB; Trainor PA. 2009. Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. Development 136(14):2329-34. PubMed: 19542352 MGI: J:150348
Ivanova A; Signore M; Caro N; Greene ND; Copp AJ; Martinez-Barbera JP. 2005. In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis 43(3):129-35. PubMed: 16267821 MGI: J:103417
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. PubMed: 19837136 MGI: J:158209
Iwao K; Inatani M; Matsumoto Y; Ogata-Iwao M; Takihara Y; Irie F; Yamaguchi Y; Okinami S; Tanihara H. 2009. Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling. J Clin Invest 119(7):1997-2008. PubMed: 19509472 MGI: J:152572
Iwata J; Hacia JG; Suzuki A; Sanchez-Lara PA; Urata M; Chai Y. 2012. Modulation of noncanonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest 122(3):873-85. PubMed: 22326956 MGI: J:184481
Iwata J; Hosokawa R; Sanchez-Lara PA; Urata M; Slavkin H; Chai Y. 2010. Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem 285(7):4975-82. PubMed: 19959467 MGI: J:159771
Iwata J; Suzuki A; Pelikan RC; Ho TV; Chai Y. 2013. Noncanonical transforming growth factor beta (TGFbeta) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem 288(41):29760-70. PubMed: 23950180 MGI: J:203843
Iwata J; Suzuki A; Pelikan RC; Ho TV; Sanchez-Lara PA; Chai Y. 2014. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet 23(1):182-93. PubMed: 23975680 MGI: J:203118
Iwata J; Suzuki A; Yokota T; Ho TV; Pelikan R; Urata M; Sanchez-Lara PA; Chai Y. 2014. TGFbeta regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development 141(4):909-17. PubMed: 24496627 MGI: J:208431
Iwata J; Tung L; Urata M; Hacia JG; Pelikan R; Suzuki A; Ramenzoni L; Chaudhry O; Parada C; Sanchez-Lara PA; Chai Y. 2012. Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor beta (TGFbeta) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem 287(4):2353-63. PubMed: 22123828 MGI: J:181386
Jackson MZ; Gruner KA; Qin C; Tourtellotte WG. 2014. A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation. Development 141(12):2452-61. PubMed: 24917501 MGI: J:221263
Jacob C; Lotscher P; Engler S; Baggiolini A; Varum Tavares S; Brugger V; John N; Buchmann-Moller S; Snider PL; Conway SJ; Yamaguchi T; Matthias P; Sommer L; Mantei N; Suter U. 2014. HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia. J Neurosci 34(17):6112-22. PubMed: 24760871 MGI: J:210607
Jacob J; Ferri AL; Milton C; Prin F; Pla P; Lin W; Gavalas A; Ang SL; Briscoe J. 2007. Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci 10(11):1433-9. PubMed: 17922007 MGI: J:128441
Jain R; Engleka KA; Rentschler SL; Manderfield LJ; Li L; Yuan L; Epstein JA. 2011. Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. J Clin Invest 121(1):422-30. PubMed: 21157040 MGI: J:171842
Jaskoll T; Zhou YM; Chai Y; Makarenkova HP; Collinson JM; West JD; Hajihosseini MK; Lee J; Melnick M. 2002. Embryonic Submandibular Gland Morphogenesis: Stage-Specific Protein Localization of FGFs, BMPs, Pax6 and Pax9 in Normal Mice and Abnormal SMG Phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) Mice. Cells Tissues Organs 170(2-3):83-98. PubMed: 11731698 MGI: J:74539
Jeong J; Mao J; Tenzen T; Kottmann AH; McMahon AP. 2004. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 18(8):937-51. PubMed: 15107405 MGI: J:89445
Jia Q; McDill BW; Li SZ; Deng C; Chang CP; Chen F. 2007. Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects. Dev Biol 311(1):172-84. PubMed: 17916348 MGI: J:126324
Jia S; Kwon HE; Lan Y; Zhou J; Liu H; Jiang R. 2016. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Dev Biol 420(1):110-119. PubMed: 27713059 MGI: J:237943
Jia S; Zhou J; Gao Y; Baek JA; Martin JF; Lan Y; Jiang R. 2013. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development 140(2):423-32. PubMed: 23250216 MGI: J:191714
Jiang X; Choudhary B; Merki E; Chien KR; Maxson RE; Sucov HM. 2002. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev 117(1-2):115-22. PubMed: 12204252 MGI: J:80934
Jiang X; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cardiac neural crest. Development 127(8):1607-16. PubMed: 10725237 MGI: J:129696
Jiang Z; Zhu L; Hu L; Slesnick TC; Pautler RG; Justice MJ; Belmont JW. 2013. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet 22(5):879-89. PubMed: 23184148 MGI: J:192577
Jin S; Martinelli DC; Zheng X; Tessier-Lavigne M; Fan CM. 2015. Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc Natl Acad Sci U S A 112(1):E73-80. PubMed: 25535338 MGI: J:218163
Johansson E; Andersson L; Ornros J; Carlsson T; Ingeson-Carlsson C; Liang S; Dahlberg J; Jansson S; Parrillo L; Zoppoli P; Barila GO; Altschuler DL; Padula D; Lickert H; Fagman H; Nilsson M. 2015. Revising the embryonic origin of thyroid C cells in mice and humans. Development 142(20):3519-28. PubMed: 26395490 MGI: J:239771
Johnson EM; Craig ET; Yeh HH. 2007. TrkB is necessary for pruning at the climbing fibre-Purkinje cell synapse in the developing murine cerebellum. J Physiol 582(Pt 2):629-46. PubMed: 17463037 MGI: J:140836
Johnston AP; Yuzwa SA; Carr MJ; Mahmud N; Storer MA; Krause MP; Jones K; Paul S; Kaplan DR; Miller FD. 2016. Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. Cell Stem Cell 19(4):433-448. PubMed: 27376984 MGI: J:238684
Joseph NM; Mosher JT; Buchstaller J; Snider P; McKeever PE; Lim M; Conway SJ; Parada LF; Zhu Y; Morrison SJ. 2008. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 13(2):129-40. PubMed: 18242513 MGI: J:131914
Kaartinen V; Dudas M; Nagy A; Sridurongrit S; Lu MM; Epstein JA. 2004. Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development 131(14):3481-90. PubMed: 15226263 MGI: J:90988
Kam MK; Cheung MC; Zhu JJ; Cheng WW; Sat EW; Tam PK; Lui VC. 2014. Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice. Cell Death Differ 21(2):278-89. PubMed: 24141719 MGI: J:229073
Kameda Y; Saitoh T; Nemoto N; Katoh T; Iseki S. 2012. Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid body. Dev Dyn 241(8):1289-300. PubMed: 22689348 MGI: J:185596
Kao SC; Wu H; Xie J; Chang CP; Ranish JA; Graef IA; Crabtree GR. 2009. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 323(5914):651-4. PubMed: 19179536 MGI: J:144171
Karpinski BA; A Bryan C; Paronett EM; Baker JL; Fernandez A; Horvath A; Maynard TM; Moody SA; LaMantia AS. 2016. A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. Dev Biol 415(2):228-41. PubMed: 26988119 MGI: J:233763
Kasberg AD; Brunskill EW; Steven Potter S. 2013. SP8 regulates signaling centers during craniofacial development. Dev Biol 381(2):312-23. PubMed: 23872235 MGI: J:200761
Katayama K; Leslie JR; Lang RA; Zheng Y; Yoshida Y. 2012. Left-Right Locomotor Circuitry Depends on RhoA-Driven Organization of the Neuroepithelium in the Developing Spinal Cord. J Neurosci 32(30):10396-407. PubMed: 22836272 MGI: J:186538
Katayama K; Melendez J; Baumann JM; Leslie JR; Chauhan BK; Nemkul N; Lang RA; Kuan CY; Zheng Y; Yoshida Y. 2011. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A 108(18):7607-12. PubMed: 21502507 MGI: J:172044
Katz SG; Williams A; Yang J; Fujiwara Y; Tsang AP; Epstein JA; Orkin SH. 2003. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A 100(24):14030-5. PubMed: 14614148 MGI: J:99745
Keryer G; Pineda JR; Liot G; Kim J; Dietrich P; Benstaali C; Smith K; Cordelieres FP; Spassky N; Ferrante RJ; Dragatsis I; Saudou F. 2011. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Invest 121(11):4372-82. PubMed: 21985783 MGI: J:178446
Khonsari RH; Ohazama A; Raouf R; Kawasaki M; Kawasaki K; Porntaveetus T; Ghafoor S; Hammond P; Suttie M; Odri GA; Sandford RN; Wood JN; Sharpe PT. 2013. Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2). Hum Mol Genet 22(9):1873-85. PubMed: 23390131 MGI: J:194970
Khonsari RH; Seppala M; Pradel A; Dutel H; Clement G; Lebedev O; Ghafoor S; Rothova M; Tucker A; Maisey JG; Fan CM; Kawasaki M; Ohazama A; Tafforeau P; Franco B; Helms J; Haycraft CJ; David A; Janvier P; Cobourne MT; Sharpe PT. 2013. The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling. BMC Biol 11:27. PubMed: 23537390 MGI: J:225060
Kim KS; Arima Y; Kitazawa T; Nishiyama K; Asai R; Uchijima Y; Sato T; Levi G; Kitanaka S; Igarashi T; Kurihara Y; Kurihara H. 2013. Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms. Mech Dev 130(11-12):553-66. PubMed: 23933587 MGI: J:204461
Kim Y; Park E; Noh H; Park S. 2013. Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development. Dev Neurobiol 73(9):702-12. PubMed: 23696555 MGI: J:241828
Kist R; Greally E; Peters H. 2007. Derivation of a mouse model for conditional inactivation of Pax9. Genesis 45(7):460-4. PubMed: 17610273 MGI: J:125026
Kist R; Watson M; Crosier M; Robinson M; Fuchs J; Reichelt J; Peters H. 2014. The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. PLoS Genet 10(10):e1004709. PubMed: 25299669 MGI: J:228858
Kizhatil K; Ryan M; Marchant JK; Henrich S; John SW. 2014. Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PLoS Biol 12(7):e1001912. PubMed: 25051267 MGI: J:215599
Klein OD; Lyons DB; Balooch G; Marshall GW; Basson MA; Peterka M; Boran T; Peterkova R; Martin GR. 2008. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development 135(2):377-85. PubMed: 18077585 MGI: J:130572
Klotz L; Norman S; Vieira JM; Masters M; Rohling M; Dube KN; Bollini S; Matsuzaki F; Carr CA; Riley PR. 2015. Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature 522(7554):62-7. PubMed: 25992544 MGI: J:222246
Knosp WM; Knox SM; Lombaert IM; Haddox CL; Patel VN; Hoffman MP. 2015. Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors. Dev Cell 32(6):667-77. PubMed: 25805134 MGI: J:239290
Ko SO; Chung IH; Xu X; Oka S; Zhao H; Cho ES; Deng C; Chai Y. 2007. Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol 312(1):435-47. PubMed: 17964566 MGI: J:128941
Kolpakova-Hart E; Jinnin M; Hou B; Fukai N; Olsen BR. 2007. Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol 309(2):273-84. PubMed: 17698054 MGI: J:124871
Kolpakova-Hart E; McBratney-Owen B; Hou B; Fukai N; Nicolae C; Zhou J; Olsen BR. 2008. Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol 321(2):407-19. PubMed: 18652813 MGI: J:139970
Komada Y; Yamane T; Kadota D; Isono K; Takakura N; Hayashi S; Yamazaki H. 2012. Origins and properties of dental, thymic, and bone marrow mesenchymal cells and their stem cells. PLoS One 7(11):e46436. PubMed: 23185234 MGI: J:195013
Kouskoura T; El Fersioui Y; Angelini M; Graf D; Katsaros C; Chiquet M. 2016. Dislocated Tongue Muscle Attachment and Cleft Palate Formation. J Dent Res 95(4):453-9. PubMed: 26701347 MGI: J:231337
Kouskoura T; Kozlova A; Alexiou M; Blumer S; Zouvelou V; Katsaros C; Chiquet M; Mitsiadis TA; Graf D. 2013. The etiology of cleft palate formation in BMP7-deficient mice. PLoS One 8(3):e59463. PubMed: 23516636 MGI: J:225061
Kretz M; Eckardt D; Kruger O; Kim JS; Maurer J; Theis M; van Rijen HV; Schorle H; Willecke K. 2006. Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43. Genesis 44(6):269-76. PubMed: 16703618 MGI: J:110142
Kumazawa A; Mita N; Hirasawa M; Adachi T; Suzuki H; Shafeghat N; Kulkarni AB; Mikoshiba K; Inoue T; Ohshima T. 2013. Cyclin-dependent kinase 5 is required for normal cerebellar development. Mol Cell Neurosci 52:97-105. PubMed: 23085039 MGI: J:203661
Kurosaka H; Trainor PA; Leroux-Berger M; Iulianella A. 2015. Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling. PLoS One 10(3):e0120821. PubMed: 25799573 MGI: J:229187
Kurosaka H; Wang Q; Sandell L; Yamashiro T; Trainor PA. 2017. Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia. Hum Mol Genet 26(7):1268-1279. PubMed: 28169399 MGI: J:241377
Kurosaka S; Leu NA; Zhang F; Bunte R; Saha S; Wang J; Guo C; He W; Kashina A. 2010. Arginylation-dependent neural crest cell migration is essential for mouse development. PLoS Genet 6(3):e1000878. PubMed: 20300656 MGI: J:159224
Kyrylkova K; Iwaniec UT; Philbrick KA; Leid M. 2016. BCL11B regulates sutural patency in the mouse craniofacial skeleton. Dev Biol 415(2):251-60. PubMed: 26453795 MGI: J:233640
Kyrylkova K; Kyryachenko S; Biehs B; Klein O; Kioussi C; Leid M. 2012. BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One 7(5):e37670. PubMed: 22629441 MGI: J:187316
Lake JI, Avetisyan M, Zimmermann AG, Heuckeroth RO. 2015. Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton Dev Biol S0012-1606(15):30272-4. PubMed: 26546974 MGI: J:225937
Lake JI; Tusheva OA; Graham BL; Heuckeroth RO. 2013. Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis. J Clin Invest 123(11):4875-87. PubMed: 24216510 MGI: J:205123
Lang D; Lu MM; Huang L; Engleka KA; Zhang M; Chu EY; Lipner S; Skoultchi A; Millar SE; Epstein JA. 2005. Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433(7028):884-7. PubMed: 15729346 MGI: J:96431
Langsdorf A; Radzikinas K; Kroten A; Jain S; Ai X. 2011. Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract. Am J Respir Cell Mol Biol 44(3):293-301. PubMed: 20139349 MGI: J:183370
Lee HY; Kleber M; Hari L; Brault V; Suter U; Taketo MM; Kemler R; Sommer L. 2004. Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science 303(5660):1020-3. PubMed: 14716020 MGI: J:90382
Lemos DR; Paylor B; Chang C; Sampaio A; Underhill TM; Rossi FM. 2012. Functionally convergent white adipogenic progenitors of different lineages participate in a diffused system supporting tissue regeneration. Stem Cells 30(6):1152-62. PubMed: 22415977 MGI: J:192692
Lepore JJ; Mericko PA; Cheng L; Lu MM; Morrisey EE; Parmacek MS. 2006. GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. J Clin Invest 116(4):929-39. PubMed: 16557299 MGI: J:107814
Levin MD; Lu MM; Petrenko NB; Hawkins BJ; Gupta TH; Lang D; Buckley PT; Jochems J; Liu F; Spurney CF; Yuan LJ; Jacobson JT; Brown CB; Huang L; Beermann F; Margulies KB; Madesh M; Eberwine JH; Epstein JA; Patel VV. 2009. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest 119(11):3420-36. PubMed: 19855129 MGI: J:154593
Li L; Lin M; Wang Y; Cserjesi P; Chen Z; Chen Y. 2011. BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. Dev Biol 349(2):451-61. PubMed: 21034733 MGI: J:168033
Li L; Wang Y; Lin M; Yuan G; Yang G; Zheng Y; Chen Y. 2013. Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation. PLoS One 8(6):e66107. PubMed: 23776616 MGI: J:204229
Li W; Xiong Y; Shang C; Twu KY; Hang CT; Yang J; Han P; Lin CY; Lin CJ; Tsai FC; Stankunas K; Meyer T; Bernstein D; Pan M; Chang CP. 2013. Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc Natl Acad Sci U S A 110(5):1738-43. PubMed: 23319608 MGI: J:193698
Liang X; Sun Y; Schneider J; Ding JH; Cheng H; Ye M; Bhattacharya S; Rearden A; Evans S; Chen J. 2007. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res 100(4):527-35. PubMed: 17272814 MGI: J:133705
Lin CY; Lin CJ; Chen CH; Chen RM; Zhou B; Chang CP. 2012. The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development. J Mol Cell Cardiol 52(5):1096-102. PubMed: 22300732 MGI: J:183686
Liu C; Liu W; Palie J; Lu MF; Brown NA; Martin JF. 2002. Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development 129(21):5081-91. PubMed: 12397115 MGI: J:79853
Liu H; Lan Y; Xu J; Chang CF; Brugmann SA; Jiang R. 2013. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proc Natl Acad Sci U S A 110(46):18555-60. PubMed: 24167250 MGI: J:202899
Liu HX; Komatsu Y; Mishina Y; Mistretta CM. 2012. Neural crest contribution to lingual mesenchyme, epithelium and developing taste papillae and taste buds. Dev Biol 368(2):294-303. PubMed: 22659543 MGI: J:186559
Liu P; Johnson RL. 2010. Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency. Dev Dyn :. PubMed: 20568247 MGI: J:161793
Liu S; Liu F; Schneider AE; St Amand T; Epstein JA; Gutstein DE. 2006. Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development 133(10):2063-73. PubMed: 16624854 MGI: J:108525
Liu Y; Jin Y; Li J; Seto E; Kuo E; Yu W; Schwartz RJ; Blazo M; Zhang SL; Peng X. 2013. Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects. Dev Biol 383(2):239-52. PubMed: 24056078 MGI: J:203790
Liu Y; Wang M; Zhao W; Yuan X; Yang X; Li Y; Qiu M; Zhu XJ; Zhang Z. 2015. Gpr177-mediated Wnt Signaling Is Required for Secondary Palate Development. J Dent Res 94(7):961-7. PubMed: 25922332 MGI: J:222257
Liu Y; Yang FC; Okuda T; Dong X; Zylka MJ; Chen CL; Anderson DJ; Kuner R; Ma Q. 2008. Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors. J Neurosci 28(1):125-32. PubMed: 18171930 MGI: J:131052
Lopes C; Liu Z; Xu Y; Ma Q. 2012. Tlx3 and runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J Neurosci 32(28):9706-15. PubMed: 22787056 MGI: J:186470
Lumb R; Wiszniak S; Kabbara S; Scherer M; Harvey N; Schwarz Q. 2014. Neuropilins define distinct populations of neural crest cells. Neural Dev 9(1):24. PubMed: 25363691 MGI: J:217420
Luo W; Enomoto H; Rice FL; Milbrandt J; Ginty DD. 2009. Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron 64(6):841-56. PubMed: 20064391 MGI: J:157722
Luo W; Wickramasinghe SR; Savitt JM; Griffin JW; Dawson TM; Ginty DD. 2007. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54(5):739-54. PubMed: 17553423 MGI: J:126484
Luo Y; High FA; Epstein JA; Radice GL. 2006. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev Biol 299(2):517-28. PubMed: 17014840 MGI: J:115264
Ma MC; Li P; Shen H; Estrada KD; Xu J; Kumar SR; Sucov HM. 2016. Dysregulated endocardial TGFbeta signaling and mesenchymal transformation result in heart outflow tract septation failure. Dev Biol 409(1):272-6. PubMed: 26522286 MGI: J:228791
MacDonald ST; Bamforth SD; Chen CM; Farthing CR; Franklyn A; Broadbent C; Schneider JE; Saga Y; Lewandoski M; Bhattacharya S. 2008. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res 79(3):448-57. PubMed: 18440989 MGI: J:137951
Maden CH; Gomes J; Schwarz Q; Davidson K; Tinker A; Ruhrberg C. 2012. NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev Biol 369(2):277-85. PubMed: 22790009 MGI: J:187616
Makita T; Sucov HM; Gariepy CE; Yanagisawa M; Ginty DD. 2008. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature 452(7188):759-63. PubMed: 18401410 MGI: J:133765
Mancini ML; Verdi JM; Conley BA; Nicola T; Spicer DB; Oxburgh LH; Vary CP. 2007. Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol 308(2):520-33. PubMed: 17628518 MGI: J:124260
Manderfield LJ; Aghajanian H; Engleka KA; Lim LY; Liu F; Jain R; Li L; Olson EN; Epstein JA. 2015. Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest. Development 142(17):2962-71. PubMed: 26253400 MGI: J:239791
Mao J; Barrow J; McMahon J; Vaughan J; McMahon AP. 2005. An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res 33(18):e155. PubMed: 16221970 MGI: J:165962
Mao Y; Reiprich S; Wegner M; Fritzsch B. 2014. Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear. PLoS One 9(4):e94580. PubMed: 24718611 MGI: J:215095
Martino VB; Sabljic T; Deschamps P; Green RM; Akula M; Peacock E; Ball A; Williams T; West-Mays JA. 2016. Conditional deletion of AP-2beta in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma. Dis Model Mech 9(8):849-61. PubMed: 27483349 MGI: J:234170
Matsui M; Klingensmith J. 2014. Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton. Dev Biol 392(2):168-81. PubMed: 24949938 MGI: J:214981
Matsumoto Y; Irie F; Inatani M; Tessier-Lavigne M; Yamaguchi Y. 2007. Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. J Neurosci 27(16):4342-50. PubMed: 17442818 MGI: J:121105
Matsuoka T; Ahlberg PE; Kessaris N; Iannarelli P; Dennehy U; Richardson WD; McMahon AP; Koentges G. 2005. Neural crest origins of the neck and shoulder. Nature 436(7049):347-55. PubMed: 16034409 MGI: J:99989
Matt N; Dupe V; Garnier JM; Dennefeld C; Chambon P; Mark M; Ghyselinck NB. 2005. Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development 132(21):4789-800. PubMed: 16207763 MGI: J:102847
Matt N; Ghyselinck NB; Pellerin I; Dupe V. 2008. Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis. Dev Biol 320(1):140-8. PubMed: 18539269 MGI: J:138405
Mavromatakis YE; Lin W; Metzakopian E; Ferri AL; Yan CH; Sasaki H; Whisett J; Ang SL. 2011. Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev 128(1-2):90-103. PubMed: 21093585 MGI: J:170258
McCarthy N; Liu JS; Richarte AM; Eskiocak B; Lovely CB; Tallquist MD; Eberhart JK. 2016. Pdgfra and Pdgfrb genetically interact during craniofacial development. Dev Dyn 245(6):641-52. PubMed: 26971580 MGI: J:232406
Mead TJ; Yutzey KE. 2012. Notch pathway regulation of neural crest cell development in vivo. Dev Dyn 241(2):376-89. PubMed: 22275227 MGI: J:179882
Memic F; Knoflach V; Sadler R; Tegerstedt G; Sundstrom E; Guillemot F; Pachnis V; Marklund U. 2016. Ascl1 Is Required for the Development of Specific Neuronal Subtypes in the Enteric Nervous System. J Neurosci 36(15):4339-50. PubMed: 27076429 MGI: J:231739
Merki E; Zamora M; Raya A; Kawakami Y; Wang J; Zhang X; Burch J; Kubalak SW; Kaliman P; Belmonte JC; Chien KR; Ruiz-Lozano P. 2005. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A 102(51):18455-60. PubMed: 16352730 MGI: J:104700
Metzis V; Courtney AD; Kerr MC; Ferguson C; Rondon Galeano MC; Parton RG; Wainwright BJ; Wicking C. 2013. Patched1 is required in neural crest cells for the prevention of orofacial clefts. Hum Mol Genet 22(24):5026-35. PubMed: 23900075 MGI: J:203133
Minchin JE; Williams VC; Hinits Y; Low S; Tandon P; Fan CM; Rawls JF; Hughes SM. 2013. Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. Development 140(14):2972-84. PubMed: 23760954 MGI: J:198637
Minett MS; Eijkelkamp N; Wood JN. 2014. Significant determinants of mouse pain behaviour. PLoS One 9(8):e104458. PubMed: 25101983 MGI: J:223160
Minett MS; Falk S; Santana-Varela S; Bogdanov YD; Nassar MA; Heegaard AM; Wood JN. 2014. Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep 6(2):301-12. PubMed: 24440715 MGI: J:208794
Minett MS; Nassar MA; Clark AK; Passmore G; Dickenson AH; Wang F; Malcangio M; Wood JN. 2012. Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun 3:791. PubMed: 22531176 MGI: J:200060
Minoux M; Antonarakis GS; Kmita M; Duboule D; Rijli FM. 2009. Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development 136(4):637-45. PubMed: 19168678 MGI: J:144017
Minoux M; Kratochwil CF; Ducret S; Amin S; Kitazawa T; Kurihara H; Bobola N; Vilain N; Rijli FM. 2013. Mouse Hoxa2 mutations provide a model for microtia and auricle duplication. Development 140(21):4386-97. PubMed: 24067355 MGI: J:204605
Miquerol L; Bellon A; Moreno N; Beyer S; Meilhac SM; Buckingham M; Franco D; Kelly RG. 2013. Resolving cell lineage contributions to the ventricular conduction system with a Cx40-GFP allele: a dual contribution of the first and second heart fields. Dev Dyn 242(6):665-77. PubMed: 23526457 MGI: J:198225
Mishra S; Choe Y; Pleasure SJ; Siegenthaler JA. 2016. Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges. Dev Biol 420(1):148-165. PubMed: 27671872 MGI: J:237944
Mittal A; Pulina M; Hou SY; Astrof S. 2010. Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest. Mech Dev 127(9-12):472-84. PubMed: 20807571 MGI: J:165711
Moenning A; Jager R; Egert A; Kress W; Wardelmann E; Schorle H. 2009. Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Mol Cell Biol 29(3):881-91. PubMed: 19047372 MGI: J:145520
Molin DG; Poelmann RE; DeRuiter MC; Azhar M; Doetschman T; Gittenberger-de Groot AC. 2004. Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development. Circ Res 95(11):1109-17. PubMed: 15528466 MGI: J:95075
Mommersteeg MT; Andrews WD; Ypsilanti AR; Zelina P; Yeh ML; Norden J; Kispert A; Chedotal A; Christoffels VM; Parnavelas JG. 2013. Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium. Circ Res 112(3):465-75. PubMed: 23255421 MGI: J:212863
Mori-Akiyama Y; Akiyama H; Rowitch DH; de Crombrugghe B. 2003. Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A 100(16):9360-5. PubMed: 12878728 MGI: J:84790
Morikawa S; Mabuchi Y; Niibe K; Suzuki S; Nagoshi N; Sunabori T; Shimmura S; Nagai Y; Nakagawa T; Okano H; Matsuzaki Y. 2009. Development of mesenchymal stem cells partially originate from the neural crest. Biochem Biophys Res Commun 379(4):1114-9. PubMed: 19161980 MGI: J:144967
Morikawa Y; Cserjesi P. 2008. Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ Res 103(12):1422-9. PubMed: 19008477 MGI: J:155265
Morikawa Y; D'Autreaux F; Gershon MD; Cserjesi P. 2007. Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol 307(1):114-26. PubMed: 17531968 MGI: J:122604
Morrison KM; Miesegaes GR; Lumpkin EA; Maricich SM. 2009. Mammalian Merkel cells are descended from the epidermal lineage. Dev Biol 336(1):76-83. PubMed: 19782676 MGI: J:154915
Mukouyama YS; Gerber HP; Ferrara N; Gu C; Anderson DJ. 2005. Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback. Development 132(5):941-952. PubMed: 15673567 MGI: J:96924
Mundell NA; Labosky PA. 2011. Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development 138(4):641-52. PubMed: 21228004 MGI: J:170647
Mundell NA; Plank JL; LeGrone AW; Frist AY; Zhu L; Shin MK; Southard-Smith EM; Labosky PA. 2012. Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Dev Biol 363(2):373-87. PubMed: 22266424 MGI: J:182762
Murray SA; Oram KF; Gridley T. 2007. Multiple functions of Snail family genes during palate development in mice. Development 134(9):1789-97. PubMed: 17376812 MGI: J:121243
Muzumdar MD; Luo L; Zong H. 2007. Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc Natl Acad Sci U S A 104(11):4495-500. PubMed: 17360552 MGI: J:120052
Mysliwiec MR; Bresnick EH; Lee Y. 2011. Endothelial jarid2/jumonji is required for normal cardiac development and proper notch1 expression. J Biol Chem 286(19):17193-204. PubMed: 21402699 MGI: J:172692
Nagoshi N; Shibata S; Hamanoue M; Mabuchi Y; Matsuzaki Y; Toyama Y; Nakamura M; Okano H. 2011. Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing. Glia 59(5):771-84. PubMed: 21351159 MGI: J:169749
Nakajima M; Matsuda K; Miyauchi N; Fukunaga Y; Watanabe S; Okuyama S; Perez J; Fernandez-Llebrez P; Shen J; Furukawa Y. 2011. Hydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages. Brain Res 1382:275-81. PubMed: 21262207 MGI: J:170860
Nakajima M; Mori H; Nishikawa C; Tsuruta M; Okuyama S; Furukawa Y. 2013. Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice. J Neurochem 124(2):241-9. PubMed: 23134367 MGI: J:192250
Nakajima M; Nishikawa C; Miyasaka Y; Kikkawa Y; Mori H; Tsuruta M; Okuyama S; Furukawa Y. 2014. Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice. Neurosci Lett 566:236-40. PubMed: 24607930 MGI: J:212007
Nakajima M; Tsuruta M; Mori H; Nishikawa C; Okuyama S; Furukawa Y. 2013. A comparative study of axon-surrounding cells in the two nasal nerve tracts from mouse olfactory epithelium and vomeronasal organ. Brain Res 1503:16-23. PubMed: 23410787 MGI: J:209343
Nakajima M; Watanabe S; Okuyama S; Shen J; Furukawa Y. 2009. Restricted growth and insulin-like growth factor-1 deficiency in mice lacking presenilin-1 in the neural crest cell lineage. Int J Dev Neurosci 27(8):837-43. PubMed: 19665542 MGI: J:157272
Nakamura T; Colbert MC; Robbins J. 2006. Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system. Circ Res 98(12):1547-54. PubMed: 16709902 MGI: J:122647
Nakamura T; Gulick J; Colbert MC; Robbins J. 2009. Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development. Proc Natl Acad Sci U S A 106(27):11270-5. PubMed: 19541608 MGI: J:150835
Nakamura T; Gulick J; Pratt R; Robbins J. 2009. Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations. Proc Natl Acad Sci U S A 106(36):15436-41. PubMed: 19706403 MGI: J:153094
Nassenstein C; Taylor-Clark TE; Myers AC; Ru F; Nandigama R; Bettner W; Undem BJ. 2010. Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs. J Physiol 588(Pt 23):4769-83. PubMed: 20937710 MGI: J:179544
Navankasattusas S; Whitehead KJ; Suli A; Sorensen LK; Lim AH; Zhao J; Park KW; Wythe JD; Thomas KR; Chien CB; Li DY. 2008. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development 135(4):659-67. PubMed: 18223200 MGI: J:131817
Nekrep N; Wang J; Miyatsuka T; German MS. 2008. Signals from the neural crest regulate beta-cell mass in the pancreas. Development 135(12):2151-60. PubMed: 18506029 MGI: J:137017
Nelms BL; Pfaltzgraff ER; Labosky PA. 2011. Functional interaction between Foxd3 and Pax3 in cardiac neural crest development. Genesis 49(1):10-23. PubMed: 21254333 MGI: J:167976
Newbern J; Zhong J; Wickramasinghe RS; Li X; Wu Y; Samuels I; Cherosky N; Karlo JC; O'Loughlin B; Wikenheiser J; Gargesha M; Doughman YQ; Charron J; Ginty DD; Watanabe M; Saitta SC; Snider WD; Landreth GE. 2008. Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc Natl Acad Sci U S A 105(44):17115-20. PubMed: 18952847 MGI: J:144862
Ngan ES; Garcia-Barcelo MM; Yip BH; Poon HC; Lau ST; Kwok CK; Sat E; Sham MH; Wong KK; Wainwright BJ; Cherny SS; Hui CC; Sham PC; Lui VC; Tam PK. 2011. Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. J Clin Invest 121(9):3467-78. PubMed: 21841314 MGI: J:178246
Nie X; Deng CX; Wang Q; Jiao K. 2008. Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol 316(2):417-30. PubMed: 18334251 MGI: J:135997
Nie X; Wang Q; Jiao K. 2011. Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mech Dev 128(3-4):200-7. PubMed: 21256960 MGI: J:171528
Nik AM; Johansson JA; Ghiami M; Reyahi A; Carlsson P. 2016. Foxf2 is required for secondary palate development and Tgfbeta signaling in palatal shelf mesenchyme. Dev Biol 415(1):14-23. PubMed: 27180663 MGI: J:234115
Nitzan E; Krispin S; Pfaltzgraff ER; Klar A; Labosky PA; Kalcheim C. 2013. A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells. Development 140(11):2269-79. PubMed: 23615280 MGI: J:198576
Noda K; Kitami M; Kitami K; Kaku M; Komatsu Y. 2016. Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci U S A 113(19):E2589-97. PubMed: 27118846 MGI: J:232190
Noda K; Nakamura T; Komatsu Y. 2015. Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice. Biochem Biophys Res Commun 466(3):585-91. PubMed: 26399686 MGI: J:232938
Ohayon D; Venteo S; Sonrier C; Lafon PA; Garces A; Valmier J; Rivat C; Topilko P; Carroll P; Pattyn A. 2015. Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons. Dev Cell 33(3):343-50. PubMed: 25942625 MGI: J:239276
Ohazama A ; Haycraft CJ ; Seppala M ; Blackburn J ; Ghafoor S ; Cobourne M ; Martinelli DC ; Fan CM ; Peterkova R ; Lesot H ; Yoder BK ; Sharpe PT. 2009. Primary cilia regulate Shh activity in the control of molar tooth number. Development 136(6):897-903. PubMed: 19211681 MGI: J:146634
Oka K; Honda MJ; Tsuruga E; Hatakeyama Y; Isokawa K; Sawa Y. 2012. Roles of collagen and periostin expression by cranial neural crest cells during soft palate development. J Histochem Cytochem 60(1):57-68. PubMed: 22205681 MGI: J:196790
Oka K; Oka S; Hosokawa R; Bringas P Jr; Brockhoff HC 2nd; Nonaka K; Chai Y. 2008. TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol 321(2):303-9. PubMed: 18684439 MGI: J:140208
Oka K; Oka S; Sasaki T; Ito Y; Bringas P Jr; Nonaka K; Chai Y. 2007. The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol 303(1):391-404. PubMed: 17204263 MGI: J:118794
Oka S; Oka K; Xu X; Sasaki T; Bringas P Jr; Chai Y. 2007. Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation. Mech Dev 124(6):409-15. PubMed: 17449229 MGI: J:121723
Okamura Y; Saga Y. 2008. Notch signaling is required for the maintenance of enteric neural crest progenitors. Development 135(21):3555-65. PubMed: 18832397 MGI: J:143441
Olaopa M; Zhou HM; Snider P; Wang J; Schwartz RJ; Moon AM; Conway SJ. 2011. Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation. Dev Biol 356(2):308-22. PubMed: 21600894 MGI: J:175400
Onishi K; Shafer B; Lo C; Tissir F; Goffinet AM; Zou Y. 2013. Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci 33(49):19071-85. PubMed: 24305805 MGI: J:204152
Oommen S; Otsuka-Tanaka Y; Imam N; Kawasaki M; Kawasaki K; Jalani-Ghazani F; Anderegg A; Awatramani R; Hindges R; Sharpe PT; Ohazama A. 2012. Distinct roles of MicroRNAs in epithelium and mesenchyme during tooth development. Dev Dyn 241(9):1465-72. PubMed: 22753148 MGI: J:186496
Ozkaynak E; Abello G; Jaegle M; van Berge L; Hamer D; Kegel L; Driegen S; Sagane K; Bermingham JR Jr; Meijer D. 2010. Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling. J Neurosci 30(10):3857-64. PubMed: 20220021 MGI: J:158973
Pan Y; Carbe C; Powers A; Zhang EE; Esko JD; Grobe K; Feng GS; Zhang X. 2008. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development 135(2):301-10. PubMed: 18077586 MGI: J:130571
Papangeli I; Scambler PJ. 2013. Tbx1 genetically interacts with the transforming growth factor-beta/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling. Circ Res 112(1):90-102. PubMed: 23011393 MGI: J:212881
Parada C; Han D; Grimaldi A; Sarrion P; Park SS; Pelikan R; Sanchez-Lara PA; Chai Y. 2015. Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development 142(21):3734-45. PubMed: 26395480 MGI: J:239772
Parada C; Li J; Iwata J; Suzuki A; Chai Y. 2013. CTGF mediates Smad-dependent transforming growth factor beta signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol 33(17):3482-93. PubMed: 23816882 MGI: J:204753
Park E; Kim Y; Noh H; Lee H; Yoo S; Park S. 2013. EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. Cell Death Differ 20(1):169-80. PubMed: 22976838 MGI: J:205629
Park EJ; Watanabe Y; Smyth G; Miyagawa-Tomita S; Meyers E; Klingensmith J; Camenisch T; Buckingham M; Moon AM. 2008. An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development 135(21):3599-610. PubMed: 18832392 MGI: J:143444
Passman JN; Dong XR; Wu SP; Maguire CT; Hogan KA; Bautch VL; Majesky MW. 2008. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A 105(27):9349-54. PubMed: 18591670 MGI: J:137825
Patterson ES; Waller LE; Kroll KL. 2014. Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation. Dev Biol 393(1):44-56. PubMed: 24995796 MGI: J:215309
Pecho-Vrieseling E; Sigrist M; Yoshida Y; Jessell TM; Arber S. 2009. Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. Nature 459(7248):842-6. PubMed: 19421194 MGI: J:149553
Pelikan RC; Iwata J; Suzuki A; Chai Y; Hacia JG. 2013. Identification of candidate downstream targets of TGFbeta signaling during palate development by genome-wide transcript profiling. J Cell Biochem 114(4):796-807. PubMed: 23060211 MGI: J:193554
Phillips HM; Papoutsi T; Soenen H; Ybot-Gonzalez P; Henderson DJ; Chaudhry B. 2012. Neural crest cell survival is dependent on Rho kinase and is required for development of the mid face in mouse embryos. PLoS One 7(5):e37685. PubMed: 22629443 MGI: J:220920
Pilon N; Raiwet D; Viger RS; Silversides DW. 2008. Novel pre- and post-gastrulation expression of Gata4 within cells of the inner cell mass and migratory neural crest cells. Dev Dyn 237(4):1133-43. PubMed: 18351674 MGI: J:132976
Plank JL; Mundell NA; Frist AY; LeGrone AW; Kim T; Musser MA; Walter TJ; Labosky PA. 2011. Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation. Dev Biol 349(2):321-30. PubMed: 21081123 MGI: J:168019
Poelmann RE; Jongbloed MR; Molin DG; Fekkes ML; Wang Z; Fishman GI; Doetschman T; Azhar M; Gittenberger-de Groot AC. 2004. The neural crest is contiguous with the cardiac conduction system in the mouse embryo: a role in induction? Anat Embryol (Berl) 208(5):389-93. PubMed: 15248063 MGI: J:154017
Porras D; Brown CB. 2008. Temporal-spatial ablation of neural crest in the mouse results in cardiovascular defects. Dev Dyn 237(1):153-62. PubMed: 18058916 MGI: J:130481
Prasad T; Wang X; Gray PA; Weiner JA. 2008. A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster. Development 135(24):4153-64. PubMed: 19029045 MGI: J:142349
Prasad T; Weiner JA. 2011. Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the gamma-Protocadherins. Front Mol Neurosci 4:54. PubMed: 22275881 MGI: J:190261
Prochazka J; Prochazkova M; Du W; Spoutil F; Tureckova J; Hoch R; Shimogori T; Sedlacek R; Rubenstein JL; Wittmann T; Klein OD. 2015. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell 35(6):713-24. PubMed: 26702830 MGI: J:239990
Pryor SE; Massa V; Savery D; Andre P; Yang Y; Greene ND; Copp AJ. 2014. Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. Development 141(16):3153-8. PubMed: 25038043 MGI: J:213956
Puig I; Yajima I; Bonaventure J; Delmas V; Larue L. 2009. The tyrosinase promoter is active in a subset of vagal neural crest cells during early development in mice. Pigment Cell Melanoma Res 22(3):331-4. PubMed: 19220779 MGI: J:149781
Qu X; Pan Y; Carbe C; Powers A; Grobe K; Zhang X. 2012. Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development 139(15):2730-9. PubMed: 22745308 MGI: J:185652
Quina LA; Tempest L; Hsu YW; Cox TC; Turner EE. 2012. Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion. Dev Biol 365(1):152-63. PubMed: 22586713 MGI: J:184845
Rabbani P; Takeo M; Chou W; Myung P; Bosenberg M; Chin L; Taketo MM; Ito M. 2011. Coordinated activation of wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell 145(6):941-55. PubMed: 21663796 MGI: J:173080
Rakhilin N; Barth B; Choi J; Munoz NL; Kulkarni S; Jones JS; Small DM; Cheng YT; Cao Y; LaVinka C; Kan E; Dong X; Spencer M; Pasricha P; Nishimura N; Shen X. 2016. Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nat Commun 7:11800. PubMed: 27270085 MGI: J:239904
Ramsbottom SA; Sharma V; Rhee HJ; Eley L; Phillips HM; Rigby HF; Dean C; Chaudhry B; Henderson DJ. 2014. Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development. PLoS Genet 10(12):e1004871. PubMed: 25521757 MGI: J:228847
Randall V; McCue K; Roberts C; Kyriakopoulou V; Beddow S; Barrett AN; Vitelli F; Prescott K; Shaw-Smith C; Devriendt K; Bosman E; Steffes G; Steel KP; Simrick S; Basson MA; Illingworth E; Scambler PJ. 2009. Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest 119(11):3301-10. PubMed: 19855134 MGI: J:154590
Ray HJ; Niswander LA. 2016. Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure. Development 143(7):1192-204. PubMed: 26903501 MGI: J:240158
Reinert RB; Cai Q; Hong JY; Plank JL; Aamodt K; Prasad N; Aramandla R; Dai C; Levy SE; Pozzi A; Labosky PA; Wright CV; Brissova M; Powers AC. 2014. Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development 141(7):1480-91. PubMed: 24574008 MGI: J:208409
Ren SY; Pasqualetti M; Dierich A; Le Meur M; Rijli FM. 2002. A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombination. Genesis 32(2):105-8. PubMed: 11857791 MGI: J:75130
Reyahi A; Nik AM; Ghiami M; Gritli-Linde A; Ponten F; Johansson BR; Carlsson P. 2015. Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier. Dev Cell 34(1):19-32. PubMed: 26120030 MGI: J:239656
Richarte AM; Mead HB; Tallquist MD. 2007. Cooperation between the PDGF receptors in cardiac neural crest cell migration. Dev Biol 306(2):785-96. PubMed: 17499702 MGI: J:122584
Richter CA; Amin S; Linden J; Dixon J; Dixon MJ; Tucker AS. 2010. Defects in middle ear cavitation cause conductive hearing loss in the Tcof1 mutant mouse. Hum Mol Genet 19(8):1551-60. PubMed: 20106873 MGI: J:158524
Rico B; Xu B; Reichardt LF. 2002. TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum. Nat Neurosci 5(3):225-33. PubMed: 11836532 MGI: J:74960
Rinkevich Y; Mori T; Sahoo D; Xu PX; Bermingham JR Jr; Weissman IL. 2012. Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol 14(12):1251-60. PubMed: 23143399 MGI: J:195251
Rinkevich Y; Walmsley GG; Hu MS; Maan ZN; Newman AM; Drukker M; Januszyk M; Krampitz GW; Gurtner GC; Lorenz HP; Weissman IL; Longaker MT. 2015. Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential. Science 348(6232):aaa2151. PubMed: 25883361 MGI: J:222263
Rinon A; Lazar S; Marshall H; Buchmann-Moller S; Neufeld A; Elhanany-Tamir H; Taketo MM; Sommer L; Krumlauf R; Tzahor E. 2007. Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis. Development 134(17):3065-75. PubMed: 17652354 MGI: J:124278
Rivera-Feliciano J; Lee KH; Kong SW; Rajagopal S; Ma Q; Springer Z; Izumo S; Tabin CJ; Pu WT. 2006. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133(18):3607-18. PubMed: 16914500 MGI: J:112458
Rooker SM; Liu B; Helms JA. 2009. Role of Wnt signaling in the biology of the periodontium. Dev Dyn 239(1):140-147. PubMed: 19530172 MGI: J:155261
Ross SE; Mardinly AR; McCord AE; Zurawski J; Cohen S; Jung C; Hu L; Mok SI; Shah A; Savner EM; Tolias C; Corfas R; Chen S; Inquimbert P; Xu Y; McInnes RR; Rice FL; Corfas G; Ma Q; Woolf CJ; Greenberg ME. 2010. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron 65(6):886-98. PubMed: 20346763 MGI: J:158273
Roybal PG; Wu NL; Sun J; Ting MC; Schafer CA; Maxson RE. 2010. Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. Dev Biol 343(1-2):28-39. PubMed: 20398647 MGI: J:162170
Rudloff S; Kemler R. 2012. Differential requirements for beta-catenin during mouse development. Development 139(20):3711-21. PubMed: 22991437 MGI: J:187739
Ruest LB; Clouthier DE. 2009. Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol 328(1):94-108. PubMed: 19185569 MGI: J:149166
Rutlin M; Ho CY; Abraira VE; Cassidy C; Woodbury CJ; Ginty DD. 2014. The cellular and molecular basis of direction selectivity of Adelta-LTMRs. Cell 159(7):1640-51. PubMed: 25525881 MGI: J:218012
Ryu YK; Collins SE; Ho HY; Zhao H; Kuruvilla R. 2013. An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation. Dev Biol 377(1):79-89. PubMed: 23454479 MGI: J:196291
Sahar DE; Longaker MT; Quarto N. 2005. Sox9 neural crest determinant gene controls patterning and closure of the posterior frontal cranial suture. Dev Biol 280(2):344-61. PubMed: 15882577 MGI: J:98269
Sandell LL; Butler Tjaden NE; Barlow AJ; Trainor PA. 2014. Cochleovestibular nerve development is integrated with migratory neural crest cells. Dev Biol 385(2):200-10. PubMed: 24252775 MGI: J:205409
Santagati F; Minoux M; Ren SY; Rijli FM. 2005. Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis. Development 132(22):4927-36. PubMed: 16221728 MGI: J:102845
Santos R; Kawauchi S; Jacobs RE; Lopez-Burks ME; Choi H; Wikenheiser J; Hallgrimsson B; Jamniczky HA; Fraser SE; Lander AD; Calof AL. 2016. Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol 14(9):e2000197. PubMed: 27606604 MGI: J:236978
Sasaki T; Ito Y; Bringas P Jr; Chou S; Urata MM; Slavkin H; Chai Y. 2006. TGF{beta}-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development 133(2):371-81. PubMed: 16368934 MGI: J:105169
Sasaki T; Ito Y; Xu X; Han J; Bringas P Jr; Maeda T; Slavkin HC; Grosschedl R; Chai Y. 2005. LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol 278(1):130-43. PubMed: 15649466 MGI: J:96501
Sasselli V; Boesmans W; Vanden Berghe P; Tissir F; Goffinet AM; Pachnis V. 2013. Planar cell polarity genes control the connectivity of enteric neurons. J Clin Invest 123(4):1763-72. PubMed: 23478408 MGI: J:197538
Schock EN; Struve JN; Chang CF; Williams TJ; Snedeker J; Attia AC; Stottmann RW; Brugmann SA. 2017. A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS One 12(3):e0174206. PubMed: 28346501 MGI: J:241357
Schwarz D; Varum S; Zemke M; Scholer A; Baggiolini A; Draganova K; Koseki H; Schubeler D; Sommer L. 2014. Ezh2 is required for neural crest-derived cartilage and bone formation. Development 141(4):867-77. PubMed: 24496623 MGI: J:208432
Schwarz Q; Vieira JM; Howard B; Eickholt BJ; Ruhrberg C. 2008. Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development 135(9):1605-13. PubMed: 18356247 MGI: J:134486
Scott A; Hasegawa H; Sakurai K; Yaron A; Cobb J; Wang F. 2011. Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. J Neurosci 31(18):6741-9. PubMed: 21543603 MGI: J:171905
Seo S; Singh HP; Lacal PM; Sasman A; Fatima A; Liu T; Schultz KM; Losordo DW; Lehmann OJ; Kume T. 2012. Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A 109(6):2015-20. PubMed: 22171010 MGI: J:181974
Serinagaoglu Y; Pare J; Giovannini M; Cao X. 2015. Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol 398(1):97-109. PubMed: 25433207 MGI: J:218609
Shalish M; Will LA; Fukai N; Hou B; Olsen BR. 2014. Role of polycystin-1 in bone remodeling: Orthodontic tooth movement study in mutant mice. Angle Orthod :. PubMed: 24559508 MGI: J:210270
Sheehy NT; Cordes KR; White MP; Ivey KN; Srivastava D. 2010. The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development 137(24):4307-16. PubMed: 21098571 MGI: J:166758
Shi M; Hu ZL; Zheng MH; Song NN; Huang Y; Zhao G; Han H; Ding YQ. 2012. Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus. J Cell Sci 125(Pt 18):4320-32. PubMed: 22718343 MGI: J:198880
Shin JE; Cho Y; Beirowski B; Milbrandt J; Cavalli V; DiAntonio A. 2012. Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron 74(6):1015-22. PubMed: 22726832 MGI: J:188356
Singh N; Trivedi CM; Lu M; Mullican SE; Lazar MA; Epstein JA. 2011. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ Res 109(11):1240-9. PubMed: 21959220 MGI: J:196561
Sinha T; Wang B; Evans S; Wynshaw-Boris A; Wang J. 2012. Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis. Dev Biol 370(1):135-44. PubMed: 22841628 MGI: J:188039
Smith TG; Laval S; Chen F; Rock MJ; Strachan T; Peters H. 2014. Neural crest cell-specific inactivation of Nipbl or Mau2 during mouse development results in a late onset of craniofacial defects. Genesis 52(7):687-94. PubMed: 24700590 MGI: J:213338
Smukler SR; Arntfield ME; Razavi R; Bikopoulos G; Karpowicz P; Seaberg R; Dai F; Lee S; Ahrens R; Fraser PE; Wheeler MB; van der Kooy D. 2011. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 8(3):281-93. PubMed: 21362568 MGI: J:171126
Song N; Schwab KR; Patterson LT; Yamaguchi T; Lin X; Potter SS; Lang RA. 2007. pygopus 2 has a crucial, Wnt pathway-independent function in lens induction. Development 134(10):1873-85. PubMed: 17428831 MGI: J:121416
Song Z; Liu C; Iwata J; Gu S; Suzuki A; Sun C; He W; Shu R; Li L; Chai Y; Chen Y. 2013. Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem 288(15):10440-50. PubMed: 23460641 MGI: J:198279
Sowa Y; Imura T; Numajiri T; Takeda K; Mabuchi Y; Matsuzaki Y; Nishino K. 2013. Adipose stromal cells contain phenotypically distinct adipogenic progenitors derived from neural crest. PLoS One 8(12):e84206. PubMed: 24391913 MGI: J:211113
Stottmann RW; Choi M; Mishina Y; Meyers EN; Klingensmith J. 2004. BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. Development 131(9):2205-18. PubMed: 15073157 MGI: J:89521
Stottmann RW; Klingensmith J. 2011. Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. Dev Dyn 240(4):755-65. PubMed: 21394823 MGI: J:169665
Stottmann RW; Tran PV; Turbe-Doan A; Beier DR. 2009. Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Dev Biol 335(1):166-78. PubMed: 19732765 MGI: J:154376
Straessler KM; Jones KB; Hu H; Jin H; van de Rijn M; Capecchi MR. 2013. Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell 23(2):215-27. PubMed: 23410975 MGI: J:194308
Stubbusch J; Narasimhan P; Hennchen M; Huber K; Unsicker K; Ernsberger U; Rohrer H. 2015. Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol 400(2):210-23. PubMed: 25661788 MGI: J:221159
Sun Y; Dykes IM; Liang X; Eng SR; Evans SM; Turner EE. 2008. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci 11(11):1283-93. PubMed: 18849985 MGI: J:141110
Sutherland MJ; Wang S; Quinn ME; Haaning A; Ware SM. 2013. Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning. Hum Mol Genet 22(10):1913-23. PubMed: 23303524 MGI: J:194989
Szeder V; Grim M; Halata Z; Sieber-Bluma M. 2003. Neural crest origin of mammalian Merkel cells. Dev Biol 253(2):258-63. PubMed: 12645929 MGI: J:81404
Szumska D; Cioroch M; Keeling A; Prat A; Seidah NG; Bhattacharya S. 2017. Pcsk5 is required in the early cranio-cardiac mesoderm for heart development. BMC Dev Biol 17(1):6. PubMed: 28446132 MGI: J:241568
Tabler JM; Barrell WB; Szabo-Rogers HL; Healy C; Yeung Y; Perdiguero EG; Schulz C; Yannakoudakis BZ; Mesbahi A; Wlodarczyk B; Geissmann F; Finnell RH; Wallingford JB; Liu KJ. 2013. Fuz Mutant Mice Reveal Shared Mechanisms between Ciliopathies and FGF-Related Syndromes. Dev Cell 25(6):623-35. PubMed: 23806618 MGI: J:198631
Tabler JM; Rice CP; Liu KJ; Wallingford JB. 2016. A novel ciliopathic skull defect arising from excess neural crest. Dev Biol 417(1):4-10. PubMed: 27395007 MGI: J:235627
Tabler JM; Rigney MM; Berman GJ; Gopalakrishnan S; Heude E; Al-Lami HA; Yannakoudiadkis BZ; Fitch RD; Carter C; Vokes S; Liu KJ; Tajbakhsh S; Egnor SR; Wallingford JB. 2017. Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx. Elife 6:. PubMed: 28177282 MGI: J:241145
Takagi T; Nishizaki Y; Matsui F; Wakamatsu N; Higashi Y. 2015. De novo inbred heterozygous Zeb2/Sip1 mutant mice uniquely generated by germ-line conditional knockout exhibit craniofacial, callosal and behavioral defects associated with Mowat-Wilson syndrome. Hum Mol Genet 24(22):6390-402. PubMed: 26319231 MGI: J:226502
Tallquist MD; Soriano P. 2003. Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development 130(3):507-18. PubMed: 12490557 MGI: J:81153
Tamura Y; Matsumura K; Sano M; Tabata H; Kimura K; Ieda M; Arai T; Ohno Y; Kanazawa H; Yuasa S; Kaneda R; Makino S; Nakajima K; Okano H; Fukuda K. 2011. Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction. Arterioscler Thromb Vasc Biol 31(3):582-9. PubMed: 21212399 MGI: J:184174
Tavares ALP; Cox TC; Maxson RM; Ford HL; Clouthier DE. 2017. Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development 144(11):2021-2031. PubMed: 28455376 MGI: J:241567
Taylor MK; Yeager K; Morrison SJ. 2007. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development 134(13):2435-47. PubMed: 17537790 MGI: J:122520
Teng L; Mundell NA; Frist AY; Wang Q; Labosky PA. 2008. Requirement for Foxd3 in the maintenance of neural crest progenitors. Development 135(9):1615-24. PubMed: 18367558 MGI: J:134482
Theis S; Patel K; Valasek P; Otto A; Pu Q; Harel I; Tzahor E; Tajbakhsh S; Christ B; Huang R. 2010. The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature. Development 137(17):2961-71. PubMed: 20699298 MGI: J:163918
Thirumangalathu S; Harlow DE; Driskell AL; Krimm RF; Barlow LA. 2009. Fate mapping of mammalian embryonic taste bud progenitors. Development 136(9):1519-28. PubMed: 19363153 MGI: J:147959
Thomas PS; Kim J; Nunez S; Glogauer M; Kaartinen V. 2010. Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations. Dev Biol 340(2):613-25. PubMed: 20184871 MGI: J:160252
Thompson H; Ohazama A; Sharpe PT; Tucker AS. 2012. The origin of the stapes and relationship to the otic capsule and oval window. Dev Dyn 241(9):1396-404. PubMed: 22778034 MGI: J:186480
Thompson H; Tucker AS. 2013. Dual origin of the epithelium of the mammalian middle ear. Science 339(6126):1453-6. PubMed: 23520114 MGI: J:195279
Tian H; Sanders E; Reynolds A; van Roy F; van Hengel J. 2012. Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells. Invest Ophthalmol Vis Sci 53(9):5139-53. PubMed: 22736606 MGI: J:213975
Tian X; Hu T; Zhang H; He L; Huang X; Liu Q; Yu W; He L; Yang Z; Zhang Z; Zhong TP; Yang X; Yang Z; Yan Y; Baldini A; Sun Y; Lu J; Schwartz RJ; Evans SM; Gittenberger-de Groot AC; Red-Horse K; Zhou B. 2013. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res 23(9):1075-90. PubMed: 23797856 MGI: J:220957
Ting MC; Wu NL; Roybal PG; Sun J; Liu L; Yen Y; Maxson RE Jr. 2009. EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis. Development 136(5):855-64. PubMed: 19201948 MGI: J:146459
Trokovic N; Trokovic R; Mai P; Partanen J. 2003. Fgfr1 regulates patterning of the pharyngeal region. Genes Dev 17(1):141-53. PubMed: 12514106 MGI: J:81179
Trokovic R; Trokovic N; Hernesniemi S; Pirvola U; Vogt Weisenhorn DM; Rossant J; McMahon AP; Wurst W; Partanen J. 2003. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J 22(8):1811-23. PubMed: 12682014 MGI: J:83004
Trowe MO; Maier H; Petry M; Schweizer M; Schuster-Gossler K; Kispert A. 2011. Impaired stria vascularis integrity upon loss of E-cadherin in basal cells. Dev Biol 359(1):95-107. PubMed: 21925491 MGI: J:178162
Turlo KA; Noel OD; Vora R; LaRussa M; Fassler R; Hall-Glenn F; Iruela-Arispe ML. 2012. An essential requirement for beta1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev Biol 365(1):23-35. PubMed: 22331032 MGI: J:184940
Turner CJ; Badu-Nkansah K; Crowley D; van der Flier A; Hynes RO. 2015. alpha5 and alphav integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. Development 142(4):797-808. PubMed: 25670798 MGI: J:218158
Valenta T; Gay M; Steiner S; Draganova K; Zemke M; Hoffmans R; Cinelli P; Aguet M; Sommer L; Basler K. 2011. Probing transcription-specific outputs of beta-catenin in vivo. Genes Dev 25(24):2631-43. PubMed: 22190459 MGI: J:178971
Vallejo-Illarramendi A; Zang K; Reichardt LF. 2009. Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development. J Clin Invest 119(8):2218-30. PubMed: 19587446 MGI: J:152558
Van Otterloo E; Feng W; Jones KL; Hynes NE; Clouthier DE; Niswander L; Williams T. 2016. MEMO1 drives cranial endochondral ossification and palatogenesis. Dev Biol 415(2):278-95. PubMed: 26746790 MGI: J:233609
Van de Putte T; Francis A; Nelles L; van Grunsven LA; Huylebroeck D. 2007. Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome. Hum Mol Genet 16(12):1423-36. PubMed: 17478475 MGI: J:125106
Vasudevan HN; Mazot P; He F; Soriano P. 2015. Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. Elife 4:. PubMed: 25951516 MGI: J:222958
Venteo S; Bourane S; Mechaly I; Sar C; Abdel Samad O; Puech S; Blostein R; Valmier J; Pattyn A; Carroll P. 2012. Regulation of the Na,K-ATPase gamma-subunit FXYD2 by Runx1 and Ret signaling in normal and injured non-peptidergic nociceptive sensory neurons. PLoS One 7(1):e29852. PubMed: 22253804 MGI: J:184316
Verzi MP; Agarwal P; Brown C; McCulley DJ; Schwarz JJ; Black BL. 2007. The transcription factor MEF2C is required for craniofacial development. Dev Cell 12(4):645-52. PubMed: 17420000 MGI: J:122483
Verzi MP; McCulley DJ; De Val S; Dodou E; Black BL. 2005. The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol 287(1):134-45. PubMed: 16188249 MGI: J:103545
Vieux-Rochas M; Mascrez B; Krumlauf R; Duboule D. 2013. Combined function of HoxA and HoxB clusters in neural crest cells. Dev Biol 382(1):293-301. PubMed: 23850771 MGI: J:202237
Vincentz JW; Barnes RM; Rodgers R; Firulli BA; Conway SJ; Firulli AB. 2008. An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol 320(1):131-9. PubMed: 18539270 MGI: J:138404
Vincentz JW; Firulli BA; Lin A; Spicer DB; Howard MJ; Firulli AB. 2013. Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet 9(3):e1003405. PubMed: 23555309 MGI: J:195264
Vincentz JW; McWhirter JR; Murre C; Baldini A; Furuta Y. 2005. Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis 41(4):192-201. PubMed: 15789410 MGI: J:97317
Vincentz JW; VanDusen NJ; Fleming AB; Rubart M; Firulli BA; Howard MJ; Firulli AB. 2012. A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. J Neurosci 32(6):2110-20. PubMed: 22323723 MGI: J:181316
Wang J; Bai Y; Li H; Greene SB; Klysik E; Yu W; Schwartz RJ; Williams TJ; Martin JF. 2013. MicroRNA-17-92, a direct Ap-2alpha transcriptional target, modulates T-box factor activity in orofacial clefting. PLoS Genet 9(9):e1003785. PubMed: 24068957 MGI: J:202467
Wang J; Nagy A; Larsson J; Dudas M; Sucov HM; Kaartinen V. 2006. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol 6:51. PubMed: 17078885 MGI: J:119667
Wang J; Xiao Y; Hsu CW; Martinez-Traverso IM; Zhang M; Bai Y; Ishii M; Maxson RE; Olson EN; Dickinson ME; Wythe JD; Martin JF. 2016. Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development 143(3):504-15. PubMed: 26718006 MGI: J:229010
Wang Y; Liu C; Rohr J; Liu H; He F; Yu J; Sun C; Li L; Gu S; Chen Y. 2011. Tissue interaction is required for glenoid fossa development during temporomandibular joint formation. Dev Dyn 240(11):2466-73. PubMed: 21953591 MGI: J:177115
Wei K; Che N; Chen F. 2007. Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression. Dev Dyn 236(2):416-25. PubMed: 17183527 MGI: J:117226
Wei K; Chen J; Akrami K; Galbraith GC; Lopez IA; Chen F. 2007. Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45(6):382-90. PubMed: 17523175 MGI: J:121871
Weider M; Wegener A; Schmitt C; Kuspert M; Hillgartner S; Bosl MR; Hermans-Borgmeyer I; Nait-Oumesmar B; Wegner M. 2015. Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells. PLoS Genet 11(2):e1005008. PubMed: 25680202 MGI: J:224004
Weng DY; Zhang Y; Hayashi Y; Kuan CY; Liu CY; Babcock G; Weng WL; Schwemberger S; Kao WW. 2008. Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice. Mol Vis 14:562-71. PubMed: 18385792 MGI: J:149921
Wickramasinghe SR; Alvania RS; Ramanan N; Wood JN; Mandai K; Ginty DD. 2008. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron 58(4):532-45. PubMed: 18498735 MGI: J:145293
Wiszniak S; Mackenzie FE; Anderson P; Kabbara S; Ruhrberg C; Schwarz Q. 2015. Neural crest cell-derived VEGF promotes embryonic jaw extension. Proc Natl Acad Sci U S A 112(19):6086-91. PubMed: 25922531 MGI: J:221661
Woo SH; Baba Y; Franco AM; Lumpkin EA; Owens DM. 2012. Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor. Development 139(4):740-8. PubMed: 22241839 MGI: J:181187
Wu B; Wang Y; Lui W; Langworthy M; Tompkins KL; Hatzopoulos AK; Baldwin HS; Zhou B. 2011. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res 109(2):183-92. PubMed: 21597012 MGI: J:185683
Wu M; Li J; Engleka KA; Zhou B; Lu MM; Plotkin JB; Epstein JA. 2008. Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J Clin Invest 118(6):2076-87. PubMed: 18483623 MGI: J:137730
Wurdak H; Ittner LM; Lang KS; Leveen P; Suter U; Fischer JA; Karlsson S; Born W; Sommer L. 2005. Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev 19(5):530-5. PubMed: 15741317 MGI: J:96359
Xie WB; Li Z; Shi N; Guo X; Tang J; Ju W; Han J; Liu T; Bottinger EP; Chai Y; Jose PA; Chen SY. 2013. Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ Res 113(8):e76-86. PubMed: 23817199 MGI: J:213386
Xiong W; He F; Morikawa Y; Yu X; Zhang Z; Lan Y; Jiang R; Cserjesi P; Chen Y. 2009. Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330(1):131-41. PubMed: 19341725 MGI: J:149232
Xu J; Liu H; Lan Y; Aronow BJ; Kalinichenko VV; Jiang R. 2016. A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. PLoS Genet 12(1):e1005769. PubMed: 26745863 MGI: J:232140
Yahiro K; Higashihori N; Moriyama K. 2017. Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development. Biochem Biophys Res Commun 482(4):883-888. PubMed: 27890611 MGI: J:241684
Yam PT; Kent CB; Morin S; Farmer WT; Alchini R; Lepelletier L; Colman DR; Tessier-Lavigne M; Fournier AE; Charron F. 2012. 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron 76(4):735-49. PubMed: 23177959 MGI: J:196985
Yamada K; Ohno T; Aoki H; Semi K; Watanabe A; Moritake H; Shiozawa S; Kunisada T; Kobayashi Y; Toguchida J; Shimizu K; Hara A; Yamada Y. 2013. EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice. J Clin Invest :. PubMed: 23281395 MGI: J:194505
Yamamoto S; Fukumoto E; Yoshizaki K; Iwamoto T; Yamada A; Tanaka K; Suzuki H; Aizawa S; Arakaki M; Yuasa K; Oka K; Chai Y; Nonaka K; Fukumoto S. 2008. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem 283(34):23139-49. PubMed: 18559345 MGI: J:140258
Yang FC; Tan T; Huang T; Christianson J; Samad OA; Liu Y; Roberson D; Davis BM; Ma Q. 2013. Genetic Control of the Segregation of Pain-Related Sensory Neurons Innervating the Cutaneous versus Deep Tissues. Cell Rep 5(5):1353-64. PubMed: 24316076 MGI: J:204139
Yang X; Kilgallen S; Andreeva V; Spicer DB; Pinz I; Friesel R. 2010. Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects. BMC Dev Biol 10:48. PubMed: 20459789 MGI: J:161412
Ye M; Coldren C; Liang X; Mattina T; Goldmuntz E; Benson DW; Ivy D; Perryman MB; Garrett-Sinha LA; Grossfeld P. 2009. Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects and abnormal ventricular morphology in mice. Hum Mol Genet :. PubMed: 19942620 MGI: J:155882
Yen HY; Ting MC; Maxson RE. 2010. Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells. Dev Biol 347(2):258-70. PubMed: 20727876 MGI: J:166632
Yingling J; Youn YH; Darling D; Toyo-Oka K; Pramparo T; Hirotsune S; Wynshaw-Boris A. 2008. Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell 132(3):474-86. PubMed: 18267077 MGI: J:135521
Yoshida T; Vivatbutsiri P; Morriss-Kay G; Saga Y; Iseki S. 2008. Cell lineage in mammalian craniofacial mesenchyme. Mech Dev 125(9-10):797-808. PubMed: 18617001 MGI: J:138865
Young K; Krebs LT; Tweedie E; Conley B; Mancini M; Arthur HM; Liaw L; Gridley T; Vary C. 2016. Endoglin is required in Pax3-derived cells for embryonic blood vessel formation. Dev Biol 409(1):95-105. PubMed: 26481065 MGI: J:228794
Yu HM; Liu B; Chiu SY; Costantini F; Hsu W. 2005. Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci U S A 102(24):8615-20. PubMed: 15941831 MGI: J:99718
Yu YR; You LR; Yan YT; Chen CM. 2014. Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome. Hum Mol Genet 23(21):5579-96. PubMed: 24895408 MGI: J:214744
Yumoto K; Thomas PS; Lane J; Matsuzaki K; Inagaki M; Ninomiya-Tsuji J; Scott GJ; Ray MK; Ishii M; Maxson R; Mishina Y; Kaartinen V. 2013. TGF-beta-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem 288(19):13467-80. PubMed: 23546880 MGI: J:198588
Zacharias AL; Gage PJ. 2010. Canonical Wnt/beta-catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development. Dev Dyn 239(12):3215-25. PubMed: 20960542 MGI: J:166528
Zehir A; Hua LL; Maska EL; Morikawa Y; Cserjesi P. 2010. Dicer is required for survival of differentiating neural crest cells. Dev Biol 340(2):459-67. PubMed: 20144605 MGI: J:160261
Zelina P; Blockus H; Zagar Y; Peres A; Friocourt F; Wu Z; Rama N; Fouquet C; Hohenester E; Tessier-Lavigne M; Schweitzer J; Roest Crollius H; Chedotal A. 2014. Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution. Neuron 84(6):1258-72. PubMed: 25433640 MGI: J:218606
Zhang J; Lin Y; Zhang Y; Lan Y; Lin C; Moon AM; Schwartz RJ; Martin JF; Wang F. 2008. Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development 135(21):3611-22. PubMed: 18832393 MGI: J:143443
Zhang Y; Li S; Yuan L; Tian Y; Weidenfeld J; Yang J; Liu F; Chokas AL; Morrisey EE. 2010. Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev 24(16):1746-57. PubMed: 20713518 MGI: J:163662
Zhang Y; Singh MK; Degenhardt KR; Lu MM; Bennett J; Yoshida Y; Epstein JA. 2009. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol 325(1):82-93. PubMed: 18992737 MGI: J:143763
Zhao C; Guo H; Li J; Myint T; Pittman W; Yang L; Zhong W; Schwartz RJ; Schwarz JJ; Singer HA; Tallquist MD; Wu M. 2014. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 141(2):281-95. PubMed: 24335256 MGI: J:206589
Zhao H; Feng J; Seidel K; Shi S; Klein O; Sharpe P; Chai Y. 2014. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14(2):160-73. PubMed: 24506883 MGI: J:210170
Zhao H; Li S; Han D; Kaartinen V; Chai Y. 2011. Alk5-mediated transforming growth factor beta signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells. Mol Cell Biol 31(10):2079-89. PubMed: 21402782 MGI: J:173972
Zhao H; Oka K; Bringas P; Kaartinen V; Chai Y. 2008. TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol 320(1):19-29. PubMed: 18572160 MGI: J:139188
Zhao J; Kawai K; Wang H; Wu D; Wang M; Yue Z; Zhang J; Liu YH. 2012. Loss of Msx2 Function Down-Regulates the FoxE3 Expression and Results in Anterior Segment Dysgenesis Resembling Peters Anomaly. Am J Pathol 180(6):2230-9. PubMed: 22503753 MGI: J:184697
Zhou B; Ma Q; Kong SW; Hu Y; Campbell PH; McGowan FX; Ackerman KG; Wu B; Zhou B; Tevosian SG; Pu WT. 2009. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 119(6):1462-76. PubMed: 19411759 MGI: J:150452
Zhou J; Gao Y; Lan Y; Jia S; Jiang R. 2013. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development 140(23):4709-18. PubMed: 24173808 MGI: J:205040
Zhu Y; Matsumoto T; Mikami S; Nagasawa T; Murakami F. 2009. SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation. Development 136(11):1919-28. PubMed: 19429788 MGI: J:149543
Zhu Y; Matsumoto T; Nagasawa T; Mackay F; Murakami F. 2015. Chemokine Signaling Controls Integrity of Radial Glial Scaffold in Developing Spinal Cord and Consequential Proper Position of Boundary Cap Cells. J Neurosci 35(24):9211-24. PubMed: 26085643 MGI: J:222550
Zohn IE; Anderson KV; Niswander L. 2007. The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol 306(1):208-21. PubMed: 17442300 MGI: J:122594
de Lange FJ; Moorman AF; Anderson RH; Manner J; Soufan AT; de Gier-de Vries C; Schneider MD; Webb S; van den Hoff MJ; Christoffels VM. 2004. Lineage and morphogenetic analysis of the cardiac valves. Circ Res 95(6):645-54. PubMed: 15297379 MGI: J:155846
van Bueren KL; Papangeli I; Rochais F; Pearce K; Roberts C; Calmont A; Szumska D; Kelly RG; Bhattacharya S; Scambler PJ. 2010. Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome. Dev Biol 340(2):369-80. PubMed: 20122914 MGI: J:160266

Additional - Tg(Wnt1-GAL4)11Rth related

Adameyko I; Lallemend F; Furlan A; Zinin N; Aranda S; Kitambi SS; Blanchart A; Favaro R; Nicolis S; Lubke M; Muller T; Birchmeier C; Suter U; Zaitoun I; Takahashi Y; Ernfors P. 2012. Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development 139(2):397-410. PubMed: 22186729 MGI: J:178973
Avetisyan M; Wang H; Schill EM; Bery S; Grider JR; Hassell JA; Stappenbeck T; Heuckeroth RO. 2015. Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. J Neurosci 35(33):11543-58. PubMed: 26290232 MGI: J:226097
Baydyuk M; Xie Y; Tessarollo L; Xu B. 2013. Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci 33(8):3363-9. PubMed: 23426664 MGI: J:194255
Brault V; Moore R; Kutsch S; Ishibashi M; Rowitch DH; McMahon AP; Sommer L; Boussadia O; Kemler R. 2001. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128(8):1253-64. PubMed: 11262227 MGI: J:67966
Brewer S; Feng W; Huang J; Sullivan S; Williams T. 2004. Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol 267(1):135-52. PubMed: 14975722 MGI: J:88826
Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. PubMed: 10725243 MGI: J:61091
Fleming MS; Li JJ; Ramos D; Li T; Talmage DA; Abe SI; Arber S; Luo W. 2016. A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. J Neurosci 36(40):10337-10355. PubMed: 27707970 MGI: J:235934
Funato N; Nakamura M; Richardson JA; Srivastava D; Yanagisawa H. 2015. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet 24(2):424-35. PubMed: 25209980 MGI: J:217210
Garrington TP; Ishizuka T; Papst PJ; Chayama K; Webb S; Yujiri T; Sun W; Sather S; Russell DM; Gibson SB; Keller G; Gelfand EW; Johnson GL. 2000. MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells. EMBO J 19(20):5387-95. PubMed: 11032806 MGI: J:193674
Hancock ML; Preitner N; Quan J; Flanagan JG. 2014. MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension. J Neurosci 34(1):66-78. PubMed: 24381269 MGI: J:205590
Inman KE; Purcell P; Kume T; Trainor PA. 2013. Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia. PLoS Genet 9(12):e1003949. PubMed: 24385915 MGI: J:223126
Johansson E; Andersson L; Ornros J; Carlsson T; Ingeson-Carlsson C; Liang S; Dahlberg J; Jansson S; Parrillo L; Zoppoli P; Barila GO; Altschuler DL; Padula D; Lickert H; Fagman H; Nilsson M. 2015. Revising the embryonic origin of thyroid C cells in mice and humans. Development 142(20):3519-28. PubMed: 26395490 MGI: J:239771
Johnston AP; Yuzwa SA; Carr MJ; Mahmud N; Storer MA; Krause MP; Jones K; Paul S; Kaplan DR; Miller FD. 2016. Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. Cell Stem Cell 19(4):433-448. PubMed: 27376984 MGI: J:238684
Kizhatil K; Ryan M; Marchant JK; Henrich S; John SW. 2014. Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process. PLoS Biol 12(7):e1001912. PubMed: 25051267 MGI: J:215599
Kurosaka H; Wang Q; Sandell L; Yamashiro T; Trainor PA. 2017. Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia. Hum Mol Genet 26(7):1268-1279. PubMed: 28169399 MGI: J:241377
Kurosaka S; Leu NA; Zhang F; Bunte R; Saha S; Wang J; Guo C; He W; Kashina A. 2010. Arginylation-dependent neural crest cell migration is essential for mouse development. PLoS Genet 6(3):e1000878. PubMed: 20300656 MGI: J:159224
Lu QR; Yuk D; Alberta JA; Zhu Z; Pawlitzky I; Chan J; McMahon AP; Stiles CD; Rowitch DH. 2000. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25(2):317-29. PubMed: 10719888 MGI: J:60773
Nakajima M; Mori H; Nishikawa C; Tsuruta M; Okuyama S; Furukawa Y. 2013. Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice. J Neurochem 124(2):241-9. PubMed: 23134367 MGI: J:192250
Nakajima M; Nishikawa C; Miyasaka Y; Kikkawa Y; Mori H; Tsuruta M; Okuyama S; Furukawa Y. 2014. Dilation of the inferior colliculus and hypersensitivity to sound in Wnt1-cre and Wnt1-GAL4 double-transgenic mice. Neurosci Lett 566:236-40. PubMed: 24607930 MGI: J:212007
Passman JN; Dong XR; Wu SP; Maguire CT; Hogan KA; Bautch VL; Majesky MW. 2008. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci U S A 105(27):9349-54. PubMed: 18591670 MGI: J:137825
Rakhilin N; Barth B; Choi J; Munoz NL; Kulkarni S; Jones JS; Small DM; Cheng YT; Cao Y; LaVinka C; Kan E; Dong X; Spencer M; Pasricha P; Nishimura N; Shen X. 2016. Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nat Commun 7:11800. PubMed: 27270085 MGI: J:239904
Rowitch DH; S.-Jacques B; Lee SM; Flax JD; Snyder EY; McMahon AP. 1999. Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 19(20):8954-65. PubMed: 10516314 MGI: J:57948
Ryu YK; Collins SE; Ho HY; Zhao H; Kuruvilla R. 2013. An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation. Dev Biol 377(1):79-89. PubMed: 23454479 MGI: J:196291
Sandell LL; Butler Tjaden NE; Barlow AJ; Trainor PA. 2014. Cochleovestibular nerve development is integrated with migratory neural crest cells. Dev Biol 385(2):200-10. PubMed: 24252775 MGI: J:205409

Also Known As: Wnt-1/GAL4/cre-11

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Expression Data

Control Suggestions

Additional Information

Selected References

Tg(Wnt1-GAL4)11Rth

Allele Symbol: Tg(Wnt1-GAL4)11Rth

Tg(Wnt1-cre)11Rth

Allele Symbol: Tg(Wnt1-cre)11Rth

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: cre related

Genotype: GAL4 related

References

Additional References

Additional - Tg(Wnt1-cre)11Rth related

Additional - Tg(Wnt1-GAL4)11Rth related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Citation

Animal Health Reports

Live Mouse

Breeder Pair

Cryorecovery - Pricing

Progeny testing is not required

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability