B6D2-Tg(Pcp2-SCA2)11Plt/J

Stock number: 003811
Product name: Q58-11
Research areas: Neurobiology Research

Description

This strain has been discontinued. Please search the JAX Mice database for other strains which may be suitable for your studies, or contact Technical Support for assistance.

In 2020, analysis performed by The Jackson Laboratory discovered Stock No. 003811 (Q58-11) does not exhibit human SCA2 RNA expression from the transgene. In addition, this strain had transgene copy number variations indicative of two or more insertion sites. Hemizygotes showed 5-8 transgene copies (homozygotes 10-16 transgene copies).

Allele

Symbol: Tg(Pcp2-SCA2)11Plt
Name: transgene insertion 11, Stefan M Pulst
MGI accession ID: MGI:3505741
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(Pcp2-SCA2)11Plt
Marker name: transgene insertion 11, Stefan M Pulst
Chromosome: UN
Strain of origin: (C57BL/6J x DBA/2J)F1
Expressed genes: SCA2,spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2),human
Molecular note: The transgene contains a full length human spinocerebellar ataxia 2 (SCA2) cDNA (with a 58 CAG repeat) as well as the mouse Pcp2 (Purkinje cell protein 2) promoter, untranslated, and poly(A) sequences. Transcripts and protein product are detected in the cerebellum.