JAX
Mouse Strain Datasheet - 003755
B6.129S4-Meox2tm1(cre)Sor/J
Also Known As: MORE
This knock-in strain expresses Cre recombinase under the control of the endogenous Meox2 promoter with Cre recombinase active in early embryos. These mice can be utilized as a deleter strain for floxed genes and provide an alternative to tetraploid embryo analysis.
Donating Investigator
Dr. Philippe Soriano, Mount Sinai School of Medicine
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N6+N36
(28-MAR-17) |
Meox2tm1(cre)Sor
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Recombinase-expressing) | Meox2 | mesenchyme homeobox 2 |
Base Price
Starting at:
| $263.00 Domestic price for female |
| $337.00 Domestic price for breeder pair |
Detailed Description
This strain expresses Cre recombinase under the control of the endogenous Meox2 promoter. Expression of Cre recombinase is observed in epiblast-derived tissues as early as embryonic day 5. The insertion creates a null allele for the Meox2 gene. Homozygous mice are viable on this background but exhibit an overall reduction in muscle mass and the absence of specific muscles resulting in abnormal limb posture and reduced motility. This phenotype is variable. As many as 80% of homozygotes are severely affected, fail to thrive and die before weaning. Some homozygotes (10%) exhibit clefting of the secondary palate. These mice can be utilized as a deleter strain for loxP flanked DNA and provide an alternative to tetraploid embryo analysis.
Development
A targeting vector containing a nuclear localization sequence-modified Cre recombinase and neomycin resistance genes, linked to a bovine growth hormone polyadenylation was used to replace the first Meox coding exon and 300 base pairs of the following intron in AK7 embryonic stem (ES) cells. Correctly targeted ES cells were used to make chimeric animals which were backcrossed to C57BL/6 mice.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | epiblast-derived tissues as early as embryonic day 5; all primitive ectoderm by embryonic day 7 (but not endoderm or trophectoderm); null allele for Meox2 gene |
Control Suggestions
- Wild-type from the colony
- 000664 C57BL/6J
Additional Information
Selected References
- Tallquist MD; Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26(2):113-5. PubMed: 10686601MGI: J:60933
Meox2tm1(cre)Sor
Allele Symbol: Meox2tm1(cre)Sor
| Allele Name | targeted mutation 1, Philippe Soriano |
|---|---|
| Allele Type | Targeted (Recombinase-expressing) |
| Allele Synonym(s) | MORE; Meox2-Cre; Meox2Cre; Meox2CreSor; More-cre; Mox2 Cre; Mox2-Cre; Mox2Cre; Mox2Cre; MoxCre |
| Gene Symbol and Name | Meox2, mesenchyme homeobox 2 |
| Gene Synonym(s) | AI528662; GAX; Gax; MOX2; Mox-2; Mox2; expressed sequence AI528662 |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | epiblast-derived tissues as early as embryonic day 5; all primitive ectoderm by embryonic day 7 (but not endoderm or trophectoderm); null allele for Meox2 gene |
| Strain of Origin | 129S4/SvJaeSor |
| Chromosome | 12 |
| Molecular Note | An nls-cre gene was inserted at the initiator ATG of the gene, followed by a neomycin selection cassette. The endogenous regulatory sequences drive expression by E5 in the epiblast and by E7 expression is detectable in all primitive ectoderm but not endoderm or trophectoderm. |
| Mutations Made By | Dr. Michelle Tallquist, University of Hawaii |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Germline/Embryonic Expression
- Developmental Biology Research
- Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Genotype: Meox2tm1(cre)Sor related
- Developmental Biology Research
- Mesodermal Defects
- Research Tools
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Genetics Research
References
- Tallquist MD; Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26(2):113-5. PubMed: 10686601MGI: J:60933
Additional - Meox2tm1(cre)Sor related
- Ackermann J; Ashton G; Lyons S; James D; Hornung JP; Jones N; Breitwieser W. 2011. Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development. PLoS One 6(4):e19090. PubMed: 21533046MGI: J:172398
- Adams EJ; Chen XW; O'Shea KS; Ginsburg D. 2014. Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem 289(30):20858-70. PubMed: 24876386MGI: J:232065
- Amsellem S; Gburek J; Hamard G; Nielsen R; Willnow TE; Devuyst O; Nexo E; Verroust PJ; Christensen EI; Kozyraki R. 2010. Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule. J Am Soc Nephrol :. PubMed: 20798259MGI: J:164025
- Ananieva O; Macdonald A; Wang X; McCoy CE; McIlrath J; Tournier C; Arthur JS. 2008. ERK5 regulation in naive T-cell activation and survival. Eur J Immunol 38(9):2534-47. PubMed: 18792406MGI: J:141229
- Anghel SI; Bedu E; Vivier CD; Descombes P; Desvergne B; Wahli W. 2007. Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. J Biol Chem 282(41):29946-57. PubMed: 17699161MGI: J:126794
- Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. PubMed: 19251646MGI: J:147154
- Aubin J; Davy A; Soriano P. 2004. In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev 18(12):1482-94. PubMed: 15198985MGI: J:90769
- Barrow JR; Howell WD; Rule M; Hayashi S; Thomas KR; Capecchi MR; McMahon AP. 2007. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 312(1):312-20. PubMed: 18028899MGI: J:130205
- Beck-Cormier S; Escande M; Souilhol C; Vandormael-Pournin S; Sourice S; Pilet P; Babinet C; Cohen-Tannoudji M. 2014. Notchless is required for axial skeleton formation in mice. PLoS One 9(5):e98507. PubMed: 24875805MGI: J:216520
- Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. PubMed: 19409885MGI: J:150767
- Berman SD; West JC; Danielian PS; Caron AM; Stone JR; Lees JA. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A 106(35):14932-6. PubMed: 19706423MGI: J:153091
- Berman SD; Yuan TL; Miller ES; Lee EY; Caron A; Lees JA. 2008. The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Mol Cancer Res 6(9):1440-51. PubMed: 18819932MGI: J:207285
- Berthoud VM; Minogue PJ; Snabb JI; Dzhashiashvili Y; Novak LA; Zoltoski RK; Popko B; Beyer EC. 2016. Connexin23 deletion does not affect lens transparency. Exp Eye Res 146:283-288. PubMed: 27038752MGI: J:231436
- Besson A; Gurian-West M; Chen X; Kelly-Spratt KS; Kemp CJ; Roberts JM. 2006. A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 20(1):47-64. PubMed: 16391232MGI: J:103819
- Beutler LR; Wanat MJ; Quintana A; Sanz E; Bamford NS; Zweifel LS; Palmiter RD. 2011. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A 108(10):4206-11. PubMed: 21368124MGI: J:170830
- Bismuth K; Skuntz S; Hallsson JH; Pak E; Dutra AS; Steingrimsson E; Arnheiter H. 2008. An unstable targeted allele of the mouse mitf gene with a high somatic and germline reversion rate. Genetics 178(1):259-72. PubMed: 18202372MGI: J:130168
- Bowman-Colin C; Xia B; Bunting S; Klijn C; Drost R; Bouwman P; Fineman L; Chen X; Culhane AC; Cai H; Rodig SJ; Bronson RT; Jonkers J; Nussenzweig A; Kanellopoulou C; Livingston DM. 2013. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A 110(21):8632-7. PubMed: 23657012MGI: J:197442
- Bozec A; Bakiri L; Hoebertz A; Eferl R; Schilling AF; Komnenovic V; Scheuch H; Priemel M; Stewart CL; Amling M; Wagner EF. 2008. Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454(7201):221-5. PubMed: 18548006MGI: J:137646
- Bradley CK; Norton CR; Chen Y; Han X; Booth CJ; Yoon JK; Krebs LT; Gridley T. 2013. The snail family gene snai3 is not essential for embryogenesis in mice. PLoS One 8(6):e65344. PubMed: 23762348MGI: J:198115
- Brewer JR; Molotkov A; Mazot P; Hoch RV; Soriano P. 2015. Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev 29(17):1863-74. PubMed: 26341559MGI: J:226497
- Bruchas MR; Schindler AG; Shankar H; Messinger DI; Miyatake M; Land BB; Lemos JC; Hagan CE; Neumaier JF; Quintana A; Palmiter RD; Chavkin C. 2011. Selective p38alpha MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction. Neuron 71(3):498-511. PubMed: 21835346MGI: J:174677
- Bush JO; Soriano P. 2009. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev 23(13):1586-99. PubMed: 19515977MGI: J:150043
- Calo E; Quintero-Estades JA; Danielian PS; Nedelcu S; Berman SD; Lees JA. 2010. Rb regulates fate choice and lineage commitment in vivo. Nature 466(7310):1110-4. PubMed: 20686481MGI: J:163313
- Cao C; Gao Y; Li Y; Antalis TM; Castellino FJ; Zhang L. 2010. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest 120(6):1971-80. PubMed: 20458145MGI: J:161644
- Catalanotti F; Reyes G; Jesenberger V; Galabova-Kovacs G; de Matos Simoes R; Carugo O; Baccarini M. 2009. A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol 16(3):294-303. PubMed: 19219045MGI: J:199705
- Chan SF; Sances S; Brill LM; Okamoto S; Zaidi R; McKercher SR; Akhtar MW; Nakanishi N; Lipton SA. 2014. ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. J Neurosci 34(13):4640-53. PubMed: 24672010MGI: J:210451
- Chattopadhyaya B; Di Cristo G; Wu CZ; Knott G; Kuhlman S; Fu Y; Palmiter RD; Huang ZJ. 2007. GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. Neuron 54(6):889-903. PubMed: 17582330MGI: J:126581
- Cheah CS; Yu FH; Westenbroek RE; Kalume FK; Oakley JC; Potter GB; Rubenstein JL; Catterall WA. 2012. Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A 109(36):14646-51. PubMed: 22908258MGI: J:189897
- Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. PubMed: 17693261MGI: J:132329
- Chen H; Vermulst M; Wang YE; Chomyn A; Prolla TA; McCaffery JM; Chan DC. 2010. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141(2):280-9. PubMed: 20403324MGI: J:167952
- Chen L; Xie Z; Turkson S; Zhuang X. 2015. A53T human alpha-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci 35(3):890-905. PubMed: 25609609MGI: J:218892
- Cheung AF; Carter AM; Kostova KK; Woodruff JF; Crowley D; Bronson RT; Haigis KM; Jacks T. 2010. Complete deletion of Apc results in severe polyposis in mice. Oncogene 29(12):1857-64. PubMed: 20010873MGI: J:160399
- Cheung AF; Dupage MJ; Dong HK; Chen J; Jacks T. 2008. Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Res 68(22):9459-68. PubMed: 19010921MGI: J:141383
- Cohn RD; Henry MD; Michele DE; Barresi R; Saito F; Moore SA; Flanagan JD; Skwarchuk MW; Robbins ME; Mendell JR; Williamson RA; Campbell KP. 2002. Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell 110(5):639-48. PubMed: 12230980MGI: J:78838
- Collaco A; Jakab R; Hegan P; Mooseker M; Ameen N. 2010. Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. J Biol Chem 285(22):17177-87. PubMed: 20351096MGI: J:163890
- Coppiello G; Collantes M; Sirerol-Piquer MS; Vandenwijngaert S; Schoors S; Swinnen M; Vandersmissen I; Herijgers P; Topal B; van Loon J; Goffin J; Prosper F; Carmeliet P; Garcia-Verdugo JM; Janssens S; Penuelas I; Aranguren XL; Luttun A. 2015. Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake. Circulation 131(9):815-26. PubMed: 25561514MGI: J:234139
- Cuadrado A; Corrado N; Perdiguero E; Lafarga V; Munoz-Canoves P; Nebreda AR. 2010. Essential role of p18(Hamlet)/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. EMBO J :. PubMed: 20473270MGI: J:160524
- Davis S; Miura S; Hill C; Mishina Y; Klingensmith J. 2004. BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol 270(1):47-63. PubMed: 15136140MGI: J:92179
- Davy A; Aubin J; Soriano P. 2004. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18(5):572-83. PubMed: 15037550MGI: J:89008
- De Bruin A; Wu L; Saavedra HI; Wilson P; Yang Y; Rosol TJ; Weinstein M; Robinson ML; Leone G. 2003. Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proc Natl Acad Sci U S A 100(11):6546-51. PubMed: 12732721MGI: J:83621
- Delgado I; Dominguez-Frutos E; Schimmang T; Ros MA. 2008. The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death. Dev Dyn 237(3):649-58. PubMed: 18265010MGI: J:132122
- Ding X; Boney-Montoya J; Owen BM; Bookout AL; Coate KC; Mangelsdorf DJ; Kliewer SA. 2012. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab 16(3):387-93. PubMed: 22958921MGI: J:189018
- Donovan A; Lima CA; Pinkus JL; Pinkus GS; Zon LI; Robine S; Andrews NC. 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1(3):191-200. PubMed: 16054062MGI: J:129846
- Dougherty KJ; Zagoraiou L; Satoh D; Rozani I; Doobar S; Arber S; Jessell TM; Kiehn O. 2013. Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons. Neuron 80(4):920-33. PubMed: 24267650MGI: J:209344
- Duan SZ; Ivashchenko CY; Whitesall SE; D'Alecy LG; Duquaine DC; Brosius FC 3rd; Gonzalez FJ; Vinson C; Pierre MA; Milstone DS; Mortensen RM. 2007. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest 117(3):812-22. PubMed: 17304352MGI: J:120750
- Duan SZ; Usher MG; Foley EL 4th; Milstone DS; Brosius FC 3rd; Mortensen RM. 2010. Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice. Diabetologia 53(7):1493-505. PubMed: 20401461MGI: J:162169
- Eferl R; Hoebertz A; Schilling AF; Rath M; Karreth F; Kenner L; Amling M; Wagner EF. 2004. The Fos-related antigen Fra-1 is an activator of bone matrix formation. EMBO J 23(14):2789-99. PubMed: 15229648MGI: J:93053
- Essalmani R; Zaid A; Marcinkiewicz J; Chamberland A; Pasquato A; Seidah NG; Prat A. 2008. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A 105(15):5750-5. PubMed: 18378898MGI: J:134264
- Fahs SA; Hille MT; Shi Q; Weiler H; Montgomery RR. 2014. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. Blood 123(24):3706-13. PubMed: 24705491MGI: J:212401
- Fan Y; Mao R; Yu Y; Liu S; Shi Z; Cheng J; Zhang H; An L; Zhao Y; Xu X; Chen Z; Kogiso M; Zhang D; Zhang H; Zhang P; Jung JU; Li X; Xu G; Yang J. 2014. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med 211(2):313-28. PubMed: 24493797MGI: J:208320
- Fantauzzo KA; Soriano P. 2016. PDGFRbeta regulates craniofacial development through homodimers and functional heterodimers with PDGFRalpha. Genes Dev 30(21):2443-2458. PubMed: 27856617MGI: J:237202
- Flaherty JP; Spruce CA; Fairfield HE; Bergstrom DE. 2010. Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). Genesis :1-8. PubMed: 20645308MGI: J:164059
- Fossat N; Ip CK; Jones VJ; Studdert JB; Khoo PL; Lewis SL; Power M; Tourle K; Loebel DA; Kwan KM; Behringer RR; Tam PP. 2015. Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development 142(11):2069-79. PubMed: 25977363MGI: J:222248
- Fossat N; Radziewic T; Jones V; Tourle K; Tam PP. 2016. Conditional restoration and inactivation of Rbm47 reveal its tissue-context requirement for viability and growth. Genesis 54(3):115-22. PubMed: 26789794MGI: J:229897
- Foster BL; Sheen CR; Hatch NE; Liu J; Cory E; Narisawa S; Kiffer-Moreira T; Sah RL; Whyte MP; Somerman MJ; Millan JL. 2015. Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia. J Dent Res 94(5):706-14. PubMed: 25716980MGI: J:237759
- Frappart PO; Lee Y; Russell HR; Chalhoub N; Wang YD; Orii KE; Zhao J; Kondo N; Baker SJ; McKinnon PJ. 2009. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A 106(6):1880-5. PubMed: 19164512MGI: J:144617
- French WJ; Creemers EE; Tallquist MD. 2008. Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol 28(18):5646-57. PubMed: 18606782MGI: J:140245
- Fukuda T; Scott G; Komatsu Y; Araya R; Kawano M; Ray MK; Yamada M; Mishina Y. 2006. Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis 44(4):159-67. PubMed: 16604518MGI: J:109498
- Funato N; Nakamura M; Richardson JA; Srivastava D; Yanagisawa H. 2012. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet 21(11):2524-37. PubMed: 22371266MGI: J:183770
- Funato N; Nakamura M; Richardson JA; Srivastava D; Yanagisawa H. 2015. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet 24(2):424-35. PubMed: 25209980MGI: J:217210
- Fuxa M; Busslinger M. 2007. Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function. J Immunol 178(5):3031-7. PubMed: 17312149MGI: J:144100
- Galabova-Kovacs G; Catalanotti F; Matzen D; Reyes GX; Zezula J; Herbst R; Silva A; Walter I; Baccarini M. 2008. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol 180(5):947-55. PubMed: 18332218MGI: J:136032
- Galabova-Kovacs G; Matzen D; Piazzolla D; Meissl K; Plyushch T; Chen AP; Silva A; Baccarini M. 2006. Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A 103(5):1325-30. PubMed: 16432225MGI: J:105998
- Galan-Caridad JM; Harel S; Arenzana TL; Hou ZE; Doetsch FK; Mirny LA; Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57. PubMed: 17448993MGI: J:149654
- Gao X; Shin YH; Li M; Wang F; Tong Q; Zhang P. 2010. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 5(11):e14005. PubMed: 21103374MGI: J:166984
- Garcia-Gonzalez MA; Menezes LF; Piontek KB; Kaimori J; Huso DL; Watnick T; Onuchic LF; Guay-Woodford LM; Germino GG. 2007. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet 16(16):1940-50. PubMed: 17575307MGI: J:125113
- Garcia-Gonzalez MA; Outeda P; Zhou Q; Zhou F; Menezes LF; Qian F; Huso DL; Germino GG; Piontek KB; Watnick T. 2010. Pkd1 and Pkd2 are required for normal placental development. PLoS One 5(9):. PubMed: 20862291MGI: J:165114
- Gerits N; Kostenko S; Moens U. 2007. In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice. Transgenic Res 16(3):281-314. PubMed: 17219248MGI: J:122230
- Goldstein JA; Bogdanovich S; Beiriger A; Wren LM; Rossi AE; Gao QQ; Gardner BB; Earley JU; Molkentin JD; McNally EM. 2014. Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. Hum Mol Genet 23(25):6722-31. PubMed: 25070948MGI: J:216218
- Golub JS; Tong L; Ngyuen TB; Hume CR; Palmiter RD; Rubel EW; Stone JS. 2012. Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin. J Neurosci 32(43):15093-105. PubMed: 23100430MGI: J:191218
- Gray EE; Winship D; Snyder JM; Child SJ; Geballe AP; Stetson DB. 2016. The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity 45(2):255-66. PubMed: 27496731MGI: J:234263
- Grote D; Boualia SK; Souabni A; Merkel C; Chi X; Costantini F; Carroll T; Bouchard M. 2008. Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet 4(12):e1000316. PubMed: 19112489MGI: J:142876
- Grote D; Souabni A; Busslinger M; Bouchard M. 2006. Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development 133(1):53-61. PubMed: 16319112MGI: J:104408
- Guimaraes-Camboa N; Stowe J; Aneas I; Sakabe N; Cattaneo P; Henderson L; Kilberg MS; Johnson RS; Chen J; McCulloch AD; Nobrega MA; Evans SM; Zambon AC. 2015. HIF1alpha Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell 33(5):507-21. PubMed: 26028220MGI: J:239361
- Harris SE; MacDougall M; Horn D; Woodruff K; Zimmer SN; Rebel VI; Fajardo R; Feng JQ; Gluhak-Heinrich J; Harris MA; Abboud Werner S. 2012. Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects. Bone 50(1):42-53. PubMed: 21958845MGI: J:180199
- Hartmann J; Dragicevic E; Adelsberger H; Henning HA; Sumser M; Abramowitz J; Blum R; Dietrich A; Freichel M; Flockerzi V; Birnbaumer L; Konnerth A. 2008. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 59(3):392-8. PubMed: 18701065MGI: J:139695
- Hasenfuss SC; Bakiri L; Thomsen MK; Hamacher R; Wagner EF. 2014. Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism. Hepatology 59(1):261-73. PubMed: 23703832MGI: J:213764
- Hasenfuss SC; Bakiri L; Thomsen MK; Williams EG; Auwerx J; Wagner EF. 2014. Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metab 19(1):84-95. PubMed: 24411941MGI: J:210545
- Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. PubMed: 14516668MGI: J:83040
- Herrick TM; Cooper JA. 2004. High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res 126(2):121-8. PubMed: 15249135MGI: J:91679
- Herrick TM; Cooper JA. 2002. A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development 129(3):787-96. PubMed: 11830577MGI: J:74239
- Heusner CL; Beutler LR; Houser CR; Palmiter RD. 2008. Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits. Genesis 46(7):357-67. PubMed: 18615733MGI: J:138586
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