MSM/Ms was derived from wild mice trapped in Mishima Prefecture, Japan. MSM exhibits resistance to the lymphoma development and carries a Tlr3 variant that results in hypo-responsiveness to poly(I:C) stimulation. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.Read More +
MSM/Ms was derived from wild mice trapped in Mishima Prefecture, Japan.
This strain has been reported to be resistant to the development of lymphoma, due to at least two loci in crosses involving strain SL/Kh (Pataer et. al., 1996). C3HxMSM F1 hybrids treated with N-methyl-N-nitrosourea (MNU) develop squamous cell carcinomas of the forestomach with about 20% and 15% having mutations in H-ras and p53, respectively (Masui et. al., 1997).
Stephan et. al. reported that wild-derived strains, MSM, CZECH (Stock No. 001144) and MOLF (Stock No. 000550), exhibit decreased secretion of TNF in response to stimulation by poly(I:C) (a synthetic analog of double-stranded RNA), the result of a P369L substitution in Tlr3. Response to Tlr2, Tlr4 and Tlr7-agonists is normal.
Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.
The MSM inbred strain was derived from Mus musculus molossinus mice trapped in Mishima Prefecture, Japan in April 1978 and maintained by Dr Kazuo Moriwaki (Okumoto et al. 1994). Mice were imported to The Jackson Laboratory May 2000 from Dr Moriwaki's colleague, Professor Toshihiko Shiroishi.
Currently there are no related genes or alleles for this strain.
When using the MSM/MsJ mouse strain in a publication, please include JAX stock #003719 in your Materials and Methods section.
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
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