This knock-out allele is located on the X-chromosome. Motor development and function are normal in homozygous mutant mice and no early neurologic deficits were evident through the first six months of age. There are no significant differences between mutant mice and wild type mice in the rotarod test and no significant difference in the performance compared to wild type 129/Sv and C57BL/6 background strains.
 Homozygous female and hemizygous male mice are viable with a normal lifespan. Most of them breed well, but due to atrophy of ovary/testis, up to 10 percent of homozygous and up to 20 percent of hemizygous mice are not fertile. Despite this, the donating investigator reported no problems breeding their colony. They have never observed the atrophy in heterozygous mice.
 In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

These Abcd1 knock-out mice exhibit no significant neurologic deficits.

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