This strain expresses Cdc37 under the direction of a probasin promoter resulting in over expression in prostatic epithelia, a tissue where the Cdc37 gene product is absent or present at low levels. While less than ten percent of wildtype littermates develop some degree of hyperplasia by twelve months of age, eighty percent of these transgenic mice exhibit prostatic growth-related disturbances by eight months. Expression is limited to the ventral lobe of the prostate. Correspondingly, hyperplasia is restricted to the ventral prostate. Hyperplasia is frequently accompanied by necrosis. The transgenic insertion site is assumed to be on the Y chromosome as all transgenics are male.

These PB-CDC37.1 mice express a transgene containing Cdc37 under the direction of a probasin promoter with males exhibiting prostatic growth-related disturbances.

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